Basic amino acids nuclear localization signals. Medical search. Frequent questions

Figure 2: Core signalling in the mammalian TGFβ-SMAD pathways. (nature.com)
Reactive oxygen species (ROS), generated as consequence of oxidative metabolism, activate signal transduction pathways, which contribute to cellular homeostasis [ 1 ]. (hindawi.com)
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Since glucocorticoids are essential for life, other cellular signaling pathways strongly regulate GR actions in many different ways, such as physical interaction via their effector transcription factors and epigenetic modifications including phosphorylation and acetylation. (brainimmune.com)
Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)
Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
Targeted therapies exploit molecular vulnerabilities unique to cancer cells and typically alter cellular signaling pathways to inhibit tumorigenic growth and promote cell death. (biomedcentral.com)
Therefore, an improved understanding of the molecular signaling pathways modulated by targeted therapies is critical to enhancing the efficacy of these agents. (biomedcentral.com)

METHODS: We have used a combination of a multiple sequence alignment of orthologous BRCA1 sequences and a measure of the chemical difference between the amino acids present at individual residues in the sequence alignment to classify missense variants and in-frame deletions detected during mutation screening of BRCA1 . (xenbase.org)
Sugars, on the other hand, have small rings of carbon atoms that are hydrophobic, but their small size means that they bind to small aromatic amino acid residues in shallow surface pits that don't usually change the shape of the proteins. (blogspot.com)
This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. (prosci-inc.com)
Phosphorylated tyrosine residues recruit various intracellular adaptor and effector molecules that result in the propagation of growth promoting signal transduction cascades [1] , [2] . (plos.org)
In a preferred embodiment, a GEF-H1 polypeptide is provided that lacks the amino acid region between residues 162 and 354 of SEQ ID NO. 2. (justia.com)

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. (wikipedia.org)
Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). (wikipedia.org)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
Proteins bearing a classical nuclear localization signal (cNLS) are imported into the nucleus by the importin / heterodimer (26, 49, 55). (irjs.info)
Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
Much has been learned regarding nuclear entry, but the cellular proteins involved are still unknown and the exact role of each viral component remains controversial [ 7 ]. (biomedcentral.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
It is more likely that steroid hormones bind to carrier proteins in the blood, and general transporters transfer the steroids either directly from their carriers to intracellular receptors (testosterone, estrogen, corticosteroids) or the carriers are transported all the way to the nucleus for transfer of the steroids to nuclear receptors (vitamin D, vitamin A, retinoic acid). (blogspot.com)
Binding of the steroids to cytoplasmic receptors displaces chaperones (heat shock proteins) and expose nuclear localization receptors (groups of basic amino acids that would function as heparin-binding domains, if the proteins ever found themselves in the extracellular environment) that result in transport into the nucleus. (blogspot.com)
instead of attempting to predict individual phosphorylation sites, we search for proteins that contain high densities of strong and weak consensus matches that are closely spaced in the primary amino acid sequence. (biomedcentral.com)
Domain commonly found in eukaryotic signalling proteins. (embl.de)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
It is thought that these amino acid changes impair menin's ability to interact with other proteins. (medlineplus.gov)
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. (cipsm.de)

Akirin is a highly conserved nuclear protein ubiquitously expressed in nonfungal eukaryotic species and is known to be involved in many biological processes such as embryonic muscle patterning and innate immune function. (kennesaw.edu)
Data shows that basic amino acids in the N-terminal region of the protein are sufficient for driving nuclear localization of the protein, though the protein isn't localized as effectively. (kennesaw.edu)
The findings of this research show implications for understanding the nuclear localization patterns of the protein and the possibility of using the endogenous bipartite Akirin NLS as a cargo protein delivery system. (kennesaw.edu)
Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2 · Author Summary. (giibi.com)
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. (utsouthwestern.edu)
RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors. (utsouthwestern.edu)
These data highlight that ESE-1 contains NLS and NES signals that play a critical role in regulating its subcellular localization and function, and that an intact SAR domain mediates MEC transformation exclusively in the cytoplasm, via a novel nontranscriptional mechanism, whereby the SAR motif is accessible for ligand and/or protein interactions. (biomedcentral.com)
Amino acid substitution during functionally constrained divergent evolution of protein sequences. (xenbase.org)
The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor. (xenbase.org)
Moloney murine leukemia virus (M-MuLV) proviruses carrying integrase (IN) protein tagged either with a simian virus 40 (SV40) nuclear localization signal (NLS) or various antigenic epitopes were generated. (researchwithrutgers.com)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. (biomedcentral.com)
Protein kinases are ubiquitous components of cellular signalling networks [ 1 ]. (biomedcentral.com)
Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human FGF12 (NP_004104.3). (prosci-inc.com)
Many of the mutations in the MEN1 gene that are associated with familial isolated hyperparathyroidism change single protein building blocks (amino acids) in the menin protein. (medlineplus.gov)
The HIF-1 protein is composed of two HIF-1α and HIF-1β/aryl hydrocarbon receptor nuclear translocator (ARNT) subunits. (biomedcentral.com)
Hypoxia stabilises HIF-1α protein by relaxing its ubiquitin-proteasome degradation [ 12 ] and affects subcellular localisation, DNA binding capacity and transcriptional activation function of the HIF-1 complex. (biomedcentral.com)
HIF-1α protein is composed of 826 amino acids [ 5 ]. (biomedcentral.com)
In the middle section of HIF-1α lies a Pro-Ser-Thr oxygen-dependent degradation domain (ODDD, amino acids 401 to 603), which is responsible for the stability of the HIF-1α protein [ 12 ]. (biomedcentral.com)
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
Phosphorylation of eIF2α on Ser51 inhibits 5' cap-dependent mRNA translation, resulting in the global suppression of protein synthesis to facilitate adaptation to a variety of stresses linked to protein synthesis, including proteotoxic stress, viral replication, heme depletion and amino acid withdrawal [ 2 ]. (biomedcentral.com)

This investigation focused on both the subcellular localization of Akirin based on a putative nuclear localization signal and the genetic interaction between Akirin and the Nucleosome Remodeling Deacetylase (NuRD) complex. (kennesaw.edu)
To assess the role of NES2 in regulating ESE-1 subcellular localization and subsequent transformation potency, we site-specifically mutagenized NES2, within full-length GFP-ESE-1 and GFP-NES2-SAR reporter constructs. (biomedcentral.com)

In contrast to the stability of the epitope tags, the SV40 NLS sequence was rapidly mutated by a frameshift mutation that introduced negatively charged amino acids into the basic NLS. (researchwithrutgers.com)

Such continuous sensing of signal intensity might involve cycling of receptors through the endocytic pathway. (nature.com)
An in-depth understanding of the pleiotropic cellular functions that can be evoked by TGFβ superfamily signalling will depend on a more quantitative knowledge of temporal and spatial characteristics of the pathway. (nature.com)
Figure 2: Retrograde signalling via the JUN kinase pathway after an axonal lesion. (nature.com)
The integrated stress response is a signaling pathway activated in cancer cells in response to both dysregulated growth and metabolism, and also following exposure to many therapies that appears one such targetable pathway for improved treatment of these diseases. (biomedcentral.com)
The integrated stress response (ISR) is an adaptive signaling pathway that contributes to the biology of a number of hematologic malignancies since they are inherently prone to numerous cellular stresses [ 2 ]. (biomedcentral.com)
The ISR (Fig. 1 ) is a complex signaling pathway that regulates cellular responses to stress stimuli and enables either adaptation or the instigation of cell death mechanisms [ 2 ]. (biomedcentral.com)

SMAD phosphorylation by active receptors, and constitutive SMAD dephosphorylation by nuclear phosphatases, are coupled through nucleocytoplasmic shuttling of SMADs. (nature.com)
Many nuclear transport procedures are mediated by soluble transportation receptors that understand particular sequences or structural characteristics of their cargoes and facilitate the passage of receptor-cargo complexes through the NPC. (irjs.info)
Transport receptors constantly shuttle between the nucleus and cytoplasm, thereby rapidly crossing the permeability barrier of nuclear pores (59). (irjs.info)
The largest class of nuclear transport receptors is the superfamily of importin -like factors (also named karyopherins) that PCI-32765 distributor can be classified as importins (import karyopherin) and exportins (export karyopherin) depending on the direction in which they transport the cargo (reviewed PCI-32765 distributor in references 25, 32, 43, 72, and 80). (irjs.info)

nuclear localization sequences, their mutation did not prevent INM localization. (wustl.edu)

Signal duration and signal magnitude are crucial determinants of the outcome of TGFβ superfamily signalling, in particular in early embryonic patterning, in which TGFβ superfamily ligands act as morphogens that elicit distinct responses in a dose-dependent fashion. (nature.com)
Ligands of the transforming growth factor-β (TGFβ) superfamily of growth factors initiate signal transduction through a bewildering complexity of ligand-receptor interactions. (nature.com)
The C domain, the central DNA-binding domain (DBD), contains two highly conserved zinc finger motifs that are characteristic of the nuclear receptor superfamily (NRs). (biomedcentral.com)
These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)
These subunits are members of the basic helix-loop-helix (bHLH) transcription factor superfamily containing a PAS [PER (Period Clock) -ARNT-SIM (Single-minded)] domain [ 2 ]. (biomedcentral.com)
The peptide transporter carbon starvation (CstA) family (transporter classification [TC] 2.A.114) belongs to the second largest superfamily of secondary transporters, the amino acid/polyamine/organocation (APC) superfamily. (cipsm.de)

and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. (gao-lab.org)
Both OT/IT and AVP/AVT are nonapeptide hormones produced from a common precursor ( 21 ) and share seven out of nine amino acids in their primary structure ( 22 ). (frontiersin.org)

Accordingly, the present invention envisions an isolated nucleic acid encoding the GEF-H1S polypeptide of SEQ ID NO:2, as well as an isolated nucleic acid comprising the sequence of SEQ ID NO:1. (justia.com)
In another embodiment, an isolated nucleic acid encoding the GEF-H1 peptide of SEQ ID NO:3 is provided. (justia.com)
In similar fashion, one other embodiment provides an isolated nucleic acid encoding the GEF-H1 peptide of SEQ ID NO:4. (justia.com)

ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a unique 40-amino acid serine and aspartic acid rich (SAR) subdomain, whereas, ESE-1's nuclear transcriptional property is required to maintain the transformed phenotype of MCF7, ZR-75-1 and T47D breast cancer cells. (biomedcentral.com)
While previous publications have established ESE-1's transcription factor function, we have reported that ESE-1 initiates transformation of MECs via a novel non-nuclear, non-transcriptional mechanism [ 13 ]. (biomedcentral.com)
To understand how the B 1 and B 2 regions influenced the transcriptional functions of nuclear HER3, we performed cyclin D1 promoter-luciferase assays in which HER3 deleted of the B 1 and B 2 regions was severely hindered in regulating this promoter. (plos.org)

In addition, nuclear accumulation of active nuclear SMAD complexes is dynamically maintained in strict accordance with the degree of receptor activation at any time of signalling. (nature.com)
Signalling then converges to nuclear accumulation of transcriptionally active SMAD complexes and gives rise to a plethora of specific functional responses in both embryos and adult organisms. (nature.com)
Importins associated with dynein are an important component of retrograde injury signalling complexes and enable transport of direct importin cargoes, such as transcription factors, as well as secondary cargoes that bind scaffolding molecules associated with importins. (nature.com)
A) Viral polymerase activities of highly pathogenic influenza A(H7N9) virus GD replication complexes harboring amino acid substitutions in PB2. (cdc.gov)

They can be monopartite, as in the simian virus 40 (SV40) large T antigen that consists of a heptapeptide containing five basic amino acids (35), or bipartite, as in nucleoplasmin. (irjs.info)

To map the minimal functional nuclear localization (NLS) and nuclear export (NES) signals, we fused in-frame putative NLS and NES motifs between GFP and the SAR domain. (biomedcentral.com)

These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
Retroviral particles must bind specifically to their target cells, cross the plasma membrane, reverse-transcribe their RNA genome, while uncoating the cores, find their way to the nuclear membrane and penetrate into the nucleus to finally dock and integrate into the cellular genome. (biomedcentral.com)
During the long journey from the cell surface to the nucleus, retroviruses will face multiple obstacles, since in addition to finding a path through the cytoplasm to the nucleus they have to cross two main barriers, the plasma and nuclear membranes, whilst at the same time avoiding or counteracting cellular defences that can interfere with many of these steps. (biomedcentral.com)
The TME consists of various cellular components, including immune cells, stromal cells, and extracellular matrix, along with soluble factors and signaling molecules. (biomedcentral.com)

Amino acids at these positions are known to alter viral polymerase activity in mammalian and avian cells at different temperatures ( 7 - 11 ). (cdc.gov)

Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL (2013) Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3. (plos.org)

Thus, SMADs both transmit the signal into the nucleus and execute the downstream effects by directly regulating target-gene transcription. (nature.com)
Signal duration and signal magnitude are relayed faithfully into the nucleus in a quantitative manner. (nature.com)
Neurons require specialized mechanisms of motor-facilitated signal transport for communication along long axonal distances to the cell body and the nucleus. (nature.com)
thus, long-distance retrograde signalling from axonal lesion sites to the soma and nucleus is required. (nature.com)
May 22, 2021 … The nucleus has a double membrane called nuclear envelope. (giibi.com)

JUN amino-terminal kinases (JNKs) and associated scaffolding and activator molecules participate in retrograde injury signalling. (nature.com)
Local translation of axonally localized mRNAs is required for retrograde injury signalling, enabling recruitment of key molecules such as importin β1 to the complex. (nature.com)
MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)

Cargo binding and release of importins and exportins is controlled by a steep RanGTP gradient, which is maintained across the nuclear envelope through the asymmetric distribution of factors that regulate the guanine nucleotide-bound state of Ran (25, 41, PCI-32765 distributor 43, 47, 76). (irjs.info)
Furthermore, dual in situ hybridization detected positive signals for itr1 and cox2 at the same site, implying that ITR1 may regulate cox2 gene expression. (frontiersin.org)

In another embodiment, serine-67 is present in a peptide of less than 30 amino acids that comprises the sequence of SEQ ID NO. 4. (justia.com)

This KPNA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KPNA5. (antibodies-online.cn)

bZIP TFs contain a bZIP domain, generally composed of 60-80 amino acids, with two functionally distinct parts, a highly conserved basic region and a variable leucine-zipper region (explaining the name bZIP) [ 2 , 3 ]. (biomedcentral.com)

Moreover, bZIP52 in rice is a negative regulator in cold signaling [ 16 ]. (biomedcentral.com)

We attempted to identify the replication-enhancing amino acids in the polymerase complex of H7N9 virus A/Guangdong/17SF003/2016 (GD), which was isolated from the first reported H7N9-infected patient ( 3 , 5 ) and harbors polymerase basic (PB) 2 with 271T, 588V, 591Q, 627E, and 701D. (cdc.gov)
The D domain, a more variable region, is referred to as a hinge region between the C and E regions and harbors nuclear localization signals. (biomedcentral.com)

Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation. (uci.edu)

As JNK signalling can have effects that range from neurite growth promotion to cell death induction, multiple regulatory mechanisms are required to ensure specificity of the signal. (nature.com)

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. (apexbt.com)
Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties. (xenbase.org)
In another embodiment, the peptide comprising the sequence of SEQ ID NO. 4 is less than 25 amino acids in length. (justia.com)
In a more preferred embodiment, the peptide comprising the sequence of SEQ ID NO. 4 is 18 amino acids long. (justia.com)

The NLS in nucleoplasmin consists of two short basic clusters separated by a spacer of 10 amino acids (19, 62). (irjs.info)

These analyses identified a bipartite region of 34 (B 1 ) and 27 (B 2 ) amino acids in length that conferred the majority of HER3's transactivation potential. (plos.org)
Next, we identified full-length nuclear HER3 association and regulation of a 122 bp region of the cyclin D1 promoter. (plos.org)

including the inner nuclear membrane (INM). (wustl.edu)

These recent findings provide a coherent mechanistic framework for axon-soma communication in the injured nerve and shed light on the integration of cytoplasmic and nuclear transport in all eukaryotic cells. (nature.com)
Numerous cholesterol-derived hormones (testosterone, estrogen, corticosterone, vitamin D, vitamin A, retinoic acid) influence gene expression by directly binding to cytoplasmic transcription factors. (blogspot.com)

The basic leucine zipper ( bZIP ) family, a supergene family encoding transcription factors (TFs), is evolutionarily conserved and widely distributed across eukaryotic organisms [ 1 ]. (biomedcentral.com)
Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
The basic leucine zipper (bZIP) transcription factor represents exclusively in eukaryotes and can be related to many biological processes. (biomedcentral.com)

How are these quantitative aspects of the extracellular signal regulated? (nature.com)
the cell surface and to transmit extracellular signals into the cytoplasm. (wustl.edu)

cNLSs consist of short stretches of positively charged amino acids. (irjs.info)

The website of exchange may be the nuclear pore complicated (NPC), among the largest macromolecular assemblies inside a eukaryotic cell, which may be traversed inside a unaggressive or a facilitated way. (irjs.info)

Results from these analyses demonstrated that the C-terminal domain of HER3 (CTD, amino acids distal to the tyrosine kinase domain) contained potent transactivation potential. (plos.org)

The instability of the NLS suggests that the strong nuclear localization of the IN-SV40 NLS may have detrimental effects on virus assembly. (researchwithrutgers.com)

Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)

important mechanism in this localization process. (wustl.edu)
TNF-a Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism PLoS Pathog. (usc.edu)

2012 ), generalizing the observation that hotspot localization is determined by the DNA-binding specificity of the zinc finger array (Grey et al. (springer.com)

These observations have implications for studying nuclear transport properties of M-MuLV and for engineering a murine-based retroviral vector for gene therapy. (researchwithrutgers.com)

We therefore tested AN/PB2-627E, which possesses an avian ancestral amino acid in PB2-627, and AN/PB2-627E-701N, which possesses polymerase-enhancing PB2-701N ( 8 ). (cdc.gov)

An equally important challenge is understanding the functional role of signal strength and duration. (nature.com)
Predicting the functional consequences of non-synonymous single nucleotide polymorphisms: structure-based assessment of amino acid variation. (xenbase.org)

But if this is not possible, oxidative stress finally activates signals that will lead to cell death. (hindawi.com)

Thus, anti-inflammatory steroids can block the signaling via NFkB from a bacterial infection (LPS triggering the TLR) by directly interfering with transcription (binding to inhibitory control elements) of inflammatory genes. (blogspot.com)

From an evolutionary perspective this spatial control is satisfied in that the distant relative S. cerevisiae Cdc24, a GEF for Cdc42, plays a key role in targeting cytoskeletal changes to different spatial domains of the cell in response to different signals O'Shea et al. (justia.com)

We have previously reported that post-transplant lymphoma patients have an acquired deficiency of signal transducer and activator of transcription 4, which results in defective IFNÎ³ production during clinical immunotherapy. (weeksmd.com)

Through transfection of Drosophila S2 cells with Akirin mutant constructs we were able to visualize the localization patterns of Akirin and how the patterns relate to the Nuclear Localization Signal (NLS). (kennesaw.edu)

The emerging picture of a combinatorial signalling system that conveys both spatial and temporal information will help to guide future translational efforts. (nature.com)
The possible importance of GEFs in the spatial localization of changes in the actin cytoskeleton is beginning to be understood. (justia.com)

Anatomy27

Organisms20

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes70

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care1

Pathways8

Residues5

Proteins14

Protein21

Subcellular localization2

Negatively charged amino acids1

Pathway6

Receptors4

Sequences1

Superfamily6

Nine amino acids2

Nucleic3

Transcriptional3

Complexes4

Simian vi1

Putative1

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Mammalian1

Transactivation domains1

Nucleus5

Molecules3

Regulate2

Serine1

KPNA51

Functionally1

Regulator1

Harbors2

Phosphorylation1

Mechanisms1

Sequence4

Clusters1

Region2

Membrane1

Cytoplasmic2

Leucine-zipper3

Extracellular2

Positively1

Pore1

Domain1

Instability1

Tumor1

Mechanism2

Specificity1

Gene1

Possesses1

Functional2

Oxidative stress1

Binding1

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Spatial2