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  • Reactions
  • Beta-ketoacyl-ACP synthases I and II only catalyze acyl-ACP reactions with malonyl ACP. (wikipedia.org)
  • Residues from both domains contribute to substrate binding and catalysis In animals and in prokaryotes, beta-ketoacyl-ACP synthase is a domain on type I FAS, which is a large enzyme complex that has multiple domains to catalyze multiple different reactions. (wikipedia.org)
  • molecules
  • The conversion of beta-carotene (provitamin A) to 2 molecules of vitamin A (retinol) is accelerated by thyroxine and hyperthyroidism, respectively. (medcapsules.com)
  • Galactoside permease is a protein coded for by the lacY gene of the "lac" operon, and is found bound to the membrane of a cell for the purpose of binding galactoside molecules that have been solubilized. (wikipedia.org)
  • gene
  • The reaction sequence is carried out by a series of individual soluble proteins that are each encoded by a discrete gene, and the pathway intermediates are shuttled between the enzymes. (wikipedia.org)
  • One known example of these transport proteins is the melibiose, or melB, carrier protein derived from the melB gene of E. coli. (wikipedia.org)
  • acetoacetyl
  • Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyric acid synthesis or steroid biogenesis. (wikipedia.org)
  • oxidation
  • Biotin is catabolized by beta-oxidation of the valeric acid side chain or oxidation of sulfur in the heterocyclic ring. (genome.jp)
  • Thiolases are ubiquitous enzymes that have key roles in many vital biochemical pathways, including the beta oxidation pathway of fatty acid degradation and various biosynthetic pathways. (wikipedia.org)
  • 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. (wikipedia.org)
  • encodes
  • The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. (wikipedia.org)
  • structural
  • The PDBFlex database explores the intrinsic flexibility of protein structures by analyzing structural variations of the same protein across the archive. (rcsb.org)
  • This allows for the easy identification of regions and types of structural flexibility present in a protein of interest. (rcsb.org)
  • Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. (genome.jp)
  • Synthesis
  • TGF beta 2 regulates cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix and is also involved in embryogenesis, tissue remodeling and wound healing. (fishersci.co.uk)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • strain
  • This strain of beta-galactoside permease is known it transport melibiose and other galactosides across the cell membrane using hydrogen, sodium, or lithium ions in cotransport. (wikipedia.org)
  • genes
  • Type II FASs are dissociated systems, meaning the component enzymes are independent proteins encoded by a series of separate genes. (wikipedia.org)
  • RhlA and RhlB respectively, are expected to form a complex because of the operonic nature of the genes which encode these two proteins and because both proteins are necessary for production of rhamnolipids. (wikipedia.org)
  • Annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • membrane
  • The protein is part of a system whose main function is to catalyze the accumulation and transport of lactose and other beta-galactosides across the permeable barrier of a membrane. (wikipedia.org)
  • Insofar, Nikaido concluded that this correlation suggested that phospholipids are involved in the process of transporting beta-galactosides through the cell membrane. (wikipedia.org)
  • coli
  • Early studies by Hiroshi Nikaido in 1962 suggest a direct relationship between the amount of beta-galactoside permease activity in a cell and the turnover rate of phospholipids in E. coli. (wikipedia.org)
  • nucleic acids
  • Nucleic acids encoding the fusion proteins, methods of preparing same and uses thereof are also described. (patentsencyclopedia.com)
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • Adaptor
  • GAB2 along with many other adaptor, scaffold, and docking proteins, was discovered in the mid-1990s during the isolation and cloning of protein tyrosine kinase substrates and association partners. (wikipedia.org)
  • intracellular
  • Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. (wikipedia.org)
  • GAB2 mediates the interactions between receptor tyrosine kinases (RTK) or non-RTK receptors, such as G protein coupled receptors, cytokine receptors, multichain immune recognition receptors and integrins, and the molecules of the intracellular signaling pathways. (wikipedia.org)
  • By providing a platform to host a wide array of interactions from extracellular inputs to intracellular pathways, GAB proteins can act as a gatekeeper to the cell, modulating and integrating signals as they pass them along, to control the functional state within the cell. (wikipedia.org)
  • regulate
  • Together with histone acetylases (HATs), HDACs regulate acetylation level of histones (H3, H2AK5, H4K5, H4K12, H2B, H4K8, and H4K16) as well as some other proteins (p65 and myocyte enhancer factor 2) [ 5 ]. (hindawi.com)
  • The structure, function and molecular biology of Ca2+ dependent regulatory proteins (particularly calmodulin) and the target proteins which they regulate is under study. (uky.edu)
  • variants
  • At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4. (wikipedia.org)
  • this transcript contains an alternate open reading frame (ARF) that specifies a protein that is structurally unrelated to the products of the other variants. (wikipedia.org)
  • coat
  • If an embryo has not initiated the thinning process naturally, a small "window" is created chemically in the wall of the protein coat using a dilute acidic solution pulsed onto the embryo surface through an extremely fine glass needle. (arizonafertility.com)
  • degradation
  • The ARF product functions as a stabilizer of the tumor suppressor protein p53, as it can interact with and sequester MDM2, a protein responsible for the degradation of p53. (wikipedia.org)
  • bound
  • Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15). (wikipedia.org)
  • vitro
  • Leukocyte cell-derived chemotaxin-2 (LECT2) is a protein first described in 1996 as a chemotactic factor for neutrophils, i.e. it stimulated human neutrophils to move directionally in an in vitro assay system. (wikipedia.org)
  • indicate
  • These findings indicate that LECT is an evolutionary conserved protein, has one or more important functions, and may be involved in various diseases. (wikipedia.org)
  • interaction
  • LMDs are docking proteins that function as platforms mediating interaction between different signaling pathways and assisting with signal integration. (wikipedia.org)
  • found
  • Serum ferritin" presents a paradox, as the iron storage protein ferritin is not synthesised in serum yet is to be found there. (rsc.org)
  • p16 was originally found in an "open reading frame of 148 amino acids encoding a protein of molecular weight 15,845 comprising four ankyrin repeats. (wikipedia.org)
  • It is on the C-terminal tail that the various conserved protein binding motifs and phosphorylation sites of GAB2 are found. (wikipedia.org)
  • functional
  • In drug-treated diabetic pregnancies in which glucose levels in the woman are uncontrolled, neural tube and cardiac defects in the early-developing brain, spine, and heart depend upon functional GLUT2 carriers, and defects in the GLUT2 gene have been shown to be protective against such defects in rats. (wikipedia.org)
  • known
  • The effects of all the pathways activated by GAB proteins are not known, but it is easy to see that amplification of signal can progress quickly and these proteins can have large effects on the state of the cell. (wikipedia.org)
  • immune
  • Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
  • Because these proteins are recognised as foreign, when they are processed by the host cells and displayed on their surface, the immune system is alerted, which then triggers immune responses. (wikipedia.org)
  • apparatus
  • A second major area of study concerns depolarization depemndent reversible phodsphorylation of various protein factors of the vesicular neurosecretory apparatus and the possible dysfunction in this system in epilepsy. (uky.edu)
  • Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (wikipedia.org)
  • cell
  • The C-terminal domain of Beta2-adaptin is a protein domain is involved in cell trafficking by aiding import and export of substances in and out of the cell. (wikipedia.org)
  • The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. (wikipedia.org)
  • In this cell-free biosystem, beta-1,4-glycosidic bond-linked cellulose is partially hydrolyzed to cellobiose. (wikipedia.org)
  • family
  • This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like domains, 7 LDL-R class A domains, and 6 LDL-R class B repeats. (wikipedia.org)
  • The N-terminal is characterized by a Pleckstrin Homology (PH) domain that is the most highly conserved region between all members of the GAB family of proteins. (wikipedia.org)
  • several
  • This theory suggests that the disordered domain is looped back to connect to the N-terminal, structured region several times to make the protein more compact. (wikipedia.org)
  • usually
  • It is the best alternative to cow's milk cheese due to its low content of lactose, easier to digest, contains type 2 casein proteins and is usually less inflammatory and allergenic. (healthbenefitstimes.com)
  • expression
  • Intron A may sometimes be included to improve mRNA stability and hence increase protein expression. (wikipedia.org)
  • Because the plasmid is the "vehicle" from which the immunogen is expressed, optimising vector design for maximal protein expression is essential. (wikipedia.org)
  • One way of enhancing protein expression is by optimising the codon usage of pathogenic mRNAs for eukaryotic cells. (wikipedia.org)
  • function
  • Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver hepatocyte cells that regulates the function of other cells: it is a hepatocyte-derived, hormone-like, signaling protein. (wikipedia.org)
  • A third domain of the protein is rich in O-linked oligosaccharides but appears to show little function. (wikipedia.org)
  • cells
  • Taking a systems approach, we develop and summarise the view that "serum ferritin" actually originates from damaged cells (and thus reflects cellular damage), that it contains some iron but has lost or liberated most of its normal content, and that since the protein part of ferritin is assumed to be benign, that it is this (initially) free iron that correlates with and is causative of disease. (rsc.org)
  • Using very sensitive methods, LECT2 protein can also be detected at low levels in the endothelial cells of hepatic arteries and veins including central veins. (wikipedia.org)
  • The DNA is injected into cells, whose "inner machinery" uses the DNA to synthesize the proteins. (wikipedia.org)
  • important
  • The archaea protein exhibits a greater symmetry in its primary sequence and in the distribution of electrostatic charge, which is important because the higher symmetry lowers the protein's ability to bind the TATA box in a polar manner. (wikipedia.org)
  • domain
  • 4. The fusion protein according claim 1, wherein the translocation domain is the H N domain of a clostridial neurotoxin. (patentsencyclopedia.com)
  • This domain has a three-layer arrangement, alpha-beta-alpha, with a bifurcated antiparallel beta-sheet. (wikipedia.org)
  • A, B and C. A and B are closely linked while C is separated by the YWTD repeat region, which adopts a beta-propeller conformation (LDL-R class B domain). (wikipedia.org)
  • GAB2 is a large multi-site docking protein (LMD) of about 100kD that has a folded N-terminal domain attached to an extended, disordered C-terminal tail rich in short linear motifs. (wikipedia.org)
  • Adjacent to the PH domain is a central, proline-rich domain that contains many PXXP motifs for binding to the SH3 domains of signaling molecules such as Grb2 (from which the name "Grb2-associated binding" protein, GAB, comes). (wikipedia.org)
  • sites
  • Polycistronic vectors (ones located at multiple genome sites) are sometimes constructed to express more than one immunogen, or to express an immunogen and an immunostimulatory protein. (wikipedia.org)
  • Discovery of multiple binding sites in GAB proteins has led to the N-terminal folding nucleation (NFN) hypothesis for the structure of the disordered region. (wikipedia.org)
  • factor
  • 5. The fusion protein according to claim 2, wherein the protease cleavage site is a protease cleavage site that is cleaved by a protease selected from Enterokinase, Factor Xa, Tobacco Etch virus (TEV), Thrombin or PreScission. (patentsencyclopedia.com)
  • highly
  • The protein in serum ferritin is considered benign, but it has lost ( i.e. dumped) most of its normal complement of iron which when unliganded is highly toxic. (rsc.org)