• 5. A compound according to claim 1 wherein the compound is cis-4-amino-5-chloro-2-methoxy-N-[3-methoxy-1-pyridinylmethyl)-4-piperidinyl]benzamide. (google.com)
  • 10. The pharmaceutical composition of claim 6 wherein the compound is cis-4-amino-5-chloro-2-methoxy-N-[3-methoxy-1-(2-pyridinylmethyl)-4-piperidinyl]benzamide. (google.com)
  • Novel N-(3-hydroxy-4-pipridinyl)benzamides and derivatives thereof, said compounds being used as stimulators of the motility of the gastro-intestinal system. (google.com)
  • Two series of benzamides compounds bearing piperidine groups were synthesized and the Gli-luc luciferase activity was screened by Gys-luc luciferase gene detection method. (mdpi.com)
  • These are compounds containing a benzamide moiety that is N-linked to a benzyl group. (drugbank.ca)
  • This compound belongs to the class of organic compounds known as benzamides. (drugbank.ca)
  • These ylides were reduced using sodium borohydride in absolute ethanol and gave the target compounds, substituted N-(4-(6-methyl-1H-benzo[d]imidazol-2-yl)-5,6-dihydropyridin-1(2H)-yl)benzamide/benzenesulfonamides. (aacrjournals.org)
  • Trabucchi, M. / Sulpiride and other benzamides as specific antagonists at the D2 dopamine receptor . (elsevier.com)
  • Sulpiride and other benzamide (BM)-displacing activity on [ 3H]-spiroperidol ([ 3H]SPIR) binding by rat striatal dopaminergic receptors was found to be uniquely. (naver.com)
  • Xu J, Lecanu L, Tan M, Greeson J, Papadopoulos V. Identification of a Benzamide Derivative that Inhibits Stress-Induced Adrenal Corticosteroid Synthesis. (mdpi.com)
  • The new benzamide derivative [125I]iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors and displays a very low nonspecific binding to membrane or autoradiographic sections. (sciencemag.org)
  • The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo. (naver.com)
  • Use appropriate chemical resistant gloves (minimum requirement use standard BS EN 374:2003). (adooq.com)
  • Tacedinaline, also known as CI-944 and PD123654, is a n orally bioavailable substituted benzamide derivative with potential antineoplastic activity. (medkoo.com)
  • Seeking a conventional drug to attenuate the cytolytic activity of tumor necrosis factor (TNF-alpha) and thereby prevent excessive tissue injury, we focused on the cytolytic action of hTNF-alpha against L929 cells, which are sensitive to TNF-alpha, and found that flecainide acetate [N-(2-piperidylmethyl) 1,5-bis-(2,2,2-trifluoroethoxy) benzamide acetate] inhibited specifically the cytolytic action of hTNF-alpha against L929 cells. (elsevier.com)
  • A highly mono-selective ortho -methylthiolation of benzamides was achieved via Co-catalyzed coupling of benzamides with DMSO. (rsc.org)
  • Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m-carboxycinnamic acid bis-h. (nih.gov)
  • Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells. (nih.gov)
  • Although protection was less than desirable during weeks 2 and 4 (less than 80%), some short-term protection against biting sand flies was obtained and will supplement other personal protective measures in the field (N,N-Diethyl-3-methyl benzamide (deet) skin repellent, permethrin-treated bed nets and uniforms). (thefreedictionary.com)
  • 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2pyrrolidinyl)methyl]benzamide and related compounds. (springer.com)
  • N-(3-Guanidino-4-methylphenyl)-4-(methylpiperazine-1-yl-methyl)benzamide Dihydrochloride is a compound useful in organic synthesis. (trc-canada.com)
  • Benzamide is less easily hydrolysed than methyl benzoate. (chemzipper.com)
  • Therefore, magnitude of positive charge on carbonyl carbon in benzamide is less than in methyl benzoate. (chemzipper.com)
  • A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2- b ]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. (ebi.ac.uk)
  • Remoxipride (Figure 1), a substituted benzamide analog of sulpiride, was developed as a potential antipsychotic agent on the assumption that the poor bioavailability of sulpiride was due to hydrolysis of the amide bond. (springer.com)
  • We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of N-[4-bromo-2-(2-pyridylcarbonyl)phenyl]benzamide. (reportsnreports.com)
  • Differentiation of MDA-MB468 breast cancer cells is induced by benzamide and hydroxamate analogs. (nih.gov)
  • We conclude that despite a different HDAC isoenzyme inhibition profile, hydroxamate and benzamide analogs as studied display similar cellular profiles. (nih.gov)
  • D.O. Kiesewetter, R. Kawai, M. Chelliah, E. Owens, C. Mclellan and R.G. Blasberg: Preparation and biological evaluation of 18F-labeled benzamide analogs as potential dopamine D2 receptor ligands, Nucl Med Biol 17: 347-356 (1990). (springer.com)
  • Trabucchi, M. / Sulpiride and other benzamides as specific antagonists at the D2 dopamine receptor . (elsevier.com)
  • The structure-affinity correlations of a series of benzamides for dopamine D 2 receptor imaging agents have been studied with SYBYL 6.4 software on SGI O 2 workstation. (pku.edu.cn)
  • This study aimed at comparing the pharmacological properties of selected second generation HDAC inhibitors with the hydroxamate and benzamide head group, namely SAHA, LAQ824/LBH589, CI994, MS275 and MGCD0103. (nih.gov)
  • In contrast, the benzamides CI994, MS275 and MGCD0103 are more selective, potent inhibitors of at least HDAC1 and HDAC3. (nih.gov)
  • Division was recently validated as an important target for antibiotics by the demonstration that low-molecular-weight inhibitors of FtsZ, called benzamides, can cure mice infected with Staphylococcus aureus. (ncl.ac.uk)
  • In psychiatry some substituted benzamides are therapeutically used as neuroleptics and/or antipsychotics (wikipedia). (hmdb.ca)
  • J. Mukherjee, B.D. Perry, M. Cooper: Fluorinated benzamide neuroleptics. (springer.com)
  • Herein we report detailed investigation into the anticancer activity of sulfamoyl benz(sulfon)amides (1a-1g, 2a-2k) and 1H-pyrazol-4-yl benzamides (3a-3j) against three cancer cell lines, breast cancer cells (MCF-7), bone-marrow cancer cells (K-562) and cervical cancer cells (HeLa). (ovid.com)
  • K.A. Neve, R.A. Henningsen, J.M. Kinzie, T. de Paulis, D.E. Schmidt, R.M. Kessler and A. Janowsky: Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand, J Pharm Exp Ther 252: 1108-1116 (1990). (springer.com)
  • C.-T. Chen, C. Ortega, R.N. Beck and M. Cooper: Dopamine D-2 receptors imaged by PET in Cebus apella using [18F]benzamide neuroleptic, Eur J Pharm 175: 363-364 (1990). (springer.com)
  • Coplanar Effect Studies on the Benzamides of Dopamine D 2 Receptor Imaging Agents[J].Acta Phys. (pku.edu.cn)
  • The present invention provides a more efficient industrial method for producing a pyrazol-3-yl-benzamide derivative expressed by a formula useful as medicine: ##STR00001## wherein R 2 , R 3 and R 4 each independently represent a lower alkyl group. (patentsencyclopedia.com)
  • [0001] The present invention relates to a more efficient and new production method for a pyrazol-3-yl-benzamide derivative useful as medical products. (patentsencyclopedia.com)
  • Further, it also relates to an intermediate for producing the pyrazol-3-yl-benzamide derivative efficiently. (patentsencyclopedia.com)
  • And it relates to crystalline of pyrazol-3-yl-benzamide derivative which is useful as medicine. (patentsencyclopedia.com)
  • Coyne et al (31) transplanted marrow stromal cells (MSCs) double-labelled with BrdU and bis- benzamide (BBZ) into the adult hippocampus or striatum noticed that BrdU labelling was colocalized to host phagocytes, astrocytes, and neurons in both regions. (thefreedictionary.com)
  • New N-(benzyl carbamothioyl)-2-hydroxy substituted benzamides 13 , 20 , and 21 were synthesized using sodium bicarbonate and benzyl amine with 2-thioxo-substituted-1,3-benzoxazines 6, 10a, b, 11c , and 12a-n . (hindawi.com)
  • Products 15a, b, e, f , and g were also synthesized by boiling the corresponding N-(benzyl carbamothioyl)-2-hydroxy substituted benzamides 13a, b, f, l , and m in acetic acid. (hindawi.com)
  • The N-(benzyl carbamoyl)-2-hydroxy substituted benzamide 23 was synthesized from the reaction of 2-oxo-substituted-1,3-benzoxazine 22 with benzylamine. (hindawi.com)
  • Benzamide is a white solid with the chemical formula of C6H5C(O)NH2. (wikipedia.org)
  • Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. (chalmers.se)
  • Benzamides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Cisapride is a substituted benzamide compound that stimulates motor activity in all segments of the gastrointestinal tract by enhancing the release of acetylcholine from the enteric nervous system Actions at enteric neuronal serotonin (5-hydroxytryptamine-[5-HT]) receptors have been implied in the prokinetic effects of cisapride. (thefreedictionary.com)
  • para-Selective Alkylation of Benzamides and Aromatic Ketones by Cooperative Nickel/Aluminum Catalysis. (bvsalud.org)
  • We report a method that ensures the selective alkylation of benzamides and aromatic ketones at the para-position via cooperative nickel / aluminum catalysis . (bvsalud.org)
  • the incorporation of 35 SO 4 2− into the trichloroacetic-acid-insoluble constituents of cell masses as well as the formation of cartilage nodules (Nishio, Nakanishi, Doull & Uyeki, 1983) occurred about 24h earlier than in untreated cultures and continued to be enhanced in benzamide-treated cultures of stage 23- to 24-chick limb bud cells. (biologists.org)
  • In vitro, the benzamides strongly promote the polymerization of FtsZ, into hyperstable polymers, which are highly curved. (ncl.ac.uk)
  • The results of conformational analysis and PM3 calculation have demonstrated that the coplanar effect of benzamides is one of the most important requirements for activity in vitro. (pku.edu.cn)
  • Greene, John F. / Toxicity and efficacy of benzamide riboside in cancer chemotherapy models . (elsevier.com)
  • A highly mono-selective ortho -methylthiolation of benzamides was achieved via Co-catalyzed coupling of benzamides with DMSO. (rsc.org)
  • We propose that benzamides act principally by promoting an FtsZ protomer conformation that is incompatible with a higher-order level of assembly needed to make a division ring. (ncl.ac.uk)
  • 2,5-Dihydroxy-N-(2-hydroxyethyl) benzamide 1a, 2,4-dihydroxy-N-(2-hydroxyethyl) benzamide 1b (Aldrich) and other chemicals and solvents were used as received. (thefreedictionary.com)
  • Benzamide is an intermediate in the Benzoate degradation via CoA ligation. (hmdb.ca)
  • Importantly, even at low concentrations, benzamides transform the structure of the Z ring, resulting in abnormal helical cell division events. (ncl.ac.uk)