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BarbituratesOpioidsAlcoholTreated with high doses of benzodiazepinesOpiatesIntoxicationDrugsIntravenousGABAReceptorsDelirium TremensEffect of ethanolFlumazenilDosesSedative effectsToxicologyChlordiazepoxideMedicationsDiscontinuationToxicityNeuronsSupportive careCommonlyIncludeWithdrawal syndromeDepressionTherapeuticPrescriptionDiagnosisDiazepamDrugAbuse

Barbiturates8

• Ethanol, which has a pharmacological profile similar to those of barbiturates and benzodiazepines, enhances [ 3 H]diazepam binding to the crude Lubrol-solubilized fraction. (aspetjournals.org)
• Discontinuation of benzodiazepines, barbiturates, and other sedatives or hypnotics after long-term use results in withdrawal symptoms resembling those of alcohol withdrawal syndrome. (medscape.com)
• Flumazenil does not antagonize the central nervous system effects of drugs affecting GABA-ergic neurons by means other than the benzodiazepine receptor (including ethanol, barbiturates, or general anesthetics) and does not reverse the effects of opioids. (nih.gov)
• Sedatives include benzodiazepines, barbiturates, and related drugs. (merckmanuals.com)
• Abused anxiolytics and sedatives include benzodiazepines, barbiturates, and other drugs taken to promote sleep. (merckmanuals.com)
• Benzodiazepines and barbiturates bind gamma-aminobutyric acid (GABA)-A receptors, increase the affinity of the receptor to GABA, and promote inhibitory neurotransmitter effects. (merckmanuals.com)
• Belonging to the azaspirodecanedione drug class, 2 buspirone is a serotonin 5-HT 1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. (arlen.com.br)
• Buspirone hydrochloride tablets, USP are an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs. (arlen.com.br)

Opioids3

• He also practices addiction medicine at the University of Utah treating substance use disorder including alcohol, methamphetamine, opioids, and benzodiazepines. (seakexperts.com)
• Dr. Moss consults on both civil and criminal cases related to toxicology testing, interpretation, impairment, intoxication and the effects of drugs and medications: -Drugs of abuse (e.g. heroin, opioids, fentanyl, methamphetamine, marijuana) -Alcohol (ethanol) impairment, intoxication and BAC interpretation -DUI/DWI -Urine drug screen testing interpre. (seakexperts.com)
• Among 83 tianeptine exposures with noted coexposures, the most commonly reported coexposures were to phenibut, ethanol, benzodiazepines, and opioids. (cdc.gov)

Alcohol11

• Benzodiazepines: Based on the Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) or the Richmond Agitation Sedation Scale (RASS), very-high-dose bolus therapy, with the addition of phenobarbital as needed, may help reduce the need for mechanical ventilation and the length of time in the ICU. (medscape.com)
• Intravenous ethanol infusions: These are not recommended for prophylaxis or treatment of alcohol withdrawal. (medscape.com)
• Mixing with alcohol, benzodiazepines, and other CNS-depressants increases the risk of intoxication, increases respiratory depression, and increases liver toxicity when in combination with paracetamol (acetaminophen). (wikipedia.org)
• Use of butalbital and alcohol, benzodiazepines, and other CNS-depressants can contribute to coma, and in extreme cases, fatality. (wikipedia.org)
• Using Panadeine Forte with other medicines that can make you feel drowsy such as sleeping tablets (e.g. benzodiazepines), other pain relievers, antihistamines, antidepressants, antipsychotics, gabapentanoids (e.g. gabapentin and pregabalin), cannabis and alcohol may result in severe drowsiness, decreased awareness, breathing problems, coma and death. (mydr.com.au)
• Alcohol Use Alcohol (ethanol) is a depressant (it slows down brain and nervous system functioning). (merckmanuals.com)
• The medical product contains up to 5.0 % m/m of ethanol (alcohol), which is up to 975 mg of alcohol in a single dose of 15 ml. (herbapol.pl)
• Symptoms and Signs Alcohol (ethanol) is a central nervous system depressant. (msdmanuals.com)
• e) Alcohol: ethanol, methanol. (revolutionpharmd.com)
• Los hombres tuvieron diagnósticos en salud mental más tardíos, uso progresó de alcohol y trastornos mentales y de comportamiento derivados del uso de sustancia psicoactiva. (bvsalud.org)
• RÉSUMÉ Tous les patients de sexe masculin soignés en psychiatrie et en médecine générale adressés à deux hôpitaux de Basra (Iraq) de septembre 2000 à avril 200l ont été soumis à un dépistage de l'alcoolisme par le test AUDIT (Alcohol Use Disorder Identification Test). (who.int)

Treated with high doses of benzodiazepines1

• GHB withdrawal can initially be treated with high doses of benzodiazepines, though anecdotally, refractory cases have responded to other sedative agents, such as pentobarbital, chloral hydrate, and baclofen. (medscape.com)

Opiates1

• Most of the clinical effects can be explained by the interaction of ethanol with various neurotransmitters and neuroreceptors in the brain, including those interacting with gamma-aminobutyric acid (GABA), glutamate (NMDA), and opiates. (medscape.com)

Intoxication2

• The mechanism of ethanol intoxication and withdrawal is complex. (medscape.com)
• Hypothermia was listed as the primary cause of death, with ethanol intoxication as a contributing factor. (cdc.gov)

Drugs8

• Withdrawal syndrome can occur with a wide range of substances, including ethanol and many illicit drugs and prescription medications. (medscape.com)
• Sedative-hypnotic withdrawal is treated by substituting drugs that have a long duration of action, either a benzodiazepine or phenobarbital, in a maintenance dose for a few days followed by a gradually decreasing dose over 2-3 weeks. (medscape.com)
• [ 2 ] Counterfeit pills often contain illicitly manufactured fentanyls (IMFs), illicit benzodiazepines (e.g., bromazolam, etizolam, and flualprazolam), or other illicit drugs, and can increase overdose risk because the pills might expose persons to drugs they did not intend to use. (medscape.com)
• Codeine phosphate may intensify depressive effects on central nervous system of some anti-depressive drugs (of benzodiazepine group), sleep-inducing drugs (barbituric acid derivatives) and neuroleptics. (herbapol.pl)
• It may intensify effects of other opioid drugs on respiratory center and the effects of ethanol. (herbapol.pl)
• Detect the presence of prescribed and illicit drugs, including ethanol. (mylabtest.net)
• Benzodiazepines: these drugs make a person feel calm and sleepy, often used for anxiety. (breathalysers.co.nz)
• Hypoglycemic drugs, benzodiazepine, and ethanol are not recommended while taking Prozac. (alterinhealth.com)

Intravenous3

• Intravenous flumazenil has been shown to antagonize sedation, impairment of recall, psychomotor impairment and ventilatory depression produced by benzodiazepines in healthy human volunteers. (nih.gov)
• These airway interventions may not be necessary if the patient is intoxicated by an opioid or a benzodiazepine and responds to intravenous naloxone or flumazenil. (mhmedical.com)
• 15 Intravenous benzodiazepines with likely admission You must also take into account the patient's history, comorbidities and previous history of ethanol withdrawal/delirium tremens. (umaryland.edu)

GABA5

• We also provide evidence that ethanol does not enhance [ 3 H]diazepam directly at the benzodiazepine binding site, but, rather, indirectly via the picrotoxinin-sensitive site of the benzodiazepine-GABA receptor-ionophore complex. (aspetjournals.org)
• Ethanol interacts with GABA receptors, enhancing activity. (medscape.com)
• Chronic ethanol abuse seems to modify the GABA receptor via several mechanisms, leading to a decrease in GABA activity. (medscape.com)
• Chronic ethanol exposure has been found to alter gene expression and to increase cellular internalization of certain subunits, affecting the type of GABA receptors that are available at the cell surface and the synapse. (medscape.com)
• Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. (nih.gov)

Receptors2

• Ethanol binds to postsynaptic GABAA receptors (inhibitory neurons). (medscape.com)
• expression of neurotransmitter receptors in the brain and self-administration of ethanol in rats. (5dok.org)

Delirium Tremens1

• Delirium tremens (DTs) is the most severe form of ethanol withdrawal, manifested by altered mental status (global confusion) and sympathetic overdrive (autonomic hyperactivity), which can progress to cardiovascular collapse. (medscape.com)

Effect of ethanol1

• The enhancing effect of ethanol was blocked by picrotoxinin and (+)-bicuculline. (aspetjournals.org)

Flumazenil6

• Flumazenil Injection, USP is a benzodiazepine receptor antagonist. (nih.gov)
• Chemically, flumazenil is ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5-a](1,4) benzodiazepine-3-carboxylate. (nih.gov)
• Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. (nih.gov)
• In animals pretreated with high doses of benzodiazepines over several weeks, flumazenil elicited symptoms of benzodiazepine withdrawal, including seizures. (nih.gov)
• The duration and degree of reversal of sedative benzodiazepine effects are related to the dose and plasma concentrations of flumazenil as shown in the following data from a study in normal volunteers. (nih.gov)
• The duration and degree of reversal are related to the plasma concentration of the sedating benzodiazepine as well as the dose of flumazenil given. (nih.gov)

Doses1

• Generally, doses of approximately 0.1 mg to 0.2 mg (corresponding to peak plasma levels of 3 to 6 ng/mL) produce partial antagonism, whereas higher doses of 0.4 to 1 mg (peak plasma levels of 12 to 28 ng/mL) usually produce complete antagonism in patients who have received the usual sedating doses of benzodiazepines. (nih.gov)

Sedative effects1

• Altered Sedative Effects of Ethanol in Mice with α1 Glycine Receptor Subunits that are Insensitive to Gβγ Modulation. (anid.cl)

Toxicology2

• The toxicology report revealed elevated levels of benzodiazepines and ethanol in her system, leading to respiratory failure, which ultimately resulted in her untimely demise. (jclarkmedia.com)
• There were no previous reports of substance abuse, but her toxicology report revealed elevated levels of benzodiazepines and ethanol. (jclarkmedia.com)

Chlordiazepoxide1

• By 1959, the benzodiazepine chlordiazepoxide was created, giving rise to at least 3000 different benzodiazepines, of which 50 are currently marketed. (medscape.com)

Medications2

• [9] One common method involves the use of benzodiazepine medications, such as diazepam . (wikipedia.org)
• Medications such as benzodiazepines can be used to avoid these complications. (bvsalud.org)

Discontinuation1

• Mr X was diagnosed with benzodiazepine withdrawal due to recent abrupt discontinuation of benzodiazepine. (medscape.com)

Toxicity1

• Perinatal use of benzodiazepines also may cause neonatal withdrawal syndrome or toxicity (eg, apnea, hypothermia, hypotonia). (merckmanuals.com)

Neurons1

• Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons. (anid.cl)

Supportive care1

• Administration of benzodiazepines and supportive care are the core elements of treatment. (msdmanuals.com)

Commonly1

• With wide safety margins and few contraindications, the benzodiazepines most commonly used by dentists are diazepam, as a mild sedation-inducing anxiolytic, midazolam, to induce sleep and amnesia, and alprazolam, lorazepam, and triazolam, each with their appropriate properties and preferred dosages. (bvsalud.org)

Include1

• Examples include benzodiazepines, ethanol, and sedativehypnotics. (revivemedicalny.com)

Withdrawal syndrome1

• Fluoxetine is effective in the treatment of alcoholism as an additional ingredient to reduce the withdrawal syndrome of ethanol. (alterinhealth.com)

Depression1

• Benzodiazepines, for example, can alter mood and trigger depression, especially if you take them for an extended period of time. (greatist.com)

Therapeutic1

• This literature review allows us to conclude that benzodiazepines are an effective therapeutic option for management of patients with anxiety during dental treatment and are available for use in both inpatient and outpatient settings. (bvsalud.org)

Prescription1

• Norway: Pregabalin is in prescription Schedule B, alongside benzodiazepines. (authenticchemicals.com)

Diagnosis1

• Significant changes in some parameters were found both at time of diagnosis and after treatment initiation (ethanol as an antidote and hemodialysis). (bvsalud.org)

Diazepam1

• Ethanol enhanced [ 3 H]diazepam to this fraction in a dose-dependent manner with a maximal enhancement of 90 ± 8.5% occurring at 100 mM and a half-maximal effect occurring at 30 mM. (aspetjournals.org)

Drug1

• The symptomatology and severity were compared adjusted for age, sex and type of drug based on whether or not ethanol had been co-ingested. (bvsalud.org)

Abuse1

• Ethanol abuse, which is strongly associated with hypothermia, results in vasodilation and interferes with peripheral vasoconstriction, an important physiologic mechanism of defense against the cold. (cdc.gov)