Loading...
  • regulation
  • Mosimann C, Hausmann G, Basler K. Beta-catenin hits chromatin: regulation of Wnt target gene activation. (springer.com)
  • Transgenic mice that over-expressed mutant presenilin-1 show an increase of beta-amyloid-42(43) in the brain, which suggest presenilin-1 plays an important role in beta-amyloid regulation and can be highly related to Alzheimer's disease. (wikipedia.org)
  • mutations
  • Grigoryan T, Wend P, Klaus A, Birchmeier W. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. (springer.com)
  • Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
  • These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). (wikipedia.org)
  • nucleus
  • This study also showed that signaling via the insulin/Insulin-like growth factor 1 receptor led to increased levels of HDAC7 in the cytosol than the nucleus and increased levels of active β-catenin, indicating that HDAC7 associates with β-catenin. (wikipedia.org)
  • modulation
  • Another study supported the conclusion that HDAC7 and β-catenin associate together by demonstrating that HDAC7 controls endothelial cell growth through modulation of β-catenin. (wikipedia.org)
  • peptide
  • synthetic peptide corresponding to the C-terminal region (amino acids 768-781) of human/mouse β-catenin, conjugated with gluteraldehyde to KLH. (genetex.com)
  • Western Blot of Catenin, beta (p120) in human brain 1) absence and 2) presence of immunizing peptide and 3) mouse brain lysate using Catenin, beta (p120) PAb. (genetex.com)
  • human
  • Over the past two decades, interdisciplinary research has tremendously advanced our knowledge of β-catenin function and its involvement in human disorders (Takemaru et al. (springer.com)
  • Molecular cloning reveals alternative splice forms of human alpha(E)-catenin. (ebi.ac.uk)
  • membrane
  • Transgenic expression of a CD97 in mice enhanced levels of nonphosphorylated membrane-bound β-catenin and phosphorylated Akt. (wikipedia.org)
  • form
  • These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). (wikipedia.org)
  • important
  • Transgenic mice that over-expressed mutant presenilin-1 show an increase of beta-amyloid-42(43) in the brain, which suggest presenilin-1 plays an important role in beta-amyloid regulation and can be highly related to Alzheimer's disease. (wikipedia.org)
  • common
  • Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. (wikipedia.org)
  • presence
  • They showed that cleavage by alpha- and beta- secretase was still normal without the presence of presenilin-1. (wikipedia.org)