• Infections caused by Carbapenemases carbapenem-resistant A. baumannii (CRAB) don't respond to common antibiotics identified in U.S. CRAB and some CRAB are resistant to all available antibiotics. (cdc.gov)
  • Carbapenem antibiotics are among the mainstays for treating infections caused by Acinetobacter baumannii , especially in the Northwest United States , where carbapenem -resistant A. baumannii remains relatively rare. (bvsalud.org)
  • A. baumannii predominantly causes hospital acquired infections, and its chronic infections are predominantly caused by the formation of biofilms. (biofilms.ac.uk)
  • So despite knowing that A. baumannii is such an important pathogen, there is still a huge gap in our knowledge of how this pathogen forms its biofilms, which is obviously really important in terms of infections. (biofilms.ac.uk)
  • The unique ability of A. baumannii to cause diseases and acquire resistance to numerous antibiotics, make it necessary to control and prevent these infections. (am-online.org)
  • Acinetobacter baumannii is a nosocomial pathogen capable of causing serious infections associated with high rates of morbidity and mortality. (preprints.org)
  • The newly isolated phages can serve as potential candidates for phage cocktails to control A. baumannii infections. (sciensano.be)
  • Biofilm-producing A. baumannii has been isolated from several infectious origins such as pneumonia and devise-associated infections. (lifeboat.com)
  • The aim of this study was to isolate A. baumannii from wound infections, determine their resistance and virulence profile, and assess the impact of AgNPs on the bacterial growth, virulence and biofilm-related gene expressions in the isolated strains. (lifeboat.com)
  • Colistin is a historic antimicrobial that has become commonly used as a treatment for MDR A. baumannii infections. (uea.ac.uk)
  • Bicarinalin and BP100 may be effective therapeutic alternatives to colistin against A. baumannii infections but further research is required to assess if they elicit cytotoxicity issues in patients. (lincoln.ac.uk)
  • These observations brings us one step closer to understanding the regulatory role of hns to combat A. baumannii infections. (siu.edu.ar)
  • 8. Karbasizade V, Heidari L, Jafari R. Detection of oxa-type carbapenemase genes in Acinetobacter baumannii isolates from nosocomial infections in Isfahan hospitals, Iran. (ac.ir)
  • Acinetobacter baumannii is a multidrug-resistant bacterium associated with nosocomial infections and known for its ability to develop resistance rapidly. (journal-asia.education)
  • This indicates a significant presence of bla SPM -mediated carbapenem resistance among A. baumannii strains in our study population.Furthermore, our findings demonstrated alarmingly high resistance rates against the majority of antibiotics commonly prescribed to treat A. baumannii infections. (journal-asia.education)
  • This poses significant challenges for effective treatment options and underscores the urgent need for alternative strategies in managing A. baumannii infections. (journal-asia.education)
  • Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species and extra-intestinal pathogenic Escherichia coli . (nih.gov)
  • these include Pseudomonas aeruginosa , Escherichia coli, Acinetobacter baumannii and Klebsiella pneumonia [ 2 ]. (biomedcentral.com)
  • Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. (nih.gov)
  • The aims of the present study were the determination of potential risk factors of a fulminant fatal course of bacteremia caused by extensively drug-resistant Klebsiella pneumoniae (XDR- Kp) and the comparison of fulminantly fatal bacteremias due to XDR-Kp versus XDR Acinetobacter baumannii (XDR-Ab) strains within a 8-years' period. (crimsonpublishers.com)
  • Acinetobacter baumannii is a species of bacteria that is an opportunistic pathogen. (cdc.gov)
  • Acinetobacter baumannii is an opportunistic nosocomial pathogen that has increasingly become resistant to carbapenems worldwide. (who.int)
  • For the opportunistic pathogen Acinetobacter baumannii, desiccation tolerance is thought to contribute significantly to the persistence of these bacteria in the healthcare environment. (ecu.edu)
  • ABSTRACT This study was conducted to determine the prevalence and the local antibiogram of multidrug-resistant Acinetobacter baumannii isolates in Al-Hussein Hospital at King Hussein Medical Centre in Amman, Jordan. (who.int)
  • Abstract: Acinetobacter baumannii is a Gram-negative saprophytic rod inhabiting both moist niches and dry surfaces. (am-online.org)
  • Emergence and spread of carbapenem-resistant strains of Acinetobacter baumannii in a tertiary-care hospital in Poland. (nih.gov)
  • Methods: Seventeen putative drug efflux systems from A. baumannii were heterologously expressed in Escherichia coli . (edu.au)
  • Cite taxon page as 'WFO (2023): Cleistocactus baumannii (Lem. (worldfloraonline.org)
  • 2023. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540003/all/Acinetobacter_baumannii. (unboundmedicine.com)
  • We focused on evaluating the susceptibility of A. baumannii to antibiotics, detecting carbapenemase enzymes using the modified Hodge test, and characterizing the presence of specific carbapenem resistance genes using PCR analysis.This cross-sectional study took place at Al-Sader Medical City and Baghdad Teaching Hospitals from October 2022 to February 2023. (journal-asia.education)
  • Aim: We sought to investigate the genetic epidemiological relatedness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains of a suspected outbreak in a Lebanese tertiary care hospital to implement necessary infection prevention and control measures. (hal.science)
  • Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) is an important pathogenic bacterium that can cause nosocomial infection in hospitalized patients with various manifestations. (ui.ac.id)
  • Identifications of meropenem-resistant A. baumannii isolates with the vitek2® system results, followed by a sensitivity test using 10 µg imipenem antibiotic disc according to CLSI guidelines to fulfill the criteria as CRAB isolates. (ui.ac.id)
  • Carbapenem-resistant A. baumannii (CRAB) is a top priority pathogen according to the World Health Organization (WHO). (journal-asia.education)
  • For phenotype identification of the proteins encoded by these genes, we developed a novel high-throughput phenotype screening strategy and demonstrated its utility in identifying phenotypes for putative efflux systems encoded by the human pathogen Acinetobacter baumannii . (edu.au)
  • In the multidrug resistant (MDR) pathogen Acinetobacter baumannii the global repressor H-NS was shown to modulate the expression of genes involved in pathogenesis and stress response. (siu.edu.ar)
  • In this study, we used three types of bacterium, namely E. coli , P. aeruginosa and A. baumannii . (biomedcentral.com)
  • E. coli NBRC 3972, P. aeruginosa NBRC 13275 and A. baumannii NBRC 110494 were obtained from the Biological Resource Center (NITE, Japan). (biomedcentral.com)
  • O objetivo do estudo foi determinar a resistência antimicrobiana das estirpes de P. aeruginosa e A. baumannii isoladas de doentes internados em contexto hospitalar. (com.pt)
  • Um número de 2.514 estirpes de P. aeruginosa e 126 A. baumannii isolados de infeções nosocomiais foram testados para suscetibilidade antimicrobiana no Vitek 2 C automático e com a Concentração Mínima Inibitória (MIC) de colistina determinada por microdiluição, de acordo com EUCAST 2021. (com.pt)
  • Neste estudo, a maioria dos β-lactâmicos e aminoglicosídeos são mais indicados na terapia de infeções produzidas por P. aeruginosa e A. baumannii. (com.pt)
  • Para P. aeruginosa e A. baumannii a colistina apresentou alta atividade. (com.pt)
  • This study aims to define various carbapenem-resistant mechanisms of isolated P. aeruginosa and A. baumannii from nine different provinces of Iran. (ac.ir)
  • In this cross-sectional study, all carbapenem-resistant P. aeruginosa and A. baumannii samples from nine provinces of Iran on a one-year time horizon were gathered. (ac.ir)
  • Twenty-one percent and 43.5% of P. aeruginosa and A. baumannii isolates were resistant to carbapenem, respectively. (ac.ir)
  • EPIs identified active efflux pumps in 20% and 28% of P. aeruginosa and A. baumannii, respectively. (ac.ir)
  • Real-time PCR confirmed gene overexpression of efflux pumps in 54% and 30% of positive EPIs in P. aeruginosa and A. baumannii, respectively. (ac.ir)
  • P. aeruginosa and A. baumannii may become multi-drug-resistant (MDR) and Extensively Drug-Resistant (XDR) strains and cause a high rate of mortality and morbidity. (ac.ir)
  • Genomic characterization of extensively drug-resistant Acinetobacter baumannii strain, KAB03 belonging to ST451 from Korea. (pacb.com)
  • Here, we isolated new sequence type of XDR A. baumannii clinical strain (KAB03) from Korean hospitals and performed comprehensive genome analyses. (pacb.com)
  • Different studies have determined the conditions that affect transformability of A. baumannii , but most results seem to be strain dependent. (acinetobacterbaumannii.no)
  • Ramirez, M.S. Human Pleural Fluid and Human Serum Albumin Modulate the Behavior of a Hypervirulent and Multidrug-Resistant (MDR) Acinetobacter baumannii Representative Strain. (preprints.org)
  • Exposure to human fluids was previously shown to alter the gene expression profile of a highly drug susceptible A. baumannii strain A118 leading to persistence and survival of this pathogen. (preprints.org)
  • Herein, we explore the impact of human pleural fluid (HPF) and human serum albumin (HSA) on the gene expression profile of a highly multi-drug resistant strain of A. baumannii AB5075. (preprints.org)
  • A. baumannii strain MAR002 possesses both twitching and surface-associated motility. (uab.cat)
  • A. baumannii KAB03 harbours three antibiotic resistance islands (AbGRI1, 2, and 3). (pacb.com)
  • 2. Has an infection caused by A. baumannii organisms known to be resistant to colistin (defined as MIC = 4 mg/L by a non-agar-based method) based on evidence from culture or susceptibility testing after at least 48 hours of antibiotic treatment. (who.int)
  • We identified completely resistant A. baumannii in 6 (4.9%) of 122 A. baumannii isolates in a retrospective chart review at two teaching hospitals. (nih.gov)
  • A. baumannii is the major species of Acinetobacter . (unboundmedicine.com)
  • Although the species is native to the Balkans, Aesculus Hippocastanum Baumannii was actually discovered as a sport in 1820 in Geneva. (paramountplants.co.uk)
  • Among the different species, Acinetobacter baumannii has evolved as global pathogen causing wide range of infection. (hal.science)
  • In the present review, we summarize the recent data about the natural reservoir of non-baumannii Acinetobacter including the novel species that have been described for the first time from environmental sources and reported during the last years. (hal.science)
  • Methods: A. baumannii isolates collected from patient's clinical cultures in two tertiary care hospitals in Malang and Manado were included. (ui.ac.id)
  • Methods: A. baumannii isolates collected from patient{\textquoteright}s clinical cultures in two tertiary care hospitals in Malang and Manado were included. (ui.ac.id)
  • It involved 59 A. baumannii isolates collected from patients. (journal-asia.education)
  • Oceanimonas baumannii is a Gram-negative and motile bacterium from the genus of Oceanimonas which has been isolated from estuarine mud from the River Wear in England. (wikipedia.org)
  • Due to the increasing multidrug resistance of A. baumannii, this bacterium belongs to the group of priority pathogens. (am-online.org)
  • Multiplex PCR revealed the presence of a blaOXA carbapenemase gene , later identified as blaOXA-237 Whole- genome sequencing of all isolates revealed a well-supported separate branch within a global A. baumannii phylogeny . (bvsalud.org)
  • Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii. (sciensano.be)
  • Based on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further characterization. (sciensano.be)
  • 5. Azimi L, Talebi M, Pourshafie MR, Owlia P, Rastegar Lari A. Characterization of carbapenemases in extensively drug resistance Acinetobacter baumannii in a burn care center in Iran. (ac.ir)
  • A. baumannii KAB03 harbours mutations in pmrB and pmrC, which are believed to confer colistin resistance. (pacb.com)
  • We aimed to identify the mechanisms associated with colistin resistance in A. baumannii using multiple high-throughput-sequencing technologies, including transposon-directed insertion site sequencing (TraDIS), RNA sequencing (RNAseq) and whole-genome sequencing (WGS) to investigate the genotypic changes of colistin resistance in A. baumannii. (uea.ac.uk)
  • We additionally found that mutations in the pmrB TCS genes were the primary colistin-resistance-associated mechanisms in three Vietnamese clinical colistin-resistant A. baumannii strains. (uea.ac.uk)
  • A. baumannii in our hospital were highly resistant to all antibiotics, including tigecycline, except for minocycline and colistin which are considered the last resort treatment for multidrug-resistant A. baumannii. (who.int)
  • A. baumannii rose to prominence in the past 20 years due to its extensive resistance to almost all antibiotics that we currently have. (biofilms.ac.uk)
  • therefore, it is necessary to analyze both genomic and proteomic characteristics of emerging XDR A. baumannii clinical strains isolated in Korea to elucidate their multidrug resistance. (pacb.com)
  • This study conducted untargeted metabolomics to investigate metabolic responses of a multidrug-resistant (MDR) A. baumannii clinical isolate, AB090342, to colistin and aztreonam alone, and their combination at 1, 4, and 24 h. (nih.gov)
  • A. baumannii is an etiological factor of ventilator-associated pneumonia, which is especially dangerous for patients in intensive care units (in Poland every fifth patient suffers from such infection). (am-online.org)
  • The increasing incidence and emergence of multi-drug resistant (MDR) Acinetobacter baumannii has become a major global health concern. (uea.ac.uk)
  • Nosocomial Outbreak of Extensively Drug-Resistant Acinetobacter baumannii Isolates Containing bla OXA-237 Carried on a Plasmid. (bvsalud.org)
  • However, between June 2012 and October 2014, an outbreak of carbapenem -resistant A. baumannii occurred in 16 patients from five health care facilities in the state of Oregon . (bvsalud.org)
  • Here, we describe a protracted hospital outbreak of multidrug-resistant A. baumannii, in which whole-genome sequencing (WGS) was used to obtain a high-resolution view of the relationships between isolates. (uea.ac.uk)
  • METHODS: To delineate and investigate the outbreak, we attempted to genome-sequence 114 isolates that had been assigned to the A. baumannii complex by the Vitek2 system and obtained informative draft genome sequences from 102 of them. (uea.ac.uk)
  • Here, we describe a protracted hospital outbreak of multidrug-resistant A. baumannii, in which whole-genome sequencing (WGS) was used to obtain a high-resolution view of the relationships between isolates.METHODS: To delineate and investigate the outbreak, we attempted to genome-sequence 114 isolates that had been assigned to the A. baumannii complex by the Vitek2 system and obtained informative draft genome sequences from 102 of them. (uea.ac.uk)
  • We undertook a genomic study of carbapenem-resistant A. baumannii in the Philippines to characterize the population diversity and antimicrobial resistance mechanisms. (who.int)
  • This is the first extensive genomic study of carbapenem-resistant A. baumannii in the Philippines, and it underscores the importance of hospital infection control and prevention measures to contain high-risk clones. (who.int)
  • These results imply that BfmR plays a role in controlling stress responses in A. baumannii which help protect cells during desiccation, and they provide a regulatory link between this organism's ability to persist in the environment and pathogenicity. (ecu.edu)
  • Using two well characterized A. baumannii model strains with distinctive resistance profile and pathogenicity traits (AB5075 and A118), complementary transcriptomic and phenotypic approaches were used to study the role of H-NS in antimicrobial resistance, biofilm and quorum sensing gene expression. (siu.edu.ar)
  • These results shed light on the key role of surface-associated motility and the limited role of twitching in the pathogenicity of A. baumannii. (uab.cat)
  • Acinetobacter baumannii Quantitative qPCR Standard is designed for the in vitro quantification of Acinetobacter baumannii genomes. (nzytech.com)
  • It is explicitly tailored for use in conjunction with the Acinetobacter baumannii qPCR Kit (MD05131). (nzytech.com)
  • The Acinetobacter baumannii Quantitative qPCR Standard is a highly specific product designed for quantitative real-time PCR (qPCR) applications, and it is explicitly tailored for use in conjunction with the Acinetobacter baumannii qPCR Kit (MD05131). (nzytech.com)
  • When a quantitative analysis of A. baumannii samples is required, a standard curve should be generated using Acinetobacter baumannii Quantitative qPCR Standard and analysed in a qPCR run. (nzytech.com)
  • Acinetobacter baumannii detection by using qPCR. (biopremier.com)
  • Nosocomially acquired completely resistant Acinetobacter baumannii strains are a major clinical concern. (nih.gov)
  • Effectiveness of infection prevention measures featuring advanced source control and environmental cleaning to limit transmission of extremely-drug resistant Acinetobacter baumannii in a Thai intensive care unit: An analysis before and after extensive flooding. (nih.gov)
  • Okasha, H. and Meheissen, M. (2017) In Vitro Activity of Colistin and Vancomycin or Azithromycin Combinations on Extensively Drug Resistant Acinetobacter baumannii Clinical Isolates. (scirp.org)
  • BACKGROUND: Multidrug-resistant Acinetobacter baumannii commonly causes hospital outbreaks. (uea.ac.uk)
  • Extensively drug-resistant (XDR) Acinetobacter baumannii strains have emerged rapidly worldwide. (pacb.com)
  • Multidrug-resistant (MDR) A. baumannii has spread to civilian hospitals. (biopremier.com)
  • We investigated the ability of A. baumannii to survive rapid drying, and found that some strains exhibited a profoundly desiccation-resistant phenotype, characterized by the ability of a large proportion of cells to survive on a dry surface for an extended period of time. (ecu.edu)
  • Carbapenem-resistant Acinetobacter baumannii (CR-AB) represents a major health-care problem, causing high rates of morbidity and mortality. (uea.ac.uk)
  • We sequenced the whole genomes of 117 A. baumannii isolates recovered by 16 hospitals in the Philippines between 2013 and 2014. (who.int)
  • Due to its antimicrobial drug resistance profile, A. baumannii is categorized as an urgent priority pathogen by the Centers for Disease Control and Prevention in the United States and priority group 1 critical microorganism by the World Health Organization. (preprints.org)
  • Acinetobacter baumannii has been identified by the WHO as a high priority pathogen. (lincoln.ac.uk)
  • Since the implementation of molecular techniques, the habitat and the role of non-baumannii Acinetobacter in human infection have been elucidated. (hal.science)
  • A. baumannii commonly occurs as a biofilm and biofilm removal assay results highlighted that both bicarinalin and BP100 had significantly greater potential than colistin. (lincoln.ac.uk)
  • All these four mechanisms of HGT have been reported in Acinetobacter baumannii , including in the context of antimicrobial resistance dissemination ( Da Silva & Domingues, 2016 ). (acinetobacterbaumannii.no)
  • Understanding how A. baumannii adapts to different host environments may provide critical insights into strategically targeting this pathogen with novel antimicrobial and biological therapeutics. (preprints.org)
  • To further contribute to the knowledge of this key transcriptional regulator in A. baumannii behavior, we studied the role of H-NS in antimicrobial resistance. (siu.edu.ar)
  • Hu Y, He L, Tao X, Meng F, Zhang J. High DNA uptake capacity of International Clone II Acinetobacter baumannii detected by a novel planktonic natural transformation assay. (acinetobacterbaumannii.no)
  • The minimum bactericidal concentration (MBC) against planktonic A. baumannii was approximately 0.5 μg/ml for colistin sulphate and ∼4 μg/ml for bicarinalin and BP100. (lincoln.ac.uk)
  • Our results outline the entire range of mechanisms employed in A. baumannii for resistance against colistin, including drug extrusion and the loss of lipid A moieties by gene disruption or modification. (uea.ac.uk)
  • Our proteogenomic results provide valuable information for multi-drug resistance in emerging XDR A. baumannii strains belonging to ST451. (pacb.com)
  • Results: Of the 17 putative drug efflux systems, phenotypeswere confirmed for two pumps and novel drug resistance phenotypes were identified for three new A. baumannii drug transporters, which exemplified the power of this method as a high-throughput screening technique. (edu.au)
  • One of the phenotypically characterized putative drug efflux systems was classified within the ATP-binding cassette superfamily of transport proteins and represents the first drug resistance protein characterized from this superfamily in A. baumannii . (edu.au)
  • 6. Mobasseri P, Azimi L, Salehi M, Hosseini F, Fallah F. Multi-drug resistance profiles and expression of adeijk and abem in Acinetobacter baumannii collected from humans by Real-time PCR. (ac.ir)
  • Incubation was carried out in a shaking incubator at 200 rpm for 18 h at 37 °C. One bead from a stock vial of A. baumannii was transferred onto a SCD agar plate (51048, Nissui Pharmaceutical Co., LTD., Japan) and incubated at 37 °C for 18 h. (biomedcentral.com)
  • Cells of A. baumannii on the agar plate were collected with an inoculating loop. (biomedcentral.com)