Quick MP, Frohlich R, Schepmann D, Wunsch B . Asymmetric synthesis of 3-substituted tetrahydro-2-benzazepines. (uni-muenster.de)
Hasebein P, Frehland B, Lehmkuhl K, Frohlich R, Schepmann D, Wunsch B . Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the alpha-substituted benzyl moiety in the 5-position. (uni-muenster.de)
Kouznetsov V, Palma A, Ewert C (2001) Synthesis and applicability of partially reduced 2-benzazepines. (springer.com)
A tandem benzannulation-ring closing metathesis strategy for the efficient synthesis of benzo-fused nitrogen heterocycles such as dihydroquinolines, benzazepines, and benzazocines has been developed. (mit.edu)
GS modulators (GSMs) reduce the level of longer, neu- used in the synthesis of benzazepine agents for the treatment of rotoxic Ab peptides (Ab42 and Ab43) by shifting the APP processing central nervous system disorders.12-15 In general, two methodolo- by c-secretase towards shorter isoforms (such as Ab37, Ab38) gies exist for the preparation of benzo[c]azepines 4 (Scheme 1). (scribd.com)
Tetrahydro-1-benzazepines2
A H 2 SO 4 -mediated intramolecular cyclization enables the preparation of biologically important tetrahydro-1-benzazepines from N-arylated homoallylamines. (organic-chemistry.org)
Aeyad T, Jones C & Coldham I (2018) Preparation of substituted tetrahydro-1-benzazepines by lithiation-trapping . (sheffield.ac.uk)
Derivatives1
The present invention relates to substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives that are modulators of the 5HT 2C receptor. (sumobrain.com)
Compounds2
Benzazepines are heterocyclic chemical compounds consisting of a benzene ring fused to an azepine ring. (wikipedia.org)
Preferred benzazepines are the compounds wherein Ri is a phenylethyl group or a 1-naphtylethyl group, R2 and Rs are both hydrogen and wherein R4 is a biolabile ester group. (allindianpatents.com)
Hydrochloride1
Its chemical name is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hemihydrate. (rxlist.com)
Agonists3
Decreased striatal dopamine efflux after intrastriatal application of benzazepine-class D1 agonists is not mediated via dopamine receptors. (semanticscholar.org)
The present experiments employed in vivo microdialysis to further examine the ability of widely used benzazepine-class D1 agonists to modulate striatal dopamine efflux. (semanticscholar.org)
We then assessed the contribution of the basal ganglia motor loops to these impairments, using open field testing and analysis of drug-induced locomotor responses to the psychostimulant cocaine, the benzazepine D 1 receptor agonists SKF83822 and SKF83959, and the NMDA receptor antagonist MK-801. (frontiersin.org)
Tolvaptan1
Tolvaptan, another benzazepine derivative, has selective antimuscarinic action may be completely reversible. (yogachicago.com)
Selective1
Fenoldopam mesylate ( Corlopam ) is a drug and synthetic benzazepine derivative which acts as a selective D 1 receptor partial agonist . (wikipedia.org)
MeSH2
Benzazepines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Indolo1
The metal-free indolo[3,2- c ]quinolines inhibit cancer cell growth in vitro, with IC 50 values in the high nanomolar range, whereas those of the related indolo[3,2- d ]benzazepines are in the low micromolar range. (springer.com)
More recently this chemical compound is claimed to have been sold as a designer drug under the name A3A,[citation needed] but since the anecdotally reported effects of the product sold under this name do not seem to bear any resemblance to the known pharmacology of genuine 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine, it seems unlikely that this is actually the compound being sold. (wikipedia.org)
Chemistry1
I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
Publication1
This graph shows the total number of publications written about "Benzazepines" by people in Harvard Catalyst Profiles by year, and whether "Benzazepines" was a major or minor topic of these publication. (harvard.edu)
Formula1
Benzazepines with the above formula are known from EP 0733642, EP 0830863, WO00/48601 and WO01/03699. (allindianpatents.com)