Basigin (BSG) also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the BSG gene. (wikipedia.org)
In this review of literature, we summarized five potential host cell receptors, as host-cell surface bindings, including angiotensin-converting enzyme 2 (ACE2), neuropilin 1 (NRP-1), dipeptidyl peptidase 4 (DPP4), glucose regulated protein-78 (GRP78), and cluster of differentiation 147 (CD147) related to the SARS-CoV-2 infection. (eurekaselect.com)
EMMPRIN2
CD147 , also known as Basigin (BSG) , or extracellular matrix metalloproteinase inducer (EMMPRIN) . (proteinkinase.biz)
Recombinant Human CD147 /EMMPRIN Protein (rhCD147), His Tag (CD7-H5222) is expressed from human 293 cells (HEK293). (proteinkinase.biz)
Antibody6
Subsequently, meplazumab, a humanized anti-CD147 antibody, was tested in patients with SARS-CoV-2 pneumonia. (wikipedia.org)
Notably, CD147 antibody-mediated blocking significantly reduced the expression of S100A9, and S100A8 on megakaryocytes following incubation with SARS-CoV-2. (wikipedia.org)
human liver tissue were subjected to SDS PAGE followed by western blot with 11989-1-AP (CD147 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. (ptglab.com)
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11989-1-AP (CD147 antibody) at dilution of 1:200 (under 10x lens. (ptglab.com)
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11989-1-AP (CD147 antibody) at dilution of 1:200 (under 40x lens. (ptglab.com)
1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
Receptor10
Basigin has been shown to be an essential receptor on red blood cells for the human malaria parasite, Plasmodium falciparum. (wikipedia.org)
Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins. (wikipedia.org)
Basigin also serves as a receptor for S100A9 and platelet glycoprotein VI, and basigin-1 acts as a receptor for the rod-derived cone viability factor. (wikipedia.org)
Basigin interacts with the fourth C-type lectin[circular reference] domain in the receptor Endo180 to form a molecular epithelial-mesenchymal transition[citation needed] suppressor complex that if disrupted results in the induction of invasive prostate epithelial cell behavior associated with poor prostate cancer survival. (wikipedia.org)
It has recently (November 2011) been found that basigin is a receptor that is essential to erythrocyte invasion by most strains of Plasmodium falciparum, the most virulent species of the plasmodium parasites that cause human malaria. (wikipedia.org)
More recent studies suggests CD147 as SARS-CoV-2 entry receptor of platelets and megakaryocytes, leading to hyperactivation and thrombosis, that differs from common cold coronavirus CoV-OC43. (wikipedia.org)
Another study states that platelets challenged with SARS-CoV-2 undergo activation, dependent on the CD147 receptor. (wikipedia.org)
All variants bound the PfRH5 receptor basigin and were recognized by a panel of monoclonal antibodies. (nature.com)
Cyclophilin A (CypA), which has peptidyl-prolyl cis-trans isomerase (PPIase) activity, regulates multiple functions of cells by binding to its extracellular receptor CD147. (bvsalud.org)
Besides ACE2, CD147 was discovered as a novel SARS-CoV-2 receptor, CD147 appears to be an alternate receptor for SARSCoV- 2 infection. (eurekaselect.com)
Extracellular2
The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. (wikipedia.org)
A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. (wikipedia.org)
Receptors1
Several receptors have been demonstrated for the interaction of spike (S) protein of SARS-CoV-2 with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands and Eph receptors, neuropilin 1 (NRP-1), P2X7, and CD147. (bvsalud.org)
HEK2931
Recombinant human basigin (BSG, CD147) produced in HEK293 cells and purified from culture supernatant. (thenativeantigencompany.com)
Ligand1
It is hoped that by developing antibodies to the parasite ligand for Basigin, Rh5, a better vaccine for malaria might be found. (wikipedia.org)
Protein4
Basigin is bound by the PfRh5 protein on the surface of the malaria parasite. (wikipedia.org)
citation needed] The host-cell-expressed basigin (CD147) may bind spike protein of SARS-CoV-2 and possibly be involved in host cell invasion. (wikipedia.org)
Some of these claims have been challenged by another group of scientists who found no evidence of a direct role for basigin in either binding the viral spike protein or promoting lung cell infection. (wikipedia.org)
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
Antibodies1
Progress in this arena, however, is being made with a new generation of merozoite antigen targets identified in recent years that exhibit relatively low levels of polymorphism and against which functional neutralizing antibodies can be raised by vaccination. (nature.com)
Tumor1
To validate the clinical significance of the CypA/CD147 interaction, we analyzed the expression levels of PPIA and BSG genes encoding CypA and CD147, respectively, in a wide range of tumor types using The Cancer Genome Atlas (TCGA) database. (bvsalud.org)
Pathways2
The development of an effective vaccine against the merozoite has proved exceptionally challenging, hindered by substantial levels of polymorphism in the most widely studied candidate antigens 4 and redundant erythrocyte invasion pathways 5 . (nature.com)
The CypA/CD147 interaction plays a crucial role in the progression of several diseases, including inflammatory diseases, coronavirus infection, and cancer, by activating CD147-mediated intracellular downstream signaling pathways. (bvsalud.org)
Proteins1
Based on previous data, the aim of this study was to find a correlation between the immunohistochemical (IHC) expression patterns of a group of matrix modifier proteins, including CD147, Matrix Metalloprotease 2 and 9 (MMP2 and 9, respectively), Epithelial Cadherin (ECAD), and Galectin-3 (GAL3) with World Health Organization (WHO)-defined grade, brain invasion, recurrence, and other clinicopathological features. (jsurgmed.com)
Targets1
Many studies have identified CypA and CD147 as potential therapeutic targets for cancer. (bvsalud.org)
Expression5
In addition to its metalloproteinase-inducing ability, basigin also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. (wikipedia.org)
It have been shown that Atorvastatin suppresses CD147 and MMP-3 expression. (wikipedia.org)
Statins altered CD147 expression, structure and function. (wikipedia.org)
As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. (proteinkinase.biz)
Methods We established new patient-derived PA cell lines that preserve molecular features of the primary tumors and can be studied in OIS and proliferation depending on expression or repression of the SV40 large T antigen. (ibecbarcelona.eu)
Appears1
Basigin appears to be required for proper placement of MCTs in the membrane. (wikipedia.org)
Patients1
Therefore, this review supports the hypothesis that targeting the CypA/CD147 interaction may improve treatment outcomes for patients with cancer. (bvsalud.org)
Member1
Basigin is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. (wikipedia.org)
Treatment1
The study results demonstrated that CD147 could be a target for diagnosis, prognosis, and treatment of meningiomas. (jsurgmed.com)
Role1
As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition (Miyauchi et al. (wikipedia.org)
Mouse1
In the Basigin null mouse, the failure of MCTs to integrate with the membrane may be directly linked to a failure of nutrient transfer in the retinal pigmented epithelium (the lactates transported by MCTs 1, 3, and 4 are essential nutrients for the developing RPE), resulting in loss of sight in the null animal. (wikipedia.org)
Cancer1
This review aims to understand the biology and interaction of CypA and CD147 and to review the roles of the CypA/CD147 interaction in cancer pathology and the therapeutic potential of targeting the CypA/CD147 axis. (bvsalud.org)