• Quick MP, Frohlich R, Schepmann D, Wunsch B . Asymmetric synthesis of 3-substituted tetrahydro-2-benzazepines. (uni-muenster.de)
  • Hasebein P, Frehland B, Lehmkuhl K, Frohlich R, Schepmann D, Wunsch B . Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the alpha-substituted benzyl moiety in the 5-position. (uni-muenster.de)
  • Kouznetsov V, Palma A, Ewert C (2001) Synthesis and applicability of partially reduced 2-benzazepines. (springer.com)
  • A tandem benzannulation-ring closing metathesis strategy for the efficient synthesis of benzo-fused nitrogen heterocycles such as dihydroquinolines, benzazepines, and benzazocines has been developed. (mit.edu)
  • GS modulators (GSMs) reduce the level of longer, neu- used in the synthesis of benzazepine agents for the treatment of rotoxic Ab peptides (Ab42 and Ab43) by shifting the APP processing central nervous system disorders.12-15 In general, two methodolo- by c-secretase towards shorter isoforms (such as Ab37, Ab38) gies exist for the preparation of benzo[c]azepines 4 (Scheme 1). (scribd.com)
  • A H 2 SO 4 -mediated intramolecular cyclization enables the preparation of biologically important tetrahydro-1-benzazepines from N-arylated homoallylamines. (organic-chemistry.org)
  • Aeyad T, Jones C & Coldham I (2018) Preparation of substituted tetrahydro-1-benzazepines by lithiation-trapping . (sheffield.ac.uk)
  • The present invention relates to substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives that are modulators of the 5HT 2C receptor. (sumobrain.com)
  • Benzazepines are heterocyclic chemical compounds consisting of a benzene ring fused to an azepine ring. (wikipedia.org)
  • Preferred benzazepines are the compounds wherein Ri is a phenylethyl group or a 1-naphtylethyl group, R2 and Rs are both hydrogen and wherein R4 is a biolabile ester group. (allindianpatents.com)
  • Its chemical name is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hemihydrate. (rxlist.com)
  • Decreased striatal dopamine efflux after intrastriatal application of benzazepine-class D1 agonists is not mediated via dopamine receptors. (semanticscholar.org)
  • The present experiments employed in vivo microdialysis to further examine the ability of widely used benzazepine-class D1 agonists to modulate striatal dopamine efflux. (semanticscholar.org)
  • We then assessed the contribution of the basal ganglia motor loops to these impairments, using open field testing and analysis of drug-induced locomotor responses to the psychostimulant cocaine, the benzazepine D 1 receptor agonists SKF83822 and SKF83959, and the NMDA receptor antagonist MK-801. (frontiersin.org)
  • Tolvaptan, another benzazepine derivative, has selective antimuscarinic action may be completely reversible. (yogachicago.com)
  • Fenoldopam mesylate ( Corlopam ) is a drug and synthetic benzazepine derivative which acts as a selective D 1 receptor partial agonist . (wikipedia.org)
  • Benzazepines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • The metal-free indolo[3,2- c ]quinolines inhibit cancer cell growth in vitro, with IC 50 values in the high nanomolar range, whereas those of the related indolo[3,2- d ]benzazepines are in the low micromolar range. (springer.com)
  • Reversible acetylcholinesterase inhibitor (benzazepine deriv). (empr.com)
  • More recently this chemical compound is claimed to have been sold as a designer drug under the name A3A,[citation needed] but since the anecdotally reported effects of the product sold under this name do not seem to bear any resemblance to the known pharmacology of genuine 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine, it seems unlikely that this is actually the compound being sold. (wikipedia.org)
  • I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
  • This graph shows the total number of publications written about "Benzazepines" by people in Harvard Catalyst Profiles by year, and whether "Benzazepines" was a major or minor topic of these publication. (harvard.edu)
  • Benzazepines with the above formula are known from EP 0733642, EP 0830863, WO00/48601 and WO01/03699. (allindianpatents.com)