UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38. (cdc.gov)
Three dyes (Red 40, Yellow 5, and Yellow 6) have been found to be contaminated with benzidine or other carcinogens. (awholehealthlife.com)
It was later decided to include nitions of carcinogens were based on pollution, occupational exposure to a review of lifestyle factors that are the January 2013 list of agents classified carcinogenic compounds, and lifestyle known to influence cancer risk. (who.int)
Organic compounds2
Pesticides are a group of organic compounds used to control weeds or insect infestations in agriculture. (bvsalud.org)
See also boiling and melting point of different kinds of organic compounds , boiling and melting point of organic nitrogen compounds , pKa of phenols, alcohols and carboxylic acids and pKa of inorganic acids and bases , as well as acid and base pH indicators and Acid-base properties of aqueous solutions of salts with ions from both acids and bases . (engineeringtoolbox.com)
Biphenyl3
Biphenyl Compounds" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Biphenyl Compounds" by people in Harvard Catalyst Profiles by year, and whether "Biphenyl Compounds" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Biphenyl Compounds" by people in Profiles. (harvard.edu)
20211
Chih-Ching Chien Ssu-Ching Chen (2021, Aug). Propolis alleviates 4-aminobiphenyl-induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells. (ncu.edu.tw)
Abstract1
1984. Covalent binding of benzidine to rat hemoglobin [Abstract]. (cdc.gov)
Liver1
Low concentrations of 4-ABP promote liver carcinogenesis in human liver cells and a zebrafish model. (ncu.edu.tw)
19931
1993. Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine. (cdc.gov)
Acid1
Values for the negative logarithm of the acid dissociation constant, pKa, of the conjugated acid of amines, diamines and cyclic organic nitrogen compounds, shown together with the molecular structure of the acids. (engineeringtoolbox.com)
Human1
Diet is the major route of human exposure to these compounds, which can cause serious health problems, even when the intake occurs at low concentrations. (bvsalud.org)
Values1
More binding was observed at both pH values with 4′-OH-ABP than ABP. (wustl.edu)
A working paper on preparing decision guidance documents for severely hazardous pesticide formulations, originally considered by the interim Chemical Review Committee at its third session, was used by an inter-sessional drafting group in preparing a decision guidance document considered at the fourth session of the interim Chemical Review Committee (UNEP/FAO/PIC/ICRC.4/7). (pic.int)
It was agreed that the co-chairs of the drafting group would work intersessionally to develop a further draft of the working paper (UNEP/FAO/PIC/ICRC.4/18, para. (pic.int)
Cancer5
The three most widely used culprits-Yellow 5, Yellow 6 and Red 40-contain compounds, including benzidine and 4-aminobiphenyl, that research has linked with cancer. (awholehealthlife.com)
The classic organ systems are influenced by ters DNA repair or causes genomic mutation theory of cancer no longer mechanistic events associated with instability, (4) induces epigenetic fully encompasses the mechanistic cancer induction. (who.int)
RÉSUMÉ Afin d'atteindre les objectifs de santé fixés par le pays pour 2011-2016, une analyse qualitative de l'exposition aux facteurs de risque de cancer au Qatar a été conduite en 2013. (who.int)
Les risques de cancer les plus élevés pour les Qatariens proviendraient de facteurs associés aux modes de vie, en particulier l'obésité, la sédentarité et le tabagisme. (who.int)
Aromatic amines, such as benzidine (BZ), initiate bladder cancer in humans. (wustl.edu)
People1
In turn, most of the evaluated compounds were higher in urine samples from people living near the Amazon River, which presents increased traffic of boats and ships than the Tapajós River. (bvsalud.org)
Standard1
Connecting threads of 5/8" x 11 UNC, 1-1/4"x 7 UNC and G1/2" fit all standard core bits. (carbourtools.com)
Products1
NO donor diethylamine (DEA) NONOate, produced two products, which were identified by MS as 4′-OH-4-aminobiphenyl (4′-OH-ABP) and 4-aminobiphenyl (ABP). (wustl.edu)
Beta-naphthylamine1
1993. Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine. (cdc.gov)
Aromatic amines1
This finding is consistent with previous in vitro results that acidic urine hydrolyzes glucuronidated aromatic amines, which enables free compounds to bind DNA. (nih.gov)
Dyes13
Recent data from animal tests, case reports, and other sources about the carcinogenic effects and metabolism of benzidine-, o-tolidine-, and o- dianisidine-based dyes have come to the attention of OSHA and NIOSH. (cdc.gov)
The intent of this document is to summarize the information available of the carcinogenic effects and metabolism of benzidine-, o-tolidine-, and o- dianisidine-based dyes and to provide guidance so that employers, employees, and physicians may work together to reduce potential health hazards that could result from excessive exposure to these dyes. (cdc.gov)
OSHA and NIOSH have reviewed the literature on benzidine-based dyes. (cdc.gov)
Available studies indicate that some benzidine-based dyes cause cancer in experimental animals and are converted in animals and humans to benzidine. (cdc.gov)
In a Special Hazard Review, NIOSH has recommended that the commercial use of benzidine-based dyes be discontinued and appropriate substitutes be utilized. (cdc.gov)
There is preliminary evidence that dyes based on o-tolidine and o-dianisidine, except for metalized dyes based on o-dianisidine, may be metabolically converted to the parent compounds. (cdc.gov)
Benzidine-based dyes may contain residual amounts of benzidine as well as other substances such as 4-aminobiphenyl, an OSHA-regulated carcinogen. (cdc.gov)
Dyes manufactured from o-dianisidine and o-tolidine may also contain residual amounts of the respective parent compounds. (cdc.gov)
Benzidine-based dyes are defined as dyes that contain benzidine attached to other substituents by diazo linkages. (cdc.gov)
At least 16 benzidine-based, 8 o- tolidine-based, and 9 o-dianisidine-based dyes are produced currently in the United States. (cdc.gov)
In addition, according to the report, FDA tests show that the three most-widely used dyes, Red 40, Yellow 5, and Yellow 6, are tainted with low levels of cancer-causing compounds, including benzidine and 4-aminobiphenyl in Yellow 5. (commondreams.org)
The human health assessment for Benzidine-based Dyes and Related Substances focuses on substances that are in commerce (based on information received in response to the section 71 survey) and/or for which available information indicates potential exposure to the general population of Canada: 3,3'-DMB and Acid Red 97. (gc.ca)
In general, Benzidine-based Dyes are used predominantly for dyeing textiles, Benzidine-based Cationic Indicators as laboratory reagents and Benzidine-based Precursors and Benzidine Derivatives as intermediates in the manufacturing of dyes, pigments, colouring agents and chemicals. (gc.ca)
19841
1984. Covalent binding of benzidine to rat hemoglobin [Abstract]. (cdc.gov)
Exposure5
Low levels of 4-ABP exposure have been associated with non-smoking-related bladder cancer. (nih.gov)
Monitoring data on levels of compounds in environmental media often represent the only information available, and average population exposure is therefore the only quantitative parameter that can be calculated. (nih.gov)
Based on the uses of these substances and the overall low volumes of Benzidine-based Substances or Benzidine Derivatives in commerce, exposure from environmental media is not expected. (gc.ca)
As none of the substances in this assessment were identified to be used in food packaging or food-related applications, these sources are not considered to contribute to exposure to Benzidine-based Substances or Benzidine Derivatives. (gc.ca)
Using the median leaching level of 3,3′-DMB (1.4 µg/kg food) under acidic and elevated temperature, conservative estimates of potential exposure from the use of polyamide cooking utensils were derived to range from 0.002 µg/kg-bw per day (12 years of age and older) to 0.0065 µg/kg-bw per day (toddlers 0.5-4 years of age). (gc.ca)
Adduct2
Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct. (chemchart.com)
Dr. Rothman and colleagues found that among workers in India exposed to the aromatic diamine benzidine, N acetylated benzidine was the predominant DNA adduct in exfoliated urothelial cells. (nih.gov)
Derivative2
4-Aminobiphenyl is an amine derivative of biphenyl. (chemchart.com)
A chemically and thermodynamically stable derivative of BENZIDINE . (nih.gov)
Humans1
This finding documented that acetylation activates rather than detoxifies benzidine in humans, in contrast to the deactivation role of acetylation for aromatic monoamines, such as 4 aminobiphenyl. (nih.gov)
Substances1
The presence of other Benzidine-based Substances or Benzidine Derivatives in products, in particular in textiles, in Canada has not been identified. (gc.ca)
Bladder cancer1
It is estimated that 9,900 people died of bladder cancer in 1978 (4). (nih.gov)
Chemical2
Get chemical information updates for 4-Aminobiphenyl sent to your email. (chemchart.com)
4. Experimental studies show that chemical compounds found in cigarette smoke are capable of inducing carcinoma of the esophagus in experimental animals. (nih.gov)
Stable1
It is not known whether these compounds are stable at the 1 atm boiling temperature or not. (engineeringtoolbox.com)
Solvents1
A further challenge is that prior art solvents solve the functional compounds in a very slow manner, such that a lot of effort is needed for the preparation of a solution. (justia.com)
Organic2
The figures below show the boiling and melting point for organic nitrogen compounds as amines, diamines, pyrroles, pyridines, piperidines and quinolines , together with the molecular structures of the different compounds. (engineeringtoolbox.com)
The present invention relates to formulations for the preparation of organic electronic devices which comprise at least one specific A/JV-dialkylaniline and at least one organic functional material selected from organic conductors, organic semiconductors, organic fluorescent compounds, organic phosphorescent compounds, organic light-absorbent compounds, organic light-sensitive compounds, organic photosensitisation agents and other organic photoactive compounds, selected from organometallic complexes of transition metals, rare earths, lanthanides and actinides. (justia.com)
Toxic2
Direct black 38 (DB38) dye is a well-established toxic and carcinogenic compound. (csircentral.net)
Benzidine and 4-aminobiphenyl (4-ABP) were identified as the DB38 metabolites, responsible for its toxic and mutagenic properties, by HPLC-MS analysis. (csircentral.net)
Carbon2
Carbon adsorption was also effective in removing the compounds from aqueous solution. (epa.gov)
Large polynuclear aromatic compounds exhibited reduced adsorption capacities due to exclusion from the small diameter pores of the carbon. (epa.gov)
Group1
This evaluation applies to the group of compounds as a whole and not necessarily to all individual compounds within the group. (wikidoc.org)
Found2
However, the levels actually could be far higher, because in the 1990s the FDA and Health Canada found a hundred times as much benzidine in a bound form that is released in the colon, but not detected in the routine tests of purity conducted by the FDA. (commondreams.org)
Further degradation of benzidine and 4-ABP was found to result in the decrease in toxicity and mutagenicity. (csircentral.net)
Reduce1
Se ha comprobado que reduce la resorción ósea en la enfermedad periodontal al inhibir la ANHIDRASA CARBÓNICA. (bvsalud.org)
Study1
Detoxification of benzidine-based azo dye by E. gallinarum: time-course study. (csircentral.net)