• Melanotic neuroectodermal tumor of infancy (MNTI) is a relatively uncommon osteolytic-pigmented neoplasm that primarily affects the jaws of newborn infants. (medscape.com)
  • Some of the terms applied to this lesion included pigmented ameloblastoma, retinal anlage tumor, melanotic progonoma, melanotic adamantinoma, and pigmented epulis of infancy. (medscape.com)
  • In 1966, Borello and Gorlin reported a case with high urinary excretion of vanillylmandelic acid (VMA), suggesting a neural crest origin, and they proposed the term melanotic neuroectodermal tumor of infancy. (medscape.com)
  • [ 6 ] Since then, numerous histochemical, immunohistochemical, electron microscopic, and tissue culture studies have supported the neural crest origin and confirmed the preferred term of melanotic neuroectodermal tumor of infancy. (medscape.com)
  • Several patients with melanotic neuroectodermal tumor of infancy (MNTI) have demonstrated a high urinary excretion of VMA. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm and approximately 485 cases have been reported in the literature to date worldwide. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy (MNTI) has a slight male predilection, with a male-to-female ratio of 1.3:1. (medscape.com)
  • [ 14 ] A few cases of melanotic neuroectodermal tumor of infancy (MNTI) have been reported in adults, notably, a 23-year-old man, a 39-year-old woman, and a 67-year-old woman. (medscape.com)
  • Most melanotic neuroectodermal tumors of infancy (MNTIs) are benign and effectively managed by aggressive surgical excision. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy is a rare neoplasm of possibly neural crest origin, and it predominantly occurs in the premaxillas of infants less than 12 months old. (smu.ac.za)
  • Melanotic neuroectodermal tumor of infancy is a very rare oral cavity tumor that is seen in patients usually at or around birth. (wikipedia.org)
  • Address the documented 20% recurrence rate of melanotic neuroectodermal tumor of infancy (MNTI) in the postoperative care by monitoring the patient with physical and radiographic examination at monthly intervals for the first two postoperative years. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy--a neoplasm of neural crese origin. (medscape.com)
  • Cutler LS, Chaudhry AP, Topazian R. Melanotic neuroectodermal tumor of infancy: an ultrastructural study, literature review, and reevaluation. (medscape.com)
  • Malignant melanotic neuroectodermal tumor of infancy: a clinical, pathologic, ultrastructural and tissue culture study. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy: 2 decades of clinical experience with 18 patients. (medscape.com)
  • Kruse-Lösler B, Gaertner C, Bürger H, Seper L, Joos U, Kleinheinz J. Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case. (medscape.com)
  • Moreover, an estimated malignant transformation rate of 6.5% highlights the possibly serious nature of this tumor and the need for careful clinical evaluation and close follow-up of affected patients, especially for tumors located in the brain and skull. (medscape.com)
  • Malignant melanotic neuroectodermal tumor: light and electron microscopic study. (medscape.com)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • 4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)
  • Definitions: A rare, biphasic, neuroblastic, and pigmented epithelial neoplasm of craniofacial sites, usually involving the oral cavity or gums. (wikipedia.org)
  • more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (lookformedical.com)
  • It is important in this age group to exclude other tumors that can have a similar appearance, such as rhabdomyosarcoma, lymphoma, Ewing sarcoma (primitive neuroectodermal tumor), or even a melanoma (although they are very very rare in infants). (wikipedia.org)
  • Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
  • This is followed by coverage of neoplasms in the more traditional categories of epithelial, mesenchymal, and other categories. (abdominalkey.com)
  • [ 13 ] Unfortunately, reports have shown that recurrent tumors tend to behave more aggressively and involve other anatomic structures such as the orbit and skull base. (medscape.com)
  • In rare cases, chemotherapy may be used for recurrent or residual tumors. (wikipedia.org)
  • The role of genotyping and ancillary tools, in particular immunohistochemistry, in correctly classifying these tumors is highlighted in the section on Renal Cell Carcinoma. (abdominalkey.com)
  • The first section will cover those tumors that characteristically are associated with the pediatric population. (abdominalkey.com)
  • Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor. (beds.ac.uk)
  • 1 - 3 Intracranial brain tumors, most commonly medulloblastoma [ Figure 2 ], can metastasize to the peritoneal cavity via ventriculo-peritoneal shunts used to divert excess cerebrospinal fluid. (cytojournal.com)
  • adenomatoid t. a small benign t. of the male epididymis and female genital tract , consisting of fibrous tissue or smooth muscle enclosing anastomosing glandlike spaces containing acid mucopolysaccharide lined by flattened cells that have ultra-structural characteristics of mesothelial cells. (en-academic.com)
  • Generally, the treatment of this benign pigmented lesion is conservative surgical excision. (smu.ac.za)
  • benign t. a t. that does not form metastases and does not invade and destroy adjacent normal tissue . (en-academic.com)
  • A tumor (abnormal growth of tissue) of the nervous system. (beds.ac.uk)
  • Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
  • Only very few tumors produce metastases and death. (medscape.com)
  • Even though there is often a very dramatic and rapidly enlarging, destructive tumor, there is usually a benign clinical course after complete local excision (usually by partial maxillectomy) with clear or free surgical margins. (wikipedia.org)
  • Wilms tumor is believed to arise from embryonic tissues called nephrogenic rests that fail to undergo normal involution ( 7 ). (abdominalkey.com)
  • The tumor is usually circumscribed by a pseudocapsule formed of compressed renal and perirenal tissues. (abdominalkey.com)
  • A comprehensive systematic review of 472 cases of MNTI found that age at diagnosis is an important prognostic indicator in these tumors. (medscape.com)
  • Patients with Beckwith-Wiedemann syndrome and Denys-Drash syndrome have an increased risk of developing Wilms tumor ( 5 , 6 ). (abdominalkey.com)
  • Specific discussions of etiology and pathogenesis are dealt with in each of the sections on individual tumors, rather than as a freestanding section, as is used elsewhere in this text. (abdominalkey.com)
  • Most patients, by some estimates more than 90%, present with the tumor in the first year of life, usually from age 1-6 months, with a peak between the second and sixth month of life. (medscape.com)
  • To include biochemical and/or immunological markers which are specific for a tumour site (Table 2). (who.int)
  • In this chapter, these will be covered using an approach that has become a standard one in dealing with this group of tumors. (abdominalkey.com)
  • A diverse array of tumors can arise in the human kidney. (abdominalkey.com)
  • The purpose of this chapter is to familiarize the reader with the tumor types encountered in the human rather than to provide a comprehensive diagnostic reference, which is better handled in more comprehensive textbooks and monographs. (abdominalkey.com)
  • Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (lookformedical.com)