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  • skeletal
  • The skeletal muscle basement membrane fulfils several crucial functions during development and in the mature myotome and defects in its composition underlie certain forms of muscular dystrophy. (biologists.org)
  • The laminin of the skeletal muscle BM, which consists of several spatially restricted isoforms ( Patton, 2000 ), is involved in two major types of linkages to the sarcolemma. (biologists.org)
  • A second mutant in this class, candyfloss ( caf ), has a mutation in the gene encoding the major α-laminin chain in skeletal muscle, laminin α2 (Lama2), and recapitulates the major features of muscle wasting in LAMA2-deficient congenital muscular dystrophy (MDC1A). (biologists.org)
  • differentiation
  • During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. (nih.gov)
  • phenotype
  • The dy 3K /dy 3K mouse is completely deficient for laminin α2 and displays very severe muscle pathology whereas the dy 2J /dy 2J mouse, which expresses reduced levels of a truncated laminin α2, displays a milder muscular phenotype. (frontiersin.org)
  • axis
  • In short, laminin α2 in the BM seems to play a crucial role in the BTB-BM axis by modulating BTB dynamics during spermatogenesis. (popcouncil.org)