Belongs to the ribosomal protein mitochondrial ribosomal protein. Medical search. Frequent questions

In the case of insects, for instance, reliable paleontological evidence is frequently lacking, which leads to applying a proposed standard rate of 2.3% divergence/My for the insect mitochondrial genome [ 2 ]. (biomedcentral.com)
We determined and documented embryonic expression patterns for 6,003 (44%) of the 13,659 protein-coding genes identified in the Drosophila melanogaster genome with over 70,000 images and controlled vocabulary annotations. (biomedcentral.com)
Plant mitochondrial (mt) genomes possess several complex features, including a variable size, a dynamic genome structure, and complicated patterns of gene loss and gain throughout evolutionary history. (springeropen.com)
The S. purpurea mt genome contains 52 genes: 31 protein-coding, 18 tRNAs, and three rRNAs. (springeropen.com)
The mitochondrial (mt) genome has drawn increased attention during the genomic and now post-genomic eras owing to its maternal pattern of inheritance and unique evolutionary features, and is often used for the phylogenetic study of plants (Gualberto et al. (springeropen.com)
Here we report the assembly and annotation of its mitochondrial genome. (usda.gov)
Sequenced using PacBio technology and error-corrected using Illumina sequences, the complete mitochondrial genome was assembled into a circular molecule of 39,618 bp, with 22.03% GC content. (usda.gov)
Further analysis of this mitochondrial genome will be presented. (usda.gov)
Mitochondrial TAT transports folded proteins in those eukaryotes with TatA and TatC subunits encoded in the mitochondrial genome. (tcdb.org)
Here we generated and characterized the mitochondrial (mt) genome of 14 specimens of the S. talpa species-group and evaluated its species limits with the cox1 barcoding locus. (unam.mx)
In this paper, we determined the complete mitochondrial genome of Octopus conispadiceus (Cephalopoda: Octopodidae). (tonmo.com)
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation. (nih.gov)
He was at the origins of the introduction of DNA analysis into forensic medical examination in our country, participated in the discovery of genes key to Alzheimer's disease, was one of the first in Russia to start working with ancient DNA and sequenced the mitochondrial genome of a mammoth. (vechnayamolodost.ru)
Most of the unread genome just belonged to centromeric regions, these are special sections of chromosomes that are necessary for cell division, and they usually consist of tandem repeating DNA sequence units. (vechnayamolodost.ru)
Limitations of the application of the COI sequences in evaluating species-differentiation are well known ( Sbordoni 2010 ), often determined by horizontal gene exchanges or hybridization, that cannot be disclosed with the mitochondrial genome. (arphahub.com)

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. (wikipedia.org)
Based upon evidence from seven genes (four nuclear protein-coding, one mitochondrial protein-coding, two nuclear ribosomal), its sister group is the Australian B. jacksoniense Guérin-Méneville, with which it shares a synapomorphic spur on the ostium of the male genitalia. (oregonstate.edu)
Unlike many genes, the RMRP gene does not contain instructions for making a protein. (medlineplus.gov)
In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
It encodes 39 protein coding genes, 25 tRNA genes, and two ribosomal RNA genes (rnl and rns). (usda.gov)
The whole mitogenome of O. conispadiceus is 16,027 basepairs (bp) in length with a base composition of 41.4% A, 34.8% T, 16.1% C, 7.7% G and contains 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a major non-coding region (MNR). (tonmo.com)
The mitogenome is 18,680 bp in length, and includes the 37 typical mitochondrial genes and a large control region (length: 1,997 bp). (researchsquare.com)
All 13 protein-coding genes use ATN or TTG as start codon, and end with TAA/G or incomplete stop codons (single T-). Twenty-one transfer RNA genes have the typical clover-leaf structures, while the dihydrouridine (DHU) arm of trnS1 is missing. (researchsquare.com)
For the most part, in this way we identified a series of protein-non-coding genes, but also some protein-coding ones. (vechnayamolodost.ru)

This gene encodes a 39S subunit protein that belongs to the L18P ribosomal protein family. (wikipedia.org)
This gene encodes a 39S subunit protein. (nih.gov)

To investigate these aspects we have conducted calibration analyses for the genus Carabus (Coleoptera, Carabidae) on five mitochondrial and four nuclear DNA fragments with 7888 nt total length, testing different clock models and partitioning schemes to select the most suitable using Bayes Factors comparisons. (biomedcentral.com)
NAM9 nuclear suppressor of mitochondrial ochre mutations in Saccharomyces cerevisiae codes for a protein homologous to S4 ribosomal proteins from chloroplasts, bacteria, and eucaryotes. (expasy.org)
Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
Results from nuclear and mtDNA sequences show that all Atlantic and Mediterranean populations belong to the same phylogroup, though microsatellite data indicate significant genetic divergence between the Azorean sample and all other locations, as well as among Macaronesian, western Iberian and Mediterranean regions. (nature.com)
Here, we analyzed three mitochondrial ( mt-atp8&6 and mt-nd2 ) and one nuclear ( nuc-s7 ) marker in order to assess the genetic diversity and population structure of T. hildebrandi . (peerj.com)
Comparison of nuclear-encoded cytoplasmic ribosomal proteins and mitochondrial ribosomal proteins showed that intron positions were conserved (Yoshihama et al. (bartleby.com)
Reduced nuclear localization of the transcription factor Msn2 and lower glycogen accumulation indicated higher protein kinase A (cAMP-dependent protein kinase, PKA) activity in many light-sensitive gene deletion strains. (biomedcentral.com)
JEV nterferes with the IFN signaling pathway by inhibiting nuclear translocation of STAT2 which is mediated by NS5 protein. (ommegaonline.org)
However, in order to strengthen the signal given by COI , we added a nuclear gene to the study, namely the ribosomal internal transcribed spacer 2 ( ITS2 ). (arphahub.com)

2022 ). The YidC transmembrane (TM) groove is essential for a high- affinity interaction, and the hydrophilic nature of the YidC groove plays an important role in protein transport across the cytoplasmic membrane bilayer to the periplasmic side. (tcdb.org)

The large subunit of the mammalian mitochondrial ribosome. (wikipedia.org)
Brix domain-containing proteins, such as Peter Pan (PPan), are essential for eukaryotic ribosome biogenesis. (silverchair.com)
As a result, the ribosome stops working on that protein and all subsequent codons are not transcribed! (mercinewyork.com)

Yeast protein NAM9 [ 3 ]. (expasy.org)
Yeast ribosomal proteins: XII. (expasy.org)
Homologues of the yeast Oxa1 protein are found in chloroplasts of plants and in a wide variety of bacteria. (tcdb.org)
Name sirtuin originates in the discovery in the yeast gene, silent data regulator two (Sir2), which was initially described as regulators of transcriptional silencing of Ras Inhibitor site mating-type loci, ribosomal DNA and lifespan of yeast5. (icbinhibitor.com)
Protein components of different pathways for carbon and nitrogen source utilization were identified, which so far has remained unexplored in yeast, offering clues for further biotechnological developments. (biomedcentral.com)
a mechanism consistent with the high levels of GpII in some α-proteobacteria (Robart & Zimmerly, 2005) and the ability of yeast mitochondrial GpII to insert themselves into double stranded genomic DNA (Zimmerly et al. (bartleby.com)
We conclude that yeast photobiology is multifaceted and that protein kinase A plays a key role in the ability of cells to grow upon visible light exposure. (biomedcentral.com)

Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)

Mitochondria import nuclearly-encoded proteins, made in the cell cytoplasm, into the mitochondrial matrix where their mitochondrial targeting sequences are removed by proteolysis. (tcdb.org)
Bacteria also export (to the periplasm) N-tails of membrane proteins synthesized without leader sequences by a Sec (Type IIPS)-independent mechanism. (tcdb.org)
The mitochondrial sequences are highly informative phylogenetic markers, but have been mostly neglected due to technical difficulties. (biomedcentral.com)
Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin. (elifesciences.org)

RNA encodes a poly-protein precursor of approximately 3400 amino acid. (ommegaonline.org)
Host cell signalases and viral encodes proteases would accomplish the processing of poly-protein and give rise to three structural proteins that includes core (C), preMembrane (prM) and envelop (E) and seven non-structural proteins NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 which are responsible for the replication, viral transcription and also involves in alteration of host immune responses [3,4] . (ommegaonline.org)

Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. (wikipedia.org)
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. (wikipedia.org)
The matrix exposed C-terminal α-helical domain of Oxa1 can bind mitochondrial ribosomes to facilitate co-translational insertion of proteins into the mitochondrial membrane ( Jia et al . (tcdb.org)
The same interaction is suspected to have the same effect in human mitochondrial ribosomes and maybe maize chloroplasts as well. (expasy.org)

With the development of next generation sequencing (NGS) technologies, such as the Roche and Illumina platforms, new strategies are being used to characterize plant mitochondrial genomes. (springeropen.com)

Mitochondria contribute to energy metabolism and play fundamental roles in plant development, fitness, and reproduction, as well as being associated with the biosynthesis of fatty acids and several active proteins (Mcbride et al. (springeropen.com)
2001 ). Mitochondria have two, one for co-translational, and one for post-translational insertion of membrane proteins. (tcdb.org)
In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)
The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
We found that PPan protein is localized in the nucleoli and mitochondria and that loss of PPan results in increased apoptosis. (silverchair.com)

These collections were at first investigated through analysis of the mitochondrial cytochrome oxidase gene I ( COI ). (arphahub.com)

The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
These 3 isoforms of sirtuins are implicated in regulating many mitochondrial-dependent metabolic pathways, including oxidative phosphorylation, ROS synthesis, urea-cycle, ATP synthesis and apoptosis14. (icbinhibitor.com)
These similarites include introns, histones, several types of RNA polymerase, and methionine as the first amino acid in protein synthesis. (bartleby.com)
It is typically discussed using the "codons" found in mRNA, as mRNA is the messenger that carries information from the DNA to the site of protein synthesis. (mercinewyork.com)

Thus, in order to avoid excessive ROS generation, they switch the utilization of metabolic pathways that require mitochondrial respiration to fermentation [ 3 ]. (hindawi.com)

Conformational diseases are often caused by mutations, altering protein folding and stability in vivo . (mdpi.com)
NAM9 has been characterized as a suppressor for ochre mutations in mitochondrial DNA. (expasy.org)
The RMRP gene mutations that cause anauxetic dysplasia alter the noncoding RNA produced from the gene, and the RNase MRP enzyme containing the altered noncoding RNA is impaired in its ribosomal RNA processing function. (medlineplus.gov)
Mutations in the RMRP gene likely result in the production of a noncoding RNA that cannot bind to some of the proteins that are normally part of the RNase MRP enzyme complex. (medlineplus.gov)
12] These errors, mutations, can affect an organism's phenotype, especially if they occur within the protein coding sequence of a gene. (mercinewyork.com)

Forms a cluster with CC proteins L3 and L24e, part of which may contact the 16S rRNA in 2 CC intersubunit bridges. (expasy.org)

An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. (hindawi.com)

Scope: Bacteria Archaea Plastid Fusion: Nter: None Cter: None Duplicate: in BARBK, LEPBL Plasmid: None Comments: In E.coli interaction of L14 with ribosomal silencing factor RsfS has been shown block formation of bridge B8, preventing association of 2 ribosomal subunits and thus causes ribosomal silencing. (expasy.org)
We show here that PLASTID REDOX INSENSITIVE 2 (PRIN2) and CHLOROPLAST STEM-LOOP BINDING PROTEIN 41 kDa (CSP41b), two proteins identified in plastid nucleoid preparations, are essential for proper plant embryo development. (frontiersin.org)

2007 ). Several Oxa1-type insertases in the ER serve as catalytically active core subunits in the ER membrane protein complex (EMC), the guided entry of tail-anchored (GET) and the GET- and EMC-like (GEL) complex. (tcdb.org)

CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)
The opposite reaction is cairred out by yet another group of enzymes named histyome deacetylases (HDACs), which take away the acetyl moiety from target proteins. (icbinhibitor.com)

[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)

Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)

The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. (hindawi.com)
In a first couple of examples, I will show how distance and shape restraints from SANS have helped to improve the uniqueness of structural models for two multi-protein-RNA complexes, in combination with NMR restraints and building blocks from crystallography [1, 2]. (lu.se)

Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)

Comparative analysis of the mitogenomes in the FOSC revealed ongoing mitochondrial recombination within, but not between phylogenetic species. (biomedcentral.com)

Several proteins attach (bind) to this RNA molecule, forming an enzyme called mitochondrial RNA-processing endoribonuclease, or RNase MRP. (medlineplus.gov)

2005 ). Knock out mutants in the human mitochondrial Oxa1 impairs biogenesis of the F-type ATPase and the NADH dehydrogenase complex I, but not complexes III and IV ( Stiburek et al . (tcdb.org)

Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. (wikipedia.org)
Proteins found in any species of algae. (lookformedical.com)
The family Gracillariidae belonging to Gracillarioidea comprises more than 2,000 described species of 75 genera in the world (Davis & Robinson, 1999). (koreascholar.com)
A wide variety of photosynthetic and non-photosynthetic species sense and respond to light, having developed protective mechanisms to adapt to damaging effects on DNA and proteins. (biomedcentral.com)
Indole excitation damages protein structure and integrity and may convert proteins into photosensitizers that produce reactive oxygen species (ROS). (biomedcentral.com)

2018 ). Through YidC, proteins are inserted into the lipid bilayer via the SecYEG-dependent complex, but YidC functions as a chaperone in protein folding processes. (tcdb.org)

The detection results in the activation and interplay of the seven main signalling cascades: the p38 mitogen-activated protein kinase (MAPK), the insulin-like receptor (ILR), the Toll-like receptor (TLR), a transforming growth factor-b (TGF-b), the programmed cell death (PCD), the extracellular signal-regulated kinase (ERK) and a c-Jun N-terminal kinase (JNK). (biomedcentral.com)

The identified proteins were subjected to subsequent bioinformatics analysis using the DAVID database. (molvis.org)

The HuProt microarray results showed that the signals of 343 proteins were higher in the recombinant CRYAA group than in the control group. (molvis.org)

The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)

The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)

The RNase MRP enzyme also processes ribosomal RNA, which is required for assembling protein building blocks (amino acids) into functioning proteins. (medlineplus.gov)
The active full-length CRYAA protein corresponding to amino acids 1-173 of CRYAA was recombined. (molvis.org)

In Escherichia coli, S4 is known to bind directly to 16S ribosomal RNA. (expasy.org)

MRP-L28 (39S ribosomal protein L28, melanoma-associated antigen recognized by T lymphocytes) is a mitochondrial protein that belongs to the ribosomal protein L28P family. (thermofisher.cn)
SIMILARITY: Belongs to the universal ribosomal protein uL14 family. (expasy.org)

This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)

CONCLUSIONS: We identified a novel lncRNA AC142119.1, which promoted the progression of NB through epigenetically initiating the transcription of MYCN via interacting with both WDR5 protein and the promoter of MYCN, indicating that AC142119.1 might be a potential diagnostic biomarker and therapeutic target for NB. (bvsalud.org)

The camellia weevil, Curculio chinensis Chevrolat, 1878, belongs to the subfamily Curculioninae (Coleoptera: Curculionidae), and is widely distributed in most of China's Camellia spp. (researchsquare.com)

Putative non-pathogenic strains belonging to this group are used as biocontrol agents against pathogens [ 5 ]. (biomedcentral.com)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)

To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)
One-hundred and twenty-seven of 17,225 human full-length proteins were identified that interact with CRYAA. (molvis.org)
Visualizing late states of human 40S ribosomal subunit maturation. (nih.gov)

In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration. (hindawi.com)
Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)

The protein was part of the Y-shaped fibrous linkers between the doublet microtubules and the flagellar membrane, as indicated by statistical analysis of post-labeled sections using anti-centrin and anti-tubulin as controls. (lookformedical.com)

Proteomics analyses resulted in the identification of 130 spots corresponding to a total of 108 differentially expressed proteins. (biomedcentral.com)

3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
In addition, S. fibuligera was cultivated alone on starchy waste in Czechoslovakia or in mixed culture with Candida utilis on potato-processing wastes in Sweden to produce single-cell protein, which was used for protein supplementation in animal feeds [ 10 ]. (biomedcentral.com)
This doesn't matter in RNA, since new RNA copies can be produced from DNA at any time, and most RNA molecules are intentionally destroyed by the cell a short time after they're produced so that the cell does not waste resources producing unneeded proteins from old RNA molecules. (mercinewyork.com)

Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)

Mitochondrial dysfunction has also been associated with ageing and most of the so-called age-related diseases [ 13 - 17 ]. (hindawi.com)

Anatomy10

Organisms7

Diseases1

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes16

Information Science3

Genome15

Genes9

Subunit protein2

Nuclear9

Cytoplasmic1

Ribosome3

Yeast7

Lipids2

Sequences4

Encodes2

Ribosomes4

Genomes1

Mitochondria5

Cytochrome oxidase1

Synthesis4

Metabolic pathways1

Mutations5

RRNA1

Cytosolic1

Plastid2

Subunits1

Target proteins2

Complement1

Accumulation1

Structural2

Actin1

Phylogenetic1

Molecule1

Impairs1

Species5

20181

Kinase1

Bioinformatics1

Recombinant1

Metabolism1

Cytoskeletal1

Amino acids2

Bind1

Family2

Oxidative stress1

Conclusions1

Coleoptera1

Putative2

Human4

Cellular3

Analysis1

Identification1

Cell4

Enzyme1

Diseases1