ELISA KitReagents distributedAnticardiolipin Antibody IgARecombinantAssayCardiolipin AntibodiesAntiphospholipid syndromeAnti-phosphatidylserineMonoclonalAssaysProteinsSerumEnzymeEbolaConjugateLupusProteinBindThrombocytopeniaDetectionAutoimmune diseasesGroupHumanMouseNeutralizationTestsAgglutinationBoundTestConvalescentFoundClinicalRoleBloodPresenceProductsPresentPatientsResults
ELISA Kit2
- Human IgG antibody Laboratories manufactures the tgf-beta 1 elisa kit reagents distributed by Genprice. (aabioetica.org)
- Description: Sandwich High Sensitivity ELISA kit for Quantitative Detection of activated Pig porcine TGF beta 1. (aabioetica.org)
Reagents distributed4
- Iga Antibody Laboratories manufactures the beta-2 glycoprotein 1 iga antibody reagents distributed by Genprice. (english-nature.org)
- Anticardiolipin Laboratories manufactures the anticardiolipin antibody iga/g/m reagents distributed by Genprice. (lentivectors.com)
- Igg Elisa Laboratories manufactures the elisa igg antibody test reagents distributed by Genprice. (crossfirebeilstein.com)
- Human IgG antibody Laboratories manufactures the abcam mouse t cell antibodies for histology reagents distributed by Genprice. (taq-polymerase.net)
Anticardiolipin Antibody IgA1
- Test Code: 161950 Specimen Type: Blood Description: Anticardiolipin Antibody IgA, IgG, IgM Blood Test (Labcorp) This test looks for 3 types of Cardiolipin Antibodies, IgA, IgM, and IgG. (dobratechnologia.pl)
Recombinant3
- ZMapp), anti-sense phosphorodiamidate morpholino oligomers (PMO AVI-6002), lipid nanoparticle small interfering RNA (LNP-siRNA: TKM-Ebola), and an EBOV glycoprotein-based vaccine using live-attenuated recombinant vesicular stomatitis virus (rVSV-EBOGP) or a chimpanzee adenovirus (rChAd-EBOGP)-based vector. (biomedcentral.com)
- human recombinant antibodies to ebola virus: preparation and characteristics]. (liverpool.ac.uk)
- human recombinant antibodies against a purified ebola virus (ev) lysate were selected from a combinatorial library of scfv-antibodies using the phage display technique. (liverpool.ac.uk)
Assay7
- The immunofluorescence ANA assay (Antibodies, Inc) utilizes the method considered the gold standard for ANA testing by the American College of Rheumatology: detecting circulating autoantibodies reactive with nuclear antigens of HEp-2 cells. (nemours.org)
- The ANCA assay (INOVA) detects the presence of IgG antibodies that bind to human neutrophil antigens using direct immunofluorescence.¹,² Screening all samples with ethanol fixed slides allows ANCA reactivity to be separated into two diagnostically useful categories. (nemours.org)
- The Diagnostic Automation Beta2GP1 IgA Enzyme-linked Immunosorbent Assay (ELISA) is intended for the detection and semiquantitative determination of IgA antibodies to Beta2GP1 in human sera or plasma. (rapidtest.com)
- 1 The Venereal Disease Research Laboratory (VDRL) test is a manual agglutination assay that detects antibodies to cardiolipin extracted from bovine heart tissue. (dobratechnologia.pl)
- Eagle Biosciences has quickly become a leading provider of ELISA assay kits, HPLC assay kits, Molecular Biology assays, antibodies, and proteins. (eaglebio.com)
- IgG/IgM antibodies to cardiolipin (aCL) and IgG/IgM anti-ß2-GP1 were determined by enzyme immunoassay (ELISA) in patients with or without APS, and IgG anti-ß2-GP1DI was determined by chemiluminescence assay (CLA) in all patients and controls. (bvsalud.org)
- The researchers used a live virus plaque reduction neutralization assay to test how well the antibodies were able to neutralize Ebola strains. (immunopaedia.org.za)
Cardiolipin Antibodies8
- Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune antiphospholipid syndrome requires the presence of β2-GP1in the cardiolipin extract. (wikipedia.org)
- The presence of anti-cardiolipin antibodies in SLE can be related to the development of thrombocytopenia, in gynaecology they are supposed to cause intrauterine death or recurrent abortion. (rapidtest.com)
- Furthermore, anti-cardiolipin antibodies have been found in some nonthrombotic neurological disorders like cerebrovascular insufficiency, cerebral ischemia or chorea and in myocardial infarction. (rapidtest.com)
- The cardiolipin antibodies blood test, IgA, IgG, and IgM is used to help investigate inappropriate blood clot formation, to help determine the cause of recurrent miscarriage, or as part of an evaluation for antiphospholipid syndrome or sometimes other autoimmune diseases. (dobratechnologia.pl)
- Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. (dobratechnologia.pl)
- A cardiolipin antibody test detects cardiolipin antibodies in the blood. (dobratechnologia.pl)
- Anti-cardiolipin antibodies are by definition a major criterion for a diagnosis of APS. (dobratechnologia.pl)
- Realtime driving directions to GiFi, Av. A cardiolipin antibody test detects cardiolipin antibodies in the blood. (dobratechnologia.pl)
Antiphospholipid syndrome4
- Development of antibodies against β2-GP1 can lead to Antiphospholipid syndrome which often leads to pregnancy complications. (wikipedia.org)
- The antiphospholipid syndrome (APS) is diagnosed in patients with recurrent thromboembolic events and/or pregnancy loss in the presence of persistent laboratory evidence for antiphospholipid antibodies. (dobratechnologia.pl)
- Antiphospholipid syndrome (APS) , also called Hughes syndrome, is a recognised group of signs and symptoms that includes the formation of thrombi (blood clots), recurrent miscarriages, thrombocytopenia, and the presence of one or more antiphospholipid antibodies. (labtestsonline.org.uk)
- The role of antiphospholipid antibodies (aPL), which are not included in the Sydney diagnostic criteria, in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) is poorly understood. (bvsalud.org)
Anti-phosphatidylserine2
- Others tested include anti-beta2 glycoprotein I and anti-phosphatidylserine. (labtestsonline.org.uk)
- Propensity score-matching method (PSM) (1:2 matching including age, sex, severity on admission, and prior history of thrombosis) was performed to compare the prevalence and titer of aPL (anti-cardiolipin (aCL) IgG/IgM, anti-ß2GPI IgG/IgM/IgA, and anti-phosphatidylserine/prothrombin antibody (aPS/PT) IgG/IgM) and serum ß2GPI concentration. (bvsalud.org)
Monoclonal1
- These may include monoclonal antibody (mAbs)-based therapies (e.g. (biomedcentral.com)
Assays1
- Unlike multiplex or ELISA assays, the HEp-2 cell substrate provides 100-150 possible autoantigens to detect ANAs with greater sensitivity than the solid phase assays. (nemours.org)
Proteins1
- Antiphospholipid antibody tests are immune proteins ( antibodies ) directed against phospholipids. (labtestsonline.org.uk)
Serum10
- β2-GP1 causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen when thrombin is present at physiological serum concentrations of β2-GP1 suggesting a regulatory role of β2-GP1 in coagulation. (wikipedia.org)
- The Beta-2 Glycoprotein 1 Iga Antibody reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (english-nature.org)
- Description: A competitive ELISA for quantitative measurement of Human β2 Glycoprotein 1 antibody IgA in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (english-nature.org)
- Description: A competitive ELISA for quantitative measurement of Rat β2 Glycoprotein 1 antibody IgG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (nfkb-p65.info)
- Description: Quantitative sandwich ELISA for measuring Mouse Anti-cardiolipin antibody IgG (ACA-IgG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (nfkb-p65.info)
- Recent studies have shown that a 50kD serum cofactor is required for anticardiolipin antibodies, to bind to cardiolipin which has been coated onto plastic plates. (rapidtest.com)
- We evaluated the prevalence of aPL and serum concentrations of beta-2 glycoprotein I (ß2GPI), a major self-antigen for aPL, in Japanese COVID-19 patients with and without thrombosis. (bvsalud.org)
- The Abcam Mouse T Cell Antibodies For Histology reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (taq-polymerase.net)
- Description: A competitive ELISA for quantitative measurement of Human Platelet antibodies IgG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (taq-polymerase.net)
- Description: Quantitative sandwich ELISA for measuring Human anti-Beta2 glycoprotein I antibodies IgG (Beta2-GP1 IgG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (taq-polymerase.net)
Enzyme2
- After adding enzyme conjugate, it binds to the antibody-antigen complex. (rapidtest.com)
- solid-phase enzyme immunoassay (eia) indicated that these antibodies were able to bind both inactivated and native ev. (liverpool.ac.uk)
Ebola10
- In an effort to bridge this gap, we evaluated cryopreserved PBMCs from 4 patients who survived Ebola virus disease (EVD) using an established mass cytometry antibody panel to characterize various cell populations during both the acute and convalescent phases. (cdc.gov)
- Therefore, it is important to understand the role antibodies play in the pathogenesis and prevention of Ebola virus. (immunopaedia.org.za)
- This study shows that antibodies from an Ebola survivor are capable of having potent anti-viral activity. (immunopaedia.org.za)
- Preventing Ebola infection through a vaccine is now a major global research focus and researchers from the Scripps Research Institute, led by Laura Walker, aimed to gain further knowledge on the role of antibodies in protection against Ebola. (immunopaedia.org.za)
- At only 3 months post infection, 3% of the donor IgG antibodies were specific to the Ebola envelope glycoprotein (GP) and bound strongly to the GP. (immunopaedia.org.za)
- They found that several of the isolated antibodies were extremely potent against Ebola virus. (immunopaedia.org.za)
- Altogether, these results provide insight into the structure and function of antibodies from an Ebola survivor. (immunopaedia.org.za)
- The epitopes bound by these antibodies could potentially be used in anti-Ebola immunogens since they can be targeted in natural infection. (immunopaedia.org.za)
- In addition, the potent antibodies studied from this donor may be useful in Ebola therapy and prevention. (immunopaedia.org.za)
- 2016. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak. (immunopaedia.org.za)
Conjugate1
- Antibody-drug conjugate (ADC) is a new generation of therapeutic drugs, consisting of antibodies, small molecule drugs (payloads), and linkers connecting antibodies and payloads. (genemedi.com)
Lupus3
- Anti-β2-GP1 antibodies are strongly associated with thrombotic forms of lupus. (wikipedia.org)
- The presence of lupus anticoagulants and anticardiolipin antibodies (aCL) has been associated with young victims of myocardial. (dobratechnologia.pl)
- Antiphospholipid antibodies are frequently seen with autoimmune disorders such as Systemic Lupus Erythematosus (SLE) . (labtestsonline.org.uk)
Protein4
- β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded by the APOH gene. (wikipedia.org)
- In addition, β2-GP1 inhibits the activation of protein C blocking its activity on phosphatidylserine:phosphatidylcholine vesicles however once protein C is activated, Apo-H fails to inhibit activity. (wikipedia.org)
- In molecular biology, the protein domain Sushi 2 is also known as the fifth protein domain of beta-2 glycoprotein 1 (β2-GP1). (wikipedia.org)
- This protein domain is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long highly flexible loop. (wikipedia.org)
Bind1
- The Anti Beta2GP1 specific antibodies, if present, bind to the antigens. (rapidtest.com)
Thrombocytopenia1
- Antiphospholipid antibodies are also associated with thrombocytopenia (low platelets) and with the risk of recurrent miscarriages (especially in the 2nd and 3rd trimester), premature labour, and pre-eclampsia . (labtestsonline.org.uk)
Detection1
- Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. (crossfirebeilstein.com)
Autoimmune diseases1
- Anti-β2-GP1 antibodies are found in both infectious and some systemic autoimmune diseases (eg. (wikipedia.org)
Group1
- IgG anti-ß2-GP1DI was detected in 37 (71%) of 52 patients with primary APS (PAPS), in 6 (50%) of 12 patients with probable APS, in 42 (71%) of 59 patients with SLE + APS, in 17 (26%) of 64 patients with SLE, in 1 (2%) of the comparison group, and in none of the control group. (bvsalud.org)
Human1
- Apart from supportive care, neither a licensed vaccine nor a specific therapy is available for the treatment of the human EBOV infection [ 2 ]. (biomedcentral.com)
Mouse2
- Virus-specific antibody responses correlated with protection from encephalitis in all mouse strains, suggesting that Tfh-B cell interactions modulate clinical outcome in this model. (cdc.gov)
- The researchers went on to test the antibodies in mouse models to examine whether they were effective as post-exposure therapy. (immunopaedia.org.za)
Neutralization1
- Vaccination resulted in generation of neutralizing antibody titers in most recipients, but neutralization titers waned over time, necessitating frequent booster doses. (cdc.gov)
Tests2
- There are two types of tests that are used to detect antiphospholipid antibodies. (labtestsonline.org.uk)
- The tests used can detect several classes (IgG, IgM, and/or IgA) of the antibodies themselves. (labtestsonline.org.uk)
Agglutination2
- β2-GP1 has a complex involvement in agglutination. (wikipedia.org)
- The activity of β2-GP1 appears to involve the binding of agglutinating, negatively charged compounds, and inhibits agglutination by the contact activation of the intrinsic blood coagulation pathway. (wikipedia.org)
Bound3
- When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in structure. (wikipedia.org)
- They next mapped the epitopes bound by these antibodies. (immunopaedia.org.za)
- They found that the donor antibodies bound to four distinct epitopes on the GP. (immunopaedia.org.za)
Test4
- Labcorp test details for Anticardiolipin Antibodies (ACA), IgG, Labcorp OnDemand Testing Toggle Labcorp OnDemand Testing. (dobratechnologia.pl)
- LabCorp test: 161950 Anticardiolipin Antibodies (ACA), IgA, IgG, IgM, Quantitative test cost max is in EconoLabs (Antiphospholipid Abs (cardiolipin) IgA, IgG & IgM) with price $250. (dobratechnologia.pl)
- The three types of anticardiolipin antibodies are the IgG, IgA and IgM types and this particular test measures the level of IgM type antibodies in the blood. (dobratechnologia.pl)
- The first is the test for cardiolipin or beta2 glycoprotein I antibodies. (labtestsonline.org.uk)
Convalescent1
- 1,2 Limitations ACA can often be observed during the convalescent phase of acute bacterial and viral infections and in individuals with syphilis. (dobratechnologia.pl)
Found4
- The determination of IgM antibodies is a valuable indicator in the diagnosis of beginning autoimmune disease, whereas IgG and/or IgA antibodies will be found in progressive stages of manifested autoimmune disorders. (rapidtest.com)
- Anticardiolipin Antibody LabcorpThey are also found in up to 20% of young stroke patients. (dobratechnologia.pl)
- Arenaviruses have been divided into 2 groups based on whether the virus is found to infect Old World (ie, Eastern Hemisphere) rodents (family Muridae, subfamily Murinae) or New World (ie, Western Hemisphere) rodents (family Muridae, subfamily Sigmodontinae). (medscape.com)
- They found that the antibodies which target the GP stalk and GP1-GP2 interface were highly effective as post-exposure prophylaxis while the antibodies towards the glycan cap and other, undefined sites had no efficacy in their models. (immunopaedia.org.za)
Clinical3
- anticardiolipin (aCL), which has three subcomponents: lgG, lgA, lgM anti-Beta-2-glycoprotein-I (aβ 2 GPI), which has the same three subcomponents LAC The LAC is the most important of these antibodies because it confers the greatest risk for developing clinical complications. (dobratechnologia.pl)
- Although antiphospholipid antibodies (aPL) are detected in COVID-19 patients, their clinical significance remains elusive. (bvsalud.org)
- The aim of this study was to determine the clinical significance of IgG antibodies for domain 1 of ß2-glycoprotein 1 (ß2-GP1), IgG anti-ß2-GP1DI, in patients with APS with and without SLE. (bvsalud.org)
Role1
- however it is known to play an important role in the binding of β2-GP1 to negatively charged compounds and subsequent capture for binding of anti-β2-GP1 antibodies. (wikipedia.org)
Blood2
- The cofactor has been identified as Beta2-glycoprotein 1 also termed apolipoprotein H. Beta2GP1 has been known as an in vitro inhibitor of the intrinsic blood coagulation pathway, ADP dependent aggregation, and prothrombinase activity of activated platelets. (rapidtest.com)
- When the antibodies attack cardiolipin, blood clots can occur. (dobratechnologia.pl)
Presence1
- β2-GP1 also inhibits the generation of factor Xa in the presence of platelets. (wikipedia.org)
Products2
- Other Beta-2 products are available in stock. (english-nature.org)
- Other Tgf-Beta products are available in stock. (aabioetica.org)
Present1
- Anticardiolipin antibodies are often present in individuals with the antiphospholipid antibody syndrome. (dobratechnologia.pl)
Patients2
- It has been shown conclusively that Beta2GP1 is indeed the antigen to which many anticardiolipin antibody patients are actually binding and furthermore showed that the phospholipid merely serves to link the Beta2GP1 to the solid phase. (rapidtest.com)
- as part of an evaluation for antiphospholipid antibody syndrome , as part of the evaluation of patients with connective tissue disease. (labtestsonline.org.uk)
Results1
- SDS-PAGE (reducing DTT & non reducing DTT) results showed that we successfully linked MMAE to the antibody. (genemedi.com)