• Fluorinated GluN2B Receptor Antagonists with a 3-Benzazepine Scaffold Designed for PET Studies. (idexlab.com)
  • item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "\u003cAbstract of Published Report\u003e1,3-Disubstituted Benzazepines as Novel, Potent, Selective Neuropeptide Y Y1 Receptor Antagonists. (nii.ac.jp)
  • 1,3-Disubstituted Benzazepines as Novel, Potent, Selective Neuropeptide Y Y1 Receptor Antagonists. (nii.ac.jp)
  • However, the GluN2B ligands eliprodil, Ro 25-6981, and the non-labeled 3-benzazepine 14 were able to abolish the specific binding of [18 F]14. (idexlab.com)
  • Analysis of the relationship between the structure and the σ1 affinity revealed that large substituents such as the butyl, benzyl or 4-phenylbutyl moiety at the benzazepine N-atom resulted in high affinity ligands. (idexlab.com)
  • The butyl- and 4-fluorobenzyl-substituted derivatives, (±)-5-benzyl-2-butyl-2,3,4,5-tetrahydro-1H-2-benzazepine (19 b) and (±)-5-benzyl-2-(4-fluorobenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine (19 m), show high selectivity over more than 50 other relevant targets, including the σ2 subtype and various binding sites of the N-methyl-D-aspartate (NMDA) receptor. (idexlab.com)
  • To date phenytoin, some benzazepine derivatives and stereoisomers of methylphenylpiracetam have been reported as PAMs of Sig1R while NAMs of Sig1R have not yet been described. (frontiersin.org)
  • Ieawsuwan, W. Synthesis of Chiral Tetrahydro-3-benzazepine Motifs by Iridium Catalyzed Asymmetric Hydrogenation of Cyclic EneCarbamates. (cri.or.th)
  • Benzazepines are heterocyclic chemical compounds consisting of a benzene ring fused to an azepine ring. (wikipedia.org)
  • A de novo synthetic method to the access of N-substituted benzazepines. (u-szeged.hu)