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  • mice
  • Neurog3 is required for development of all pancreatic endocrine cell types in mice ( 5 - 7 ) and does this through direct and indirect regulation of downstream targets, including the transcription factors NeuroD1 ( 8 ), Rfx6 ( 9 ), Pax4 ( 10 ), Nkx6.1 ( 11 , 12 ), Arx ( 13 ), and others. (diabetesjournals.org)
  • genetic risk factors
  • As a result, there are no confirmed genetic risk factors for erectile dysfunction. (pnas.org)
  • Twin studies support the role of genetic risk factors underlying erectile dysfunction, but no specific genetic variants have been identified. (pnas.org)
  • In type 2 diabetes (T2D), pancreatic β-cells fail to respond appropriately to metabolic stresses brought on by age, obesity, and genetic risk factors. (diabetesjournals.org)
  • mechanism
  • However, here we show that Ig loci are not opened globally but that recombination is localized.The induced repertoire seen at 24 hours does not change significantly over time indicating the absence of many secondary rearrangements and also suggesting a direct targeting mechanism.We propose that accessibility occurs in a local manner, and that binding sites for factors facilitating accessibility are therefore likely to be associated with individual gene segments. (nih.gov)
  • induction
  • Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells. (nih.gov)
  • Furthermore, in some families, induction of germline transcription correlates with the level of induced recombination, while in others there is no correlation, suggesting that recombination is not simply initiated by induction of germline transcription. (nih.gov)
  • target
  • Here, we identify the circadian clock transcription factor SHARP1 as a novel oncogenic target in MLL-AF6 AML, which has the worst prognosis among all subtypes of MLL-rearranged AMLs. (eur.nl)
  • cell
  • One such factor is chronic elevation in the concentration of intracellular Ca 2+ ([Ca 2+ ] i ), sometimes called excitotoxicity ( 4 ), which may be triggered by sustained β-cell depolarization resulting from chronic stimulation. (diabetesjournals.org)
  • In males, INSL3 regulates testicular descent during fetal life, whereas in adults, it acts as a germ cell survival factor. (biomedsearch.com)
  • result
  • Samples from cells that had only been transfected with the transcription factors alone did not result in measurable PCR products and were excluded from quantitation. (nih.gov)
  • likely
  • We propose that accessibility occurs in a local manner, and that binding sites for factors facilitating accessibility are therefore likely to be associated with individual gene segments. (nih.gov)