Basic helix inhibitor of differentiation protein 2. Medical search. Frequent questions

MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors which mediate cellular proliferation, differentiation, and apoptosis, through regulating BCL6. (biomedcentral.com)
It promotes cell proliferation and restrains differentiation. (ashpublications.org)
Additionally, we were able to reconstruct the three developmental phases during osteoblast differentiation: proliferation, matrix maturation, and mineralization, and illustrate the activation of the SMAD signaling pathways by TGF-β2 and BMPs. (biomedcentral.com)
We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
Inhibitor of differentiation 2 ( Id2 ) is a critical factor for cell proliferation and differentiation in normal vertebrate development. (biomedcentral.com)
The effects of Id2 and its mutants on cell proliferation were determined by [ 3 H]-thymidine incorporation assay and the 3- [4, 5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) dye method. (biomedcentral.com)
Different conditions can affect survival, proliferation, and differentiation of RAW264.7 cells. (sciforschenonline.org)
They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators. (bvsalud.org)

At the molecular level, pitavastatin induced expression of the cyclin dependent kinase (CDK) inhibitor p21 in a cholesterol independent manner, blocked repressive phosphorylation of the Retinoblastoma tumor suppressor protein at CDK targeted sites, and reduced expression of E2F target genes required for progression through the G1/S boundary. (oncotarget.com)
Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. (uchicago.edu)
Overexpression of Id2 in ERα-positive epithelial tumor cells indeed increases the cells' invasive potential through a novel mechanism independent of dimerization to basic helix-loop-helix factors. (biomedcentral.com)
During this step, a small proportion of epithelial tumor cells lose cell-cell adhesion and gain higher mobility, thus allowing them to invade the adjacent tissues [ 2 , 3 ]. (biomedcentral.com)
Although the general role of Id2 proteins has been considered pro-growth and anti-differentiation in various human tumors [ 13 - 15 ], their role in modulating invasion and metastasis of some specific tumor cells remain to be investigated. (biomedcentral.com)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
Masemann D, Meissner R, Schied T, Lichty BD, Rapp UR, Wixler V, and Ludwig S. (2021) Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers. (uni-muenster.de)
We show that in the nephron BPGM is constitutively expressed, and up-regulated under conditions like acute kidney injury, clear cell renal carcinoma, or knock-out of the tumor suppressor von Hippel Lindau protein (VHL). (charite.de)

In this study we asked whether global epigenetic mechanisms regulate timing of progenitor cell differentiation into myelin-forming oligodendrocytes in vivo. (rupress.org)
Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. (embl.de)
Genes of the E(spl)-C and AS-C regulate neurogenesis and related differentiation pathways. (sdbonline.org)
Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina is non-cell-autonomous, suggesting that Id2a functions upstream of the extrinsic pathways that regulate retinogenesis. (biologists.com)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

This has led to the development of a range of ERK1/2 inhibitors (ERKi) that either inhibit kinase catalytic activity (catERKi) or additionally prevent the activating pT-E-pY dual phosphorylation of ERK1/2 by MEK1/2 (dual-mechanism or dmERKi). (babraham.ac.uk)
However, MEKi pre-treatment, which blocks ERK2 pT-E-pY phosphorylation and dissociation from MEK1/2, prevents ERK2 turnover. (babraham.ac.uk)
In C2C12 myogenic cells, blocking the IGF1/PI3K/Akt pathway using LY294002 inhibitor reduced MSY3 phosphorylation levels resulting in its accumulation in the nuclei. (biomedcentral.com)
Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. (embl.de)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
To screen for small molecule inhibitors of ATM kinase exercise, an in vitro kinase assay was designed, and an assay produced which measured the phosphorylation status of the ATM downstream target p53. (hdacassay.com)

The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)

1 MYC is a basic helix-loop-helix-leucine zipper transcription factor that dimerizes with the related protein MAX. (ashpublications.org)
2021. Isoform-specific reduction of the basic Helix-Loop-Helix transcription factor TCF4 levels in Huntington's disease . (cardiff.ac.uk)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
Both transcription factor-based reprogramming and directed differentiation approaches ultimately exploit transcription factors to influence cellular identity. (silverchair.com)
The expressional changes of Hes1, a transcription factor negatively regulating OPC-differentiation, were studied. (biomedcentral.com)
Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
TWIST1 is a transcription factor belonging to the basic helix-loop-helix (bHLH) superfamily. (biomedcentral.com)

During the first 10 postnatal days, administration of valproic acid (VPA), the specific inhibitor for histone deacetylase activity, resulted in significant hypomyelination with delayed expression of late differentiation markers and retained expression of progenitor markers. (rupress.org)
Revers ible lysine acetylation represents a common modification of proteins that is carried out by histone acetyl trans ferases and Inhibitors,Modulators,Libraries histone deacetylases. (ampk-signal.com)
Post-translational modification of proteins at lysine residues by reversible acetylation is catalyzed by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs), which act on both histone and non-histone substrates despite their names. (biomedcentral.com)

Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)

The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. (wikipedia.org)
They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
MSY3 is a DNA binding protein, which acts as a transcriptional repressor. (biomedcentral.com)
Inhibitors,Modulators,Libraries Consistent with chromatin structure dependent activation of gene expression, many transcriptional co activators possess HAT activity whereas transcriptional co repressors are associated with HDACs. (ampk-signal.com)
2022. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants . (cardiff.ac.uk)
In Drosophila, the majority of Notch target genes known so far is located in the Enhancer of split complex , encoding small basic helix-loop-helix (bHLH) proteins that presumably act as transcriptional repressors. (sdbonline.org)
Cellular identity is determined by the transcriptional profile which comprises the subset of mRNAs, and therefore proteins, being expressed by a cell at a given point in time. (silverchair.com)

BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. (uchicago.edu)
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. (uchicago.edu)
Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. (uchicago.edu)
Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. (uchicago.edu)
Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. (uchicago.edu)
Biphasic effects of TGFß1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells. (uchicago.edu)
BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential. (uchicago.edu)
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. (uchicago.edu)
The results showed that MSC did not alter their osteogenic differentiation capacity, surface marker profile, and the expression profiles of MSC during expansion. (biomedcentral.com)
Microarray analysis of MSC during osteogenic differentiation identified three candidate genes for further examination and functional analysis: ID4, CRYAB, and SORT1. (biomedcentral.com)
Finally we analyzed the gene expression profiles of MSC during osteogenic differentiation. (biomedcentral.com)

A survey of agricultural technologies influencing the biosynthesis and accumulation of phenolic compounds in crop plants is presented, including observations on the effects of light, temperature, mineral nutrition, water management, grafting, elevated atmospheric CO 2 , growth and differentiation of the plant and application of elicitors, stimulating agents and plant activators. (mdpi.com)

The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. (babraham.ac.uk)

Herein, carbodiimide hydrochloride/N-hydroxysuccinimide was used to mediate the grafting of gallic acid (GA) (0.005, 0.0015, and 0.025 wt%) with soybean protein isolate (SPI) in the preparation of SPI-GA conjugates and hydrogels. (bvsalud.org)

Several MYC-induced pathways, such as activation of the p53/ARF pathway, changes in expression, and activity of BCL2 proteins or alterations in death receptor signaling have been linked to apoptosis. (ashpublications.org)
The RAW264.7 cell line is most commonly used to study osteoclast differentiation and its signaling pathways. (sciforschenonline.org)

This protein may play a role in negatively regulating cell differentiation. (wikipedia.org)
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA bindingThis protein may play a role in negatively regulating cell differentiation. (novusbio.com)

Cultured oligodendrocyte progenitor cells (OPCs) were incubated with HD ± BMSC-derived conditional medium (BMSC-CM). OPC differentiation was studied by immunostaining and morphometric analysis. (biomedcentral.com)

Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)
All genes in the ANTP-C and BX-C code for homeodomain proteins. (sdbonline.org)
The five genes described in this paper are arrayed between mbeta and m7 , both coding for bHLH proteins. (sdbonline.org)
The expression patterns suggest that both genes are under the same regulatory control as are the E(spl) bHLH genes and thus, might play a part in Notch mediated cell differentiation. (sdbonline.org)

Timely differentiation of progenitor cells is critical for development. (rupress.org)

Herein in this review, we aimed to address the roles delivered by MECs in breast cancer progression and decipher the molecular mechanisms regulating proper MECs' physiology, integrity, and terminal differentiation. (biomedcentral.com)

The identification of mechanisms modulating timing of cellular differentiation is critical for morphogenesis and proper development. (rupress.org)
I use a range of molecular biology techniques to determine the cellular function of proteins involved in the aforementioned disorders. (cardiff.ac.uk)
Reprogramming techniques continue to evolve as we learn more about the developmental and molecular cues which govern cellular differentiation and identity. (silverchair.com)
This proposal tests the paradigm-shifting hypothesis that mitochondrial-derived proteins (MPDs) play a previously unappreciated role in the regulation of cellular and organismal function, and that disregulation of MDPs is important in disease development. (nih.gov)

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. (wikipedia.org)
ID2 may be an inhibitor of tissue-specific gene expression. (novusbio.com)
Our findings demonstrate that acquisition of MEK inhibitor resistance often occurs through gene amplification and can be suppressed by impeding cell cycle entry in drug. (babraham.ac.uk)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

Innate or acquired resistance to small molecule BRAF or MEK1/2 inhibitors (BRAFi or MEKi) typically arises through mechanisms that sustain or reinstate ERK1/2 activation. (babraham.ac.uk)
This latter observation highlights components of these DDR paths as possible therapeutic targets for the development of small molecule inhibitors that could enhance the sensitivity of tumefaction cells to the cytotoxic ramifications of radio /chemo therapeutic agents. (hdacassay.com)
The notion of applying small molecule inhibitors to interrupt ATM function and sensitize tumefaction cells to radio /chemo therapeutic agents is not a novel concept. (hdacassay.com)

The specific reduction in the SREBP1c isoform seen in the adipose tissue of obese and type 2 diabetic subjects can be recapitulated ex vivo by TNF-α, suggesting a possible mechanism for this association. (diabetesjournals.org)
Nevertheless, probably the most frequently used ATM inhibitors are neither specific nor of use in vivo, which includes fueled a pursuit in identifying more specific and potent inhibitors and led to the recent recognition of KU55933. (hdacassay.com)

This hypothesis implied that OL differentiation proceeded by default once the cells exited from the cell cycle. (rupress.org)
While there is some controversy surrounding recent research that claims that miR-155 may display anti-oncogenic or pro-immunological benefits (Cell Rep 2:1697-1709, 2012), most research seems to point to the importance of anti-miRs, with anti-miR-155 in particular, for cancer therapy. (biomedcentral.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
The protein quantity V in a cell is defined as the total fluorescent intensity in a segmented region of correspond ing cell. (ampk-signal.com)
KEGG pathway term mTOR signaling pathway is observed to be meliorated in this tricluster and has been reported to be associated Inhibitors,Modulators,Libraries with estrogen induced breast cancer cell. (ampk-signal.com)
Activation domains influence the way proteins interact with the trancription apparatus of the cell (Dawson, 1995). (sdbonline.org)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
Here, we explore the evolution of reprogramming and directed differentiation approaches within the context of hepatocyte to β-cell transdifferentiation focussing on how the introduction of new techniques has improved our ability to generate β-cells. (silverchair.com)
Cell Microbiol.22(2):e13143. (uni-muenster.de)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
A cell line to study osteoclasts and a thorough study of osteoclast differentiation and culturing is currently lacking. (sciforschenonline.org)
Since then it has become an important cell line to study monocyte differentiation. (sciforschenonline.org)
Recently, this cell line has become a valuable tool to study osteoclast differentiation and activity due to its expression of RANK and differentiation to osteoclast in response to RANKL [7]. (sciforschenonline.org)
CD4 T-cell-dependent differentiation of CD23 follicular B cells contributes to the pulmonary pathology in a primary Sjögren's syndrome mouse model. (tokushima-u.ac.jp)
Furthermore, the CD23 FB cell differentiation was found to be enhanced in a CD4 T-cell-dependent manner under a Th2-type condition in the lungs of herein examined pSS model mice. (tokushima-u.ac.jp)
Two major cell types cooperate to build up the ductal units: inner polarized luminal epithelial cells (LECs) embraced by a layer of myoepithelial cells (MECs), both cell types are rimmed by a cohesive basement membrane (BM) [ 2 ]. (biomedcentral.com)
HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)

MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
In normal organisms, Id proteins are key regulators in development. (biomedcentral.com)
Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. (bvsalud.org)

The bZIP (basic region/leucine zipper motif) class of TFs have already been demonstrated to play a part in regular plant improvement (seed, floral, leaf, and vascular improvement), and responses to abiotic and biotic stresses [44]. (itkinhibitor.com)

A Th2-type response in the pSS lung may promote the progression of autoimmune lesions through an enhanced abnormal differentiation of B cells. (tokushima-u.ac.jp)

In vitro cultured OPCs showed more differentiation after incubation with BMSC-CM. Hes1 expression was found to be significantly increased by HD and decreased by BMSC or BMSC-CM. The change of Hes1 was found, however, independent of Notch1 activation, but dependent on TNFα/RelB signaling. (biomedcentral.com)
Consistently, MD simulations highlighted a clear decrease in the stability of the α-helix during the dimerization of the mutated R154P TWIST1/E12 dimer compared to the wild-type TE complex, which was further confirmed in vitro using immunoassays. (biomedcentral.com)
Using an in vitro kinase assay, we tested a precise selection of approximately 1500 small chemical compounds for possible ATM inhibitors Caspase-8 inhibitor and recognized CP466722. (hdacassay.com)
This compound inhibited ATM kinase activity in vitro, but did not restrict phosphatidylinositol 3 kinase or closely associated PI3K like protein kinase household members. (hdacassay.com)

This led to protein unfolding, exposure of Trp residues, and orderly aggregation, forming a dense cross-linked gel network. (bvsalud.org)
These substitutions either create premature termination codons, which lead to truncated proteins, or substitute highly conserved residues in the bHLH region. (biomedcentral.com)

Over 160 TWIST mutations have been described in SCS patients, a majority of which are present in the bHLH domains, mediating protein dimerization, and involving a single base pair substitution (54% of mutations). (biomedcentral.com)

2 Complex regulatory networks control MYC activity leading to up-regulation of its expression in response to mitogens or suppression upon growth inhibitory signals. (ashpublications.org)
Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. (springer.com)
The MYB TFs are believed to interact with the simple helix-loop-helix (bHLH) TFs in the regulation of a variety of processes like cold-stress tolerance, phytochrome signaling, and flavonoid biosynthesis [379]. (itkinhibitor.com)
In addition, these two binding sites play different roles in the regulation of Sema4D expression in HUVEC and Caco-2 cells. (jcancer.org)

Arising from the reinforced intermolecular interactions upon chemical covalent bonds and physical hydrogen bonds, the maximum tensile strength and the elongation at break were increased from 10.61 MPa and 20.67 % for sodium carboxymethyl cellulose film to 42.15 MPa and 24.8 % for the optimized soybean protein isolate-graft-sodium carboxymethyl cellulose composite mulch film, respectively. (bvsalud.org)
Since DNA binding domains are invariably missing from HATs and HDACs, they are recruited to their target promoters and enhancers via protein protein interactions. (ampk-signal.com)

Direct evidence linking the INK4A locus to tumorigenesis was provided by the targeted disruption of exon 2 of INK4A in mice. (medscape.com)

AHNAK nucleoprotein 2 [Source:H. (gsea-msigdb.org)

MECs were found to express numerous proteinase inhibitors, anti-angiogenic factors, and tumour suppressors proteins. (biomedcentral.com)

These resistance mechanisms frequently involve reinstatement of ERK1/2 signalling and BRAFi are now deployed in combination with one of three approved MEK1/2 inhibitors (MEKi) to provide more durable, but still transient, clinical responses. (babraham.ac.uk)
The chemoreceptors are probably G-protein coupled and mechanotransduction involves transient receptor potential (TRP) ion channels, which are responsible for detecting a range of chemical and mechanical stimuli in vertebrates. (biomedcentral.com)
CP466722 is just a fast reversible inhibitor of ATM function and transient coverage used in clonogenic survival assays suggests that temporary inhibition of ATM function is enough to sensitize cells to IR. (hdacassay.com)

These findings offer a practical approach to enhancing traditional acid-induced protein gel-based functional foods using naturally sourced chitin nanocrystals. (bvsalud.org)

Highly sensitive detection of nucleocapsid protein from SARS-CoV-2 using a near-infrared surface plasmon resonance sensing system, Optics Continuum, Vol.11, No.1, 2336-2346, 2022. (tokushima-u.ac.jp)

Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
Here, we investigate amplification events that underlie resistance to the MEK inhibitor selumetinib (AZD6244/ARRY-142886) in COLO205 cells, a well-characterized model for reproducible emergence of drug resistance, and show that amplifications acquired are the primary cause of resistance. (babraham.ac.uk)
Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair. (uchicago.edu)
Comparative effects of bone morphogenetic proteins and sox9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells. (uchicago.edu)
3 Increased amounts of MYC protein are found in many types of human cancer because control mechanisms keeping MYC in check are inactivated during malignant transformation of cells. (ashpublications.org)
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
The degeneration aspect is characterized by the appearance of holes in the muscle (vacuoles), deposits of amyloid-related proteins within the cells and filamentous inclusions (hence the name inclusion body myositis) of abnormal proteins. (wikidoc.org)
MCF-7 and SKOV-3 cells were stably transfected with the wild-type, degradation-resistant full-length or helix-loop-helix (HLH)-deleted Id2, respectively. (biomedcentral.com)
Wilden JJ, van Krüchten A, Gieselmann L, Hrincius ER, Deinhardt-Emmer S, Haupt KF, Preugschas HF, Niemann S, Ludwig S, and Ehrhardt C. (2020) The influenza replication blocking inhibitor LASAG does not sensitize human epithelial cells for bacterial infections. (uni-muenster.de)
Semaphorin 4D (Sema4D) belongs to the semaphorin family, which binds to receptors such as Pleixn-B1 (transmembrane structure receptor), CD72 (cluster of differentiation antigen 72, mainly expresses on lymphocyte cells), then activates downstream signaling molecules. (jcancer.org)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Also, the amount of cells that are isolated and their properties depend on the origin and differentiation protocols. (sciforschenonline.org)
Consequently, the recruitment of immune cells during chronic inflammation increases oxidative stress (OS) in the microenvironment [ 2 ]. (hindawi.com)
Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)

This theory emphasizes the abnormal intracellular accumulation of many proteins, protein aggregation and misfolding, proteosome inhibition, and endoplasmic reticulum (ER) stress. (wikidoc.org)

Together, these data identify global modifications of nucleosomal histones critical for timing of oligodendrocyte differentiation and myelination in the developing corpus callosum. (rupress.org)

This difference is reflected in the activation domains of the respective proteins. (sdbonline.org)

Y-box proteins act via diverse mechanisms, as they work by DNA binding and non-DNA binding mechanisms. (biomedcentral.com)

We observed that, as skeletal muscle progressed from perinatal to postnatal and adult developmental stages, MSY3 protein became gradually dephosphorylated and accumulated in the nucleus. (biomedcentral.com)

Knocking down Akt expression increased the amount of dephosphorylated MSY3 and reduced myogenin expression and muscle differentiation. (biomedcentral.com)
To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
The ratios between median values represent fold change in protein expression. (ampk-signal.com)
E-cadherin protein expression and transactivation of the proximal E-cadherin promoter were markedly suppressed by the degradation-resistant full-length or HLH-deleted Id2 but not wild-type Id2. (biomedcentral.com)
In skeletal muscle, SREBP1 expression was significantly reduced in type 2 diabetic subjects but not in obese subjects. (diabetesjournals.org)

This study aimed to enhance the rheological properties and thermal stability of acid-induced soy protein isolate (SPI) gels by incorporating chitin nanocrystals (ChNCs) and proposing a gelation mechanism. (bvsalud.org)

m1 might code for a protease inhibitor of the Kazal family, and m6 for a novel peptide. (sdbonline.org)

The TWIST1 protein is highly conserved from Drosophila to humans, where it plays a key role during embryonic morphogenesis, mesoderm patterning and development. (biomedcentral.com)

The bHLH protein, OsbHLH148, was shown to interact with proteins inside the jasmonate signaling pathway and to confer drought tolerance when OsbHLH148 was overexpressed in rice [43]. (itkinhibitor.com)

The mammalian HDACs are Inhibitors,Modulators,Libraries divided into the classical family of 11 zinc dependent hydrolases and the non classical family of seven NAD dependent HDACs called sirtuins. (ampk-signal.com)

Type I interferon antagonistic properties of influenza B virus polymerase proteins. (uni-muenster.de)

Whereas AS-C coded proteins are proneural, meaning they initiate neurogenesis or nerve generation, E(spl)-C coded proteins are inhibitory for neurogenesis. (sdbonline.org)

15] demonstrated the importance of L-Gln for osteoclast differentiation of murine BMMs. (sciforschenonline.org)

This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

The effects of different heat treatment conditions (65â for 30 min, 75â for 15 min, and 95â for 2, 15 and 30 min) on the evolution of off-flavor compounds in soy protein isolate (SPI) were investigated in terms of lipid oxidation, Maillard reaction and protein structural characteristics. (bvsalud.org)
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)

Minicollagens constitute a major subgroup of these nematocyst-specific extracellular proteins, but another important constituent, dubbed 'cnidoin' is non-collagenous, resembling the spider silk protein spidroin-2. (biomedcentral.com)

Anatomy56

Organisms10

Diseases6

Chemicals and Drugs82

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes68

Disciplines and Occupations1

Information Science5

Proliferation8

Tumor11

Regulate5

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Cyclin depend1

Transcription factor7

Histone3

Osteoblast differentiation2

Transcriptional8

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Signalling pathway1

Mediate1

Pathways2

Negatively2

Oligodendrocyte progenitor1

Genes4

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Terminal differentiation1

Cellular4

Gene4

Small molecule3

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Residues2

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Regulation5

Interactions2

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Nucleoprotein1

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20221

Cells14

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