Beta 1 integrins. Medical search. Frequent questions

In Western blots, approximately 50% cross-reactivity with recombinant mouse (rm) Integrin alpha 5 is observed and less than 2% cross-reactivity with recombinant human Integrin alpha M, rmIntegrin alpha 2, rmIntegrin alpha 4, and rmIntegrin alpha E is observed. (rndsystems.com)

Integrin beta-1 is the most abundant beta-integrin expressed and associates with at least 10 different integrin-alpha subunits. (wikipedia.org)
The Integrin beta 1 subunit, also known as VLA-beta chain or CD29, associates with at least ten different Integrin alpha subunits. (rndsystems.com)

Integrin receptors exist as heterodimers, and greater than 20 different integrin heterodimeric receptors have been described. (wikipedia.org)
Human Integrin alpha 8 beta 1 is a heterodimeric glycoprotein composed of integrin alpha 8 and integrin beta 1 that mainly expressed in smooth muscle cells. (kactusbio.com)
The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. (rcsb.org)
Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)

The monocyte alpha(v)beta(3) integrin was involved in TNF synthesis since peptides containing RGD sequences and blocking antibodies against alpha(v)beta(3) integrin inhibited TNF transcripts induced by C. burnetii. (nih.gov)
Integrin α-m/β-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. (lu.se)

Anti-Integrin beta 3 antibody [SP324] by Abcam, Cat. (lucerna-chem.ch)
Be the first to review Human Integrin alpha 5/CD49e Biotinylated Antibody and earn rewards! (rndsystems.com)
Have you used Human Integrin alpha 5/CD49e Biotinylated Antibody? (rndsystems.com)
The WT.5 monoclonal antibody specifically binds to CD11b, the α subunit of Mac-1 found on neutrophils and myeloid cells, but not on lymphocytes. (bdbiosciences.com)
Antibody inhibitors and siRNA were used to manipulate the expression profiles of LX-2 cells that were incubated under normal culture conditions or after treatment with TGF-Β, a known ligand for the αv integrins and a pro-fibrotic cytokine, to mimic a pro-fibrotic environment in vitro. (harvard.edu)
The integrin profile of LX-2 cells was not changed by antibody treatment targeting αvβ3 or αvβ5. (harvard.edu)
Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. (xenbase.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Beta 4 (ITGb4) in tissue homogenates, cell lysates and other biological fluids. (hudsen.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Beta 4 (ITGb4) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hudsen.org)

VLA-3 (Very Late Antigen 3) is a member of the integrin family, beta1 subfamily, of cell membrane adhesion molecules (1-3). (bio-techne.com)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)

Herein, we generated IL-3 receptor beta common (IL-3Rβc) extracellular domain-derived fusion proteins (Fc) to elucidate the molecular mechanisms regulating these processes. (unito.it)
The ability of the fusion proteins to interfere with IL-3Rβc/β1 integrin interaction was assessed on endothelial cells (ECs), EPCs and murine-derived ECs. (unito.it)
Pull-down experiments showed that Fc1.4 and Fc4 fusion proteins specifically interacted with β1 integrin. (unito.it)
Integrin trafficking may also guide mRNA to ribosomes associated with the protrusive regions of metastatic cells, and thus localise the synthesis of pro-migratory proteins. (gla.ac.uk)
A major aim of our research is to characterise the mechanisms by which integrin-associated proteins command mRNA transport and translation during the invasive migration of cancer cells. (gla.ac.uk)
Integrins are cell adhesion molecules that reside on the surface of cells as transmembrane proteins made of an alpha and beta subunit. (harvard.edu)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)

Sequences involving the first three repeats are associated with ligand binding (1). (bio-techne.com)

Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. (wikipedia.org)
The integrin beta-1B isoform appears to act as a dominant negative in that it inhibits cell adhesion. (wikipedia.org)
30%) suppressed firm adhesion to collagen mediated primarily by the alpha(2)beta(1) integrin. (reading.ac.uk)
Integrin alpha 5 beta 1 is a receptor for fibronectin and neural adhesion molecule L1. (rndsystems.com)
Mac-1 mediates adhesion to ICAM-1 (CD54) and C3bi. (bdbiosciences.com)
The Focal Adhesion Assembly Pathway has been researched in relation to Cell Adhesion, Cell Migration, Cell Motility, Localization, Integrin Activation. (novusbio.com)
Agonist activity at alpha5beta1 integrin in human K562 cells assessed as increase of fibronectin-mediated cell adhesion after 30 mins by fluorescence. (bindingdb.org)
In accordance, inhibition of NF-kB translocation by a synthetic inhibitor Bay 11-7082 significantly diminished homocysteine-induced ICAM-1 expression and adhesion of monocytes to endothelial cells. (uni-muenchen.de)
In support of the role of increased oxidant stress for the above mentioned effects, treatment of endothelial cells with the superoxide scavengers MnTBAP or Tiron together with homocysteine abolished homocysteine-induced monocyte adhesion, ICAM-1 expression and the nuclear translocation of NF-kB. (uni-muenchen.de)
Incubation of THP-1 monocytes with Tiron abolished homocysteine-induced beta-2 integrin expression on these cells and adhesion to unstimulated endothelial cells. (uni-muenchen.de)
Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. (wikidoc.org)
Similarly, depletion of either Rasip1 or Arhgap29 in cultured ECs blocks in vitro lumen formation, fundamentally alters the cytoskeleton, and reduces integrin-dependent adhesion to ECM . (xenbase.org)
Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)

Within aa 21-728, human Integrin beta 1 subunit is 94% aa identical to pig and sheep Integrin beta 1 subunits. (rndsystems.com)
Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
There are 24 known integrin molecules classified into different families depending on the subunits (i.e. αv family of integrins) or by the ligands they bind to (i.e. (harvard.edu)

Integrin beta-1D is specifically localized to costameres and intercalated discs of cardiac muscle and costameres, myotendinous junctions and neuromuscular junctions of skeletal muscle, and it appears to function in general like other integrins, as the clustering of beta-1D integrins on the surface of CHO cells resulted in tyrosine phosphorylation of pp125FAK and induced mitogen-activated protein kinase activation. (wikipedia.org)
Recombinant Human Integrin alpha 8 beta 1 (ITGA8&ITGB1)-Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe39-Leu1012(ITGA8) acidic tail & Gln21-Asp728(ITGB1) basic tail. (kactusbio.com)
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. (kactusbio.com)
0.10 EU per 1 μg of the protein by the LAL method. (bio-techne.com)
Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
The CD49b protein is an integrin alpha subunit. (wikidoc.org)
We show that endothelial tubulogenesis requires the Ras interacting protein 1, Rasip1 , and its binding partner, the RhoGAP Arhgap29 . (xenbase.org)

Description: A sandwich quantitative ELISA assay kit for detection of Mouse Integrin Alpha 4 (ITGa4) in samples from tissue homogenates, cell lysates or other biological fluids. (ibiomagazine.org)

Integrin beta-1D appears to be developmentally regulated during myofibrilogenesis, appearing immediately following the fusion of myoblasts in C2C12 cell with rising levels throughout myofibrillar differentiation. (wikipedia.org)
Integrin/cytokine receptor interaction provides permissive signals leading to neoangiogenesis, and integrins are crucial for differentiation of endothelial progenitor cells (EPCs). (unito.it)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Integrins α-m/β-2 and α-x/β-2 are receptors for the IC3B fragment of the third complement component and for fibrinogen. (lu.se)
Integrin α-x/β 2 recognizes the sequence g-p-r in fibrinogen α-chain. (lu.se)
Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss. (cdc.gov)

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. (wikipedia.org)
Detects human Integrin beta 1/CD29 in direct ELISAs and Western blots. (rndsystems.com)
Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29. (online-medical-dictionary.org)
The alpha 5 subunit, also known as CD49e and VLA-5 alpha subunit, forms a heterodimer with the Integrin beta 1 subunit (CD29). (rndsystems.com)

Cells were analyzed by qPCR and flow cytometry to assess the changes in the integrin expression profile. (harvard.edu)

Type 1 results from mutations in the integrin beta-2 gene ( ITGB2 ), encoding CD18 beta-2 integrins. (msdmanuals.com)
TREATMENT: The plasmid carrying neuropilin-1 (NRP1) gene was transfected into ESC for overexpression. (bvsalud.org)

1% expression of CD18). (medscape.com)

The cytoplasmic domain of integrin beta-1 binds to the actin cytoskeleton. (wikipedia.org)
Integrins link the actin cytoskeleton with the extracellular matrix and they transmit signals bidirectionally between the extracellular matrix and cytoplasmic domains. (wikipedia.org)
Integrin beta-1B is transcribed when the proximal 26 amino acids of the cytoplasmic domain in exon 6 are retained and then succeeded by a 12 amino acid stretch from an adjacent intronic region. (wikipedia.org)
The cytoplasmic domain of integrin beta-1D replaces the distal 21 amino acids (present in integrin beta-1A) with an alternative stretch of 24 amino acids (13 unique). (wikipedia.org)
Tyrosine phosphorylation as a conformational switch: a case study of integrin Beta3 cytoplasmic tail. (expasy.org)
It is synthesized as a 1051 amino acid (aa) precursor that undergoes proteolytic cleavage to generate a disulfide-linked 110 kDa, 843 aa extracellular heavy chain and a 30 kDa, 176 aa TM/cytoplasmic light chain (1, 4, 5, 6). (bio-techne.com)

It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. (wikipedia.org)
Beta-integrins are primarily responsible for targeting integrin dimers to the appropriate subcellular locations, which in adhesive cells is mainly focal adhesions. (wikipedia.org)

Description: A sandwich ELISA kit for detection of Integrin Beta 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hudsen.org)
Description: Quantitativesandwich ELISA kit for measuring Rat Integrin beta-4 (ITGB4) in samples from serum, plasma, tissue homogenates, cell lysates. (hudsen.org)

Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells , and may play a role in angiogenesis. (online-medical-dictionary.org)
Exposure of endothelial monolayers to D,L- and L-homocysteine resulted in a time- and dose-dependent increase in adherent THP-1 cells by upregulating ICAM-1 expression on endothelial cells. (uni-muenchen.de)
The increased endothelial expression of ICAM-1 seems to be mediated by increased activation of the nuclear transcription factor NF-kB, as shown by increased nuclear translocation of NF-kB in homocysteine-incubated endothelial cells. (uni-muenchen.de)
In addition, incubation of monocytes with D,L- homocysteine and L-homocysteine resulted in significant increase in the number of adhering monocytes to unstimulated endothelial monolayer by upregulating the expression of beta-2 integrins. (uni-muenchen.de)
In addition to previous studies that indicated that a significant source of reactive oxygen species in homocysteine-treated endothelial cells might be endothelial nitric oxide synthase, experiments using inhibitors of nitric oxide synthase in THP-1 cells indicated that nitric oxide synthase-dependent generation of superoxide anion also occurs in homocysteine-incubated THP-1 cells. (uni-muenchen.de)

2011. The tyrosine kinase PYK2 mediates the cross-talk between platelet integrins alpha 2 beta 1 and alpha iib beta 3, pp. 737-737. (edu.au)

In the Current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. (maastrichtuniversity.nl)
The integrins' involvement in all of these processes can facilitate the communication between extracellular matrix, inflammatory cells, fibroblasts, and parenchymal cells through their ability to bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. (harvard.edu)

In conclusion, these data identify the β1 integrin-interacting domain in the juxta-membrane IL-3Rβc extracellular domain, and provide the rational for targeting this interaction to impair vascular growth. (unito.it)

These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens. (wikipedia.org)
Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. (uchicago.edu)
Mac-1 expression is rapidly upregulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. (bdbiosciences.com)
They are encoded by separate but linked genes termed regulation of complement activation (RCA) genes, located on the q32 region of chromosome 1. (medscape.com)

This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. (wikipedia.org)
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN . (online-medical-dictionary.org)

The objectives of this study were to characterize how the αv integrins regulate each other in both a normal and pro-fibrotic environment in order or decipher any mutual regulation between the αv integrins and to assess if there is a good in vitro model to look at potential compensation mechanisms specifically in an inflammatory environment. (harvard.edu)

Detects human Integrin alpha 2/CD49b. (novusbio.com)
Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells . (wikidoc.org)

Coxiella burnetii, the agent of Q fever, enters human monocytes through alpha(v)beta(3) integrin and survives inside host cells. (nih.gov)
Reacts with human Integrin Beta 5. (covalab.com)
Detects human Integrin alpha 5/CD49e in Western blots. (rndsystems.com)
Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. (nih.gov)
Further, HAdV-52 ( 7 ) isolated from Adenoviruses, which can cause infectious diarrhea or a patient with gastroenteritis has been found to be very respiratory infections in humans, were isolated from dissimilar to all previously isolated human adenoviruses monkeys soon after their initial characterization by Rowe but closely related to monkey adenoviruses SAdV-1 and et al. (cdc.gov)
In the study, the authors dissect a new mechanism driven by cutaneous beta human papillomavirus (HPV) type 38 in altering the function of p53. (who.int)
Although the strategy of ICE is risk (HR) HPV infection in the etiology of beta human papillomavirus (HPV) types global, work is natural y focused on low- head and neck cancer. (who.int)

Despite their critical role in fibrosis, integrin compensatory regulation is not fully understood. (harvard.edu)

He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)

SAdV-6, SAdV-18, and SAdV-20) were also completely Committee on Taxonomy of Viruses has 1 defi ned species, sequenced. (cdc.gov)

The I domain-containing beta 1 integrins ( alpha 1 beta 1, alpha 2 beta 1, alpha 10 beta 1 and alpha 11 beta 1) all bind collagens, with alpha 2 beta 1 preferring collagens I‑III (4, 5). (novusbio.com)

RDG binding family of integrins). (harvard.edu)

Anatomy30

Organisms8

Diseases4

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes47

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Cross-reactivity with recombinant human1

Different integrin-alpha subunits2

Heterodimeric4

Peptides2

Antibody9

Antigen2

Proteins7

Ligand1

Adhesion16

Subunits4

Protein7

Mouse Integrin1

Differentiation3

Fibrinogen3

CD294

Flow Cytometry1

Gene2

CD181

Cytoplasmic6

Dimers2

ELISA KIT2

Endothelial5

Platelet1

Ligands2

Membrane1

Activation4

Collagen2

Vitro1

CD49b2

Human7

Fibrosis1

Tumor1

Species1

Alpha 2 beta1

Family1