Biobreeding rat, also known as the BB or BBDP rat, is an inbred laboratory rat strain that spontaneously develops autoimmune Type 1 Diabetes. (wikipedia.org)
Lymphopenia ( lyp ) is a prerequisite for spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) diabetes prone (DP) rat [ 1 ]. (hindawi.com)
Chromosome3
Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
Congenic2
Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)
Type 1 diabet5
Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. (wikipedia.org)
Recently, 8 additional loci on rat chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat. (wikipedia.org)
NOD mice Type 1 Diabetes Autoimmunity Mordes JP, Poussier P, Blankenhorn EP, Greiner DL: Rat models of type 1 diabetes: Genetics, environment and autoimmunity. (wikipedia.org)
Rat models of type 1 diabetes: genetics, environment, and autoimmunity. (wikipedia.org)
A recent study using a rat model found significant differences at the time of diabetes onset in the bacterial communities responsible for type 1 diabetes modulation. (biomedcentral.com)
Diabetic4
Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome. (wikipedia.org)
To examine gender-dimorphic regulation of skeletal muscle proteins between healthy control and STZ-induced diabetic rats of both genders, we performed differential proteome analysis using two-dimensional electrophoresis combined with mass spectrometry. (karger.com)
Proteomic analysis of skeletal muscle identified a total of 21 proteins showing gender-dimorphic differential expression patterns between healthy controls and diabetic rats. (karger.com)
The current proteomic study revealed that impaired protein regulation was more prominent in the muscle tissue of female diabetic rats, which were more susceptible to STZ-induced diabetes. (karger.com)
Diabetes5
Diabetes in BB rats can be prevented by a single injection of mycobacterial adjuvants such as complete Freund's adjuvant (FCA). (wikipedia.org)
Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. (wikipedia.org)
Sadelain MW, Qin HY, Sumoski W, Parfrey N, Singh B, Rabinovitch A. Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant. (wikipedia.org)
Animal experiments revealed that STZ treatment rendered female rats more susceptible to induction of diabetes than their male littermates with significantly lower plasma insulin levels due to hormonal regulation. (karger.com)
rats, where 2 Mb of DP DNA was introgressed onto the BB diabetes resistant (DR) genetic background, are lymphopenic and 100% develop spontaneous T1D by 84 days of age [ 4 ]. (hindawi.com)
Lymphopenia1
The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells. (wikipedia.org)
Onset1
They were originally derived from a Canadian colony of outbred Wistar rats that spontaneously develop hyperglycemia and ketoacidosis, characteristic of clinical onset of T1D. (wikipedia.org)
Model4
BB rats are the most extensively studied rat model of T1D. (wikipedia.org)
In the present study, epigastric arteries of kidney transplant recipients, a rat model of VC, and an in vitro model of VC exhibiting catalase (Cts) overexpression were analysed. (bvsalud.org)
In the rat model, advanced aortic VC concurred with lower levels of the H2O2-scavenger glutathione peroxidase 3 compared to controls. (bvsalud.org)
Study1
The study was performed in aortas and serum from rats fed standard and high-phosphorus diets, and in VSMCs exposed to different concentrations of phosphorus. (bvsalud.org)
Results1
In vivo results showed that in rats with normal renal function fed a high P diet, a significant increase in serum phosphorus was observed which was associated to a significant decrease in the aortic α-actin expression which paralleled the decrease in aortic and serum miR-145 levels, with no changes in the osteogenic markers. (bvsalud.org)
Analysis1
Analysis of the lyp phenotype in the F344 DNA recombinant rats helped us define the critical lyp interval as a region of approximately 33 Kb between D4Rhw6 (76.83 Mb) and IIsnp3 (77.16 Mb) containing Gimap1 , Gimap5 , and Gimap3 (formerly known as Ian2 , Ian5 , and Ian4 , resp. (hindawi.com)
Strain3
The Rat Strain Ontology (RS) is currently being developed at the Rat Genome Database. (mcw.edu)
Biobreeding rat, also known as the BB or BBDP rat, is an inbred laboratory rat strain that spontaneously develops autoimmune Type 1 Diabetes. (wikipedia.org)
One in Worcester, Massachusetts, has been inbred and known as BBDP/Wor and another one in Ottawa, Canada, an outbred strain known as BBdp. (wikipedia.org)
Ketoacidosis2
Diabetes onset in the BB rat is typically accompanied by ketoacidosis. (medscape.com)
They were originally derived from a Canadian colony of outbred Wistar rats that spontaneously develop hyperglycemia and ketoacidosis, characteristic of clinical onset of T1D. (wikipedia.org)
Diabetes in the BB rat3
The natural history of diabetes in the BB rat is comparable to that observed in humans at both the clinical and cellular levels. (medscape.com)
Recently, 8 additional loci on rat chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat. (wikipedia.org)
Sadelain MW, Qin HY, Sumoski W, Parfrey N, Singh B, Rabinovitch A. Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant. (wikipedia.org)
Injection1
Diabetes in BB rats can be prevented by a single injection of mycobacterial adjuvants such as complete Freund's adjuvant (FCA). (wikipedia.org)
Cells2
The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells. (wikipedia.org)
Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. (wikipedia.org)
Animal1
Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. (wikipedia.org)
Canada1
The BB rat was discovered in Canada in the mid 1970s. (medscape.com)