ApoptosisProto-Oncogene Proteins c-bcl-2bcl-2-Associated X ProteinApoptosis Regulatory Proteinsbcl-2 Homologous Antagonist-Killer ProteinCaspasesbcl-X ProteinProto-Oncogene ProteinsBH3 Interacting Domain Death Agonist Proteinbcl-Associated Death ProteinCaspase 3Cell Line, TumorMitochondriaCell SurvivalCytochromes cGenes, bcl-2Signal TransductionMembrane ProteinsTumor Suppressor Protein p53Myeloid Cell Leukemia Sequence 1 ProteinCaspase 9Carrier ProteinsCaspase InhibitorsIn Situ Nick-End LabelingCaspase 8Cell LineBlotting, WesternEnzyme ActivationCell DeathTumor Suppressor ProteinsCells, CulturedTransfectionPhosphorylationDown-RegulationAntineoplastic AgentsAdaptor Proteins, Signal TransducingMice, KnockoutRNA, Small InterferingDNA FragmentationCell ProliferationDNA-Binding ProteinsAntigens, CD95Caspase 7Inhibitor of Apoptosis ProteinsNitrophenolsCytochrome c GroupNeoplasm ProteinsProtein BindingMitochondrial MembranesTNF-Related Apoptosis-Inducing LigandMice, Inbred C57BLFas Ligand ProteinUp-RegulationX-Linked Inhibitor of Apoptosis ProteinApoptosis Inducing FactorApoptotic Protease-Activating Factor 1Lymphoma, B-CellGene Expression Regulation, NeoplasticNF-kappa BReverse Transcriptase Polymerase Chain ReactionProto-Oncogene Proteins c-aktRNA, MessengerGene Expression RegulationMolecular Sequence DataTumor Cells, CulturedJurkat CellsMitochondrial ProteinsFlow CytometryProtein-Serine-Threonine KinasesTranscription FactorsProtein Structure, TertiaryCARD Signaling Adaptor ProteinsXenograft Model Antitumor AssaysHeLa CellsMembrane Potential, MitochondrialTranscription Factor CHOPEnzyme InhibitorsDrug Resistance, NeoplasmRNA InterferenceNuclear ProteinsMutationDrug SynergismBoronic AcidsCell CycleImmunoblottingTranslocation, GeneticJNK Mitogen-Activated Protein KinasesAmino Acid SequenceReactive Oxygen SpeciesIntracellular Signaling Peptides and ProteinsImmunoprecipitationChromosomes, Human, Pair 14Tumor Necrosis Factor-alphaImmunohistochemistryStaurosporineMice, NudeDNA DamagePyrazinesProtein TransportMice, Transgenic