Recoverin, an NCS protein operating in vision, regulates the activity of rhodopsin kinase, GRK1, in a Ca 2+-dependent manner. (univr.it)
Using pull-down assays, surface plasmon resonance spectroscopy and rhodopsin phosphorylation assays, we demonstrated that truncation of recoverin at the C-terminus significantly reduced the affinity of recoverin for rhodopsin kinase. (univr.it)
Based on these results we suggest that Phe 3 from the N-terminal helix of rhodopsin kinase and Lys 192 from the C-terminal segment of recoverin form a cation-π interaction pair which is essential for target recognition by recoverin. (univr.it)
Taken together, the results of the present study reveal a novel rhodopsin-kinase-binding site within the C-terminal region of recoverin, and highlights its significance for target recognition and regulation. (univr.it)
Neuronal3
Neurocalcin is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. (wikipedia.org)
NCS (neuronal Ca 2+ sensor) proteins belong to a family of calmodulin-related EF-hand Ca 2+-binding proteins which, in spite of a high degree of structural similarity, are able to selectively recognize and regulate individual effector enzymes in a Ca 2+-dependent manner. (univr.it)
Recoverin is neuronal calcium-binding protein that plays a position in the inhibition of rhodopsinosopsin kinase which is a regulator in the where A(i) is the gene expression price of ith sample and maxi' fA(i')g and mini' fA(i')g are the optimum and minimal gene expression stages respectively. (gpr44.com)
Photoreceptor1
The NCS family were defined by the photoreceptor cell-specific protein, recoverin. (wikipedia.org)
Protein2
Site-directed mutagenesis of single amino acids in combination with structural analysis and computational modelling of the recoverin-kinase complex provided insight into the protein-protein interface between the kinase and the C-terminus of recoverin. (univr.it)
The selected genes with their gene ids in SRBCT classification are Fc fragment of IgG, receptor, transporter, alpha (FCGRT) (70394), transmembrane protein (812105), fibroblast expansion issue receptor four (784224), ESTs (295985), recoverin (383188). (gpr44.com)
Proteins2
With this unique pattern of expression it is thought that neurcalcin offers a different physiological role than similar proteins visinin and recoverin. (wikipedia.org)
Paraneoplastic and autoimmune retinopathies belong to a spectrum of uncommon ophthalmic disorders in which autoantibodies directed at various retinal proteins cause progressive vision loss. (medscape.com)
Family1
Cell Adhesion Molecule 1, also known as CADM1 belongs to the nectin family. (neuromics.com)