• Benzofuran is the "parent" of many related compounds with more complex structures. (wikipedia.org)
  • Benzofuran compounds such as 6-APB and 5-APB can be swallowed or snorted in lines. (talktofrank.com)
  • What is benzofuran compounds cut with? (talktofrank.com)
  • FRANK is currently not aware of any evidence that shows that benzofuran compounds are being cut (having powders added to bulk them up and increase profits) or that they have been contaminated during being made and shipmed. (talktofrank.com)
  • Benzofuran compounds are similar to drugs like ecstasy and amphetamines that can be addictive. (talktofrank.com)
  • Hence, it's reasonable to assume that you could become addicted to benzofuran compounds, such as 6-APB or 5-APB and could suffer similar withdrawal symptoms seen with speed and ecstasy if used regularly. (talktofrank.com)
  • Benzofuran-compounds have been illegal from 10th June 2014. (talktofrank.com)
  • Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. (benzofurans.com)
  • 2-(4-Hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-carboxylic acid belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. (np-mrd.org)
  • We observed that benzofuran compounds bearing a phenyl or tert-butyl substituent α to the methoxycarbonyl group significantly inhibited anchorage-dependent and -independent cell growth, and induced G0/G1 cell cycle arrest in human estrogen receptor alpha positive (MCF-7 and T47D) and in triple negative MDA-MB-231 breast cancer cells, without affecting growth of MCF-10A normal breast epithelial cells. (unical.it)
  • Benzofuran derivatives are important pharmaceutical intermediates. (chemenu.com)
  • 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. (benzofurans.com)
  • A series of benzofuran derivatives of hydroxyurea, e.g. (benzofurans.com)
  • In this study, we tested the antiproliferative effects of a series of benzofuran-2-acetic methyl ester derivatives, synthesized by a palladium-catalyzed carbonylative heterocyclization approach, on breast cancer cells. (unical.it)
  • Mechanistically, benzofuran derivatives enhanced the cyclin-dependent kinase inhibitor p21Cip/WAF1 expression at both mRNA and protein levels and this occurs transcriptionally in an Sp1-dependent manner. (unical.it)
  • Moreover, benzofuran derivatives induced apoptosis, increased poly (ADP-ribose) polymerase cleavage and Bax/Bcl-2 ratio along with a marked DNA fragmentation along with a marked DNA fragmentation and a strong increase in TUNEL-positive breast cancer cells. (unical.it)
  • Overall, we provide evidence that the newly tested benzofuran derivatives showed antiproliferative and pro-apoptotic activities against breast cancer cells regardless estrogen receptor status, suggesting their possible clinical development as anticancer agents. (unical.it)
  • We examined here the sulfur-arene interactions between the fused aromatic heterocycle benzofuran and two prototype sulfur divalent triatomics (sulfur dioxide and hydrogen sulfide). (uva.es)
  • Benzofuran is an aromatic heterocyclic organic compound with the chemical formula C8H6O. (chemenu.com)
  • Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. (benzofurans.com)
  • Novel benzofuran-2-carboxamide ligands, which are selective for sigma receptors, have been synthesized via a microwave-assisted Perkin rearrangement reaction and a modified Finkelstein halogen-exchange used to facilitate N-alkylation. (savannahstate.edu)
  • The ligands synthesized are the 3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides (KSCM-1, KSCM-5 and KSCM-11). (savannahstate.edu)
  • Benzofuran is the heterocyclic compound consisting of fused benzene and furan rings. (wikipedia.org)
  • Benzofuran is a molecule that combines a benzene ring with one or more connected heterocyclic furan rings. (benzofurans.com)
  • The benzofuran-2-carboxamide structure was N-arylated and N-alkylated to include both N-phenyl and N-(3-(piperidin-1-yl)propyl substituents, respectively. (savannahstate.edu)
  • As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce. (benzofurans.com)
  • 2,3-Benzofuran is not used for any commercial purposes, but the part of the coal oil that contains 2,3-benzofuran is made into a plastic called coumarone-indene resin. (cdc.gov)
  • We do not know how often the resin is used or whether any 2,3-benzofuran in the coating or packaging gets into the food. (cdc.gov)
  • Very little is known about the stability or breakdown of 2,3-benzofuran or of the coumarone-indene resin. (cdc.gov)
  • We do not know how often the resin is used or whether any 2,3-benzofuran in the coating or o Breathing contaminated air around manufacturing or hazardous waste sites. (cdc.gov)
  • 2,3-benzofuran or of the coumarone-indene resin. (cdc.gov)
  • Benzofurans purity test kits include reagent tests, TLC kits and test strips. (protestkit.eu)
  • Test kits for Benzofurans were created so that the purity of the substance could be identified and/or confirmed. (protestkit.eu)
  • What are the differences between Benzofurans purity tests ? (protestkit.eu)
  • 2-(4-Hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-carboxylic acid is an extremely weak basic (essentially neutral) compound (based on its pKa). (np-mrd.org)
  • It is a benzofuran-derived, iodine-rich compound with some structural similarity to thyroxine (T4). (medscape.com)
  • For example, psoralen is a benzofuran derivative that occurs in several plants. (wikipedia.org)
  • Initially, o-alkyl derivative of salicyaldehyde readily furnish corresponding 2-acetyl benzofuran 2 in good yield, on treatment with 1,8-diaza bicyclo5.4.0undec-7-ene (DBU) in the presence of molecular sieves. (uni-mysore.ac.in)
  • 2,3-Benzofuran is a colorless, sweet-smelling, oily liquid made by processing coal into coal oil. (cdc.gov)
  • Perkin rearrangement, where a coumarin is reacted with a hydroxide: Diels-Alder reaction[clarification needed] of nitro vinyl furans with various dienophiles: Cycloisomerization of alkyne ortho-substituted phenols: Substituted benzofurans Dibenzofuran, an analog with a second fused benzene ring. (wikipedia.org)
  • Consumption of Benzofurans always involves risks. (protestkit.eu)
  • Using fluorescent microscopy with sodium-binding benzofuran isophthalate (SBFI) is the most commonly used method for measuring [Na + ] i . (biomedcentral.com)
  • MDMA (Ecstasy) Test (1 test) - is a single-use Benzofurans tester . (protestkit.eu)
  • The TGA and DSC revealed slight loss in the chitosan-benzofuran' thermal stability compared to chitosan hydrogel and that could be regarded to the increase in porosity as shown in the SEM. (scholarsresearchlibrary.com)
  • In search for a new antioxidant and antimicrobial agent with improved potency, we synthesized a series of benzofuran based 1,3,5-substituted pyrazole analogues (5a-l) in five step reaction. (uni-mysore.ac.in)
  • That is why we have prepared drug test kits for Benzofurans . (protestkit.eu)
  • How to use drug test kits for Benzofurans ? (protestkit.eu)
  • Drug test kits for Benzofurans show their results by changing the color of the reagent added to the sample. (protestkit.eu)
  • Animal studies have shown effects on the liver, kidneys, lungs, and stomach from exposure to high levels of 2,3-benzofuran. (cdc.gov)
  • Very little is known about the possible harmful effects of 2,3-benzofuran to human health. (cdc.gov)
  • Rats and mice that ingested high levels of 2,3-benzofuran over a short time had liver and kidney damage. (cdc.gov)
  • Moreover, the cellular cytotoxicity of baby hamster kidney cells culture by adding different concentrations of chitosan-benzofuran hydrogel were greater than those obtained from benzofuran or chitosan alone as they were 4.81±2%, 5.27±2% and 9.43±5%, respectively. (scholarsresearchlibrary.com)
  • A series of aryloxy propargyl malonates was efficiently converted into various chromenes by a gold-catalyzed cyclization/Brønsted acid catalyzed isomerization sequence, and the chromenes were subsequently converted into benzofurans by implementing an additional photochemical rearrangement. (hal.science)
  • Ligand KSCM-1 with two methoxy substituents at C-5 and C-6 of the benzofuran ring, and Ki = 27.5 nM at sigma-1 was found to be more selective for sigma-1 over sigma-2. (savannahstate.edu)
  • The benzofuran⋯sulfur dioxide dimer exhibits a stacked structure with sulfur closer to benzofuran, while in benzofuran⋯hydrogen sulfide the two S-H bonds are oriented towards the bicycle. (uva.es)
  • The fluorinated dihydrobenzofuran product can be transformed into dihydrobenzofuran and benzofuran products decorated with a 2-trifluoromethyl group. (arizona.edu)
  • o 2,3-Benzofuran may enter the air, water, and soil during o Drinking contaminated human breast milk. (cdc.gov)
  • Benzofuran can be volatilized with water vapor and can be decomposed by potassium permanganate and other oxidants. (chemenu.com)
  • Benzofurans have also made significant and distinctive contributions to biology. (benzofurans.com)
  • We value your input so if you have suggestions regarding new applications for Benzofuran-2-Carboxylic Acid email us and we will include your contribution on the website. (discofinechem.com)
  • Is there a medical test to show whether I've been exposed to 2,3-benzofuran? (cdc.gov)
  • One study reported detecting 2,3-benzofuran in human breast milk, indicating that the mother had been exposed. (cdc.gov)
  • Benzofurans can be prepared by various methods in the laboratory. (wikipedia.org)
  • 2,3-Benzofuran is not expected to accumulate in fish or aquatic animals to any great extent. (cdc.gov)
  • 2,3-Benzofuran is not used for any commercial purposes, aquatic animals to any great extent. (cdc.gov)
  • The Department of Health and Human Services has not classified 2,3-benzofuran as to its human carcinogenicity. (cdc.gov)
  • There is a test to measure 2,3-benzofuran in the blood or in breast milk. (cdc.gov)
  • This test may only measure 2,3-benzofuran from a recent exposure. (cdc.gov)
  • How does a test kit for Benzofurans work? (protestkit.eu)
  • Test kits for Benzofurans involve using special reagents that are added to a sample of the substance. (protestkit.eu)