• Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • Although this most common gynecologic cancer carries the best prognosis, it is important to differentiate between the classic endometrioid tumors that tend to be estrogen dependent and well differentiated, from other less common high-risk uterine malignancies, such as uterine papillary serous carcinomas (UPSCs), clear cell carcinomas, mixed mullerian tumors (MMTs), or sarcomas, which appear to have a different biology. (medmuv.com)
  • Clinically, angiokeratoma of Fordyce over the vulva should be differentiated from angiomas (cherry angiomas, pyogenic granuloma, and lymphangioma), verrucous lesions (seborrhoeic keratosis, condyloma acuminata, nodular prurigo, condyloma lata, and certain nevi), and malignancies (melanoma and vulvar intraepithelial neoplasia). (natoursprung.de)
  • In a series of 635 patients with extragonadal germ cell tumors, 17 patients developed hematologic malignancies at a median of 6 months after the extragonadal germ cell tumor was diagnosed. (health.am)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
  • Depending on location they may have a variety of clinical presentations and even simulate malignant neoplasms. (bvsalud.org)
  • A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. (lookformedical.com)
  • A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
  • No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
  • Four of 22 consecutive patients (18%) treated at Indiana University for primary mediastinal germ cell tumors had karyotypic confirmation of Klinefelter syndrome, and an additional patient had clinical features. (health.am)
  • Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. (oncolink.org)
  • Biology, clinical characteristics, and management of adrenocortical tumors in children. (oncolink.org)
  • 68 With the current expansion of literature regarding neoplastic disease in this species as well as our desire to expand the discussion of available and emerging clinical treatments, frequency data of common neoplasms are presented based on the available literature for this species. (veteriankey.com)
  • The clinical behavior, prognosis, and paraneoplastic syndromes in ferrets are often far different from what is seen with similar neoplasms in dogs or cats. (veteriankey.com)
  • Mutation of the transforming growth factor (TGF) beta receptor type II gene is common in RER+ colon and gastric cancers, but uncommon in RER+ endometrial cancers even those arising in HNPCC kindreds, suggesting that the genesis of RER+ tumors even within the same familial cancer syndrome is not the same. (medmuv.com)
  • Among sporadic endometrial cancers, when present, the microsatellite instability is confined to the malignant cells, and is not seen in the adjacent normal epithelium. (medmuv.com)
  • Although inactivation of both alleles of either hMSH2 or MLH1 (DNA mismatch repair genes) appears to underlie microsatellite instability in tumors of HNPCC kindreds, similar to the findings in sporadic colon cancers, sporadic endometrial cancers were not associated with mutations of any of the four known human mismatch repair genes. (medmuv.com)
  • These data strongly suggest that some gene on chromosome 18, is a tumor suppressor gene in endometrial cancers. (medmuv.com)
  • Notable was the almost complete absence of Ki-ras mutations in an aggressive form of endometrial cancer, UPSC, when compared to the usual endometrioid tumors. (medmuv.com)
  • It proved to be a valid biomarker especially in detecting squamous intraepithelial lesions in cervical liquid-based samples and in discerning these lesions from their mimickers, as well as in ovarian, endometrial, vulvar, primary and metastatic melanomas, breast, pancreatic and renal cell carcinomas. (medsci.org)
  • Vulvar neoplasms are divided into cystic or solid lesions and other mixed types. (wikipedia.org)
  • Folliculomas are benign, asymptomatic lesions with no malignant potential. (medscape.com)
  • Patients should be informed of the benign nature of these lesions and that they require no follow-up care. (medscape.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. (allenpress.com)
  • These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography-guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. (allenpress.com)
  • Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)
  • To provide an updated review on the fine-needle aspiration cytology of mediastinal tumors/lesions, with an emphasis on diagnostic challenges. (allenpress.com)
  • The mediastinum is the site for a variety of lesions, both benign and malignant. (allenpress.com)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • There are four main groups of vaginal neoplasms: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. (wikipedia.org)
  • Note: Pilocytic/juvenile astrocytoma M-9421 moved from behavior /3 (malignant) to /1 (borderline malignancy) in ICD-O-3. (cancer.gov)
  • However, SEER registries will CONTINUE to report these cases and code behavior as /3 (malignant). (cancer.gov)
  • Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
  • Foci of malignant lymphoblasts have been recognized histologically in several mediastinal germ cell tumors. (health.am)
  • Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (lookformedical.com)
  • Folliculoma, also known as trichofolliculoma , is a type of benign cutaneous adnexal tumor. (medscape.com)
  • [ 1 ] Cutaneous adnexal tumors are neoplasms that are classified based on their morphologic differentiation towards at least one type of normal skin structure: hair follicles, apocrine glands, eccrine glands, or sebaceous glands. (medscape.com)
  • Obaidat NA, Alsaad KO, Ghazarian D. Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. (medscape.com)
  • Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells. (lookformedical.com)
  • 1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
  • My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
  • Primary Mediastinal Large B-Cell Lymphoma (PMBL) is a rare neoplasm that arises in the mediastinum, and then forms a mass. (jcimcr.org)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • Women with lichen sclerosus have a higher risk of developing differentiated vulval intraepithelial neoplasia (dVIN), which can progress to vulval cancer if left untreated. (docvatsa.com)
  • A tumor is an abnormal growth of body tissue. (medlineplus.gov)
  • A benign mass composed of mature cells that are native to the tissue of origin but have abnormal tissue organization (e.g. (amboss.com)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
  • Vulvar cancer, also known as vulval cancer, refers to the abnormal growth and division of cells in the vulva, which is a part of the female reproductive system. (docvatsa.com)
  • The medical term for these abnormal cells is vulval epithelial neoplasm or VIN , which is not an indication of cancer itself but rather a precancerous condition. (docvatsa.com)
  • VIN refers to abnormal cell growth in the surface layers of the vulvar skin. (docvatsa.com)
  • Epithelial and mesenchymal tissue are the origin of vulvar tumors. (wikipedia.org)
  • Mixed mesenchymal and epithelial tumors are of Mullerian origin. (cytojournal.com)
  • Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
  • They can be benign or malignant (vulvar cancer). (wikipedia.org)
  • Malignant vulvar neoplasms makes up 6% of all reproductive organ cancer and 0.7% of the total cancers in women in the United States. (wikipedia.org)
  • One out of every 333 women will develop vulvar cancer. (wikipedia.org)
  • In the United States, vulvar cancer accounts for nearly 6% of cancers of the female reproductive organs and 0.7% of all cancers in women. (wikipedia.org)
  • Tumor is also not synonymous with cancer. (wikipedia.org)
  • While cancer is by definition malignant, a tumor can be benign, precancerous, or malignant. (wikipedia.org)
  • What Is Vulvar Cancer? (wikipedia.org)
  • What's New in Vulvar Cancer Research and Treatment? (wikipedia.org)
  • Your health care provider might see a tumor, such as skin or oral cancer. (medlineplus.gov)
  • Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
  • Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
  • Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
  • Malignant Melanoma -- Part V. Breast Cancer -- 22. (nshealth.ca)
  • Vaginal cancer is a disease in which malignant (cancer) cells form in the vagina. (oncologyforwomen.org)
  • Having had a hysterectomy for tumors that were benign (not cancer) or cancer. (oncologyforwomen.org)
  • Principles of cancer care , paraneoplastic syndromes , and tumor markers are covered in detail in their respective articles. (amboss.com)
  • It is the most advanced stage of vulvar cancer, indicating that the cancer has spread beyond the vulva to other areas of the body. (docvatsa.com)
  • Vulvar cancer typically develops slowly, often starting on the outer vaginal lips. (docvatsa.com)
  • To our knowledge this is the first reported case of an isolated vesicocutaneous fistula related to previous radiation therapy for recurrent vulvar cancer. (annals.edu.sg)
  • The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
  • Outcomes/Resolutions) Angiokeratoma of Vulva is a common, benign (non-cancerous) condition that has an excellent prognosis with appropriate treatment. (natoursprung.de)
  • Experience based clues are given throughout as aids to tumour typing, grading, staging, and gauging prognosis and response to treatment. (nshealth.ca)
  • thus we present only the major types of neoplasms, including their diagnosis, treatment, and prognosis. (veteriankey.com)
  • Mast cell tumors, often malignant (and fatal) in the dog, are invariably benign and associated with a good prognosis in ferrets. (veteriankey.com)
  • Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)
  • Lipomas of the gastrointestinal tract are uncommon benign tumors of mature adipocytes and may occur in any portion along the gut. (bvsalud.org)
  • Secondary tumors are uncommon. (cytojournal.com)
  • Urogenital fistulas are a known but uncommon complication of gynaecological surgery, especially those involving a malignant process. (annals.edu.sg)
  • Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
  • All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group. (health.am)
  • The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
  • Internationally, however, the incidence of adrenocortical tumors appears to vary substantially. (oncolink.org)
  • In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
  • In general, tumors occur when cells divide and grow excessively in the body. (medlineplus.gov)
  • Most of the cervical epithelial neoplasms and their precursors occur at the squamocolumnar junction or within the transformation zone. (cytojournal.com)
  • Autoimmune vesiculobullous conditions, drug-induced vulvar dermatoses and many such, which occur as part of generalized disease, are not discussed here. (jsstd.org)
  • A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
  • Immature teratoma is the malignant counterpart of the mature teratoma and contains immature tissues which typically show primitive or embryonal neuroectodermal histopathology. (mdwiki.org)
  • Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (mdwiki.org)
  • Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (mdwiki.org)
  • Vulvar cancers are those malignant neoplasms that originate from vulvar epithelium, while vulvar sarcomas develop from non-epithelial cells such as bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. (wikipedia.org)
  • Red, scaly plaque, microscopically characterized by the spread of malignant cells within the epithelium, occasionally with invasion of underlying dermis. (brainscape.com)
  • therefore, the association with mediastinal germ cell tumor seems specific. (health.am)
  • In addition, patients who are successfully treated for extragonadal germ cell tumors have a markedly increased risk of developing a subsequent testicular germ cell tumor. (health.am)
  • Recent evidence indicates that the hematologic neoplasms in this setting are not treatment related, but rather arise from clones of malignant lymphoblasts or myeloblasts contained within the mediastinal germ cell tumor. (health.am)
  • More importantly, several patients have had an identical chromosomal abnormality (an isochromosome of the short arm of chromosome 12) in the neoplastic cells from the mediastinal germ cell tumor and the hematologic neoplasm, providing strong evidence for a common origin. (health.am)
  • They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs ). (mdwiki.org)
  • Mature teratomas generally are benign, with 0.17-2% of mature cystic teratomas becoming malignant. (mdwiki.org)
  • Vulvar and vaginal neoplasms make up a small percentage (3%) of female genital cancers. (wikipedia.org)
  • Malignant neoplasms are also simply known as cancers.Tumor (American English) or tumour (British English), Latin for swelling, one of the cardinal signs of inflammation, originally meant any form of swelling, neoplastic or not. (wikipedia.org)
  • Chromosome 18q contains the DCC gene, a putative tumor suppressor gene frequently mutated in colon cancers. (medmuv.com)
  • Because endocrine neoplasia is extremely common in American ferrets today (and is increasing in global frequency), it comes as no surprise that middle-aged and geriatric ferrets have multiple tumors developing over time. (veteriankey.com)
  • When a tumor is found, a piece of the tissue is removed and examined under a microscope. (medlineplus.gov)
  • Benign tumors near or in the brain may be removed because of their location or harmful effect on the surrounding normal brain tissue. (medlineplus.gov)
  • An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
  • A benign tumor that arises from glandular epithelial cells. (amboss.com)
  • [4] Mature teratomas include dermoid cysts and are generally benign . (mdwiki.org)
  • [5] Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (mdwiki.org)
  • Both procedures are invasive and expensive and therefore cytology is often used as first approach to investigate on a possible neoplasia, being a safe and cost-effective diagnostic modality of evaluation. (medsci.org)
  • Gestational trophoblastic diseases (GTD) encompass a spectrum of interrelated conditions: Hydatidiform mole (HM) Invasive mole (IM) Choriocarcinoma (CC) Placental site trophoblastic tumour (PSTT) This article is available only as. (annals.edu.sg)
  • Symptoms depend on the type and location of the tumor. (medlineplus.gov)
  • Some tumors may not cause any symptoms. (medlineplus.gov)
  • Sometimes benign tumors may be removed for cosmetic reasons or to improve symptoms. (medlineplus.gov)
  • Start therapy with DOTTI 0.0375 mg/day applied to the skin twice weekly for the treatment of moderate to severe vasomotor symptoms due to menopause or moderate to severe symptoms of vulvar and vaginal atrophy symptoms due to menopause. (nih.gov)
  • Treatment of moderate to severe vasomotor symptoms due to menopause )  Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to Limitation of Use: When prescribing solely for the treatment of moderate to severe Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism. (gotomydoctor.com)
  • [4] Symptoms may be minimal if the tumor is small. (mdwiki.org)
  • It is important to seek medical attention if any symptoms or abnormalities are noticed in the vulvar area. (docvatsa.com)
  • Histological analysis helps to determine tumor type and grade, whereas the TNM classification system is used to assess staging. (amboss.com)
  • Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
  • In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
  • If the tumor is cancerous, the outcome depends on the type and stage of the tumor at diagnosis. (medlineplus.gov)
  • Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. (lookformedical.com)
  • Adrenocortical tumors appear to follow a bimodal distribution, with peaks during the first and fourth decades. (oncolink.org)
  • Childhood adrenocortical tumors typically present during the first 5 years of life (median age, 3-4 years), although there is a second, smaller peak during adolescence. (oncolink.org)
  • Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. (oncolink.org)
  • Rodriguez-Galindo C: Adrenocortical tumors in children. (oncolink.org)
  • Germline TP53 mutations are almost always the predisposing factor for adrenocortical tumors. (oncolink.org)
  • They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)
  • Characterized byvtche presence of tumor necrosis, cytologic atypia and mitotic activity. (brainscape.com)
  • Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)