• Frontiers in Behavioral Neuroscience. (lu.se)
  • One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)
  • Many of the symptoms of Parkinson's disease are brought on by loss of or damage to dopamine neurons in this region, which encompasses the striatum, the subthalamic nucleus, and the substantia nigra. (michaeljfox.org)
  • Dopamine acting in the striatum is necessary for normal movement and motivation. (jneurosci.org)
  • Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
  • Dopamine acts in the striatum through the D 1 and D 2 subfamilies of G-protein-coupled receptors. (jneurosci.org)
  • A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. (lookformedical.com)
  • It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE. (lookformedical.com)
  • Immobilization of the nonimpaired forelimb resulted in chronic prevention of dendritic growth and severe and chronic behavioral deficits. (jneurosci.org)
  • Thus, dendritic growth may be associated with an interaction between brain injury and learning-dependent use of the intact forelimb in compensating for lesion-induced deficits in the impaired forelimb. (jneurosci.org)
  • Double-point infarct lesioning that fully compromised the hMFs resulted in persistent hand motor and walking deficits whereas single-point lesioning did not. (en-journal.org)
  • However, functional neuroimaging and electrophysiological studies suggest that some degree of consciousness or awareness that has not been or could not be determined by behavioral evaluations alone may be present in some of these patients who, hence, have covert consciousness. (medlink.com)
  • Functional neuroimaging and electrophysiological technologies may indicate consciousness through neural correlates, surrogates, or proxies in patients without behavioral evidence of consciousness owing to loss of appropriate motor function. (medlink.com)
  • BALB/c mice demonstrate pronounced autism-relevant behavioral phenotype characterized by low level of social relations, high levels of anxiety and aggression, increased brain weight, undeveloped corpus callosum, and lower serotonin concentration in the brain [7,12]. (epiphanyasd.com)
  • The initial aim of the study was to address whether there was an optimal period for lesion-induced changes in the contralateral homotopic cortex and for behavioral recovery. (jneurosci.org)
  • In the present study, the long-term behavioral and anatomical effects of limb immobilization were examined. (jneurosci.org)
  • Immobilization of a single forelimb in nonlesioned rats resulted in no significant behavioral or anatomical changes. (jneurosci.org)
  • The present study examined the long-term anatomical and behavioral consequences of immobilizing the unimpaired forelimb (i.e., forcing use of the impaired forelimb). (jneurosci.org)
  • The unimpaired forelimb in lesioned rats was immobilized with a one-sleeved cast during the period of dendritic enhancement (days 1-15 postlesion). (jneurosci.org)
  • It is becoming increasingly clear that, particularly for chronic neurodegenerative disorders occurring late in life, a complex combination of risk factors can initiate disease development and modify proteins that have a physiological function into ones with pathological roles via a number of defined mechanisms (Moreno-Gonzalez and Soto, 2011). (maxwellmagneticmeds.co.za)
  • As a result of dependence upon higher brain centers, certain lesions or diseases of the brain (eg, stroke, cancer, dementia) can result in a loss of voluntary control of the normal micturition reflex as well as symptoms such as urinary urgency. (medscape.com)
  • Certain lesions or diseases of the brain, including stroke, cancer, or dementia, result in loss of voluntary control of the normal micturition reflex. (medscape.com)
  • Additionally, restricting the unimpaired forelimb in animals with FL-SMC damage results in significantly greater behavioral dysfunction when examined 2 d after cast removal (compared to that after impaired-limb immobilization, or no limb immobilization). (jneurosci.org)
  • As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. (cdc.gov)
  • Purpose : Perinatal asphyxia occurring in newborn is one of the major causes of acute mortality and chronic neurological disability in survivors. (e-cep.org)
  • Cognitive-motor dissociation has been shown to occur in approximately 15% to 20% of clinically unresponsive patients with both acute and chronic disorders of consciousness. (medlink.com)
  • The activity of NO synthase increased in acute separation (in the cerebellum) and chronic separation (in all studied structures). (ihna.ru)
  • Disentangling the relationship between epilepsy and its behavioral comorbidities-the need for prospective studies in new-onset epilepsies. (gov.gy)
  • Immobilization of the impaired forelimb resulted in no detectable neural changes and in only slightly increased and longer-lasting behavioral asymmetries (compared to nonimmobilized, lesioned animals), presumably attributable to mild disuse of the impaired limb. (jneurosci.org)
  • Together, these results suggest that although behavioral experience can enhance neural growth after brain injury, the region surrounding the injury may be vulnerable to behavioral pressure during the early postlesion period. (jneurosci.org)
  • After the casts were removed, behavioral events and neural morphology were examined at different time points. (jneurosci.org)
  • Chronic isolation did not significantly affect the activity of the enzyme. (ihna.ru)
  • Wild-type and bacterial artificial chromosome transgenic mice (D1R-tomato and D2R-green fluorescent protein) mice were lesioned with 6-hydroxydopamine and subsequently treated with L-DOPA to induce dyskinesia. (nih.gov)
  • Suchankova P, Engel JA , Jerlhag E. Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice. (neurotree.org)
  • In experiments, the models of idiopathic ASD are based on inbred mice selected by behavioral phenotype. (epiphanyasd.com)
  • Behavioral and subjective effects of ketamine and psilocybin were assessed with the Brief Psychiatric Rating Scale and the OAV Scale-a rating scale developed to measure altered states of consciousness. (neurotransmitter.net)
  • Classification of activity tolerance is of importance in chronic progressive myopathies, not only to better understand functional implications of the disease state itself, but also for purposes of exercise prescription for health maintenance. (stanford.edu)
  • Journal of Developmental and Behavioral Pediatrics. (wustl.edu)
  • The largest component, the striatum (dorsal and ventral), receives input from various brain areas but only sends output to other components of the basal ganglia. (wikipedia.org)
  • Regardless of the development of reactive gliosis within the striatum, loss of the grey matter is extensive and results in the compensatory enlargement of lateral brain ventricles. (hindawi.com)
  • Behavioral results demonstrated that the DCD group and DCD+ASD group scored on average poorer than the TD and ASD groups on various motor measures. (edu.au)
  • Chronic L-DOPA treatment, which induced dyskinesia and aberrant FosB expression, restored spine density in D2R-MSNs but not in D1R-MSNs. (nih.gov)
  • The 1st line of treatment is stimulant medications but may include non-stimulant medications and behavioral therapy. (lecturio.com)
  • The minimally conscious state (MCS) requires intermittent evidence of behavioral awareness. (medlink.com)
  • In humans and some primates, differences exist, primarily in the division of the globus pallidus into external and internal regions, and in the division of the striatum. (wikipedia.org)
  • We used the photothrombotic infarct lesioning technique to precisely destroy the hMFs within the internal capsule. (en-journal.org)
  • When one-sleeved casts were used to prevent animals with an FL-SMC lesion from using their unimpaired forelimb during the period of expected overgrowth, lesion-induced dendritic enhancement was not present when examined 2 d after cast removal. (jneurosci.org)
  • Animals with FL-SMC lesions were fitted with casts immediately after the lesion that immobilized the impaired forelimb, the unimpaired forelimb, or neither forelimb for 15 d. (jneurosci.org)
  • The globus pallidus receives input from the striatum and sends inhibitory output to a number of motor-related areas. (wikipedia.org)
  • In conclusion, our findings underscore the potential of QL-007 as an effective agent against HBV replication and introduce it as a novel CpAM for the antiviral treatment of chronic hepatitis B. (bvsalud.org)
  • 15-364 days), and chronic (365 days or more). (cdc.gov)
  • The objective of this study was to examine the impact of neuroticism as a moderator of physical symptoms and development of depression in patients with amyotrophic lateral sclerosis (ALS), chronic obstructive pulmonary disease (COPD), end-stage renal disease (ESRD), and frailty in the last 6 months of life. (cambridge.org)