Beta 1 integrin integrin laminin. Medical search. Frequent questions

The Integrin alpha 6 subunit, also known as CD49f and VLA-6 alpha subunit, forms a heterodimer with Integrin beta 1 (CD29) or beta 4 (CD104) subunits. (rndsystems.com)
Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit. (rupress.org)
Antibodies against the beta 1 integrin subunit inhibited HT-1080 cell adhesion and neurite outgrowth on surfaces adsorbed with peptides GD-3 and GD-4. (rupress.org)
Furthermore, these results suggest that the sequences comprising peptides GD-3 and GD-4 use an integrin as a receptor, of which the beta 1 integrin subunit is a component for these various cell types. (rupress.org)
Integrins are nondisulfide-linked transmembrane (TM) heterodimers that contain an alpha- and beta-subunit (1). (bio-techne.com)
It only associates with the beta1 integrin subunit. (bio-techne.com)
ELAV - like1 , methyltransferase like 7A , dolichyl-phosphate mannosyltransferase , laminin subunit beta-1 , gremlin 1 , BCL6 corepressor-like 1 , and three genes of unknown identity. (biomedcentral.com)
The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. (embl.de)
Dependence on beta subunit association and prediction of domains. (embl.de)
The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
By contrast, four mAbs to the beta-propeller domain did not react with the unassociated alphaM precursor nor with the uncomplexed alphaM subunit expressed on COS cell surface. (embl.de)
These results suggest that folding of different beta-propeller subregions is coordinate and is dependent on association with the beta2 subunit. (embl.de)
This suggests that much of the region C-terminal to the beta-propeller domain folds independently of association with the beta2 subunit. (embl.de)
Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
The basic subunit of beta-crystallins. (lookformedical.com)
GxxxA design at the correct position in TM1 of 1 imparts a new function to the 1 subunit that's perhaps not seen in the wild type protein. (plasignaling.com)
1 currents from the 6 subunit, we performed single channel patch clamp experiments. (plasignaling.com)
Cells, in turn, may regulate the strength of adhesion by increasing or decreasing the number of integrins, by synthesizing different integrin subunit subtypes, or by changing the adhesion affinity after modulation of the intracellular domain, which in turn will modify the adhesion ability of the extracellular domain. (uvigo.es)
Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. (assaygenie.com)
This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. (assaygenie.com)
β1 integrin is the major β integrin subunit in pancreatic beta-cells and forms heterodimers with 12 α integrin subunits, which interact with components of the extracellular matrix (ECM) to control intracellular signaling via the focal adhesion kinase (FAK) and extracellular signal related kinase 1 and 2 (ERK1/2) pathways [ 4 ]. (oncotarget.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. (curehunter.com)
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta 1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [ 4 ]. (biomedcentral.com)
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN . (online-medical-dictionary.org)
Other profibrotic, collagen synthesis stimulating cytokines include endothelin, interleukin (IL)-1 and mast cell tryptase. (biomedcentral.com)
An intracellular domain that interacts with actin filaments of the cytoskeleton (sometimes with intermediate filaments), an extracellular domain that binds collagen, fibronectins and laminins, and an intramembrane domain containing hydrophobic amino acid sequences inserted among the lipid fatty acid chains. (uvigo.es)

thus, beta-1D associates with alternate alpha subunits (alpha-5, alpha-6A) prior to alpha-7. (wikipedia.org)
They contain both alpha and beta subunits. (embl.de)
The four mAbs were mapped to three subregions in three different beta-sheets, making it unlikely that each recognized an interface between the alpha and beta subunits. (embl.de)
Our data provide new insights into how different domains in the integrin alpha and beta subunits may interact. (embl.de)
Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
Beta-crystallins exist as oligomers formed from acidic (BETA-CRYSTALLIN A CHAIN) and basic (BETA-CRYSTALLIN B CHAIN) subunits. (lookformedical.com)
1 current that is not seen with other subunits. (plasignaling.com)
1 in cardiomyocytes, indicating a powerful interaction between these two calcium-channel subunits under physiological conditions. (plasignaling.com)
They are composed of two subunits (alpha and beta) (Figure 1). (uvigo.es)
The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. (assaygenie.com)
Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. (assaygenie.com)

Integrin alpha 6 beta 1 is a receptor for laminin. (rndsystems.com)
Integrin alpha 6 beta 4 is also a receptor for laminin and is a structural component of hemidesmosomes in stratified epithelia. (rndsystems.com)
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. (cusabio.com)
Acts as Schwann cell receptor for laminin-2. (cusabio.com)
It is widely expressed during development, but in the adult is the predominant laminin receptor ( RECEPTORS, LAMININ ) in mature SMOOTH MUSCLE CELLS , where it is important for maintenance of the differentiated phenotype of these cells . (online-medical-dictionary.org)

Cell motility measurements by computer-assisted time-lapse videomicroscopy of the alpha 7-transfected cells revealed an 8-10-fold increase in motility on laminin-1 and its E8 fragment, but not on fibronectin. (uea.ac.uk)
This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (wikipedia.org)
In adult striated muscle cells, alpha-7 integrin (complexed to beta-1 integrin) is localized to Z-discs and costamere structures, bound to the four and one half LIM domain proteins, FHL1 and FHL2. (wikipedia.org)
Mice died within 1 month of birth and had severe muscle degeneration, suggesting that the roles of these proteins may overlap to maintain the stability of the sarcolemma. (wikipedia.org)
Previously we have shown that the locomotion of murine skeletal myoblasts is specifically and significantly enhanced on laminin but not on other matrix proteins. (uea.ac.uk)
In SF, mRNAs encoding α1, β1 and γ1 laminin - which encode the proteins for LN1 - were detected by quantitative RT-PCR and transcript amounts encoding the α1 and β1 chains of LN1 were higher than mRNA encoding the LN1 γ1 chain. (biomedcentral.com)
However, using monoclonal antibodies to laminin α1 or β1 proteins, staining signals were very weak. (biomedcentral.com)
The expression of Insulin and Pancreatic and duodenal homeobox-1 mRNA was significantly reduced in MIPβ1KO islets, along with reductions in insulin exocytotic proteins. (oncotarget.com)

One of the major laminin receptors of myoblasts is the alpha 7 beta 1 integrin, which was first described in human MeWo melanoma cells and Rugli glioblastoma cells. (uea.ac.uk)
Furthermore, integrins may change the behavior of the cell according to the molecular composition of the extracellular matrix (they behave like receptors). (uvigo.es)

Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. (wikipedia.org)
ITGA7 encodes the protein alpha-7 integrin. (wikipedia.org)
Alpha-7 integrin undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. (wikipedia.org)
Integrin alpha 3, also known as CD49c and VLA-3 alpha, is a type I membrane protein that heterodimerizes with Integrin beta 1. (rndsystems.com)
ten-1 is the C. elegans teneurin homolog with two transcripts, ten-1a and ten-1b , that respectively encode a long (TEN-1L) and short (TEN-1S) form of the protein. (biomedcentral.com)
In C. elegans , the ten-1 gene can be transcribed from two distinct promoters to produce the transcripts ten-1a and ten-1b , which respectively encode two isoforms of the protein: TEN-1L, which contains all the teneurin domains described above (see Fig. 1F ), and TEN-1S, which lacks the ICD but contains the rest of the protein including the transmembrane domain. (biomedcentral.com)
0.10 EU per 1 μg of the protein by the LAL method. (bio-techne.com)
Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. (cusabio.com)
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (lookformedical.com)
In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. (assaygenie.com)

VLA-3 (Very Late Antigen 3) is a member of the integrin family, beta1 subfamily, of cell membrane adhesion molecules (1-3). (bio-techne.com)
Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
In general, the adhesion strength of integrins is weaker than that of other adhesion molecules. (uvigo.es)

Be the first to review Human Integrin alpha 6/CD49f Alexa Fluor® 405-conjugated Antibody and earn rewards! (rndsystems.com)
1. Cell lysates were immunoprecipitated with FLAG antibody and then probed with anti Cav3. (plasignaling.com)
1 antibody to spot /3. (plasignaling.com)
1 antibody to recognize 6/3. (plasignaling.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Beta 4 (ITGb4) in tissue homogenates, cell lysates and other biological fluids. (hudsen.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Beta 4 (ITGb4) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hudsen.org)

Significant reductions in the phosphorylation of signaling molecules focal adhesion kinase, extracellular signal-regulated kinases 1 and 2, and v-Akt murine thymoma viral oncogene were observed in male MIPβ1KO islets when compared to controls. (oncotarget.com)

The purpose of this study was to investigate the effects of extra corporeal shock waves (ESW) therapy on the metabolism of healthy and osteoarthritic human chondrocytes, and particularly on the expression of IL-10, TNF-alpha and beta1 integrin. (biomedcentral.com)
At baseline, osteoarthritic chondrocytes expressed significantly lower levels of beta1 integrin and higher levels and IL-10 and TNF-alpha levels. (biomedcentral.com)
Following ESW application, while beta1 integrin expression remain unchanged, a significant decrease of IL-10 and TNF-alpha intracellular levels was observed both in osteoarthritic and healthy chondrocytes. (biomedcentral.com)

CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)

Expression of the α1, β1 and γ1 chains of LN1 laminin by SF was investigated by quantitative RT-PCR and immunocytochemistry. (biomedcentral.com)
Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)

Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29. (online-medical-dictionary.org)

Alpha-7/beta-1 integrin promotes the adhesion and motility of myoblasts, and is likely important in the recruitment of myogenic precursors during muscle differentiation. (wikipedia.org)
During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. (cusabio.com)

Subsequent screening for structural variants in candidate genes located in the same regions identified a homozygous deletion that includes exons 17 to 23 of the integrin beta 4 ( ITGB4 ), a gene that was previously associated with the same defect in humans. (biomedcentral.com)
β1 integrin is essential for pancreatic beta-cell development and maintenance in rodents and humans. (oncotarget.com)

Alpha-7 integrin is 128.9 kDa in molecular weight and 1181 amino acids in length. (wikipedia.org)
This is possible because the adhesion state of integrins is transmitted to their intracellular domain by conformational change, triggering molecular interaction cascades in the cytosol, that eventually change gene expression. (uvigo.es)
Integrin, molecular conformation (Modified from Luo et al. (uvigo.es)

In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)

In support of this, a double knockout of gamma-sarcoglycan and alpha-7 integrin produced a phenotype that was far worse than either knockout alone. (wikipedia.org)
Moreover, the double knockout of dystrophin and alpha-7 integrin produced a Duchenne muscular dystrophy-like phenotype, and demonstrated that alterations in alpha-7 integrin affect the pathological changes observed in dystrophin deficiencies. (wikipedia.org)
These findings prove that alpha 7 integrin expression confers a gain of function-motile phenotype to immobile cells and may be responsible for transduction of the laminin-induced cell motility. (uea.ac.uk)
The novel ten-1(et5) allele is a hypomorph since its post-embryonic phenotype is weaker than the null alleles ten-1(ok641) and ten-1(tm651) . (biomedcentral.com)

Description: Quantitativesandwich ELISA kit for measuring Rat Integrin beta-4 (ITGB4) in samples from serum, plasma, tissue homogenates, cell lysates. (hudsen.org)

Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (lookformedical.com)

In direct 3H-heparin binding assays, peptides GD-1 and GD-2 bound high levels of 3H-heparin, while peptides GD-3 and GD-4 bound lower levels of 3H-heparin, and GD-5 bound essentially no 3H-heparin. (rupress.org)
In addition, solutions of these peptides or antibodies generated against these peptides inhibited laminin-mediated HT-1080 cell adhesion. (rupress.org)
Sixteen different laminin-mimetic peptides are immobilized on the surface of cell culture plates for the study and identification of these peptides on different cell behaviors. (biomaterialsusa.com)
This kit can help researchers to quickly identify the best laminin-mimetic peptides supporting cell attachment and growth. (biomaterialsusa.com)

TSP-1, thrombospondin-1. (rupress.org)
A subfamily of ADAM proteases that are distinguished by the presence of one or more THROMBOSPONDIN type-1 repeats (TSRs). (bvsalud.org)

targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, and it led to a significant delay in tumor engraftment plus a strong reduction in tumor size and invasion. (cusabio.com)

Alpha-7 integrin is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. (wikipedia.org)
Alpha-7 integrin is highly expressed in striated muscle, namely skeletal and cardiac muscle, and functions as the major laminin-binding integrin. (wikipedia.org)
alpha-7A integrin is expressed solely in skeletal muscle, however alpha-7B integrin is expressed more loosely in striated muscle as well as the vasculature. (wikipedia.org)
In human skeletal muscle, alpha-7 integrin is also developmentally regulated, being first detected at age 2. (wikipedia.org)
It has also been proposed that alpha-7 integrin and gamma-sarcoglycan have overlapping functions in skeletal muscle. (wikipedia.org)
In support of this notion, AAV overexpression of ITGA7 in skeletal muscle of Duchenne muscular dystrophy (DMD) mice showed a significant protective effect against adverse functional parameters associated with DMD, combined with a reversal of these negative features, suggesting that alpha-7 integrin may be a potential therapeutic candidate to treat Duchenne muscular dystrophy. (wikipedia.org)

ten-1 mutants have defects in all pharyngeal neurons that we examined, and in vivo reporters show that only the long form of the ten-1 gene is expressed in the pharynx, specifically in six marginal cells and the M2 neurons. (biomedcentral.com)
We therefore investigated gene expression patterns in SF upon attachment to LN1 (EHS laminin) in comparison with LN10. (biomedcentral.com)
The product of this gene belongs to the integrin alpha chain family. (assaygenie.com)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)

Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane. (lookformedical.com)
Interleukin-1 stimulates glucose transport in rat adipose cells. (eurekamag.com)
The effect of interleukin 1 (IL-1) on glucose transport activity in isolated rat adipose cells was examined. (eurekamag.com)

Addition of insulin and IL-1 beta resulted in an additive stimulation of transport, suggesting different mechanisms. (eurekamag.com)
We utilized a mouse insulin 1 promoter driven tamoxifen-inducible Cre-recombinase β1 integrin knockout mouse model (MIPβ1KO) to investigate β1 integrin function in adult pancreatic beta-cells. (oncotarget.com)

Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury. (cusabio.com)

Alpha-7 integrin is critical for modulating cell-matrix interactions. (wikipedia.org)
The function of alpha-7 integrin, as is the case for most integrins is to mediate cell membrane interactions with extracellular matrix. (wikipedia.org)
1 calcium present while sequence variations in other and 4 sub-units modify their interactions with 3. (plasignaling.com)

Sequences involving the first three repeats are associated with ligand binding (1). (bio-techne.com)
Integrin alpha (beta-propellor repeats). (embl.de)

Mutations in ITGA7 have been associated with congenital myopathies and noncompaction cardiomyopathy, and altered expression levels of alpha-7 integrin have been identified in various forms of muscular dystrophy. (wikipedia.org)

It is synthesized as a 1051 amino acid (aa) precursor that undergoes proteolytic cleavage to generate a disulfide-linked 110 kDa, 843 aa extracellular heavy chain and a 30 kDa, 176 aa TM/cytoplasmic light chain (1, 4, 5, 6). (bio-techne.com)
The N-terminal region has been predicted to fold into a beta-propeller domain composed of seven beta-sheets each about 60 amino acid residues long, with the I-domain inserted between beta-sheets 2 and 3. (embl.de)

Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)
The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)
Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. (cusabio.com)

Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). (cusabio.com)

Elevated expression of laminins (LN) and integrins in the synovial membrane of rheumatoid arthritis (RA) versus osteoarthritis patients has been reported but metabolic effects of attachment of synovial fibroblasts (SF) to LN are not well studied. (biomedcentral.com)
Hereditary junctional epidermolysis bullosa (JEB) is a recessive inherited blistering disorder of the skin and mucous membrane in which tissue separation occurs within the lamina lucida (i.e. under the basal plasma membrane of the basal keratinocytes and above the basement membrane) of the basement membrane zone (BMZ) at the dermal-epidermal junction [ 1 ]. (biomedcentral.com)
α2β1γ1) stimulates oligodendrocytes to extend elaborate membrane sheets in vitro (cell spreading), mediated by integrin α6β1. (rupress.org)
The strength of the adhesion of a cell to the extracellular matrix depends on the number, the active state and type of integrins that are expressed in the plasma membrane. (uvigo.es)

However, the effects of a temporal beta-cell specific β1 integrin knockout on adult islet function are unknown. (oncotarget.com)

Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)

In cSCC cells, S6 recreated the pro-differentiating effects of SIRT6 silencing, as the levels of Keratin 1, Keratin 10 and Loricrin were upregulated compared to controls. (bvsalud.org)

Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. (uchicago.edu)
Expression of IL-1α, IL-1β, IL-6, IL-8, IL-16, IL-18 as well as matrix metalloproteinase (MMP)-1 and MMP-3 were investigated in RA SF ( n = 6) or osteoarthritis SF ( n = 7) in primary or early passage cultures. (biomedcentral.com)
Attachment to LN1-laminin in the presence of TGF-β induces elevated MMP-3 expression in SF. (biomedcentral.com)
After that, chondrocytes were cultured in 24-well plate in DMEM supplemented with 10% FCS for 48 hours and then beta 1 integrin surface expression and intracellular IL-10 and TNF-alpha levels were evaluated by flow-cytometry. (biomedcentral.com)
The over-expression of MMPs is induced by several cytokines, such as IL-1, TNF-alpha, IL-17, IL-10, and many others, which have been detected increased in OA cartilage. (biomedcentral.com)
1% expression of CD18). (medscape.com)

The segment C-terminal to the beta-propeller domain, residues 599-1092, was studied with nine mAbs. (embl.de)

Splice variants of alpha-7 integrin that differ in both the extracellular and cytoplasmic domains exist in the mouse and are developmentally regulated in mouse and rat muscle tissue. (wikipedia.org)
In order to investigate and directly test the role of the alpha 7 integrin in cell migration on laminin, we expressed the murine alpha 7B splice variant in human 293 kidney cells and 530 melanoma cells which cannot migrate on laminin and are devoid of endogenous alpha 7. (uea.ac.uk)

Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)

Divalent cations and intracellular (inside-out) signaling convert it to its most active, extended and open conformation (1, 2). (novusbio.com)

residues 2,110-3,060) of the A chain of murine-derived laminin has been shown to promote heparin binding, cell adhesion, and neurite outgrowth. (rupress.org)

Epidermolysis bullosa is classified into four major categories: (1) epidermolysis bullosa simplex (intraepidermal skin separation), (2) junctional epidermolysis bullosa (skin separation in lamina lucida or central BMZ), (3) dystrophic epidermolysis bullosa (sublamina densa BMZ separation, as in the images below), and (4) Kindler syndrome (extremely rare, blistering at any level). (medscape.com)

Detects human Integrin alpha 6/CD49f. (rndsystems.com)
Human adult articular cartilage was obtained from 9 patients (6 male and 3 females), with primary knee osteoarthritis (OA), undergoing total joint replacement and from 3 young healthy donors (HD) (2 males, 1 female) with joint traumatic fracture. (biomedcentral.com)
Detects human Integrin alpha 2/CD49b. (novusbio.com)
Fibroblasts produce TIMPs (1-4), which were previously called human fibroblast collagenase inhibitors. (biomedcentral.com)
Description: A sandwich ELISA kit for detection of Integrin Beta 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hudsen.org)

As knockdown of Integrin alpha7 (ITGA7) can effectively reduce the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could be a potential therapeutic target in OSCC treatment. (cusabio.com)

In hemidesmosomes, the cytosolic domains of integrins are connected to intermediate filaments, instead of actin filaments. (uvigo.es)

Anatomy29

Organisms9

Diseases6

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes50

Disciplines and Occupations1

Technology, Industry, Agriculture1

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Subunit22

Collagen5

Subunits11

Receptor5

Fibronectin2

Proteins7

Receptors2

Protein10

Adhesion molecules3

Antibody6

Kinase1

Beta1 integrin3

Antigen1

Chains2

CD291

Myoblasts2

Humans2

Molecular3

Basal lamina1

Phenotype4

ITGB41

Avian1

Peptides4

Thrombospondin2

Tumor1

Skeletal6

Gene4

Interleukin3

Insulin2

Pathways1

Interactions3

Repeats2

Muscular dystrophy1

Amino acid2

Genes3

Isoform1

Membrane4

Knockout1

Deficiency3

Keratin1

Expression6

MAbs1

Splice2

Basement1

Intracellular1

Murine1

Junctional epiderm1

Human5

ITGA71

Hemidesmosomes1