• One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. (genenames.org)
  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. (abcam.com)
  • Several factors regulate Bach2 activity and localization (reviewed in Ref. 2 ), including PI3K signaling in B cells, which leads to phosphorylation of Ser 512 and cytosolic accumulation. (jimmunol.org)
  • During his post-doctoral years in the US, Chattopadhyay worked on the regulatory switch of seedling development in plant and propounded the theory that the first transcription factor of light signaling pathways which interacted with COP1 was HY5. (wikipedia.org)
  • Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). (abcam.com)
  • This binding to DNA leads to the increased transcription of the target genes. (wikipedia.org)
  • Known target genes (confirmed by at least two independent sources) of this transcription factor include, Additional genes identified by a microarray study (which confirmed the above targets) include the following, The LysRS-Ap4A-MITF signaling pathway was first discovered in mast cells, in which, the MAPK pathway is activated upon allergen stimulation. (wikipedia.org)