• IL-3 amplified the number of PC in vitro, and acted synergistically with basophils in enhancing Ab production. (jimmunol.org)
  • Compared to the control group, patients with NCWSS and multiple food sensitivity revealed significantly higher incidence of food allergy in the paediatric age group, and in the groups with coexistent atopic diseases, positive serum IgG anti-gliadin antibodies (AGAs) and IgG anti-betalactoglobulin antibodies, in vitro basophil activation, and eosinophil presence in the colon mucosa biopsies. (thefreedictionary.com)
  • Basophil activation test for the in vitro diagnosis of nonsteroid. (ingentaconnect.com)
  • The basophil activation test is useful for the in vitro diagnosis of NSAID hypersensitivity, providing good specificity and positive predictive value and diagnostic reliability in the assessment of NSAID intolerance. (ingentaconnect.com)
  • Furthermore, they are able to respond to various mediators because of their expression of different receptors for cytokines, TLR ligands ( 15 , 16 ), thymic stromal lymphopoietin ( 17 ), and IgG (FcγRIIa/IIb) ( 18 ) and IgE (FcεRIα) ( 19 ), facilitating Ag-specific basophil responses. (jimmunol.org)
  • Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. (textbookx.com)
  • Article by Stephen F Kemp, MD, FACP on this acute multiorgan system reaction caused by the release of chemical mediators from mast cells and basophils. (dmoztools.net)
  • In patients with chronic urticaria who respond clinically to omalizumab, the proteome of blood basophils will be measured at baseline (pre-treatment) and at weeks 6 and 13 (post-treatment). (clinicaltrials.gov)
  • The purpose of this study is to evaluate for changes in the proteins produced in white blood cells (basophils) in patients with chronic hives who are treated with and respond to omalizumab. (clinicaltrials.gov)
  • There are other substances that can activate basophils to secrete which suggests that these cells have other roles in inflammation. (wikipedia.org)
  • Herpesvirus-6 , herpesvirus-7, and herpesvirus-8 produce a CD200 homolog which also inhibits basophil function. (wikipedia.org)
  • Doctors may also order a specific test called a basophil activation test (BAT) to check for particular allergens. (medicalnewstoday.com)
  • Separate markers (e.g. as CD123+ HLA-DR-) are used to specifically identify basophils in addition to those used for assessment of activation. (openwetware.org)
  • The purpose of this study was to assess the reliability of one such diagnostic, the basophil activation test. (ingentaconnect.com)
  • This is highly relevant with respect to human allergy and autoimmunity because a possible modulation of B cell differentiation by basophils could point to new therapeutic targets. (jimmunol.org)
  • Using two different methods to induce PC differentiation, we found that human basophils enhance B cell proliferation, class switching, differentiation into PC, maturation of PC, and production of Igs, especially IgG. (jimmunol.org)
  • Basophil supernatants enhanced the expression of the B cell markers CD23 and CD40, which are important for B cell differentiation into IgG-producing PC. (jimmunol.org)
  • Thus, human basophils modulate B cell differentiation into Ab-producing PC. (jimmunol.org)
  • Our data demonstrate that human basophils support PC differentiation in an IL-3- and IL-4-dependent way. (jimmunol.org)
  • Doctors believe that the role of basophils in the body is reactionary, meaning that their number will generally only rise or fall due to an invader or underlying chronic issue. (medicalnewstoday.com)
  • Increase in basophil leucocytes (counts above 0.1 X 10^9/liters) is uncommon, but this is seen in myeloproliferative disorders such as chronic myeloid leukemia and polycythemia vera. (hubpages.com)
  • Basophils have been associated with fatal asthma, acute and chronic allergy, and have been shown to play an exacerbating role in lupus nephritis. (worldallergy.org)
  • B cell-basophil interaction might also impact the pathogenesis of autoimmune diseases as indicated by the fact that basophils are differently activated in systemic lupus erythematosus (SLE) depending on the disease severity ( 10 ). (jimmunol.org)
  • Basophils were discovered in 1879 by German physician Paul Ehrlich , who one year earlier had found a cell type present in tissues that he termed mastzellen (now mast cells). (wikipedia.org)
  • The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. (textbookx.com)
  • There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. (textbookx.com)
  • This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. (textbookx.com)
  • Our understanding of basophils and their roles has been increasing steadily over the past few years, due to the introduction of murine basophil knockout models. (worldallergy.org)
  • Therefore, the interaction between human B cells and basophils and the mechanism underlying this interaction were investigated in detail. (jimmunol.org)
  • In the current study, we therefore investigated whether human basophils and B cells interact and which mechanisms underlie this interaction. (jimmunol.org)
  • With this, we provide an in-depth insight into the impact and mechanism by which human basophils modulate B cell functions in the healthy situation. (jimmunol.org)
  • However some questions still remain regarding the relevance of these models to human basophil immunobiology. (worldallergy.org)