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  • Benzoic Acid
  • In general, the most active salicylanilide was N -(4-bromophenyl)-4-chloro-2-hydroxybenzamide and among esters, the corresponding 2-(4-bromophenylcarbamoyl)-5-chlorophenyl 4-(trifluoromethyl) benzoate exhibited the lowest MIC of 0.49 µmol/L. However, the esterification of salicylanilides by 4-(trifluoromethyl)benzoic acid did not result unequivocally in a higher antifungal potency. (mdpi.com)
  • esters
  • However, in the 1950s, longer-acting estradiol esters that require less frequent injections like estradiol valerate and estradiol cypionate were developed and have since mostly superseded estradiol benzoate. (wikipedia.org)
  • As prodrugs of estradiol, estradiol benzoate and other estradiol esters are estrogens, or agonists of the estrogen receptors (ERs). (wikipedia.org)
  • Compared to two other commonly used estradiol esters (which were also assessed in the study), estradiol benzoate had the shortest duration, at approximately 4 to 5 days, whereas estradiol valerate and estradiol cypionate were found to last for 7-8 days and 11 days, respectively. (wikipedia.org)
  • Estradiol benzoate was patented by Schering-Kahlbaum in 1936 in an oil preparation for injectable use and was introduced later that year under the brand name Progynon-B. Following its introduction, estradiol benzoate, along with estradiol dipropionate, were the most widely used esters of estradiol for many years. (wikipedia.org)
  • However, estradiol valerate and estradiol cypionate, which are esters with improved pharmacokinetics which require less frequent administration, were developed and introduced in the 1950s, and have since largely superseded estradiol benzoate in clinical practice. (wikipedia.org)
  • acetate
  • As of copper(II) acetate, the benzoate adopts a "Chinese lantern" structure, wherein a pair of copper centers are linked by four bridging carboxylate ligands. (wikipedia.org)
  • concentrations
  • A single intramuscular injection of 5 mg estradiol benzoate has been found to result in peak circulating concentrations of 940 pg/mL estradiol and 343 pg/mL estrone, which occurred at about 2 days post-injection (see table). (wikipedia.org)
  • synthesize
  • Schwenk and Hildebrant discovered estradiol via reduction of estrone in 1933, and they proceeded to synthesize estradiol benzoate from estradiol the same year. (wikipedia.org)
  • doses
  • Under the tentative brand name Unimens, estradiol butyrate benzoate was studied in combination with the progestogen algestone acetophenide (dihydroxyprogesterone acetophenide) as a once-monthly combined injectable contraceptive (at doses of 10 mg and 150 mg, respectively). (wikipedia.org)
  • include
  • These highlights do not include all the information needed to use RIZATRIPTAN BENZOATE TABLETS safely and effectively. (nih.gov)
  • levels
  • A single dose of 2.5 mg estradiol benzoate by intramuscular injection was found to produce plasma estradiol levels of >400 pg/mL, measured 24 hours post-injection, in a group of patients with minimal baseline levels of estradiol (due to GnRH analogue therapy with triptorelin). (wikipedia.org)
  • treat
  • If a patient has no response for the first migraine attack treated with rizatriptan benzoate tablets, the diagnosis of migraine should be reconsidered before rizatriptan benzoate tablets are administered to treat any subsequent attacks. (nih.gov)
  • upon
  • Upon ingestion, regardless of the route of administration, estradiol benzoate behaves as a prodrug via cleavage by esterases into estradiol and the natural fatty acid benzoic acid. (wikipedia.org)