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Base SequenceBase PairingBase CompositionMolecular Sequence DataNucleic Acid ConformationDNABase Pair MismatchCloning, MolecularAmino Acid SequenceOligodeoxyribonucleotidesTranscription, GeneticGenesPlasmidsPromoter Regions, GeneticEscherichia coliDNA Restriction EnzymesHydrogen BondingRestriction MappingSkull BaseMutationSequence Homology, Nucleic AcidModels, MolecularBinding SitesSchiff BasesThymineNucleic Acid DenaturationNucleic Acid HybridizationRepetitive Sequences, Nucleic AcidOligonucleotidesAdenineGuanineRNANucleic Acid HeteroduplexesCytosineRNA, MessengerDNA, BacterialThermodynamicsDNA-Binding ProteinsKineticsPolymerase Chain ReactionIntronsRegulatory Sequences, Nucleic AcidDNA, RecombinantMagnetic Resonance SpectroscopyGene Expression RegulationIntercalating AgentsSequence Analysis, DNAChromosome DeletionGenes, BacterialOperonSingle-Strand Specific DNA and RNA EndonucleasesDeoxyribonuclease IOligonucleotide ProbesUracilTranscription FactorsCodonChromosome MappingDNA PrimersExonsSubstrate SpecificityAnticodonPolydeoxyribonucleotidesChloramphenicol O-AcetyltransferasePoly dA-dT2-AminopurineSequence AlignmentGenes, RegulatorDNA, ViralNucleotidesCell LineDNA ReplicationTransfectionSkull Base NeoplasmsSequence DeletionDNA, ComplementaryProtein BindingRNA, TransferBlotting, SouthernSaccharomyces cerevisiaeSequence Homology, Amino AcidSpecies SpecificityNuclear Magnetic Resonance, BiomolecularRNA, BacterialMolecular StructureEchinomycinTemperatureRNA, Transfer, AlaDNA-Directed DNA PolymeraseBacterial ProteinsStructure-Activity RelationshipMutagenesisBacteriophage lambdaDNA RepairTemplates, GeneticDNA Mutational AnalysisEnhancer Elements, GeneticMutagenesis, Site-DirectedDNA Transposable ElementsNetropsinRNA, Ribosomal
AdenineWobble baseWatson-CrickPyrimidine basesMolecularMismatchesHelixMutations2017ComplementaryHydrogen bondMeSHNucleotideChromosomeInteractionBiologyOccurTranslationsParallelSoldDetectionTransformationSpecificPolesYearRulesPropertiesInfluenceFoundDiameterFinishTotalStructureAppliesUniversityWood baseWorkStepCompatible
Adenine7
  • Dictated by specific hydrogen bonding patterns, "Watson-Crick" (or "Watson-Crick-Franklin") base pairs (guanine-cytosine and adenine-thymine) allow the DNA helix to maintain a regular helical structure that is subtly dependent on its nucleotide sequence. (wikipedia.org)
  • This is particularly important in RNA molecules (e.g., transfer RNA), where Watson-Crick base pairs (guanine-cytosine and adenine-uracil) permit the formation of short double-stranded helices, and a wide variety of non-Watson-Crick interactions (e.g. (wikipedia.org)
  • was paired with thymine (T), adenine (A) and G revealing substantial binding energies comparable to those of classical G-C and A-T base pairs. (wjgnet.com)
  • Adenine-guanine base pairing ribosomal RNA. (wikidata.org)
  • Additionally, since the guanine-cytosine pair involves one additional hydrogen bond than the adenine-thymine pair, DNA strands have a stronger affinity to one another with higher guanine-cytosine pairs or higher "GC" content. (chemistrytalk.org)
  • In Hoogsteen base pairing, guanine still pairs with cytosine and adenine still pairs with thymine. (chemistrytalk.org)
  • Contrastingly, for the Watson-Crick base pair with adenine , base pairing was also observed, but metalation was found to affect hydrogen bonding considerably. (bvsalud.org)
Wobble base1
  • The GU pairing, with two hydrogen bonds, does occur fairly often in RNA (see wobble base pair). (wikipedia.org)
Watson-Crick7
  • Watson-Crick base pairing's contribution to global structural stability is minimal, but its role in the specificity underlying complementarity is, by contrast, of maximal importance as this underlies the template-dependent processes of the central dogma (e.g. (wikipedia.org)
  • In this biochemistry tutorial, we learn all about Watson and Crick base pairs, including their importance, structure, and chemistry, as well as some important non-Watson-Crick base pairs. (chemistrytalk.org)
  • By far the most groundbreaking detail of the model was the pairing of nitrogenous bases, appropriately named Watson-Crick base pairing. (chemistrytalk.org)
  • Considered a staple of DNA biochemistry, Watson-Crick base pairing involves Adenines pairing with Thymines and Guanines pairing with Cytosines. (chemistrytalk.org)
  • Although DNA, and RNA as well, tend to involve Watson-Crick base pairs exclusively, there exist more "non-canonical" base pairs. (chemistrytalk.org)
  • Biochemists call this "flipped" orientation the syn confirmation, as opposed to the anti orientation in Watson-Crick base pairing. (chemistrytalk.org)
  • Base pairing interactions were measured for complex 1, either for self - base pairing or for the Watson-Crick base pair . (bvsalud.org)
Pyrimidine bases1
Molecular3
  • In addition, base-pairing between transfer RNA (tRNA) and messenger RNA (mRNA) forms the basis for the molecular recognition events that result in the nucleotide sequence of mRNA becoming translated into the amino acid sequence of proteins via the genetic code. (wikipedia.org)
  • A kilobase (kb) is a unit of measurement in molecular biology equal to 1000 base pairs of DNA or RNA. (wikipedia.org)
  • An ensemble of reaction coordinates and the rate coefficients of tautomerism for each base pair in aqueous DNA is calculated using quantum mechanics/molecular mechanics (QM/MM) methods. (ucl.ac.uk)
Mismatches2
  • Löwdin proposed that the base pair double proton transfer (DPT) tautomers, A*T* and G*C*, may cause mutations during the replication process via mismatches, e.g. the pairing of A* with C, and G* with T. This thesis uses multiscale modelling techniques to study base pair tautomerism in a realistic DNA system. (ucl.ac.uk)
  • Repair of defined single base-pair mismatches in Escherichia coli. (wikidata.org)
Helix2
  • The regular structure and data redundancy provided by the DNA double helix make DNA well suited to the storage of genetic information, while base-pairing between DNA and incoming nucleotides provides the mechanism through which DNA polymerase replicates DNA and RNA polymerase transcribes DNA into RNA. (wikipedia.org)
  • High-resolution structure of a DNA helix containing mismatched base pairs. (wikidata.org)
Mutations5
  • The aims of this thesis are to i) reassess the viability of base pair tautomerism as a contributory mechanism towards spontaneous single point mutations in DNA and ii) predict how external electric fields (ranging from strengths of 10⁴ V/m to 10⁹ V/m) influence the thermodynamic stability of the tautomers and the kinetics of the DPT reaction. (ucl.ac.uk)
  • The results show that DPT between base pairs has a negligible contribution towards spontaneous mutations in DNA. (ucl.ac.uk)
  • In the context of mutations in human beings, the effect of external electric fields on base pair tautomerism is deemed insignificant. (ucl.ac.uk)
  • No, you would probably not find the exact same number of base pairs because mutations do no only change one nucleotide to another (what we call a substitution) but sometimes add or delete few (or sometimes many) nucleotides. (stackexchange.com)
  • Ames tests have confirmed that TDI caused frameshift and base pair mutations through its active metabolite 2,4-toluenediamine (95807). (cdc.gov)
20172
Complementary5
  • The complementary nature of this based-paired structure provides a redundant copy of the genetic information encoded within each strand of DNA. (wikipedia.org)
  • DNA Base Pairs, and Erwin Chargaff Click for larger version (32K) Erwin Chargaff's groundbreaking research, which showed that DNA base pairs had a complementary relationship, laid the foundation for James Watson's and Francis Crick's DNA model. (the-scientist.com)
  • Erwin Chargaff's groundbreaking research, which showed that DNA base pairs had a complementary relationship, laid the foundation for James Watson's and Francis Crick's DNA model. (the-scientist.com)
  • If you would like to make a complementary set for your dining room, we also offer the matching Baron Trestle Table Base (Part #378872). (osbornewood.com)
  • About 20 base pairs long, siRNAs seek out a complementary target mRNA, attached to it, and call in a group of proteins to destroy it. (medscape.com)
Hydrogen bond1
  • Appropriate geometrical correspondence of hydrogen bond donors and acceptors allows only the "right" pairs to form stably. (wikipedia.org)
MeSH1
  • Base Pairing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Nucleotide1
  • Paired DNA and RNA molecules are comparatively stable at room temperature, but the two nucleotide strands will separate above a melting point that is determined by the length of the molecules, the extent of mispairing (if any), and the GC content. (wikipedia.org)
Chromosome3
  • Are the number of base pairs in a given chromosome same between different individuals? (stackexchange.com)
  • Is the number of base pairs in a particular chromosome the same in all individuals? (stackexchange.com)
  • For example if I take an X-chromosome from two random humans would I count exactly 155,270,560 base pairs in both cases? (stackexchange.com)
Interaction1
  • Hydrogen bonding is the chemical interaction that underlies the base-pairing rules described above. (wikipedia.org)
Biology1
  • Covering the base-pairs in iodothyronine deiodinase-1 biology: holes remain in the lineup. (rush.edu)
Occur2
  • Intramolecular base pairs can occur within single-stranded nucleic acids. (wikipedia.org)
  • The ensemble-based methodology utilised in this study has shown that several different proton transfer reaction pathways, each with varying probabilities, occur within the same base pair. (ucl.ac.uk)
Translations1
  • The translations are along the x , y , and z axes of the base frame, respectively. (mathworks.com)
Parallel3
  • How to prove two triangles are similar using a line parallel to a base. (brightstorm.com)
  • The application of larger electric fields (10⁹ V/m) parallel to base pair hydrogen bonds is found to increase the lifetime of the tautomers by one order of magnitude at most. (ucl.ac.uk)
  • Before the rotation, the axes of the follower are parallel to the corresponding axes of the base frame. (mathworks.com)
Sold1
Detection1
  • Aptamers and Antibiotics: Detection, Monitoring, and Continuous Dosing Base Pair Aptamers to Antibiotics Base Pair has selected natural DNA aptamers to the antibiotics ampicillin and tetracycline. (basepairbio.com)
Transformation1
  • The follower frame can have a 3-D transformation with respect to the base frame. (mathworks.com)
Specific1
Poles1
  • Our TACO Outrigger Base Reducer is the perfect complement to allow your current poles to be used, by reducing the base without missing a beat. (tuppens.com)
Year1
  • This graph shows the total number of publications written about "Base Pairing" by people in this website by year, and whether "Base Pairing" was a major or minor topic of these publications. (rush.edu)
Rules1
Properties2
  • Synthesis, Base Pairing Properties, and Biological Activity Studies of Platinum(II) Complexes Based on Uracil Nucleosides. (bvsalud.org)
  • The synthesis and base pairing properties of platinum complexes based on uridine and deoxyuridine nucleosides and preliminary studies of their antiproliferative activity are described. (bvsalud.org)
Influence1
  • From a modest start, Base Pair has exerted a significant, positive influence over science education, locally in the ����ԭ Metro area, throughout the state of Mississippi, regionally in the southeast and nationally through conferences, workshops, and presentations. (retro-motors.com)
Found2
  • These alternate base pairs can be found in DNA under acidic conditions or certain RNA structures. (chemistrytalk.org)
  • Complex 1 undergoes self - base pairing in CDCl3, and this aggregation was found not to be dependent on metalation. (bvsalud.org)
Diameter2
  • Stainless Steel Feet Pair Kit - compatible with all 1″ diameter AngleGuards. (alltackle.com)
  • This kit includes: TWO stainless steel feet 316-grade stainless steel Mirror polished finish Round base with a footprint diameter of 2.75″ Six mounting screws (#14 x 1″ Phillips Oval Head) Allen/hex wrench for included foot set screws. (alltackle.com)
Finish1
Total1
  • The total number of DNA base pairs on Earth is estimated at 5.0×1037 with a weight of 50 billion tonnes. (wikipedia.org)
Structure2
  • Purine-pyrimidine base-pairing of AT or GC or UA (in RNA) results in proper duplex structure. (wikipedia.org)
  • Boyce M, Scott F, Guogas LM, Gehrke L. Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex. (rush.edu)
Applies2
  • The block applies the force equally and oppositely to the base and follower frames of the joint along the x -axis of the base frame. (mathworks.com)
  • The block applies this force to both the base and follower frames of the joint primitive in order to accelerate the relative position back to the free region. (mathworks.com)
University1
  • Initiated in 1992 at Murrah High School, Base Pair was developed as a biomedical research mentorship program that paired faculty from the University of Mississippi Medical Center (UMMC) with high school students and educators from one of the largest public school districts in the state of Mississippi, the ����ԭ Public School District. (retro-motors.com)
Wood base2
  • Galvanized metal and wood artichokes on wood base. (1stdibs.com)
  • Pair of x-base stools featuring a chenille (taupe) animal print fabric and a white painted wood base. (theperfectthing.net)
Work1
  • Jobs can be submitted and the first steps (Base recalibration and Mutect2) in the pipeline seems to work. (lu.se)
Step2
  • Our BAM files are not fully "analysis-ready" since GATK recommends that a "base quality recalibration" step is performed ( ​ https://gatk.broadinstitute.org/hc/en-us/articles/360035535912 ). (lu.se)
  • So we will keep our BAM files as the are and run the recalibration step as part of the variant calling (it should take about 3-4 hours for a pair of BAMs with 30x coverage). (lu.se)
Compatible1
  • These replacement Glock magazine base come in pairs and the plates snugly fit G17, G18 and all other compatible magazines. (projectairsoft.co.uk)