ApoptosisProto-Oncogene Proteins c-bcl-2CaspasesApoptosis Regulatory ProteinsCaspase 3Inhibitor of Apoptosis ProteinsDNA Fragmentationbcl-2-Associated X ProteinIn Situ Nick-End LabelingCell Line, TumorX-Linked Inhibitor of Apoptosis ProteinCell SurvivalApoptosis Inducing FactorSignal TransductionCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase 9Caspase InhibitorsMitochondriaTumor Suppressor Protein p53Caspase 8Fas Ligand Proteinbcl-X ProteinEnzyme ActivationCytochromes cProto-Oncogene ProteinsTumor Cells, CulturedCells, CulturedGenes, bcl-2Cell ProliferationCell LineBlotting, WesternAnnexin A5Flow CytometryAmino Acid Chloromethyl KetonesCell CycleCysteine Proteinase InhibitorsAntineoplastic AgentsPoly(ADP-ribose) PolymerasesJurkat CellsTransfectionRNA, Small InterferingEnzyme InhibitorsDown-RegulationTNF-Related Apoptosis-Inducing LigandReactive Oxygen SpeciesCell DivisionCaspase 7HL-60 CellsMembrane Potential, MitochondrialNF-kappa BMyeloid Cell Leukemia Sequence 1 ProteinPhosphorylationDose-Response Relationship, Drugbcl-2 Homologous Antagonist-Killer ProteinUp-RegulationTumor Necrosis Factor-alphaRNA, MessengerCell DeathGene Expression Regulation, NeoplasticNeoplasm ProteinsReverse Transcriptase Polymerase Chain ReactionDNA-Binding ProteinsNecrosisDNA DamageMembrane GlycoproteinsMice, Inbred C57BLCytochrome c GroupBH3 Interacting Domain Death Agonist ProteinTime FactorsProto-Oncogene Proteins c-aktStaurosporinebcl-Associated Death ProteinImmunohistochemistryCarrier ProteinsMice, KnockoutGene Expression RegulationAntineoplastic Agents, PhytogenicRNA InterferenceCeramidesProtein-Serine-Threonine KinasesOxidative StressDrug SynergismReceptors, TNF-Related Apoptosis-Inducing LigandGene ExpressionTranscription FactorsMembrane ProteinsCaspase 2HeLa CellsFas-Associated Death Domain ProteinCysteine EndopeptidasesAdaptor Proteins, Signal TransducingMitogen-Activated Protein KinasesCell NucleusMutationEpithelial CellsDrug Resistance, NeoplasmApoptotic Protease-Activating Factor 1Tumor Suppressor ProteinsProtein BindingCell Differentiation