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Interleukin-1betaInterleukin-1Interleukin-6beta 2-MicroglobulinInterleukin-2Receptors, InterleukinCytokinesCells, CulturedReceptors, Adrenergic, betaIntegrin beta3RNA, MessengerTumor Necrosis Factor-alphaInterleukin-4Transforming Growth Factor betaInterleukin 1 Receptor Antagonist ProteinRecombinant ProteinsInterleukin-8InterleukinsInterleukin-10Cell LineT-LymphocytesMice, Inbred C57BLInterferon-gammaReceptors, Interleukin-2Signal TransductionLymphocyte ActivationBase SequenceIntegrin alpha5beta1Gene Expression RegulationIntegrin beta4Interleukin-12Mice, Inbred BALB CIntegrin alpha6beta4Integrin beta Chainsbeta 2-Glycoprotein IIntegrin alpha4beta1Molecular Sequence DataLipopolysaccharidesInterleukin-3Receptors, Interleukin-1InflammationGene ExpressionInterleukin-18Integrin alpha2beta1Receptors, Adrenergic, beta-2Interleukin-5Tumor Cells, CulturedTransfectionCell DivisionIntegrinsMice, KnockoutAntibodies, MonoclonalFlow CytometryAntigens, CDAntigens, CD29KineticsMonocytesEnzyme-Linked Immunosorbent AssayDose-Response Relationship, DrugReverse Transcriptase Polymerase Chain ReactionIntegrin alpha6beta1MacrophagesCell AdhesionReceptors, Adrenergic, beta-1NF-kappa BTransforming Growth Factor beta1Receptors, Interleukin-4Receptors, ImmunologicInterleukin-13PhosphorylationTime FactorsReceptors, Interleukin-6Integrin alpha1beta1Cell DifferentiationGlycogen Synthase Kinase 3SpleenUp-RegulationInterleukin-11Transcription, GeneticTh2 CellsInflammation MediatorsEstrogen Receptor betaCaspase 1CD4-Positive T-LymphocytesSialoglycoproteinsInterleukin-17Blotting, WesternDisease Models, AnimalBinding SitesReceptors, Adrenergic, beta-3Killer Cells, NaturalMice, TransgenicInterleukin-15Th1 CellsImmunohistochemistryMacromolecular SubstancesAdrenergic beta-AgonistsDNA PrimersCloning, MolecularInterleukin-7
IL1BCytokinesProteinsProteinSubunitCytokineTumorProduced by activated macrophagesConvertaseIL8RbMediatorsELISALipopolysaccharideInhibitionPrecursorRecombinantExpressionSynovialStimulatesGenesMetabolismAffinityStimulationDetectionHumanKineticsSecretionIncreasesInflammationSignificantlySynthesisLevelsLocalizeNitric oxideCellsInflammatoryAlphaMolecularChainDoseEffects
IL1B9
  • Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene. (wikipedia.org)
  • Description: Quantitativesandwich ELISA kit for measuring Mouse pro interleukin 1 beta (pro-IL1B) in samples from serum, plasma, cell culture supernates, tissue homogenates. (bioanalitica.it)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (bioanalitica.it)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 1 Beta (IL1b) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (bioanalitica.it)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (bioanalitica.it)
  • Subsequently, a biotin-conjugated antibody specific to Interleukin 1 Beta (IL1b) is introduced. (affigen.com)
  • After TMB substrate solution is added, only those wells that contain Interleukin 1 Beta (IL1b) , biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (affigen.com)
  • By comparing the optical density (OD) of the samples to the standard curve, the concentration of Interleukin 1 Beta (IL1b) in the samples can be determined. (affigen.com)
  • IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. (rndsystems.com)
Cytokines3
  • IL-1β is a member of the interleukin 1 family of cytokines. (wikipedia.org)
  • changes in expression of the immunomodulating cytokines interleukin (IL)-1 beta, IL-6, and IL-8. (nih.gov)
  • ABSTRACT The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. (who.int)
Proteins1
Protein4
  • Recombinant IL 1 beta Porcine produced in E.coli cells is a non-glycosylated, homodimeric protein containing 153 amino acid chain and having a molecular mass of 17.6kDa. (prospecbio.com)
  • IL-1 beta also induces the accumulation of cGMP by the insulinoma cell line Rin-m5F, and both NMMA as well as the protein synthesis inhibitor cycloheximide prevent this cGMP accumulation. (jci.org)
  • Active immunization with fibrillar beta-amyloid peptide (AB42) as well as passive transfer of anti-AB antibodies significantly reduces AB plaque deposition, neuritic dystrophy, and astrogliosis in the brain of mutant amyloid precursor protein (APP)-transgenic mice. (ecu.edu)
  • IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. (rndsystems.com)
Subunit2
  • This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
  • Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
Cytokine3
  • This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. (wikipedia.org)
  • Interleukin-1 (IL-1), originally described as lymphocyte activating factor (LAF) for its effects on thymocytes, is a polypeptide cytokine with two molecular forms. (eaglebio.com)
  • Interleukin-36 is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. (watson-bio.cn)
Tumor2
  • To localize and determine the levels of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), and tumor necrosis factor (TNF) gene expression in the process of endotoxin-induced uveitis (EIU) in rats. (nih.gov)
  • In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
Produced by activated macrophages1
  • Interleukin-1b is produced by activated macrophages, IL-1B stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. (prospecbio.com)
Convertase1
  • IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β. (wikipedia.org)
IL8Rb6
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 8 Receptor Beta (IL8Rb) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (scalegen.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 8 Receptor Beta (IL8Rb) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interleukin 8 Receptor Beta (IL8Rb) were tested 20 times on one plate, respectively. (biomatik.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interleukin 8 Receptor Beta (IL8Rb) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
  • This assay has high sensitivity and excellent specificity for detection of Interleukin 8 Receptor Beta (IL8Rb). (biomatik.com)
  • No significant cross-reactivity or interference between Interleukin 8 Receptor Beta (IL8Rb) and analogues was observed. (biomatik.com)
Mediators2
  • Thus, indomethacin was used to determine whether PGs are mediators of the ACTH response to IL-1 beta delivered into the ME. (cornell.edu)
  • This treatment induced a significant increase in the levels of proinflammatory mediators including the inducible Nitric Oxide Synthase (iNOS), interleukin 1 Beta (IL-1β) and Interleukin-12 (IL-12). (lu.se)
ELISA6
  • In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
  • Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)
  • Description: A sandwich ELISA kit for detection of Interleukin 8 Receptor Beta from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
  • The IL-1 Beta Human ELISA Assay (enzyme-linked immunoassay kit) is intended for the quantitative determination of human Interleukin 1 Beta (IL-1β) concentrations in cell culture supernates, serum, and plasma. (eaglebio.com)
  • The Human Interleukin 1 Beta (IL-1β) ELISA Assay Kit is for research use only and not to be used in diagnostic procedures. (eaglebio.com)
  • The Human Interleukin 1 Beta (IL-1β) ELISA Assay employs the quantitative sandwich enzyme immunoassay technique. (eaglebio.com)
Lipopolysaccharide1
Inhibition3
  • Nitric oxide has recently been implicated as the effector molecule that mediates IL-1 beta-induced inhibition of glucose-stimulated insulin secretion and beta-cell specific destruction. (jci.org)
  • Pretreatment of beta-cells, purified by FACS with IL-1 beta results in a 40% inhibition of glucose-stimulated insulin secretion that is prevented by the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (NMMA). (jci.org)
  • This is further demonstrated by IL-1 beta-induced inhibition of glucose oxidation by purified beta-cells, mitochondrial aconitase activity of dispersed islet cells, and mitochondrial aconitase activity of Rin-m5F cells, all of which are prevented by NMMA. (jci.org)
Precursor1
  • Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. (rndsystems.com)
Recombinant4
  • Additional rats received recombinant human IL-1 beta (0.2-25.0 ng in 100 nl) into the ME (intra-ME). (cornell.edu)
  • Recombinant Murine Interleukin-36 beta, 153a.a. (rMuIL-36beta,153a.a. (watson-bio.cn)
  • 您现在的位置： 主页 / 其他重组蛋白 / Recombinant Murine Interleukin-36 beta, 153a.a. (rMuIL-36beta,153a.a. (watson-bio.cn)
  • Shows less than 5% cross-reactivity with recombinant mouse (rm) IL‑1 beta and rpIL‑1 beta and no cross-reactivity with rrIL‑1 beta, rmIL‑1 alpha, rhIL‑1ra, rmIL‑1ra, or rrIL‑1 alpha. (rndsystems.com)
Expression6
  • Little expression of IL-1 alpha, IL-1 beta, and TNF genes was observed in normal ICB. (nih.gov)
  • Expression of IL-1 beta and TNF genes showed a pattern similar to that of IL-1 alpha. (nih.gov)
  • Expression of IL-1 alpha, IL-1 beta, and TNF genes was dramatically up-regulated in the process of EIU. (nih.gov)
  • Hill T, Krougly O, Nikoopour E, Bellemore S, Lee-Chan E, Fouser LA, Hill DJ and Singh B. The involvement of Interleukin-22 in the expression of Pancreatic Beta cell Regenerating REG genes. (bepress.com)
  • Culture temperature had a marked effect on IL-1 beta expression, with low temperatures inhibiting transcription. (elsevierpure.com)
  • Indeed, an eight-fold increase in IL-1 beta transcript level was seen between cells cultured at 4 degrees C and 22 degrees C. Preincubation with cortisol was also shown to inhibit LPS-induced IL-1 beta expression. (elsevierpure.com)
Synovial1
  • IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin and it can stimulate production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. (watson-bio.cn)
Stimulates1
  • Interleukin-1 stimulates glucose transport in rat adipose cells. (eurekamag.com)
Genes2
  • There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). (wikipedia.org)
  • Three hours after LPS treatment, IL-1 beta and TNF genes were found by in situ hybridization histochemistry to be expressed by "histiocyte-like" cells in the stroma of the ICB. (nih.gov)
Metabolism2
  • Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)
  • IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. (rndsystems.com)
Affinity1
  • IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. (rndsystems.com)
Stimulation1
  • Addition of insulin and IL-1 beta resulted in an additive stimulation of transport, suggesting different mechanisms. (eurekamag.com)
Detection1
Human5
  • The fever-producing property of human leukocytic pyrogen (interleukin 1) was purified by Dinarello in 1977 with a specific activity of 10-20 nanograms/kg. (wikipedia.org)
  • Detects human IL-1 beta /IL-1F2 in Western blots. (rndsystems.com)
  • Human PBMC stimulated with 250 ng/ml LPS overnight were stained with either (A) Mouse Anti-Human IL-1 beta /IL-1F2 Alexa Fluor® 594-conjugated Monoclonal Antibody (Catalog # IC201T) or (B) Mouse IgG1Isotype Control ( IC002T ) and Mouse Anti-Human CD14 APC-conjugated Monoclonal Antibody ( FAB3832A ). (rndsystems.com)
  • IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. (rndsystems.com)
  • The 17 kDa molecular weight mature human IL-1 beta shares 96% aa sequence identity with rhesus and 67%-78% with canine, cotton rat, equine, feline, mouse, porcine, and rat IL-1 beta. (rndsystems.com)
Kinetics1
  • Glu-4, a relatively inactive IL-1 beta analogue in most cells, stimulated glucose uptake in a time and dose dependent manner with kinetics indistinguishable from those of IL-1 beta. (eurekamag.com)
Secretion6
  • The ability of extracts to affect the secretion of IL-1 beta, IL-6, and IL-8 were assessed by enzyme-linked immunosorbent assay. (nih.gov)
  • Scholars@Duke publication: Aging and dietary modulation of elastase and interleukin-1 beta secretion. (duke.edu)
  • In this study, in vivo neutrophil degranulation was assessed by plasma elastase concentrations, and mononuclear cell function was assessed by interleukin-1 beta (IL-1 beta) secretion in vitro. (duke.edu)
  • Direct injections of IL-1 beta into the hypothalamic median eminence (ME), a site which lacks a blood-brain barrier, has been shown to rapidly induce ACTH secretion. (cornell.edu)
  • Therefore, the ME is a likely site whereby circulating IL-1 beta can access the brain to stimulate CRH and, consequently, ACTH secretion. (cornell.edu)
  • Indomethacin, an inhibitor of prostaglandin (PG) synthesis, has been shown to block both the induction of CRH secretion by IL-1 beta from hypothalamic explants, as well as the ACTH response to intravenous IL-1 beta. (cornell.edu)
Increases1
  • Kinase activities were compared to measurements of organic dust-stimulated increases in interleukin-8 release. (cdc.gov)
Inflammation1
Significantly2
  • Water extract of I'm-Yunity also significantly increased IL-1 beta and IL-6 while substantially lowering IL-8. (nih.gov)
  • Organic dust-induced release of interleukin-8, a process dependent upon PKC activation, was significantly diminished in response to PKA activating agents. (cdc.gov)
Synthesis1
  • Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. (cusabio.com)
Levels3
  • IL-1 beta does not appear to affect FACS-purified alpha-cell metabolic activity or intracellular cGMP levels, suggesting that IL-1 beta does not exert any effect on alpha-cells. (jci.org)
  • There was a significant negative correlation between IL-12 and IL-13 levels among beta-thalassaemia cases (r = -0.42). (who.int)
  • This study demonstrated significant differences in the blood levels of IL-1 beta between people with epilepsy and healthy subjects. (cusabio.com)
Localize1
  • To further evaluate this hypothesis, an angular stereotaxic approach was developed to localize the spread of IL-1 beta to the ME and to optimally separate the injectate from the hypothalamic paraventricular nucleus (PVN), another proposed site of IL-1 action. (cornell.edu)
Nitric oxide6
  • Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. (jci.org)
  • Evidence for the beta-cell as a source and site of action of nitric oxide. (jci.org)
  • The purpose of this investigation was to determine if the beta-cell, which is selectively destroyed during insulin-dependent diabetes mellitus, is both a source of IL-1 beta-induced nitric oxide production and also a site of action of this free radical. (jci.org)
  • IL-1 beta induces the formation of nitric oxide by purified beta-cells as evidenced by the accumulation of cGMP, which is blocked by NMMA. (jci.org)
  • IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes. (jci.org)
  • These results demonstrate that the islet beta-cell is a source of IL-1 beta-induced nitric oxide production, and that beta-cell mitochondrial iron-sulfur containing enzymes are one site of action of nitric oxide. (jci.org)
Cells2
  • The effect of interleukin 1 (IL-1) on glucose transport activity in isolated rat adipose cells was examined. (eurekamag.com)
  • We observed that pretreating bronchial epithelial cells with beta agonists, forskolin, or cell-permeable cAMP analogs blocked organic dust-induced PKC epsilon activation. (cdc.gov)
Inflammatory1
  • IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. (rndsystems.com)
Alpha3
  • Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
  • While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. (rndsystems.com)
  • IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. (rndsystems.com)
Molecular1
  • We constructed a DNA minigene with AB fused to mouse interleukin-4 (pAB42-IL-4) as a molecular adjuvant to generate anti-AB antibodies and enhance the Th2-type of immune responses. (ecu.edu)
Chain1
  • It is an accessory chain essential for the active interleukin 10 receptor complex. (creativebiomart.net)
Dose3
  • IL-1 beta stimulated 3-O-methylglucose (3OMG) transport in a time and dose dependent manner. (eurekamag.com)
  • Responses appeared to be dose-dependent and ACTH was maximally stimulated by 2.0 ng IL-1 beta. (cornell.edu)
  • 0.005) when a low dose of indomethacin (1 mg/kg i.v.) was administered 20 min before intra-ME IL-1 beta (25 ng). (cornell.edu)
Effects1
  • Beta-carotene derivatives have marked effects on keratinizing epithelia. (medscape.com)