Belongs to the adaptor family of proteins. Medical search. Frequent questions

The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. (wikipedia.org)
Crk is mainly composed of Src homology 2 (SH2) and Src homology 3 (SH3) domains, which serve as docking sites for signalling proteins, including various receptors, cytoplasmic kinases, and GTPase regulators. (rndsystems.com)
FRK belongs to a family of SRC kinases. (atlasgeneticsoncology.org)
SRC is the prototype for a family of genes that encode non-receptor tyrosine kinases implicated in a variety of cellular processes. (atlasgeneticsoncology.org)
BRAF is a protein kinase and part of the MAP kinase signalling cascade which involves transduction of a growth signal from the cell membrane to the nucleus via a chain of protein kinases and is responsible for cellular proliferation and survival. (hindawi.com)
The BRAF (v-raf murine sarcoma viral oncogene homolog B) gene encodes a protein that belongs to the Raf family of serine/threonine protein kinases. (hindawi.com)
EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. (thermofisher.com)
Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
Activated TCR triggers the assembly of a signalosome, with key components including tyrosine kinases like Lck and Zap70, scaffold proteins such as Lat, SLP76, and Themis, and phospholipase Cγ1 (PLC γ1), as well as tyrosine phosphatases and E3 ubiquitin ligases like SHP1 and Cbl, among others. (medicaltrend.org)
These motifs are phosphorylated by Src family kinases (SFKs) upon receptor activation and play crucial roles in regulating the immune system. (medicaltrend.org)
Potential roles of heme and steroid/sterol ligands are reviewed, as well as the implications of apparent target sequences within PGRMC1 for binding by SH2- and SH3-domain proteins as well as kinases. (edu.au)

Crk belongs to a family of adaptor molecules, which link extracellular growth and differentiation stimuli with formation of signal transduction protein complexes. (rndsystems.com)
Unlike SIRP alpha that has cytoplasmic ITIM domains, SIRP beta 1 possesses positively charged residues that allow association with ITAM motif containing adaptor molecules. (rndsystems.com)
These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. (maayanlab.cloud)
Endothelial cell selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. (reliatech.de)
Karyopherins are proteins that help eukaryotic cells transport molecules between their cytoplasm and nucleus. (prospecbio.com)
Like its counterparts in Drosophila, TLRs signal through adaptor molecules. (novusbio.com)
The plasma membrane is not only the first point of encounter for many types of environmental stress, but given the diversity of receptor proteins and their associated molecules also represents the site at which many cellular signal cascades originate. (cell-stress.com)

ETV6 encodes an ETS family transcription factor. (atlasgeneticsoncology.org)
CRKL (CRK Like Proto-Oncogene ) belongs to the Crk family and is a 39-kDa adapter protein that encodes SH2 and SH3 (src homologs) domains. (bvsalud.org)
Human genome encodes four major UBQLN proteins (UBQLN1-4) that belong to the non-proteasomal UBL-UBA family by containing an ubiquitin-like (UBL) domain at the N-terminus and an ubiquitin-associated domain (UBA) at the C-terminus (Figure 1). (encyclopedia.pub)

SIRP beta 1 is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. (rndsystems.com)
Signaling Lymphocytic Activation Molecule Family (SLAMF) receptors are a group of nine type I transmembrane receptors that are mainly expressed on a variety of immune cells. (nature.com)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
Ubiquilins or UBQLNs, members of the ubiquitin-like and ubiquitin-associated domain (UBL-UBA) protein family, serve as adaptors to coordinate the degradation of specific substrates via both proteasome and autophagy pathways. (encyclopedia.pub)

Members of this family are characterized by an extracellular region containing a V-set Ig domain containing a J-like sequence and two C1-set Ig domains. (rndsystems.com)
Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. (reliatech.de)

Rho proteins belong to the Ras superfamily. (biomedcentral.com)
Rho GTPases are small (20-30 kDa) GTP-binding proteins of the Ras superfamily. (biomedcentral.com)
Programmed cell death protein 1 (PD-1, CD279) is a transmembrane glycoprotein that belongs to the CD28 receptor superfamily. (medicaltrend.org)

ITIMs negatively modulate cell activation by recruiting phosphatases such as protein tyrosine phosphatases 1 and 2 (SHP-1 and SHP-2), as well as inositol 5′-phosphatases 1 and 2 (SHIP-1 and SHIP-2). (medicaltrend.org)

They are able to bind specific motifs containing a phosphorylated tyrosine residue, propagating the signal downstream by promoting protein-protein interactions and/or modifying enzymatic activities. (eu.org)
The Src Homology 2 (SH2) domain is a major protein interaction module that is central to tyrosine kinase signaling. (eu.org)
Among these are immunosuppressive receptors that belong to the Axl/Mer/Tyro3 receptor tyrosine kinase family, T cell immunoglobulin mucin domain name (TIM) receptors, integrins, and the scavenger receptor family (Birge et al. (cell-metabolism.com)
The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. (exbio.cz)
Compact disc300a is an immunoreceptor tyrosine-based inhibitory theme (ITIM) containing molecule that belongs to the Compact disc300 family members of paired causing/inhibitory receptors. (healthyguide.info)

Activated TNF receptors mediate the association of distinct adaptor proteins that regulate a variety of signalling processes including kinase or phosphatase activation, lipase stimulation, and protease induction. (uea.ac.uk)
2014). Although some receptors directly bind to PS, other require an adaptor protein (e.g. (cell-metabolism.com)
These include an annexin V fusion protein, blocking antibodies that target PS and inhibitors of PS receptors. (cell-metabolism.com)
The plasma membrane can be envisioned as a central compartment in the cellular adaptation to diverse stress conditions as it shapes the interactions between cells and their environment by harboring an elaborate complement of transmembrane proteins, e.g. transporters, channels, receptors, or adhesion proteins. (cell-stress.com)

Cytoplasmic protein NCK2 (also known as NCK-beta and Grb4) is a protein that in humans is encoded by the NCK2 gene. (wikipedia.org)
The protein encoded by this gene belongs to the LIM-domain binding family. (maayanlab.cloud)
Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. (thermofisher.com)
A considerable repertoire of apoptotic protein domains was detected inActinomycetes and Cyanobacteria, which suggests a major contribution ofhorizontal gene transfer to the early evolution of apoptosis. (embl.de)
these proteins are also important in regulating gene transcription. (biomedcentral.com)
In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. (utsouthwestern.edu)
In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. (utsouthwestern.edu)
The BICD2 gene provides instructions for making one of a family of proteins called golgins. (medlineplus.gov)
The BICD2 gene mutations that cause SMA-LED replace single protein building blocks (amino acids). (medlineplus.gov)
This change and the other BICD2 gene mutations increase the activity of the BICD2 protein. (medlineplus.gov)
Transmembrane protein 131 (TMEM131) is a protein that is encoded by the TMEM131 gene in humans. (wn.com)
A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (expasy.org)

The family includes a group of uncharacterized plant proteins containing an N-terminal VHS (Vps27p/Hrs/STAM)-domain and a GAT (GGA and TOM1) domain. (nih.gov)
Finally, the further GIX sPLA 2 s are found in venom of marine snails, and GXIA and GXIB sPLA 2 s are plant proteins. (ijbs.com)

The NLRP3 inflammasome consists of the NLRP3 scaffold, the apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) adaptor and caspase-1 ( 5 , 6 ). (spandidos-publications.com)

NCK is a major adaptor protein involved in membrane receptor signalling and modulation of actin cytoskeleton dynamics. (eu.org)
and proteins that interact with members of the Arp2/3 complex and hence the actin cytoskeleton (Table 1 ). (biomedcentral.com)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
A central adaptor protein of the noncanonical NF-κB pathway is NF-κB-inducing kinase (NIK), which activates the downstream kinase IKKα to process p100 to p52, thereby forming the RelB/p52 heterodimer to initiate the expression of target genes. (xiahepublishing.com)
The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)
The impaired function of specific organelles indicates that the causative genes encode protein complexes that regulate vesicle trafficking in the endolysosomal system including AP-3, BLOC-1, BLOC-2, and BLOC-3. (medscape.com)
The impaired function of specific organelles indicates that the causative genes encode proteins operative in the formation of lysosomes and vesicles. (medscape.com)

Following recognition of TLR ligands, TLRs elicit innate immunity by activating multiple intracellular signaling cascades including variable adaptor proteins and transcriptional factors. (frontiersin.org)
The main goal of this thesis was to gain detailed molecular insights into the transcriptional and post-translational regulation of these protein quality control networks in the ecologically, medically and industrially important phylum of low GC, Gram-positive bacteria. (uni-greifswald.de)
In these bacteria the core protein quality control systems are under the transcriptional control of the global repressor CtsR. (uni-greifswald.de)
In addition to the transcriptional regulation of CtsR low GC, Gram-positive protein quality control systems are regulated post-transcriptionally. (uni-greifswald.de)

ETV6 protein contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with other proteins, and a C-terminal DNA-binding domain. (atlasgeneticsoncology.org)

Adaptor proteins, GRB2 and SOS, are then sequentially recruited to stimulate the release of GDP from KRAS which permits binding of GTP to activate KRAS. (hindawi.com)
Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. (thermofisher.com)

SH2 domains are phosphotyrosine recognition domains, often mediating transient interactions with target proteins. (eu.org)
We reveal the potential to exploit interactions of sPLA 2 s with other proteins in medical terms, for the development of original diagnostic and therapeutic procedures. (ijbs.com)
These motifs are modelled using the cytochrome b5 domain NMR structure of the Arabidopsis protein 1J03, implicating a possible function for PGRMC1 as an adaptor protein involved in regulating protein interactions and intracellular signal transduction and/or membrane trafficking. (edu.au)

Both domains are also present in Golgi-localized gamma ear-containing Arf-binding proteins (GGAs), which belong to a family of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins that regulate clathrin-mediated trafficking of cargo proteins from the trans-Golgi network (TGN) to endosomes. (nih.gov)

In resting cells, the binding of members of the IκB family, such as the prototypical IκB member IκBα, to classical NF-κB complexes, particularly NF-κB1 p50-RelA and NF-κB1 p50-c-Rel dimers, inhibit the nuclear translocation of NF-κB complexes. (xiahepublishing.com)
Belongs to the adaptor complexes large subunit family. (lu.se)

Basically, DAZ family proteins have been proposed to function as adaptors for target mRNA transport and activators of their translation. (expasy.org)

In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI1. (reliatech.de)
Tumour necrosis factor-alpha (TNFalpha) is a multifunctional cytokine belonging to a family of ligands with an associated family of receptor proteins. (uea.ac.uk)

Snake venom sPLA 2 s are orthologous to mammalian GIIA, GIIB or GIIE sPLA 2 s, or they belong to the unique GIA sPLA 2 s [ 3 ]. (ijbs.com)
In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)
PGRMC1 and the related PGRMC2 mammalian family member diverged sometime after the evolution of segmented metazoan body plan and the appearance of vertebrates. (edu.au)

These dynamic transitions are mainly ensured by large GTPases belonging to the Dynamin family. (cam.ac.uk)
Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)
A structural feature that distinguishes the Rho proteins from other small GTPases is the so-called Rho insert domain located between a β strand and an α helix within the small GTPase domain [ 1 - 3 ]. (biomedcentral.com)
In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)
Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)

Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
Moreover, the cytokine regulates the activities of transcription factors, heterotrimeric or monomeric G-proteins and calcium ion homeostasis in order to orchestrate its cellular functions. (uea.ac.uk)

miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
Changes in the overall endocytic flux or in the endocytic regulation of select proteins conceivably can help to counteract adverse environmental conditions. (cell-stress.com)

In contrast to GGA proteins, members in this family do not have either a GAE (gamma-adaptin ear homology) domain or a clathrin-binding motif. (nih.gov)
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signalling pathways. (eu.org)
Phylogenetic analysis of complete genome sequences indicated that the virus belongs to the Ngari virus group and showed high homology to previous NRIV isolates in all 3 segments ( Figure ). (cdc.gov)

cellular components containing LDB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. (maayanlab.cloud)
cellular components co-occuring with LDB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. (maayanlab.cloud)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Much has been learned regarding nuclear entry, but the cellular proteins involved are still unknown and the exact role of each viral component remains controversial [ 7 ]. (biomedcentral.com)
Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. (utsouthwestern.edu)
The protein attaches (binds) to a group of proteins called the dynein complex, turning it on (activating it) and helping it bind to other cellular materials for transport. (medlineplus.gov)
Consistent with reorganization of the Golgi the 3A proteins from multiple enteroviruses will also be responsible for the shutdown in cellular secretion associated with enteroviral illness (7). (health-ground.com)
These assist with protein folding and, thereby, help to keep the cellular protein machinery functional in spite of adverse thermal conditions. (cell-stress.com)
These cell surface proteins impinge on the vast majority of all cellular functions by mediating nutrient uptake, preserving ion homeostasis and initiating complex signaling cascades in response to extracellular cues. (cell-stress.com)

Adaptor protein TNFR2 interacts with CD40 and functions as a mediator of the signal transduction. (neuromics.com)

Golgins help maintain the structure of a cell component called the Golgi apparatus, in which newly produced proteins are modified so they can carry out their functions. (medlineplus.gov)
As a result, the Golgi apparatus breaks down into small fragments and the altered BICD2 protein becomes trapped within these fragments. (medlineplus.gov)
Recent work has suggested the binding of the protein Golgi-specific brefeldin A resistance guanine nucleotide exchange element 1 (GBF1) by enteroviral 3A is required for the secretion phenotype and viral replication (2 21 Recent work has also demonstrated the importance of the phosphatidylinositol 4-phosphate (PI4P) composition of membranes associated with positive-stranded-RNA replication (17). (health-ground.com)
We found that transiently indicated Strep-Tagged 3A proteins from Aichi computer virus and bovine kobuvirus both copurified PI4KIIIβ and a Golgi adaptor protein acyl-CoA binding website protein 3 (ACBD3 or GCP60) RO4927350 under stringent capture and wash conditions. (health-ground.com)
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. (lu.se)

The DAPIN (Domain in Apoptosis and INterferon response) domain is an 80-100- residue domain which is found in the N terminus of diverse vertebrate and vertebrate-specific viral proteins involved in apoptosis, cancer, inflammation, and immune response. (embl.de)
We report the discovery of a protein domain, hereafter referred to as DAPIN, indiverse vertebrate and viral proteins that is associated with tumor biology,apoptosis and inflammation. (embl.de)
The recent incursions of African swine fever (ASF), a severe, highly contagious, transboundary viral disease that affects members of the Suidae family, in Europe and China have had a catastrophic impact on trade and pig production, with serious implications for global food security. (mdpi.com)
We isolated the viral RNA from cell culture with TRIzol reagent (Invitrogen, Carlsbad, CA, USA) and used it to prepare a sequencing library according to a recently published protocol ( 7 ) but using Illumina adaptors (Illumina, San Diego, CA, USA). (cdc.gov)

Different families of SH2 domains may have different binding specificity, which is usually determined by a few residues C-terminal with respect to the pY (positions +1 to +4). (eu.org)
Typically Rho proteins are 190-250 residues long and consist only of the GTPase domain and short terminal C-terminal extensions. (biomedcentral.com)

The structural diversity of sPLA 2 -BPs reveals sPLA 2 s as very promiscuous proteins, and we offer some structural explanations for this nature that makes these proteins evolutionarily highly advantageous. (ijbs.com)
The analysis of Cdc42 and Rac function in evolutionarily distant organisms is useful as a tool to uncover the basic activities of these proteins. (biomedcentral.com)

The protein contains three SH3 domains and one SH2 domain. (wikipedia.org)
The only known candidate endogenous downstream component of FRK is the SH2-domain adaptor protein SHB (Hosoya et al. (atlasgeneticsoncology.org)
In the resultant ETV6/FRK fusion protein, the entire PNT oligomerization domain of ETV6 and the kinase domain of FRK are fused in frame. (atlasgeneticsoncology.org)
Mutations identified in many SH2 domain-containing proteins as well as the SH2 domain itself are associated with human diseases ranging from cancers, diabetes, to immunodeficiencies. (eu.org)
Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. (maayanlab.cloud)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
This similarity may mean that this is a protein-protein interaction domain. (embl.de)
Taxonomic distribution of proteins containing PYRIN domain. (embl.de)
The complete taxonomic breakdown of all proteins with PYRIN domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing PYRIN domain in the selected taxonomic class. (embl.de)
A comparison of the proteins encoded in the recently (nearly) completed humangenome to those from the fly and nematode genomes reveals a major increase in thecomplexity of the apoptotic molecular machinery in vertebrates, in terms of both the number of proteins involved and their domain architecture. (embl.de)
The pyrin domain: a possible member of the death domain-fold family implicated inapoptosis and inflammation. (embl.de)
PAAD - a new protein domain associated with apoptosis, cancer and autoimmunediseases. (embl.de)
A new protein domain was found in several proteins involved in apoptosis,inflammation, cancer and immune responses. (embl.de)
The DAPIN family: a novel domain links apoptotic and interferon responseproteins. (embl.de)
Based on a secondary structure prediction, we suggestan all-alpha fold for DAPIN, which is also adopted by apoptotic protein domainsof the CARD, death domain and death effector domain type. (embl.de)
This domain has not been found in proteins other than TMEM53 and its orthologs. (wn.com)
The Toll-like receptor (TLR) family in mammals comprises a set of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain, and in the IL-1 receptor motif in the cytoplasmic domain. (novusbio.com)
domain protein 3 (ACBD3/GPC60) including those from Aichi computer virus bovine kobuvirus human being rhinovirus 14 poliovirus and coxsackievirus B2 B3 and B5. (health-ground.com)
Aruffo A, Melnick MB, Linsley PS, Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. (hcdm.org)
Progesterone receptor membrane component 1 (PGRMC1) contains a cytochrome b5 domain fold and belongs to the so-called membrane-associated progesterone receptor (MAPR) protein family that is widespread in eukaryotes. (edu.au)
The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome plays pivotal roles in inflammation and autoimmunity. (spandidos-publications.com)
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is currently one of the most fully characterized inflammasomes. (spandidos-publications.com)

Several different binding motifs are known, for example: pYEEI (Src-family SH2 domains), pY [IV]. (eu.org)
The human NCK1 (Nckα) and NCK2 (Nckβ/GRB4) SH2 domains show a degree of partner specificity but share the same mode of ligand binding ( Frese,2006 ) and belong to the class IA family which contains an aromatic residue (Phe) at the specificity-determining βD5 position ( Kaneko,2010 ). (eu.org)
The Tir protein of EPEC binds NCK1/NCK2 SH2 domains through a high affinity pYDEV motif ( Frese,2006 ). (eu.org)
There are 4728 PYRIN domains in 4335 proteins in SMART's nrdb database. (embl.de)
Within their GTPase domains, they share approximately 30% amino acid identity with the Ras proteins and 40-95% identity within the family. (biomedcentral.com)
The TMEM131 protein contains three domains of unknown function 3651 (DUF3651) and two transmembrane domains . (wn.com)
UBQLN1, UBQLN2 and UBQLN4 proteins have very similar UBA and UBL domains, encode structurally identical proteins containing four STI domains and are related by successive duplications [ 7 ] . (encyclopedia.pub)

To further define which neurons express Eph, antibodies were generated to the cytoplasmic portion of the Eph protein. (sdbonline.org)

First, it binds importin alpha, a form of karyopherin that binds the cargo protein in the cytoplasm, before the cargo protein is imported into the nucleus through the nuclear pore driven by energy from the Ran gradient. (prospecbio.com)

By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)
The BICD2 protein helps the dynein complex with protein transport, positioning of cell compartments, mobility of structures within the cell, and many other cell processes. (medlineplus.gov)
This protein has been implicated has having a role in T cell function and development. (wn.com)
They protect the cell from irreversible protein aggregation. (uni-greifswald.de)
SLP-76 7 , T cell-specific adaptor protein 8 , TCR/CD3 complex 9 and Syntenin-1. (hcdm.org)
Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A. CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. (hcdm.org)
DAZ Family Proteins, Key Players for Germ Cell Development. (expasy.org)

All members contain the sequence motifs characteristic of all GTP-binding proteins, bind to GDP and GTP with high affinity. (biomedcentral.com)
Overactivity of the BICD2 protein changes its ability to bind with the dynein complex, leading to reduced movement of proteins, synaptic vesicles, and other materials within cells. (medlineplus.gov)
Accordingly, McsB cannot be activated as an adaptor protein during thiol-specific stress because McsA is no longer able to bind to McsB under these conditions. (uni-greifswald.de)
Affinity purification of ACBD3 confirmed connection with multiple picornaviral 3A proteins and exposed the ability to bind PI4KIIIβ in the absence of 3A. (health-ground.com)

Ap-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. (lu.se)

We identified a subset of Chronic Lymphocytic Leukemia (CLL) patients with high Signaling Lymphocytic Activation Molecule Family (SLAMF) receptor-related signaling that showed an indolent clinical course. (nature.com)
ITSMs can transmit positive or negative signals by recruiting adapters like signaling lymphocytic activation molecule (SLAM)-associated protein (SAP). (medicaltrend.org)

This activity is strongly conserved and probably represents a primordial function of these proteins. (biomedcentral.com)

Transmembrane protein 53 , or TMEM53 , is a protein that is encoded on chromosome 1 in humans. (wn.com)

Importin beta is a form of karyopherin that helps cargo proteins get into the nucleus. (prospecbio.com)

We focus on six 'core' effectors that operate in almost all these species - members of the Pak, WASP/WAVE, formin, lipid-kinase, IQGAP and NADPH oxidase families. (biomedcentral.com)

CD4 (T4) is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. (exbio.cz)

It is regulated by the recruitment of the GTPase Dynamin-related protein 1 (Drp1) by adaptors at actin- and endoplasmic reticulum-mediated mitochondrial constriction sites. (cam.ac.uk)

Its location within these proteins andpredicted fold suggests that it functions as a protein-protein interactiondomain, possibly uniting different signaling pathways. (embl.de)

Anti-human ESAM was purified by affinity chromatography with immobilized Protein A. (reliatech.de)

One mutation that has been found in multiple affected individuals and families replaces the amino acid serine with the amino acid leucine at position 107 in the BICD2 protein (written as Ser107Leu or S107L). (medlineplus.gov)

The B. subtilis ClpC protein is unlike most members of the Hsp100 family because it not only requires several adaptor proteins for substrate recognition but also for its general ATP- dependent activity. (uni-greifswald.de)
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. (novusbio.com)

Anatomy33

Organisms8

Chemicals and Drugs153

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Psychiatry and Psychology1

Phenomena and Processes38

Information Science3

Kinases12

Molecules7

Encodes3

Type I transmembrane2

Ubiquitin2

Extracellular region2

Superfamily3

Phosphatases1

Tyrosine5

Receptors4

Gene13

Plant proteins2

Scaffold1

Actin cytoskeleton2

Genes7

Transcriptional4

Involved in protein-protein inte1

GRB22

Interactions3

Regulate1

Complexes2

MRNA1

Multifunctional2

Mammalian3

GTPases5

Transcription factors2

Regulation2

Homology3

Cellular9

Interacts1

Golgi5

Viral4

Residues2

Evolutionarily2

Domain23

Domains7

Cytoplasmic1

Binds1

Cell7

Bind4

Lysosomes1

Activation2

Function1

Chromosome1

Cargo1

Effectors1

Immunoglobulin1

GTPase1

Pathways1

Affinity1

Amino acid1

Recognition2