Benign histiocytosis histiocytosis non langerhans cell. Medical search. Frequent questions

Pulmonary Langerhans cell histiocytosis (LCH) is the histiocytic disorder that most frequently manifests with thoracic involvement in adults and is associated with cigarette smoking. (elsevierpure.com)
Pulmonary Langerhans Cell Histiocytosis Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)

These benign tumors grow slowly and tend to produce few symptoms other than a conductive hearing loss in the affected ear correlating with the degree of ossicular involvement. (medscape.com)
In LCH, extra Langerhans cells spread through the blood and build up in certain parts of the body, where they can damage tissue or form tumors. (dana-farber.org)
Our expertise also includes treating non-malignant conditions such as Langerhans cell histiocytosis, histiocytic and hemophagocytic lymphohistiocytosis (HLH) disorders, fibromatosis and benign tumors that may require surgery and surveillance. (cookchildrens.org)
The treatment of solid tumors may require a range of therapies, including surgery, radiation therapy, chemotherapy, stem cell therapy, biologic or targeted therapies, or a combination of these treatment modalities. (cookchildrens.org)
To summarize the general characteristics, management principles and prognosis of benign and aggressive bone tumors (BABT) involving the acetabulum. (shsmu.edu.cn)
Of the 7 giant cell tumors of bone, one recurred (14.3%), in comparison to 3 local recurrence (75.0%) of the 4 cases of atypical cartilage hyperplasia. (shsmu.edu.cn)
Benign acetabular tumors without cortical bone damage have a low recurrence rate following lesion curettage. (shsmu.edu.cn)
Surgical approach and prognosis evaluation of primary benign and aggressive bone tumors involving the acetabulum[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(11): 1470-1477. (shsmu.edu.cn)
reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)
Minimally Invasive Resection of Benign Osseous Tumors of the Spinal Column: 10 Years' Experience and Long-Term Outcomes of a Specialized Center. (medifind.com)
Juxta-articular giant cell tumors of the lower end radius are common and present a special problem of reconstruction after tumor excision. (jbstjournal.com)
Giant cell tumors (GCT) of the bone are aggressive and are recognised for variable clinical behaviour, which is not always related to radiographic or histological appearance [1]. (jbstjournal.com)

Radiologists need to be aware that additional eosinophilic granuloma of bone, occurring as long as 4 years after initial diagnosis, should be interpreted as a localized form of Langerhans cell histiocytosis. (medscape.com)
The most benign and common form of Langerhans-cell histiocytosis which involves localized nodular lesions predominantly of the bones but also of the gastric mucosa, small intestine, lungs, or skin, with infiltration by EOSINOPHILS. (bvsalud.org)

[13] Histologically, the cutaneous infiltrate includes a mixture of foamy histiocytes, lymphocytes, fibroblasts and multinucleated giant cells, including Touton-type giant cells, with a moderate amount of collagen deposition (Figures 4-5). (eyewiki.org)
Figure 5: High-power view reveals a mixture of multinucleated giant cells, including Touton-type giant cells, foamy histiocytes, lymphocytes, and fibroblasts with a moderate amount of collagen deposition. (eyewiki.org)
A non-Langerhans-cell histiocytosis is characterized as a benign skin lump or bump caused by a collection of cells called histiocytes. (xenbase.org)
Benign disorder of infants and children caused by proliferation of HISTIOCYTES , macrophages found in tissues. (nih.gov)
These histiocytes, usually lipid-laden non-Langerhans cells, form multiple yellow-red nodules most often in the skin, the eye, and sometimes in the viscera. (nih.gov)
Histiocytosis is an umbrella term for an emerging spectrum of "syndromes" or disorders that involve abnormal proliferation of specialized white blood cells (histiocytes). (petmoo.com)
In general, Histiocytosis refers to an abnormally large amount of histiocytes. (petmoo.com)
A cutaneous histiocytoma is an abnormal proliferation of histiocytes in Langerhans cells. (petmoo.com)
Class IIa dermal dendritic cell histiocytosis is a reactive increase in the number of non-Langerhans' cell histiocytes. (dermnetnz.org)
When lung tissue becomes inflamed from an infection or other cause, cells called histiocytes cluster to form nodules called granulomas. (healthline.com)
The typical histologic appearance of JXG consists of a dense dermal infil- trate of foamy histiocytes, foreign body and Touton giant cells, the latter being nearly pathognomonic of JXG [ 1 ]. (who.int)
Juvenile xanthogranuloma (JXG) is a benign, self-limiting reactive prolif- erative disorder of non-Langerhans cell histiocytes seen predominantly in infants and young children and occa- sional y in adults. (who.int)

Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young adults. (scirp.org)
Rosai-Dorfman disease is a rare disorder characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body (lymphadenopathy), most often those of the neck (cervical lymphadenopathy). (rarediseases.org)
Juvenile xanthogranuloma (JXG) is a rare benign histiocytic proliferation that develops in infants and young children. (eyewiki.org)
Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
As a result of such normal processes, the lymph nodes can enlarge through either proliferation of normal cells or infiltration by abnormal cells. (medscape.com)
To date, it has been proven that the proliferation process (neoplasm of cells and intracellular structures - mitochondria, endoplasmic reticulum, ribosomes, etc.) of Langerhans cells with histiocytosis X is characterized by a monoclonal (belonging to the same cell clone) character. (antibiotic-store.com)
LCH is characterized by the proliferation of CD1a-positive activated Langerhans (not atypical Langerhans cell, morphologically)-like cells (LCH cells) generating inflammatory granuloma. (mayabouchenaki.com)
Pre-treatment biopsy demonstrates bland spindle cell proliferation and irregular bony trabeculae resembling fibrous dysplasia. (medscape.com)

A Melanocytic Nevus, also known as nevocytic nevus, nevus-cell nevus and commonly as a mole, is a type of melanocytic tumor that contains nevus cells. (aboutface.ca)
Postoperative pathology confirmed a benign tumor in 23 cases, 8 of which were accompanied by bone cortical damage (34.8%), and only 2 patients had local recurrence. (shsmu.edu.cn)
Specifically, lesion curettage with bone cement or enbloc resection with endoprosthesis reconstruction could be an appropriate option for giant cell tumor of bone, while enbloc resection with endoprosthesis reconstruction should be always recommended for atypical cartilage tumor. (shsmu.edu.cn)
Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
They found a benign tumor that still afflicts humans, particularly children under the age of 10. (techexplorist.com)
Malignant histiocytic diseases include malignant histiocytosis (now it is called localized and disseminated histiocytic sarcoma) and cutaneous histiocytoma, which is a benign histiocytic tumor. (petmoo.com)
Treatment protocol for malignant histiocytosis is directed towards controlling the local tumor and tackling the concern for metastasis. (petmoo.com)
Researchers at Tel Aviv University, led by Dr. Hila May of the Department of Anatomy and Anthropology at TAU's Sackler Faculty of Medicine and Dan David Center for Human Evolution and Biohistory Research , have identified this benign tumor as part of the pathology of LCH (Langerhans cell histiocytosis), a rare and sometimes painful disease that still afflicts humans, particularly children under the age of 10. (tautrust.org)
The mast cell tumor , which is highly inflammatory, sometimes malignant, and must be excised widely so as to prevent recurrence, can have an identical appearance. (marvistavet.com)
Most of the time the histiocytoma is small enough for easy removal and the diagnosis comes up on the biopsy report, confirming that the tumor is benign and will not grow back. (marvistavet.com)
Less costly but also less accurately, cells can be withdrawn from the lesion by a needle or simply collected from the tumor surface by pressing a microscope slide to the tumor surface. (marvistavet.com)
Some researchers believe that langerhans cell histiocytosis in children is a malignant disease, while others consider this form of histiocytosis as a non-tumor process. (antibiotic-store.com)
Non-Vascularised Ipsilateral Fibular strut - A Modality to Treat Giant cell tumor of lower end radius using Anterior Approach. (jbstjournal.com)
Giant cell tumor is a benign bone tumor, locally aggressive with low malignant potential. (jbstjournal.com)
Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor with tendency for local recurrence [2]. (jbstjournal.com)
We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)

A surgical biopsy showed an infiltrate of eosinophilic cells with oval, grooved and convoluted nucleus, associated with eosinophils, lymphocytes and plasma cells ( Figure 2 ). (scirp.org)
In immunohistochemical study, these eosinophilic cells expressed CD1a and S100 protein. (scirp.org)
It consists of Langerhans cells with oval, grooved and convoluted nucleus and slightly eosinophilic cytoplasm, associated with eosinophils, lymphocytes and plasma cells (H & E × 400). (scirp.org)
Eosinophilic granuloma (EG) is the benign form of the 3 clinical variants of Langerhans cell histiocytosis, which include Letterer-Siwe disease, Hand-Schüller-Christian disease, and EG (formerly termed histiocytosis X). (medscape.com)
Localized histiocytosis is known as eosinophilic granuloma, as well as Langerhans cell granuloma. (antibiotic-store.com)

M group: Includes Malignant Histiocytosis. (petmoo.com)
Malignant histiocytosis cannot be completely cured even with medical management. (petmoo.com)
Malignant Histiocytosis is a potentially life-threatening disease in dogs but the mortality rate of dogs is not documented. (petmoo.com)
Malignant histiocytosis prognosis for recovery is poor. (petmoo.com)
With malignant histiocytosis, a high mortality rate. (antibiotic-store.com)

L group: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, etc. (petmoo.com)

Benign lesions of the middle ear comprise a diverse spectrum of local and systemic diseases that have manifestations within the temporal bone. (medscape.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The clinical manifestations of the currently recognized disease entities are highly variable and range from benign localized lesions to highly aggressive systemic diseases[ 4 ]. (oncotarget.com)
JXG does not carry BRAF V600E mutation, except in patients with both Langerhans' cells histiocytosis (LCH) and JXG (non-Langerhan cells histiocytosis) diseases and in the aggressive forms of JXG. (eyewiki.org)
Histiocytosis in children is a group of diseases that are quite rare in medical practice, proceed in different ways, but are combined by proliferative processes in the monocytic-macrophage system. (antibiotic-store.com)
Histiocytosis UK is dedicated to promoting and funding scientific research into uncovering not only the causes of all histiocytic diseases, which include Langerhans's Cell Histiocytosis and Haemophagocytic Lymphohistiocytosis, but also ensuring early diagnosis, effective treatment and a cure. (histiouk.org)

Despite their benign histopathological characteristics, these lesions may be locally destructive. (medscape.com)
In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
It is impossible to avoid skin lesions with a generalized form of histiocytosis X. Most often the skin is affected in children. (antibiotic-store.com)
This work represents an important advance in understanding how the lesions of Langerhans Cell Histiocytosis develop. (histiouk.org)
The cells of the cancer originate in the bone marrow but make lots of destructive lesions in the bone, skin, brain, lungs and blood forming organs. (histiouk.org)

Nonmalignant Nonneoplastic - Reactive (cutaneous or systemic) histiocytosis. (petmoo.com)

Malignant Histiocytoma is an aggressive, pedunculated, or nodular neoplasm that arises from monocyte-macrophage cells in the skin. (petmoo.com)
Histiocytosis can be both a systemic neoplasm, and can be expressed in the formation of benign single granulomas. (antibiotic-store.com)

One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. (nih.gov)
Cutaneous histiocytoses are classified according to the type of histiocyte within the skin. (dermnetnz.org)
cell histiocytosis characterized by for evaluation of an asymptomatic skin Complete cutaneous examination re- accumulation of lipid-laden macro- lesion on the penile shaft that has been vealed 10 variably sized CALMs rang- phages. (who.int)

Langerhans cell histiocytosis (LCH) is a rare disorder that occurs when a child has too many of a certain type of cell called Langerhans cells. (dana-farber.org)
Langerhans cell histiocytosis (LCH) is a dendritic cell (antigen-presenting cell) disorder. (msdmanuals.com)
Rosai-Dorfman disease (RDD) is an uncommon, benign histiocytic proliferative disorder of unknown origin. (surgicalneurologyint.com)
Sinus histiocytosis with massive lymphadenopathy (SHML), initially described in 1969 by Rosai and Dorfman,[ 22 ] is a rare, nonneoplastic lymphoproliferative disorder that is characterized by its histological features. (surgicalneurologyint.com)

Actinic keratosis was associated with squamous cell carcinoma in 22% of the cases and to basal cell carcinoma in 38%, which shows that both neoplasms may have contiguous actinic keratosis. (bvsalud.org)

OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
Although the pathogenesis is not fully understood, it is now apparent that some of these disorders are associated with activating mutations in cell proliferative/regulatory pathways. (elsevierpure.com)

We present a case of multiorgan, multisite Langerhans cell histiocytosis (LCH), positive for the oncogenic BRAF V600E mutation, in a preterm neonate. (thieme-connect.de)

HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
The biopsy specimen from the right maxillary sinus showed soft tissue infiltration with myeloid leukemic cells, consistent with a chloroma. (contemporarypediatrics.com)

We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)
In addition, it has been found to successfully treat complications of leprosy, systemic lupus erythematosus (SLE), Behcet's syndrome, Langerhans cell histiocytosis, and graft vs. host disease, due to its potent anti-inflammatory properties. (emra.org)

The histological (associated with the microscopic structure of tissues) manifestations of various clinical variants of histiocytosis in their course do not have particularly significant differences. (antibiotic-store.com)

Langerhans cell histiocytosis: skeletal sites commonly involved, age and incidence ratio F:M. The femoral region has been circled, showing the object of our case [1]. (pacs.de)

They all share histologically a significant infiltration of affected tissues by langerhans cells. (scirp.org)
A PET/CT scan can provide information about both the structure and function of cells and tissues in the body during one imaging session. (dana-farber.org)

Erdem AP, Kasimoglu Y, Sepet E, Gencay K, Sahin S, Dervisoglu S. Oral manifestations may be the first sign of Langerhans cell histiocytosis. (mayabouchenaki.com)

Contains new and updated tables on psoriasis co-morbidities, genetic syndrome classifications, acne therapies, pediatric histiocytoses, PHACE syndrome criteria, HSV therapies and juvenile dermatomyositis. (medicscenter.com)

It may be possible to tell which type of histiocytosis is present by the appearance of the skin lesion or rash , but a skin biopsy is usually necessary. (dermnetnz.org)
Thus, a benign fibro-osseous lesion was diagnosed and follow-up was recommended. (medscape.com)

The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
A retrospective study of 18 children with subcutaneous panniculitis-like T-cell lymphoma: multidrug combination chemotherapy or immunomodulatory therapy? (medifind.com)
Sintilimab combined with chidamide in the treatment of extranodal nature killer/T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis: Two case reports and literature review. (medifind.com)

Symptoms and signs of Langerhans cell histiocytosis vary considerably depending on which organs are infiltrated. (msdmanuals.com)

Langerhans cell histiocytosis may occur at any age, but is most common in young children under 10. (dana-farber.org)

A histiocytosis is a disease in which there are too many histiocyte cells in the skin and other organs. (dermnetnz.org)
Normal histiocyte cells are part of the immune system, alerting infection -fighting cells to the presence of foreign material such as bacteria ( antigen presentation). (dermnetnz.org)
Normal histiocyte cells are originally formed within the bone marrow and then migrate throughout the body via the bloodstream. (dermnetnz.org)

The histiocytic disorders follow variable clinical courses ranging from benign disease to life-threatening aggressive disorders. (elsevierpure.com)

The marrow specimen showed extensive replacement of normal hematopoietic elements by immature monocytic cells. (contemporarypediatrics.com)

People with leukemia may develop lung granulomas due to lymphomatoid granulmatosis, a rare condition caused by the overproduction of lymphocytes, or white blood cells. (healthline.com)

Clinicians need to recognize these benign skin conditions and differentiate them from more serious conditions, such as infectious pustular eruptions from bacterial, viral, and fungal causes, and inflammatory conditions, such as Langerhans cell histiocytosis. (nih.gov)
Other inflammatory cells may be present to varying degrees. (eyewiki.org)
An inflammatory issue in which inflammatory cells can form clumps in various organs like the lungs. (healthline.com)

Pilot study to estimate the safety and effectiveness of hydroxyurea and methotrexate recurrent langerhans cell histiocytosis (LCH-HU-pilot). (medifind.com)

Classical Hairy Cell Leukemia (HCL) and HCL-like disorders are a very heterogeneous group of mature B-cell Chronic Lympho proliferative Disorders (B-CLPD). (fortuneonline.org)

In LCH, abnormally proliferating dendritic cells infiltrate one or more organs. (msdmanuals.com)

Our data from micro-dissected LC in both dermatopathic lymphadenopathy [12] and LCS [13] suggest that monocytes, precursor Langerhans cells, or Langerhans cells are one of the reservoir cells for MCPyV. (mayabouchenaki.com)

Juvenile Xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis that is usually benign and self-limiting. (aboutface.ca)

Clonal integration of a polyomavirus in human Merkel cell carcinoma. (mayabouchenaki.com)

An accurate diagnosis is necessary given that different clinical management is required: the first step in a definitive diagnosis is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and a specific Flow Cytometric Analysis (FCA). (fortuneonline.org)
Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in langerhans cell histiocytosis of bone. (mayabouchenaki.com)
Campanacci's staging system for giant cell tumour of the bone [5] was used for cortical breach. (jbstjournal.com)

Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). (nih.gov)

Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)

A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint. (xenbase.org)
This omits the ability to see the architecture of the tissue and just the cells are available for examination. (marvistavet.com)
An International team of Researchers including researchers from Newcastle, Dr Paul Milne and Prof Matthew Collin have made progress in understanding how the childhood cancer Langerhans Cell Histiocytosis (LCH) damages tissue in the body. (histiouk.org)

A chest CT scan revealed a tumoral process measuring 25 mm at the lower lobe of the left lung evoking a Langerhans cell histiocytosis ( Figure 3 ). (scirp.org)

Final diagnosis was therefore Langerhans cell histiocytosis of the dorsal spine complicated by spinal cord compression. (scirp.org)

[16] JXG cells stain positive for CD68, have variable reactivity for factor XIIIa and stain negative for CD1a, S100, CD20716. (eyewiki.org)

Histiocytosis UK and its partners have years of history in funding medical research with many notable successes. (histiouk.org)

Because there are other growths that can look just like the histiocytoma, it is important to get the right diagnosis as the other conditions may not be as benign. (marvistavet.com)

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