Beta ccaat enhancer binding proteins. Medical search. Frequent questions

In particular, mutations in DNA binding sites recognized by transcription factors can alter regulator binding affinities and, consequently, expression of target genes. (biomedcentral.com)
Cancer somatic mutations in binding sites of selected transcription factors have been found under positive selection. (biomedcentral.com)
For many transcription factors, including multiple members of FOX, HOX, and NR families, we show that human cancers accumulate fewer mutations than expected by chance that increase or decrease affinity of predicted binding sites. (biomedcentral.com)
Frequencies of synonymous and non-synonymous substitutions allow studying selection of cancer somatic mutations in protein-coding regions [ 11 ]. (biomedcentral.com)
Mutations in WDR45 and WDR45B are genetically linked with beta-propeller protein-associated neurodegeneration (BPAN) and intellectual disability (ID), respectively. (biomed.news)

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene. (wikipedia.org)
Upon further investigation, it was noted that CEBPB has close to 8,600 similar correlations with biological manipulations ranging from molecules to proteins or abstracted microRNAs. (wikipedia.org)
Genes coding for transporter proteins that confer multidrug resistance to the cells have also been found to be activated by CEBPB. (wikipedia.org)
Since CEBPB is a transcription factor in regulating gene expression, patients with metastatic melanoma may benefit long-term by blocking proteins such as CTLA-4 Other. (wikipedia.org)
Moreover, we found that the upregulation of AQP9 by G-CSF depends on the transcription factor CCAAT enhancer binding protein beta (CEBPB). (biomedcentral.com)
CCAAT/enhancer-binding protein beta (Cebpb) is a key factor of Runx2 expression and our previous study has reported two CCD signs including hyperdontia and elongated coronoid process of the mandible in Cebpb deficient mice. (biomedcentral.com)

Employing chromatin immunoprecipitation, we demonstrate that C/EBP beta, CREB, ATF-2, and CHOP10 are bound to the Pgc-1 alpha proximal CRE, but CHOP10 does not bind in HIB-1B cell lysates. (elsevierpure.com)

Forskolin stimulation and C/EBP beta overexpression in 3T3-L1 cells increased C/EBP beta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1 alpha proximal CRE. (elsevierpure.com)
CREB binding protein [Source:HGNC Symbol;Ac. (gsea-msigdb.org)

The lab currently focuses on functions of transcription factors of the CCAAT Enhancer Binding Protein family (C/EBPs). (mdc-berlin.de)
CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular growth and differentiation, metabolism, and inflammation [ 18 ]. (biomedcentral.com)

The protein encoded by this intronless gene is a bZIP transcription factor that can bind as a homodimer to certain DNA regulatory regions. (wikipedia.org)
Figure 4: Identification of enriched motifs within the estrogen receptor binding sites and validation of transcription factor binding. (nature.com)
The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
upstream binding transcription factor [Sour. (gsea-msigdb.org)
transforming growth factor beta 2 [Source:H. (gsea-msigdb.org)
myocyte enhancer factor 2C [Source:HGNC Sym. (gsea-msigdb.org)
Here we present analysis of transcription factor binding motifs co-localized with non-coding variants. (biomedcentral.com)
The main inhibitor of the insulin gene is a leucine factor enhancer of the form CCAAT of the binding protein (Poretsky, 2010). (brillianttermpapers.org)
The article shows how the binding factor was improved by increasing its density to balance on the high complexity of the GWAS system. (brillianttermpapers.org)
Mesenchymal stem cells (MSCs), which are activated by secreted, active transforming growth factor beta 1 (TGFβ) to migrate to bone-resorptive sites and differentiate into osteoblasts (see below). (biomedcentral.com)

TATA-box binding protein [Source:HGNC Symbo. (gsea-msigdb.org)
E1A binding protein p300 [Source:HGNC Symbo. (gsea-msigdb.org)
GATA binding protein 3 [Source:HGNC Symbo. (gsea-msigdb.org)

Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)
Currently, we concentrate on the functions of "pioneering transcription factors" CCAAT Enhancer Binding Proteins alpha and beta ( C/EBPα,β ) in development and disease. (mdc-berlin.de)
Hematopoietic transcription factors (= gene regulatory proteins) concertedly control cell proliferation, lineage commitment, and cell differentiation. (mdc-berlin.de)
Here, we discuss how transcription factors, and their unique position as the gatekeepers of cellular identity, are exploited in cell reprogramming protocols by exploring work focusing on one reprogramming paradigm - the transdifferentiation of hepatocytes to pancreatic beta cells (β-cell). (silverchair.com)
Further analysis of transcription factors with conserved binding motifs can reveal cell regulatory pathways crucial for the survivability of various human cancers. (biomedcentral.com)

The "AUG" start codons, resulting in multiple protein isoforms" [39]. (wikipedia.org)

Myostatin binding to type IIB activin receptor (ActRIIB) on muscle surface induces the recruitment and activation of activin receptor-like kinase 5 (ALK5), and eventually leads to forkhead box O3 (FoxO3a)-dependent transcription to promote muscle protein breakdown via the ubiquitin-proteasome system ( 23 ). (spandidos-publications.com)
The response to GLP-1 was mimicked by forskolin and largely inhibited by the protein kinase A (PKA) inhibitors, H89 and myristoylated PKI(14-22) amide, indicating partial mediation via a cAMP/PKA pathway. (diabetesjournals.org)
S-phase kinase associated protein 2 [Source. (gsea-msigdb.org)
mitogen-activated protein kinase 11 [Source. (gsea-msigdb.org)

2014. Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. . (oregonstate.edu)

mice unable to express CEBP-beta have macrophages that cannot differentiate (specialize) and thus are unable to perform all their biological functions - including macrophage-mediated muscle repair. (wikipedia.org)
Here we show that in mice exposed to a cold environment for 24 h, Pgc-1 alpha, Ucp1, and C/ebp beta but not C/ebp alpha or C/ebp delta expression were increased in BAT. (elsevierpure.com)
2002. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)
To demonstrate the flexibility and modular nature of the liposome system, 10 recombinant surface antigens representing distinct influenza virus strains were bound simultaneously to generate a highly multivalent protein particle that with 5 ng individual antigen dosing induced antibodies in mice that specifically recognized the constituent immunogens and conferred protection against heterologous H5N1 influenza virus challenge. (cdc.gov)

The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. (wikipedia.org)
Expression and regulation of the meprin beta gene in human cancer cells. (uni-muenster.de)
2003. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. . (oregonstate.edu)

Antibodies towards S and N proteins of other coronaviruses (MERS, 229E, OC43, NL63 and HKU1) were detected in all groups without a significant correlation with SARS-CoV-2 antibody levels. (bvsalud.org)
The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following SARS-CoV-2 infection are unknown. (cdc.gov)

The activity of this protein is important in regulating genes involving the immune and inflammatory responses, among other processes. (wikipedia.org)
It binds to the regulatory regions of several phase and cytokine genes"[38]. (wikipedia.org)
We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
AhR regulates the transcription of diverse genes through binding to the xenobiotic-responsive element (XRE). (biomedcentral.com)
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that the candidate reference genes were significantly enriched in cellular metabolic process, protein metabolic process and ribosome in early development and normal adult tissues as well as in cellular localization and endocytosis in the hindgut under sulfide stress. (biomedcentral.com)
Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. (lookformedical.com)
Here, we report the identification of two genes encoding beta-defensin homologues in the rat. (lookformedical.com)
The beta-defensin genes mapped closely on rat chromosome 16 and were closely linked to the alpha-defensins genes, suggesting that they are part of a gene cluster, similar to the organization reported for humans. (lookformedical.com)

We have previously reported that C/EBP beta specifically binds to the CRE on the proximal Pgc-1 alpha promoter and increases forskolin-sensitive Pgc-1 alpha and Ucp1 expression in white 3T3-L1 preadipocytes. (elsevierpure.com)
In HIB-1B, brown preadipocytes, forskolin increased expression of Pgc-1 alpha, Ucp1, and C/ebp beta early in differentiation and inhibited Chop10 expression. (elsevierpure.com)

As previously mentioned, "It contains a leucine zipper (bZIP) domain and the encoded protein functions as a homodimer. (wikipedia.org)

nuclear protein 1, transcriptional regula. (gsea-msigdb.org)

protein phosphatase 2 catalytic subunit alp. (gsea-msigdb.org)

The AhR is activated by binding to ligands, including dioxins, translocates from the cytoplasm to the nucleus and then binds to the consensus sequence known as XRE (xenobiotic responsive element) [ 7 ]. (biomedcentral.com)
DNA-triggered cGAS activation is normally an essential initial part of the pathway, which is normally believed to take place in the cytoplasm, as STING is a transmembrane proteins that's anchored in the endoplasmic reticulum network generally. (mycareerpeer.com)

Observational work has shown that expression of CEBP-beta in blood leukocytes is positively associated with muscle strength in humans, emphasizing the importance of the immune system, and particularly macrophages, in the maintenance of muscle function. (wikipedia.org)
They have been isolated in several species, and in humans, two beta-defensins have been identified. (lookformedical.com)
Rice Protein Matrix Enhances Circulating Levels of Xanthohumol Following Acute Oral Intake of Spent Hops in Humans. (oregonstate.edu)

Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)
Figure 2: Estrogen-mediated transcript changes and correlation with estrogen receptor binding. (nature.com)
Figure 3: Estrogen receptor and RNA PolII binding relative to specific gene targets. (nature.com)
Figure 7: Assessment of estrogen receptor binding properties in different cell systems. (nature.com)
In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)
ATO can target and degrade the promyelocytic leukemia-retinoic acid receptor-α (PML/RARα) protein, which is the abnormal protein product generated by APL-specific t(15;17) chromosomal translocation and is essential for the leukemogenesis of APL [ 4 , 5 ]. (biomedcentral.com)
Angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and calcium channel blockers, rather than beta-adrenergic blockers, should be considered as first-line therapy for hypertension in patients with type 2 diabetes mellitus who are obese. (medscape.com)
80%) against epitopes residing outside the receptor-binding domain (RBD). (cdc.gov)
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a candidate vaccine antigen that binds angiotensin-converting enzyme 2(ACE2), leading to virus entry. (cdc.gov)

It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)
MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)

One gene was highly similar to the human beta-defensin-1 (HBD-1) gene and mouse beta-defensin-1 gene at both the nucleic acid and amino acid levels and was termed rat beta-defensin-1 (RBD-1). (lookformedical.com)

Human beta-defensins may play an important role in the innate defenses against oral microorganisms. (lookformedical.com)

surfactant protein D [Source:HGNC Symbol;Ac. (gsea-msigdb.org)
C-reactive protein [Source:HGNC Symbol;Ac. (gsea-msigdb.org)
interleukin 1 beta [Source:HGNC Symbol;Ac. (gsea-msigdb.org)

Different from the APL cells, most non-APL AML cells express low levels of the ATO transporter Aquaporin-9 (AQP9) protein, making them less sensitive to ATO treatment. (biomedcentral.com)

When overexpressed in the murine myoblast cell line C2C12 or in primary myoblasts, C/EBPβ reduced MyoD and other myogenic protein levels during differentiation, in addition to reducing myoblast fusion. (biomedcentral.com)

It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. (wikipedia.org)
It can also form heterodimers with enhancer-binding proteins such as alpha, delta, and gamma. (wikipedia.org)
Knockdown of Chop10 in 3T3-L1 cells using siRNA increased Pgc-1 alpha transcription, whereas siRNA against C/ebp beta in HIB-1B cells decreased Pgc-1 alpha and Ucp1 expression. (elsevierpure.com)
CCAAT enhancer binding protein alpha [Sourc. (gsea-msigdb.org)

In this study, we characterized the expression of HBD-1 and HBD-2 mRNAs within the major salivary glands, tongue, gingiva, and buccal mucosa and detected beta-defensin peptides in salivary secretions. (lookformedical.com)
Cellular identity is determined by the transcriptional profile which comprises the subset of mRNAs, and therefore proteins, being expressed by a cell at a given point in time. (silverchair.com)

The mRNA and protein expression were respectively measured by quantitative reverse transcription PCR (RT-qPCR) and western blotting. (biomedcentral.com)
Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. (bvsalud.org)
A microRNA strand is transferred to the Argonaute complex (AGO), forming an RNA-induced silencing complex (RISC), and guides it to pair with the target mRNA through binding of the microRNA seed sequence with the microRNA recognition site on the mRNA. (archivesofmedicalscience.com)

In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. (wikipedia.org)
NFAT binds to three distinct NFAT elements within the rat I insulin promoter and activates insulin gene transcription. (diabetesjournals.org)

Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. (lookformedical.com)
beta-Defensins are cationic peptides with broad-spectrum antimicrobial activity that are produced by epithelia at mucosal surfaces. (lookformedical.com)
beta-Defensins are cationic peptides with broad-spectrum antimicrobial activity that may play a role in mucosal defenses of several organs. (lookformedical.com)
Moreover, the transplantation of BMMSCs can decrease aberrant amyloid-beta peptides as well as tau aggregates, inhibit neuroinflammation, and stimulate synaptogenesis. (biomedcentral.com)
The pathological characteristics of AD are exhibited by the extracellular plaques of amyloid beta (Aβ) peptides and the hyper-phosphorylation of tau protein in neurofibrillary tangles [ 6 ]. (biomedcentral.com)
RESULTS: All patients exhibited high IgG reactivity against the central region and C-terminus peptides of both SARS-CoV-2 N and S proteins. (bvsalud.org)
Notably, we revealed a differential antibody response to SARS-CoV-2 peptides of M protein between adults, mainly reacting against the C-terminus epitopes, and children, who were highly responsive to the N-terminus of M protein. (bvsalud.org)

We disclose molecular and functional interactions between regulatory proteins and determine how they orchestrate the complex process of proper gene expression and thereby reveal novel therapeutic targets. (mdc-berlin.de)
However, little is known about the expression of HBD-1 or HBD-2 in tissues of the oral cavity and whether these proteins are secreted. (lookformedical.com)
To test whether beta-defensin expression was inducible, gingival keratinocyte cell cultures were treated with interleukin-1beta (IL-1beta) or bacterial lipopolysaccharide (LPS) for 24 h. (lookformedical.com)
Because beta-defensins are salt-sensitive epithelial products, we looked for pulmonary beta-defensin expression. (lookformedical.com)

3%). The organic phase is mainly formed by collagen type I fibers, which provide elasticity and flexibility to bone, but also non-collagenous proteins as well, such as cytokines, growth factors, and proteoglycans. (biomedcentral.com)

Key gene regulatory proteins control cell multiplication and instruct cells to adopt distinct cell fates. (mdc-berlin.de)

Increasing evidence indicates that pro-inflammatory mediators, protein degradation-associated factors, and some other circulating mediators drive this process ( 18 ). (spandidos-publications.com)

This increases the glucose levels in the beta cells. (brillianttermpapers.org)

Such stability of binding motifs is even more exhibited in DNase accessible regions. (biomedcentral.com)

Extended hyperglycemia causes insulin impairment in the beta cells. (brillianttermpapers.org)
Varying insulin impairment is caused when the insulin gene is not regulated well by the binding proteins. (brillianttermpapers.org)

WDR45 and WDR45B are β-propeller proteins belonging to the WIPI (WD repeat domain, phosphoinositide interacting) family. (biomed.news)

Assessment of potential binding affinity changes induced by substitutions allows studying selection of sequence variants in binding sites in a way resembling usage of non-synonymous and synonymous substitutions in codons. (biomedcentral.com)

Beef has high nutritional value from children to seniors, is a rich source of protein (essential amino acids), iron, zinc, B vitamins and essential polyunsaturated fatty acids such as linoleic and linolenic acid [ 2 ]. (biomedcentral.com)

Anatomy31

Organisms8

Diseases6

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes66

Disciplines and Occupations1

Information Science3

Mutations5

CEBPB6

Chromatin1

CREB2

EBPs2

Factor13

Source:HGNC Symbo3

Transcription factors5

Isoforms1

Kinase4

Deficiency1

Mice4

Regulation3

Antibodies2

Genes8

Forskolin2

Leucine1

Nuclear protein1

Phosphatase1

Cytoplasm2

Humans3

Receptor9

MicroRNAs2

Nucleic acid1

Innate1

Symbol3

Transporter1

Differentiation1

Alpha4

MRNAs2

MRNA3

Promoter2

Peptides7

Expression4

Cytokines1

Distinct1

Inflammatory1

Glucose1

Motifs1

Insulin2

Family1

Substitutions1

Zinc1