Belong cell lineage. Medical search. Frequent questions

IL-13 secreted by ILC2s also promotes migration of activated lung dendritic cells into the draining lymph node, which then results in naive T cell priming and differentiation into Th2 cells. (wikipedia.org)
Second, altering the MSC state by inducing differentiation into multiple lineages did not affect the exosomal properties or endocytosis but triggered the expression of lineage-specific genes and proteins in vitro and in vivo respectively. (frontiersin.org)
Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
CSF-1 signaling through CSF-1R regulates the proliferation and differentiation of cells in the monocytic lineage. (thermofisher.com)
In the mouse, the differentiation of this new lineage is initiated by TGFbeta-1 and IL-6 or IL-21, which activates Stat3 and induces the expression of the transcription factor retinoic acid-related orphan receptors (RORγt and RORα). (biolegend.com)
Thus, understanding the molecular events driving the successful differentiation of stem cells into several lineages is essential for its better manipulation of human applications. (techscience.com)
It has been also shown to play an important role in the proliferation and differentiation of B cells. (wikidoc.org)
Most of the lineage differentiation SNPs are related to cell wall biosynthetic pathways. (biomedcentral.com)
Huang and Chang then looked at the proteins GATA1 and PU.1, transcription factors that normally favor differentiation into red and white blood cells, respectively. (sciencedaily.com)
Chimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients. (frontiersin.org)
Combined signaling through interleukin-7 receptors and Flt3 selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. (biolegend.com)
It has been postulated that exposure to mastic essential oil affects directly or indirectly signaling pathways that modulate gene expression, cell proliferation, and differentiation. (mingsheng88.org)
Granulocyte Colony Stimulating Factor (G-CSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. (rndsystems.com)
Objective: To establish cultures of cells from the pulp of permanent teeth by the explant method assessing parameters usually presented by stem cells, such as the expression of certain markers and the differentiation ability into osteogenic, adipogenic, and chondrogenic lineages. (bvsalud.org)
In addition, cells were assessed for multi-differentiation potential. (bvsalud.org)
Similarly, the cells showed differentiation ability into all three lineages of cells tested. (bvsalud.org)
The isolated cells may be considered stem cells, based on the current criteria for their characterization, such as plastic adherence, expression of certain markers, and the absence of others, as well as multi-differentiation potential, which showed to be promising for the application in tissue regeneration. (bvsalud.org)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

While APC cells come from the so-called myeloid lineage, which includes, for example, macrophages or dendritic cells, "our" RORγt+ APCs actually belong to cells from the lymphoid lineage, which includes, for example, T-cells. (cuni.cz)
It is expressed as a membrane-bound type II transmembrane protein [2] on various cell types including monocytes , dendritic cells and bone marrow stromal cells. (wikidoc.org)
The constant region at the carboxyl-terminal end of the heavy chain, called the Fc region, binds to the Fc receptors of neutrophils, eosinophils, macrophages, dendritic cells, B cells, and the natural killer (NK) cells. (medscape.com)
In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)
Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

ILC2 cells, or type 2 innate lymphoid cells are a type of innate lymphoid cell. (wikipedia.org)
They are derived from common lymphoid progenitor and belong to the lymphoid lineage. (wikipedia.org)
They express characteristic surface markers and receptors for chemokines, which are involved in distribution of lymphoid cells to specific organ sites. (wikipedia.org)
IL-17A was initially identified from a subtracted cDNA library between closely related murine lymphoid cells and called CTLA-8. (biolegend.com)
A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS . (online-medical-dictionary.org)
It is expressed on early B lymphoid lineage cells in bone marrow, on primitive myeloid progenitors within the BM CD34+ cell population. (biolegend.com)
Ligation of Flk-2 with Flt3 ligand regulates the growth of hematopoietic stem cells and promotes the survival of primitive hematopoietic progenitor cells with myeloid as well as B lymphoid potential. (biolegend.com)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
The cells that have the inherent property of innate and adaptive immunity within the body are present at different sites including the blood, lymphatic system (lymph, lymphoid nodules and lymphoid organs), epithelium, and connective tissues. (medscape.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

We used fluorescence activated cell sorting (FACS) to isolate organelles, rolling circle amplification (RCA) to amplify the plastid genome, followed by shotgun sequencing to 8X depth coverage, and then we assembled these reads to obtain the plastid genome sequence. (usu.edu)
Together, results indicate fluorescence activated cell sorting methodology is a powerful addition to the toolbox for the study of low biomass systems or at sites where only small sample volumes are available for analysis. (darkenergybiosphere.org)
fication and isolation via fluorescence-activated cell sort- ing (FACS). (lu.se)

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
Furthermore, we describe a subset of myeloid cells with immunosuppressive activity (known as myeloid-derived suppressor cells). (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
These mature blood cells include red blood cells (erythrocytes), white blood cells (leukocytes), and cells belonging to the myeloid lineage. (medicalnewstoday.com)
G-CSF R is expressed in mature neutrophils, neutrophilic precursors, myeloid leukemia cells, and placenta. (rndsystems.com)

Vasculogenesis is the coalescence of new blood vessels from individual endothelial cells or progenitor cells. (hindawi.com)
These cells were therefore described as bone marrow derived endothelial progenitor cells (EPCs). (hindawi.com)
Besides producing daughter HSCs after cell division, HSCs also produce different progenitor cell types that, in turn, divide to produce specific types of mature blood cells. (medicalnewstoday.com)
Besides housing hematopoietic stem cells and their progeny, the endosteum and the central marrow also contain distinct cell populations that express molecules or secrete proteins, such as cytokines that regulate the formation, development, and function of HSCs and progenitor cells. (medicalnewstoday.com)
These changes in the hematopoietic system include a decline in the ability of HSC to produce new HSC and progenitor cells, especially those that produce white blood cells. (medicalnewstoday.com)
Regulate the growth of hematopoietic stem cells and promote the survival of primitive hematopoietic progenitor cells. (biolegend.com)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

This peptide-MHC complex signals through the T cell receptor and its associated proteins. (nih.gov)
Signal 2 is provided by costimulatory proteins, especially the B7 proteins (CD80 and CD86), which are recognized by the co-receptor protein CD28 on the surface of the T cell. (nih.gov)
The expression of B7 proteins on an antigen-presenting cell is induced by pathogens during the innate response to an infection. (nih.gov)
Effector T cells act back to promote the expression of B7 proteins on antigen-presenting cells, creating a positive feedback loop that amplifies the T cell response. (nih.gov)
In addition to binding ACE2, increasing evidence suggests that SARS-CoV-2 can also bind other surface proteins to gain cell entry. (abcam.com)
To advance functional investigations and structure determination of integral membrane proteins, we developed DirectMX, a method that allows the re-constitution of target proteins with their surrounding lipids directly from crude cell membranes into Salipro nanoparticles (paper IV). (kth.se)
This Special Issue, "Plant Cell Wall Proteins and Development", will cover a selection of recent research topics in the field of cell wall biology focused on cell wall proteins and their roles during development. (mdpi.com)
They mainly comprise polymers like polysaccharides and lignin in lignified secondary walls and a minute amount of cell wall proteins (CWPs). (mdpi.com)
Cell wall proteomics, as well as numerous genetic or biochemical studies, have revealed the high diversity of CWPs, among which proteins acting on polysaccharides, proteases, oxido-reductases, lipid-related proteins and structural proteins. (mdpi.com)
New monoclonal antibodies recognizing phosphorylated proteins in mitotic cells. (mpg.de)
This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. (nih.gov)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
These may be different molecules within the cells like proteins, polysaccharides, or nucleoproteins and may also be the whole cell, like a tumor cell or organisms like bacteria, viruses, fungi, parasites, or agents containing genetic material such as nucleic acids or lipids. (medscape.com)
The proteins produced from the NLRP7 and KHDC3L genes are critical for normal egg cell (oocyte) development, which impacts embryonic development. (medlineplus.gov)

They not only help activate B cells to secrete antibodies and macrophages to destroy ingested microbes, but they also help activate cytotoxic T cells to kill infected target cells. (nih.gov)
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)

This taxon belongs to a major lineage (marattioid ferns) that, in most recent phylogenetic analyses, emerges near the base of the monilophytes. (usu.edu)
The genomes' seasonal dynamics follow phylogenetic patterns, but with fine-grained lineage-specific variations, reflected in gene-content. (biomedcentral.com)

[4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
SIRP beta 1 is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. (rndsystems.com)

In the present study, the researchers performed several analysis in the hindlimb, forelimb, and pelvic bones from young and old mice to examine the impact of aging on the interaction between the bone marrow niche and hematopoietic cells. (medicalnewstoday.com)

One promising approach to study these lineages is single cell genomics (SCG), whereby an individual cell is captured from nature and genome data are produced from the amplified total DNA. (nature.com)
Here we tested the efficacy of SCG to generate a draft genome assembly from a single sample, in this case a cell belonging to the broadly distributed MAST-4 uncultured marine stramenopiles. (nature.com)
Here we used SCG to generate the first draft genome assembly from a cell belonging to the broadly distributed group of MAST-4 uncultured marine stramenopiles 18 . (nature.com)
Even with low coverage genome sequencing, sorting cells from less than one milliliter of crustal fluid results in similar interpretation of dominant taxa and functional profiles as compared to 'omics analysis that typically filter orders of magnitude more fluid volume. (darkenergybiosphere.org)
In a final step, Huang and Chang used microarrays to look at the cells' entire genome. (sciencedaily.com)
However, single-cell sequencing requires a highly specialized laboratory facility, and single amplified genomes (SAGs) typically have fairly low genome coverage, due to the small amount of DNA in each cell and associated whole-genome amplification biases [ 9 ]. (biomedcentral.com)
This is critical because, while individual genes or genome fragments provide useful information on the metabolic potential of a community, in practice most biochemical transformations take place inside a cell, involving sets of genes structured in controlled pathways. (biomedcentral.com)

Although MSC EVs show great promise for regenerative medicine applications, insights into their uptake mechanisms by different target cells and the ability to control MSC EV properties for defined function in vivo have remained elusive knowledge gaps. (frontiersin.org)
Although many breakthroughs have been reported and hailed in scientific journals over the years, the number of regenerative medicine treatments in medical use today is still limited and the efficacy is variable and transient because more comprehensive investigation is required for understanding the biology of tissue-repair and regeneration and the cellular mechanism of stem cell niche. (techscience.com)
Atta-ur-Rahman, Shazia Anjum , " Frontiers in Stem Cell and Regenerative Medicine Research ", Bentham Science Publishers (2017). (eurekaselect.com)

The conventional view of how stem cells differentiate assumes that cells are "instructed" to progress along prescribed signaling pathways. (sciencedaily.com)
A new study suggests that the conventional view, which assumes that cells are "instructed" to progress along prescribed signaling pathways, is too simplistic. (sciencedaily.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
They function as carriers to the cell surface in post-golgi recycling pathways. (nih.gov)
Different pathways regulate different immune cells to help the body differentiate the bodies own healthy cells from disease-causing agents including bacteria, viruses, fungi, parasites, cancerous cells, and many more. (medscape.com)

SIRP beta 1 is expressed on cells of monocyte, macrophage or dendritic lineages. (rndsystems.com)
Conversely, when stem cells were exposed to granulocyte--macrophage colony-stimulating factor, which stimulates white blood cell formation, those that were highest in Sca-1 were the most likely to become white cells. (sciencedaily.com)
gene encodes for the and by enhancing the production of reactive oxygen species (ROS) GNE-0439 within macrophage-lineage cells [50]. (mingsheng88.org)
The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)

Although Jakub Abramson's research was not specifically focused on these cells, his research on thymus cells, which are characterised by the expression of the biologically very important AIRE gene, which regulates the expression of about 6000 other genes, was a connecting factor. (cuni.cz)
The accumulated karmic tendencies, inherited in the course of previous lives, at times play a far greater role than the hereditary parental cells and genes in the formation of both physical and mental characteristics. (budsas.org)
It is obvious from this unique case that karmic tendencies could not only influence our physical organism, but also nullify the potentiality of the parental cells and genes hence the significance of the Buddha s enigmatic statement, - 'We are the heirs of our own actions. (budsas.org)
Other applications that rely on MDA of single cells include targeted metagenomics, whereby marker genes are PCR-amplified from the DNA sample to decipher their distribution in ecosystems or larger fragments of DNA are assembled for analysis of gene content 11 , 17 . (nature.com)
The two forms were equally immunogenic, but only the latter elicited neutralizing antibodies by stimulating a more restricted expansion of B cells to a narrower set of IGH/IGK/IGL-V genes that represented a small fraction (0.003-0.02%) of total B cells. (plos.org)
Instead, it supports the idea that cells differentiate through the collective behavior of multiple genes in a network that ultimately leads to just a few endpoints -- just as a marble on a hilltop can travel a nearly infinite number of downward paths, only to arrive in the same valley. (sciencedaily.com)
Again, they found tremendous variability within the apparently uniform cell population: more than 3,900 genes were differentially expressed (turned "on" or "off") between the low- and high-Sca-1 cells. (sciencedaily.com)
Other genes affected by the mastic oil diet belong to the family of the very large interferon inducible GTPases (VLIG) that also contribute to the host cellular response to IFNs [47]. (mingsheng88.org)
For most genes, both copies of the gene (one copy inherited from each parent) are active in all cells. (medlineplus.gov)
A small number of cases of recurrent hydatidiform mole have been found to be caused by mutations in genes that play important roles in the production of oocytes and sperm cells. (medlineplus.gov)

B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikidoc.org)

After being stimulated via IL-33 during an infection, they begin to secrete IL-5, leading to an activation of B1 B cells and the production of IgM antibodies. (wikipedia.org)
Thus, our current understanding on how the expansion of particular B cell lineages by Env may be linked to the development of non-neutralizing antibodies is limited. (plos.org)
We report that the variable domains of recombinant HIV-1 Env immunogens activate a large number of B cell clones that give rise to many non-neutralizing antibodies, and that removing the variable domains from the immunogen reduces the number of activated B cell lineages and leads to the development of autologous neutralizing antibodies, a step towards bNAb-production. (plos.org)
In the field of cancer immunotherapy, the recently described effectiveness of checkpoint inhibitors such as anti-PD1 blocking antibodies to boost anti-tumor T cell responses is very encouraging [ 1 ]. (oncotarget.com)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
The cellular response is mainly a lymphocyte-mediated reaction, whereas the humoral response includes production of antibodies against the antigen by the plasma cells. (medscape.com)
Immunoglobulins (Igs), the term is sometimes used interchangeably with "antibodies," are glycoprotein molecules produced by B lymphocytes and plasma cells in response to an immunogen or after recognition of specific epitopes on the antigen. (medscape.com)
Antibodies can be found on the surface of lymphocytes as an integral part of the cell membrane protein or can be freely circulating in the blood or be part of one of the body's gland secretion. (medscape.com)
Antibodies belong to immunoglobulin family of protein and have 5 isotypes (G, A, M, E, D) with further subclasses of G and A. The classes are differentiated with the characteristics of the Ig heavy chain of the antibody. (medscape.com)

Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
Blood cell and serum markers, along with clinical data of DLBCL patients who were scheduled for CART cell therapy were evaluated to search for biomarkers predicting CART cell responsiveness. (frontiersin.org)
In this study, we investigate the expression of differentiated Schwann cell markers by exposing of endometrial stem cells with induction media including FGF2/FSK/HRG/RA. (scirp.org)
Using immunocytochemistry, we show that differentiated cells express S100 and P75 markers. (scirp.org)
During this process, leukocytes lose lineage-associated markers home and undergo homocytic aggregation, upregulate expression of stem cell antigens, and subsequently redifferentiate to give rise original tissue or, transdifferentiate into a different tissue altogether. (eurekaselect.com)
Cells were tested for the expression of surface markers and for ALDH1 enzyme activity, by flow cytometry. (bvsalud.org)
Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

When blood-forming hematopoietic stem cells that reside in the bone marrow age, the production of blood cells is altered, and the body's ability to regenerate lost cells is impaired. (medicalnewstoday.com)
A recent study in mice shows that aging is linked to the inflammation of cells in the bone marrow. (medicalnewstoday.com)
The bone marrow is the main site for hematopoiesis , the process of new blood cells forming via the hematopoietic stem cells (HSC) dividing and differentiating. (medicalnewstoday.com)
All these cells, along with blood vessels and the extracellular matrix, form the bone marrow niche . (medicalnewstoday.com)
The bone marrow niche includes cells belonging to the stroma, which includes mesenchymal stromal cells , adipocytes (fat cells), nerve cells, connective tissue cells, and cells involved in bone formation and remodeling. (medicalnewstoday.com)
The endothelial cells that form the lining of these blood vessels are also a major part of the bone marrow niche. (medicalnewstoday.com)
The study found that bone marrow niche cells that support the functioning of HSCs played a key role in blood aging. (medicalnewstoday.com)
Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)

The pool of total DNA resulting from this process can be used to reconstruct the genomes of the host and associated symbionts, pathogens, or "food" DNA presumably present in cell vacuoles. (nature.com)
To determine genomic variation and selection pressure within methanogenic populations at vents, we examined five Methanothermococcus single cell amplified genomes (SAGs) in conjunction with 15 metagenomes and 10 metatranscriptomes from venting fluids at two geochemically distinct hydrothermal vent fields on the Mid-Cayman Rise in the Caribbean Sea. (darkenergybiosphere.org)
Through the process of binning, contigs or scaffolds derived from the same lineage can be clustered and genomes reconstructed. (biomedcentral.com)
The population of P. aeruginosa was diverse, with clonal expansions of XDR genomes belonging to MLSTs ST235, ST244, ST309 and ST773. (who.int)
Most of the ST235 genomes formed a distinct lineage from global genomes, thus raising the possibility that they may be unique to the Philippines. (who.int)

Furthermore, in vitro stimulation of PBMC from 6 healthy donors with overlapping peptides from MELOE-1 or MELOE-3 revealed a very scarce MELOE-3 specific T cell repertoire as compared to the abundant repertoire observed against MELOE-1. (oncotarget.com)

These approaches provide limited information on the ontogenies and clonal B cell lineages that expand following Env-immunization. (plos.org)

These cells lack antigen specific B or T cell receptor because of the lack of recombination activating gene. (wikipedia.org)
The T cell receptor does not act on its own to transmit signal 1 into the cell. (nih.gov)
The T cell receptor and its associated CD3 complex. (nih.gov)
A recent study conducted in mice shows that blocking the receptor for the proinflammatory protein IL-1 using the FDA-approved rheumatoid arthritis drug Anakinra may attenuate the deficits in the functioning of hematopoietic stem cells due to aging. (medicalnewstoday.com)
This protein contains two subunits: the S1 subunit that contains the receptor-binding domain (RBD) and N-terminal domain (NTD), and a second S2 subunit that mediates the fusion of the viral and host cell membranes 4 . (abcam.com)
SARS-CoV-2 S protein binds to the ACE2 receptor at the surface of host cells, initially through the S1 RBD. (abcam.com)
Within the trimeric S protein, only one of the three RBD heads is present in the accessible conformation to bind the human Angiotensin 2 (hACE2) host cell receptor 10 . (abcam.com)
It plays an important role in immune homeostasis and cell -mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS . (online-medical-dictionary.org)
It was reported that the receptor tyrosine kinase Flt3 is required for dendritic cell development. (biolegend.com)
A 135-150 kD molecule belonging to the tyrosine kinase receptor family. (biolegend.com)
Cell activation by G-CSF is mediated by a type I membrane protein belonging to the cytokine receptor superfamily. (rndsystems.com)

It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)

These findings, published in Nature Cell Biology , suggest that inhibiting IL-1 function could potentially improve deficits in blood production in older adults. (medicalnewstoday.com)
Such a staggeringly high number is the impact factor of the Nature Review Immunology journal, whose latest issue has just published a paper with Jan Dobeš from the Department of Cell Biology at the Faculty of Science, Charles University as the co-author. (cuni.cz)
The focus of this special issue is to capture the current advances in cell membrane repair and stem cell regenerative biology. (techscience.com)
Led by Sui Huang, MD, PhD, a Visiting Associate Professor in the Children's Hospital Boston Vascular Biology Program (now also on the faculty of the University of Calgary), and Hannah Chang, an MD/PhD student in Children's Vascular Biology Program, the researchers examined how blood stem cells "decide" to become white blood cell progenitors or red blood cell progenitors. (sciencedaily.com)

This cytokine is a ligand for receptors TNFRSF13B /TACI, TNFRSF17 /BCMA, and TNFRSF13C /BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. (wikidoc.org)

2022. Cell Rep. 41:111677. (biolegend.com)
2022. Cell Res. (biolegend.com)

Mesenchymal stromal cells can divide and differentiate into a number of cell types, including bone, cartilage, and adipocytes. (medicalnewstoday.com)
The present study found that aged mice showed a decrease in the population of mesenchymal stromal cells and osteoprogenitor cells that are involved in bone formation in the endosteum. (medicalnewstoday.com)
In contrast, there was an increase in the number of mesenchymal stromal cells in the central marrow of aged mice. (medicalnewstoday.com)
Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
During limb epimorphic regeneration: committed mesenchymal cells at the stump site dedifferentiate, forming a cluster of heterogeneous population of stem cells, known as the blastema. (eurekaselect.com)

Besides the type 2 cytokines, ILC2s can also produce IL-6, which induces antibody production by B-cells, acts as a growth factor for plasmablasts and contributes in regulation of T follicular helper cells. (wikipedia.org)
This lineage selectively produces proinflammatory cytokines including IL-17, IL-17F, IL-21, and IL-22. (biolegend.com)
In vitro , CD3 + CD8 + CD27 - CD28 - compared to CD3 + CD8 + CD27 + CD28 + CART cells displayed similar CD19 + target cell-specific cytotoxicity, but were hypoproliferative and produced less cytotoxic cytokines (IFN-γ and TNF-α). (frontiersin.org)

PV can also persistently infect primary cultures of human fetal brain cells and the majority of cells which survive infection belong to the neuronal lineage. (pasteur.fr)

However, a significant number of patients are non responders to these therapies and thus, there is still room for improvement using antigen-specific immunotherapy, whether through vaccination or through T cell transfer. (oncotarget.com)

2021. Stem Cell Reports. (biolegend.com)
2021. Cell Metab. (biolegend.com)

The signaling events initiated by the binding of peptide-MHC complexes to T cell receptors (signal 1). (nih.gov)
Indeed, the increased transmissibility of SARS-CoV-2 compared with SARS-CoV could potentially be explained by an increased number of cellular receptors allowing the virus to penetrate host cells. (abcam.com)
BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. (wikidoc.org)
These receptors are expressed mainly on mature B lymphocytes and their expression varies in dependence of B cell maturation (TACI is also found on a subset of T-cells and BCMA on plasma cells ). (wikidoc.org)
Our study provides new information on how Env antigenic differences drastically affect the expansion of particular B cell lineages and supports immunogen-design efforts aiming at stimulating the expansion of cells expressing particular B cell receptors. (plos.org)
bNAbs are derived from B cells that express B cell receptors formed by specific VH/VL alleles. (plos.org)

Results: Our findings document that the dying WM cells belong to the oligodendrocyte (OL) lineage. (wustl.edu)

13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
How does a stem cell decide what specialized identity to adopt -- or simply to remain a stem cell? (sciencedaily.com)
We decided to use the three-dimensional culture of Schwann cells differentiated from endometrial stem cell in fibrin gel. (scirp.org)
In response to ligation of monomorphic regions of MHC class II antigens with monoclonal antibody CR3/43, human leukocytes retrodifferentiate into a variety of heterogeneous stem cell types belonging to the mesoderm, ectoderm or endoderm lineage, depending on culture media and conditions. (eurekaselect.com)
The ease by which various stem cell types can be generated from human peripheral blood has allowed the design of various kits to guarantee the specificity, sterility and efficacy of stem cells production for various clinical and research applications. (eurekaselect.com)

The mesenchyme that fills the pharyngeal arches is derived from the following 3 origins: the paraxial mesoderm, the lateral plate mesoderm, and the neural crest cells. (medscape.com)
Although paraxial mesoderm and lateral plate mesoderm contribute to the musculature that develops in each particular arch, neural crest cells contribute to the skeletal portion of each arch. (medscape.com)
These cells originate from the paraxial mesoderm and migrate into the facial primordia. (medscape.com)

Within each subtype, multiple hemagglutinin (HA) and neuraminidase (NA) lineages or clades cocirculate. (cdc.gov)
Positive samples were inoculated in MDCK cells and virus phenotypic susceptibility to neuraminidase inhibitors (NAIs) was assessed using fluorescent NA inhibition. (who.int)

We also consider how innate immune responses determine the nature of adaptive responses by stimulating helper T cells to differentiate into either T H 1 or T H 2 effector cells. (nih.gov)
To activate a cytotoxic or helper T cell to proliferate and differentiate into an effector cell , an antigen-presenting cell provides two kinds of signals. (nih.gov)
The combined actions of signal 1 and signal 2 stimulate the T cell to proliferate and begin to differentiate into an effector cell by a curiously indirect mechanism. (nih.gov)
It reveals an elegant yet simple system that maintains cells in a stable state, yet enables them to differentiate under the right conditions. (sciencedaily.com)
But most important, the differences in Sca-1, GATA1 and PU.1 levels across the three cell groups became less pronounced over time, as did the variability in the cells' propensity to differentiate, suggesting that the differences are transient. (sciencedaily.com)
Together, the findings make the case that a slow fluctuation or cycling of gene activity tends to maintain cells in a stable state, while also priming them to differentiate when conditions are right. (sciencedaily.com)

Despite resembling 'true' fungi in terms of morphological features, oo-mycetes form a distinct eukaryotic lineage of filamentous microorganisms that belongs to the stramenopiles, a group of protists also comprising the closely-related brown algae and diatoms. (kth.se)
Oomycetes are not directly related to the true fungi, but belong to a lineage known as the heterokonts or stramenopiles. (fieldofscience.com)

Signal 1 is provided by a foreign peptide bound to an MHC protein on the surface of the presenting cell. (nih.gov)
TMPRSS2 cleavage of the SARS-CoV-2 S protein is believed to enable the fusion of the viral capsid with the host cell to permit viral entry 5 , 6 . (abcam.com)
Both Neuropilin-1 and Neuropilin-2 have been shown to bind the cleaved form of the SARS-CoV-2 S protein to mediate host cell entry 13, 14 . (abcam.com)
They began by examining populations of seemingly identical blood stem cells, and found that a cell marker of "stemness," a protein called Sca-1, was actually present in highly variable amounts from cell to cell -- in fact, they found a 1,000-fold range. (sciencedaily.com)
Notably, Irg1 protein is usually localized in mitochondria, a cellular compartment recently recognized as a platform orchestrating anti-inflammatory and immune cell defense mechanisms [51]. (mingsheng88.org)
encodes a protein that belongs to the mucin family of. (mingsheng88.org)
Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells. (mpg.de)
Prognostic significance of tumor cell proliferation rate as determined by the MIB-1 antibody in breast carcinoma: Its relationship with vimentin and p53 protein. (mpg.de)
Two IDV lineages, D/swine/Oklahoma/1334/2011 and D/bovine/Oklahoma/660/2013 (D/660), have been identified in swine and cattle in Europe on the basis of the hemagglutinin-esterase fusion protein (HEF). (cdc.gov)

In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected. (cdc.gov)

Kim and Park, 2017 ) and make HMSCs attractive cells for regenerative therapies. (frontiersin.org)

Although the cell wall (CW) is critical for the viability and morphogenesis of the organism it surrounds, our knowledge of oomycete CW architecture and biosynthetic enzymes is limited. (kth.se)

It is a 150 kDa c-fms gene product and belongs to immunoglobulin family. (thermofisher.com)

To test the capacity of PV to establish persistent infections in human cells, three models were developed. (pasteur.fr)
Many PV strains, which are generally lytic in primate cell lines, are able to establish persistent infections in human neuroblastoma cells. (pasteur.fr)
The results obtained with the three models of persistent PV infection in human cells suggest that several mechanisms are used by PV to establish and maintain persistent infections in neural and non-neural cells. (pasteur.fr)
Critical to the hypothesis is the experimental fact that human endometrial-derived stem cells (hEnSCs) as multipotent accessible source of cells are known as useful cell candidates in the field of nerve tissue engineering. (scirp.org)
These results show that for the first time, human endometrial stem cells can be differentiated into Schwann cells in 2D and 3D culture. (scirp.org)
Until now, studies regarding the effects of mastic essential oil on human health are limited, since experimental strategies have been based mostly on cell culture systems. (mingsheng88.org)
RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome. (mpg.de)
Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. (nih.gov)
Background: In utero exposure of the fetal non-human primate (NHP) brain to alcohol on a single occasion during early or late third-trimester gestation triggers widespread acute apoptotic death of cells in both gray and white matter (WM) regions of the fetal brain. (wustl.edu)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

To unravel fundamental genetic mechanisms that control cell fate choice in vivo , we study embryonic development in a simple marine invertebrate, the ascidian Ciona intestinalis , belonging to the vertebrate sister group, the tunicates. (uibk.ac.at)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)

This is one mechanism by which a T cell can become tolerant to self antigens. (nih.gov)
MELOE-1 and MELOE-2, two highly specific melanoma antigens involved in T cell immunosurveillance are produced by IRES-dependent translation of the long « non coding » and polycistronic RNA, meloe . (oncotarget.com)
In conclusion, within the MELOE family, IRES-dependent antigens represent the best T cell targets for immunotherapy of melanoma. (oncotarget.com)
In this respect, the choice of the targeted antigens remains a critical issue [ 2 ] and the ideal antigen(s) should have the following characteristics : be as tumor specific as possible and stimulate a broad T cell repertoire in the majority of patients (i.e. generate many epitopes in various HLA contexts). (oncotarget.com)
Antigens are the molecules that are recognized and stimulate the cells of immune system. (medscape.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)

Moreover, these strains belong to 2 distinct geno- sequenced on both strands (AY701413). (cdc.gov)
All the strains belong to Lineage 2 and Lineage 4, except for one in Lineage 1. (biomedcentral.com)
It is suggested that strains from the ancestors of modern Beijing lineage is circulating in Guangxi. (biomedcentral.com)
Strains of modern Beijing lineage (OR=2.04) were more likely to acquire drug resistances than Lineage 4. (biomedcentral.com)

However, the specific life cycle of tardigrades, where energy intake and depletion, egg development, and moulting is highly intertwined and synchronized, make conclusions about the functional role of mitosis in storage cells difficult, however, and more studies are needed to reveal the mechanisms inducing mitosis in these interesting cells. (researchgate.net)

Pregnancy confers partner-specific protection against complications in future pregnancy that parallel persistence of fetal microchimeric cells (FMcs) in mothers after parturition. (bvsalud.org)
Here, we present new findings regarding the magnitude, identity and maturational status of the dying WM cells in these alcohol-exposed fetal NHP brains. (wustl.edu)

This particular gene is also expressed in "our" RORγt+ APC cells, although it probably does completely different things there ," explains Jan Dobeš, who now heads the Laboratory of Microbial Immunology at the Faculty of Science of Charles University. (cuni.cz)
This genetic inventory was sufficient to place the cell within the ToL using multigene phylogenetics and provided preliminary insights into the complex evolutionary history of horizontal gene transfer (HGT) in the MAST-4 lineage. (nature.com)
70% of the expected gene inventory of the MAST-4 lineage. (nature.com)
Using these partial data we included the MAST-4 cell in the ToL using multigene phylogenetics and gained insights into its complex evolutionary history of horizontal gene transfer (HGT). (nature.com)
And again, this variability was dynamic: the differences diminished over time, with gene activity in both the low- and high-Sca-1 cells becoming more like that in the middle group. (sciencedaily.com)
Specific RNAi Mediated Gene Knockdown in Zebrafish Cell Lines. (mpg.de)
In women with NLRP7 or KHDC3L gene mutations, a hydatidiform mole will develop in every pregnancy that occurs with her egg cells. (medlineplus.gov)

Despite this heterogeneous response, blood pre-infusion biomarkers predicting responsiveness to CART cell therapy are currently understudied. (frontiersin.org)

Here we test a methodology that applies redox-sensitive fluorescent molecules for flow cytometric sorting of cells for single cell genomic sequencing from small volumes of low biomass (approximately 103 cells ml-1) crustal fluid. (darkenergybiosphere.org)
The immune system is an inherent self-defense system consisting of cells that helps the body distinguish between self and non-self molecules. (medscape.com)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)

The first is that although they have the properties and capabilities of known antigen-presenting cells (APCs), they belong to a distinct cell lineage. (cuni.cz)

The earliest cell in B-lymphocyte lineage that produces Ig is the pre-B lymphocyte. (medscape.com)

Anatomy72

Organisms24

Diseases1

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Psychiatry and Psychology1

Phenomena and Processes70

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care1

Differentiation18

Dendritic cells9

Lymphoid10

Fluorescence activated cell3

Myeloid11

Progenitor8

Proteins14

Macrophages4

Phylogenetic2

Transmembrane2

Hematopoietic cells1

Genome7

Regenerative Medicine3

Pathways5

Macrophage5

Genes10

Tumor necros2

Antibodies9

Markers9

Bone marrow8

Genomes5

Abundant1

Clonal1

Receptor11

Endothelial cells3

Biology4

Cytokine1

20222

Mesenchymal5

Cytokines3

Neuronal1

Antigen specific1

20212

Receptors6

Oligodendrocyte1

Stem cell5

Mesoderm3

Neuraminidase2

Differentiate6

Stramenopiles2

Protein9

Subtype1

20171

Organism1

Immunoglobulin family1

Human10

Embryonic2

Antigens8

Strains4

Conclusions1

Fetal2

Gene7

Heterogeneous1

Molecules3

Distinct cell1

Produces1