Basal keratinocyte layers. Medical search. Frequent questions

Keratin 1 and Keratin 10 are specifically expressed in the spinous and granular layers of the epidermis. (wikipedia.org)
The predominant cell type in the epidermis is keratinocytes and they are located in the stratified squamous epithelia. (3hbiomedical.com)
Progenitors of keratinocytes reside and divide in the basal layer of the epidermis. (3hbiomedical.com)
Immunohistochemical staining revealed a gradient of psoriasin expression in the psoriatic epidermis with highest expression in the suprabasal, differentiated layers. (medicaljournals.se)
In this process, the keratinocytes progress from the basal layer of the epidermis through distinct stages to form the spinous, granular and cornified layers. (medicaljournals.se)
The high expression level in psoriatic epidermis in conjunction with the disturbed differentiation process suggests that psoriasin is involved in keratinocyte differentiation. (medicaljournals.se)
It penetrates further into the skin, passing the epidermis and reaching the dermis, with damage described on both layers. (gattefosse.com)
The epidermis is a living epithelium, composed of 90% keratinocytes arranged in layers, renewing every 3 weeks on average. (gattefosse.com)
In the skin, the keratinocyte stem cells can be considered as the "mother" cells of the epidermis. (gattefosse.com)
Indeed, DNA lesions induced by UVA in keratinocytes are associated to a weakening of their self-renewal capacity, their so-called "stemness" potential, ultimately related to functional and structural alterations of the epidermis. (gattefosse.com)
In normal epidermis, β1 integrin expression is confined to the basal layer, whereas in hyperproliferative epidermis, integrins are also expressed in the suprabasal layers. (jci.org)
Constitutive activation of MAPK increased the growth rate of human keratinocytes and delayed the onset of terminal differentiation, recreating many of the histological features of psoriatic epidermis. (jci.org)
In animals , such as vertebrates, the epidermis is made up of four or five layers (each called stratum). (biologyonline.com)
In humans, the epidermis consists of the following layers: (1) stratum corneum , (2) stratum lucidum , (3) stratum granulosum , (4) stratum spinosum , and (5) stratum basale or germinativum). (biologyonline.com)
The stratum germinativum is the layer of the epidermis that is closest to the basement membrane, which is a thin sheet of fibers between the epidermis and the dermis . (biologyonline.com)
Definition noun The innermost layer of the epidermis comprised of keratinocyes capable of proliferating by mitosis, melanocytes, Langerhans cells, and Merkel cells Supplement In animals, such as vertebrates, the epidermis is made up of four or five layers (each called stratum). (biologyonline.com)
Epidermal stem cells (ESCs) are specific stem cells derived from the embryonic ectoderm, which can be differentiated into various layers of the skin to activate the state of proliferation and differentiation and the apoptotic state of the epidermis. (aging-us.com)
Epidermis in mammals is constantly being replaced by new cells that transform from the bottom layer of the epidermis up to the stratum corneum. (vin.com)
The skin is composed of three layers including epidermis, dermis, and the subcutaneous layer (fat layer). (blackpaint.com.sg)
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin . (online-medical-dictionary.org)
The integument consists of 2 mutually dependent layers, the epidermis and dermis, which rest on a fatty subcutaneous layer, the panniculus adiposus. (medscape.com)
The epidermis is a stratified, squamous epithelium that consists primarily of keratinocytes in progressive stages of differentiation from deeper to more superficial layers. (medscape.com)
The named layers of the epidermis include the stratum germinativum, stratum spinosum, stratum granulosum, and stratum corneum. (medscape.com)
Keratinocytes are the most prevalent type of skin cells, comprising nearly 95% of the epidermis. (altogen.com)
Keratinocyte cells originate in the basal skin layer and grow densely outward through the layers of the epidermis. (altogen.com)
Keratinocyte cells are tightly interwoven and form seams between the nerves and underlying tissues of the epidermis. (altogen.com)
Skin also helps control body temperature and stores water, fat, and vitamin D . The skin has several layers, but the two main layers are the epidermis (top or outer layer) and the dermis (lower or inner layer). (cancer.gov)
Thin, flat cells that form the top layer of the epidermis. (cancer.gov)
Melanocytes are in the layer of basal cells at the deepest part of the epidermis. (cancer.gov)
Determining the polarity of basal keratinocytes, the spatial organisation of keratinocytes and thus the structure of the epidermis. (chloeevelyn.com)
Melanocytes are found in the basal layer of the epidermis and together with the surrounding keratinocytes form the epidermal unit, whose main function is to produce and distribute melanin by a complex process called melanogenesis ( 4-7 ). (spandidos-publications.com)
Mammalian skin is composed of two primary layers: the epidermis, which forms a protective barrier on the surface of the body, and the dermis, which serves as a location for the appendages of skin. (heraldopenaccess.us)
The epidermis is a stratified squamous epithelium consisting of proliferating basal and differentiated suprabasal keratinocytes that are the major cells of the epidermis. (heraldopenaccess.us)
Keratinocytes in the basal layer of the epidermis proliferate, and the daughter cells move up and undergo multiple stages of cell differentiation, in order to eventually become nucleated. (heraldopenaccess.us)
In this article, we will explore the different types of skin cells (cells of the Epidermis), the layers of skin cells and the functions of the skin cells. (bioexplorer.net)
A keratinocyte is the primary cell type (about 90%) within the epidermis which is the outermost layer of the skin. (bioexplorer.net)
They are found in the bottom layer of the skin's epidermis. (bioexplorer.net)
Langerhans cells are found in all layers of the epidermis. (bioexplorer.net)
The epidermis, the superficial layer of the skin, is composed mainly of cells called keratinocytes which are continuously renewed according to a cycle of approximately 28 days. (typology.com)
Besides the keratinocyte, there are three types of specialised cells in the epidermis. (virtualbeauty.co.nz)
The keratinocyte is the predominant cell of the epidermis and accounts for 70 to 80% of the cellular population. (virtualbeauty.co.nz)
But over the past 20 years, studies have shown that UVA damages skin cells called keratinocytes in the basal layer of the epidermis. (creativeimagelasersolutions.com)
Application of acridine orange enabled imaging of the layers of the epidermis. (cambridge.org)
Histopathology showed loss of superficial layers of epidermis, basal layer showed vacuolar interface, and few necrotic keratinocytes. (ijdd.in)

Histopathological examination of the hematoxylin-eosin (HE)-stained sections showed a cystic cavity lined by orthokeratinized stratified squamous epithelium lining, with surface showing sheaves of keratin arranged in many layers. (bvsalud.org)

SALPs inhibited LP-induced phosphorylation of NF-κB p65 and p38 MAPK and reduced cytokine release and gene expression in primary human keratinocytes and dermal fibroblasts. (nature.com)
We synthesized the peptide LKEKK (Np5) corresponding to the sequence 16-20 of thymosin-α 1 and to the sequence 131-135 of interferon-α 2 , prepared [ 3 H]Np5 and found that it binds with high affinity and specificity to human keratinocytes. (heraldopenaccess.us)
The purpose of this study is to characterize the effect of Np5 on normal human keratinocytes. (heraldopenaccess.us)
1999. Response of normal human keratinocytes to sulfur mustard (HD): Cytokine release using a non-enzymatic detachment procedure. (cdc.gov)

Keratinocyte proliferation, differentiation, and programmed cell death are complex and carefully choreographed processes. (3hbiomedical.com)
The aim of this study was to investigate the effect of endogenous psoriasin on disturbed keratinocyte differentiation in psoriasis. (medicaljournals.se)
Induction of keratinocyte differentiation caused concurrent expression of psoriasin and the differentiation marker involucrin. (medicaljournals.se)
To establish the skin barrier and the epidermal structure, keratinocytes undergo a tightly regulated process of differentiation. (medicaljournals.se)
The keratinocytes in active psoriatic lesions display an altered sequence and altered expression levels of the differentiation markers (2). (medicaljournals.se)
However, the mediators that are responsible for the dysregulated differentiation of psoriatic keratinocytes have not been identified. (medicaljournals.se)
In a spectrum of conditions of dysregulated keratinocyte differentiation, we have previously demonstrated strong psoriasin expression in differentiated squamous cell carcinoma and a lack of expression in undifferentiated basalioma (9). (medicaljournals.se)
Previous studies of the role of psoriasin in keratinocyte differentiation have focused on the effects of extracellular psoriasin, but as the psoriasin in psoriasis is keratinocyte-derived, it is imperative to consider the effects of psoriasin as an endogenously produced intracellular mediator. (medicaljournals.se)
Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell , spinous or prickle cell, and the granular cell. (online-medical-dictionary.org)
For example, studies have shown that defects in keratinocyte differentiation and proliferation can contribute to the development of skin disorders such as psoriasis, atopic dermatitis, and skin cancer. (altogen.com)
They can be grown in culture and used as a model system for studying various aspects of skin biology, including the mechanisms underlying keratinocyte differentiation and proliferation, wound healing, and the response of skin cells to environmental stressors. (altogen.com)
This paper was the first I had read that gave a detailed account of the keratinocyte life cycle and differentiation. (virtualbeauty.co.nz)

But large, severe wounds that have lost multiple layers of skin no longer have any basal keratinocytes. (workerscompensation.com)
But large, severe wounds such as cutaneous ulcers no longer have any basal keratinocytes. (singularityhub.com)

In contrast, SALPs did not affect proliferation of keratinocytes. (nature.com)
The study results show that tumor growth is carried out mostly due to the proliferation of basal layer keratinocytes and differentiated epithelial cells. (worldaquacultureconference.com)
Manifest illness stage (days to weeks postexposure)--The basal layer is repopulated through proliferation of surviving clonogenic cells. (cdc.gov)

Due to its capacity to penetrate deeper layers of the skin, UVA was mainly related to structural alterations of the dermis through the breakdown of collagen and elastin networks amongst others. (gattefosse.com)
The dermis comprises two layers: the papillary region and the reticular region. (blackpaint.com.sg)
Melanoma is easier to cure if the tumor is found before it spreads to the dermis (inner layer of skin). (cancer.gov)
Dermis cover the significant portion of the skin's layer. (bioexplorer.net)
The dermis is made up of two inner layers namely - a thin upper layer called the papillary dermis, and a thick lower layer called the reticular dermis. (bioexplorer.net)
The answer lies hidden in the second layer of the skin (Dermis). (bioexplorer.net)
The permanent tattoo ink is injected till the dermis layer so that it stays permanent. (bioexplorer.net)

In electron microscopic study, many melanosomes were observed in melanocytes and surrounding keratinocytes. (nih.gov)
Melanocytes also come from the basal layer. (blackpaint.com.sg)
Melanin is synthesized in melanocytes present in the basal layer of the skin and metastasizes to surrounding keratinocytes to give human skin color. (justia.com)
There are 4 types of skin cells in humans namely Keratinocytes , Melanocytes , Langerhans cells , and Merkel cells . (bioexplorer.net)

Darier correlated the presence of Wickham's striae with an increase in thickness of the granular cell layer [ 8 ]. (hindawi.com)
The researchers first compared the levels of different proteins of the two cell types (inflammation and keratinocytes) to get a sense of what they'd need to change to reprogram the cells' identities. (workerscompensation.com)
Keratinocytes are named after keratin, which is the most abundant protein in this cell. (3hbiomedical.com)
On the non-melanoma side, there are basal cell and squamous cell skin cancers," says Patel. (cspinet.org)
Basal cell cancers often look like a raised nodule that is pink, red, or pearly. (cspinet.org)
Although squamous cell (left) and basal cell (right) cancers are rarely deadly, it's important to get any changes to your skin checked out. (cspinet.org)
Basal cell cancer has an extremely low risk of spreading to other parts of the body, notes Patel. (cspinet.org)
Basal and squamous cell cancers are directly linked to how much UV radiation you've had," says Patel. (cspinet.org)
Among keratinocyte cancer, the most common forms include squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). (news-medical.net)
But only a specific population of keratinocytes can proliferate and initiate the cell renewal process: they are named keratinocyte stem cells. (gattefosse.com)
The oral mucosa includes three layers: the epithelium, the cellar film, and the lamina propria, and contains dynamic organizations of extracellular network, different cell types, and neuro-vascular frameworks. (alliedacademies.org)
It has primary properties, for example, delineation and cornification of the keratinocytes and explicit cell-to-cell communications to keep up with its hindrance capability. (alliedacademies.org)
Hence, the furthest cell layer is dead cells. (alliedacademies.org)
This single cell layer of keratinocytes is attached to the basement membrane via hemidesmosomes. (medscape.com)
Keratinocytes are sometimes divided into smaller cell types, such as basal keratinocytes, which are located near the basal layer. (altogen.com)
These kits can be utilized for the development of stable keratinocyte cell lines and yield high transfection efficiency, as detected by qRT-PCR. (altogen.com)
Cancer that forms in basal cells is called basal cell carcinoma . (cancer.gov)
Basal cell carcinoma. (cancer.gov)
Basal cell carcinoma and squamous cell carcinoma of the skin, also called nonmelanoma skin cancer or keratinocyte carcinoma, are the most common forms of skin cancer. (cancer.gov)
Most basal cell and squamous cell skin cancers can be cured . (cancer.gov)
A postdoctoral research associate in my lab, Masakazu Kurita , who has a background in plastic surgery, knew that a critical step in wound healing was the migration of stem-cell-like cells called basal keratinocytes-from nearby, undamaged skin-into wounds. (singularityhub.com)
Green is keratinocytes, red is mesenchymal cells, blue is the cell nucleus and magenta marks the innermost layer of skin epithelium. (singularityhub.com)
Furthermore, SALPs markedly promoted cell migration via EGFR transactivation and ERK1/2 phosphorylation and accelerated artificial wound closure in keratinocytes. (nature.com)
Nonmelanoma skin cancer (NMSC) includes basal cell carcinoma and squamous cell carcinoma. (limamemorial.org)
Human Keratinocyte Medium EpiGro was obtained from Cell Applications, Inc. (USA), IL-17A, TNF-a, IL-1a, and other chemicals were obtained from Sigma (St. Louis, MO). (heraldopenaccess.us)
I discovered that the keratinocyte has an unlimited stem cell resource, along with a short and eventful life cycle that ultimately ended in desquamation. (virtualbeauty.co.nz)
with this information about the Melanocyte and keratinocyte, how can the epidermal cell turn over in 30 days statement be substantiated, and do you believe it now? (virtualbeauty.co.nz)
Keratinocytes are programmed to undergo cell death, this process is known as apoptosis, with a life of around 8 to 10 days from mitosis to arriving in the stratum corneum, depending on age and environment. (virtualbeauty.co.nz)
Not surprisingly, people who use tanning salons are 2.5 times more likely to develop squamous cell carcinoma, and 1.5 times more likely to develop basal cell carcinoma. (creativeimagelasersolutions.com)
3 Irritative symptoms are frequent in seborrheic keratosis, and the swelling of these lesions can be mistaken for basal cell carcinoma or malignant melanoma. (ekjo.org)
Exposure to radiation can damage the basal cell layer of the skin and result in inflammation, erythema, and dry or moist desquamation. (cdc.gov)
In this document, the absorbed dose refers to that dose received by at least 10 cm2 of the basal cell layer of the skin. (cdc.gov)
The epithelial lining was about 6-8 layers with a distinct granular cell layer subjacent to cornified layer and basal layer exhibited low cuboidal morphology with absence of palisading of nuclei ( Figure 3 ). (bvsalud.org)
It is mediated by circulating autoantibodies directed against keratinocyte cell surfaces. (medscape.com)
The term pemphigus refers to a group of autoimmune blistering diseases of the skin and mucous membranes characterized histologically by intraepidermal blister and immunopathologically by the finding of in vivo bound and circulating immunoglobulin G (IgG) antibody directed against the cell surface of keratinocytes. (medscape.com)
Pemphigus vulgaris is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes and is mediated by circulating autoantibodies directed against keratinocyte cell surfaces. (medscape.com)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)
The incidence of keratinocyte cancer (basal cell and squamous cell carcinomas of the skin) is 17-fold lower in Singapore than the UK, despite Singapore receiving 2-3 times more ultraviolet (UV) radiation. (cdc.gov)

In contrast, basal layer keratinocytes express little to no Keratin 1. (wikipedia.org)
This difference is likely due to Keratin 9, rather than Keratin 10, being the major binding partner of Keratin 1 in acral (palm and sole) keratinocytes. (wikipedia.org)

Histology showed an increase of melanin in the basal layer. (nih.gov)
Studies show an increased expression of keratinocytes in age spots, which interrupts the normal upward transfer of melanin from the basal layer. (blackpaint.com.sg)
Melanin accumulates in organelles termed melanosomes that are incorporated into dendrites anchoring the melanosome to the surrounding keratinocytes. (medscape.com)

The keratinized type contains four layers of cells: the basal layer, spinous layer, granular layer, and the shallow layer (keratinized layer). (alliedacademies.org)

We observed activation of mitogen-activated protein kinase (MAPK) in basal and suprabasal keratinocytes of human and transgenic mouse psoriatic lesions and healing mouse skin wounds, correlating in each case with suprabasal integrin expression. (jci.org)
Transgene-positive keratinocytes produced more IL-1α than controls did, and keratinocyte MAPK could be activated by ligation of suprabasal integrins or treatment with IL-1α. (jci.org)

Also, keratinocytes play an essential role in wound healing, demonstrating a higher expression of PDGF A (fibroblast stimulating platelet-derived growth factor) than fibroblasts and regulating fibroblast activity. (altogen.com)

The stratum germinativum is a Latin term, which translates to germinative layer . (biologyonline.com)
The stratum germinativum, or the basal layer, is immediately superficial to the dermoepidermal junction. (medscape.com)

Basal and squamous cells are two types of keratinocytes, the most abundant type of skin cells that make up the outermost layer of skin. (cspinet.org)

It is the outermost layer and acts as a waterproof barrier. (blackpaint.com.sg)

Whereas the expression of syndecan-4 and glypican in intact skin was mostly in the pericellular regions of keratinocytes, the epidermal cells from the wound edge contained mostly intracellular PGs. (lu.se)

In the concentration range of 50-1000 nM Np5 increased in a dose-dependent manner the soluble guanylate cyclase activity in keratinocytes, significantly reduced IL-17A-induced secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1α) and increased the production of the anti-inflammatory cytokine IL-10 by the cells in vitro . (heraldopenaccess.us)

The changes in the production of vital cells like keratinocyte and melanocyte as a result of aging also change the structure of the skin. (blackpaint.com.sg)
It was much later when further research led me to pursue more knowledge about the melanocyte, that I discovered that the keratinocyte and melanocyte were very different but worked in synergy with one another. (virtualbeauty.co.nz)

The typical histopathologic pattern of skin lesions is named interface dermatitis and characterized by a lymphocytic infiltrate and necroptotic keratinocytes at the dermo-epidermal junction. (frontiersin.org)
Lupus erythematosus (LE) skin lesions typically feature a histopathologic pattern termed interface dermatitis, defined by the presence of necroptotic keratinocytes and an epitheliotropic cytotoxic lymphocytic infiltrate at the dermo-epidermal junction ( 7 , 8 ). (frontiersin.org)
More precisely, research show that UVA is very likely to induce DNA lesions in the epidermal basal layer, which hosts the keratinocytes stem cells. (gattefosse.com)

The oral epithelium is the shallow layer that isolates the climate from hidden tissues. (alliedacademies.org)
It is a defined squamous epithelium comprising of cells firmly connected to one another and organized in layers. (alliedacademies.org)
Besides, the non-keratinized oral epithelium has no granular layer [ 2 ]. (alliedacademies.org)

New cells (keratinocytes) originate from stratum basale (basal layer) and move all the way up to the stratum corneum. (blackpaint.com.sg)

Cutaneous ulcers -- wounds that can extend through multiple layers of the skin -- are typically treated surgically, by transplanting existing skin to cover the wound. (workerscompensation.com)
These cancers include cutaneous malignant melanoma and keratinocyte cancer. (news-medical.net)
People with severe burns, bedsores, or chronic diseases such as diabetes are at risk for developing wounds known as cutaneous ulcers, which can extend through multiple layers of the skin. (singularityhub.com)

Izpisua Belmonte and Salk Research Associate Masakazu Kurita, who has a background in plastic surgery, knew that a critical step in wound recovery was the migration -- or transplantation -- of basal keratinocytes into wounds. (workerscompensation.com)
Apart from their protective functions, keratinocytes express adhesion molecules and cytokines, further suggesting an implication in skin innate immunity, tissue homeostasis, wound healing, cancer development, and skin-based gene-therapy. (3hbiomedical.com)
These four factors reprogrammed the mesenchymal cells in the wound into keratinocytes which then grew into the many cells types that make up healthy skin, closing and healing the sore. (singularityhub.com)
In the wound edge, syndecan-4 was predominantly expressed by epidermal basal layer cells. (lu.se)

Each of these layers is characterized by specific features in terms of gene expression, function and cellular mor-phology (1). (medicaljournals.se)
We identified 55 proteins, which we call "reprogramming factors," that are potentially involved in determining and maintaining the cellular identity of basal keratinocytes. (singularityhub.com)
Cellular and nuclear membranes of keratinocytes of the skin were visualised by the use of acridine orange and DIOC5(3). (cambridge.org)

Apoptosis of TUNEL-positive basal layer cells was confirmed by results of caspase 3 immunohistochemical staining. (avma.org)
Conclusions and Clinical Relevance -The large number of apoptotic basal layer cells detected in the lamellar tissue of horses with acute naturally acquired laminitis suggests that apoptosis may be important in the development of acute laminitis. (avma.org)
By applying in vivo imaging, we demonstrate that Hai1-deficient keratinocytes acquire mesenchymal-like characteristics, lose contact with each other, and become mobile and more susceptible to apoptosis. (biologists.com)
Studies have found that Bcl-2 overexpression protects keratinocytes from induced apoptosis. (altogen.com)

Nehal, K. S. & Bichakjian, C. K. Update on keratinocyte carcinomas. (nature.com)

Psoriasin (S100A7) was first identified for its overexpression in psoriatic keratinocytes (3), where it was found to be located to the nucleus and the cytoplasm (4). (medicaljournals.se)

Keratinocytes are used to develop in vitro techniques to assess skin irritants. (altogen.com)
We conducted further experiments on each potential reprogramming factor and narrowed the list down to four factors that would transform mesenchymal cells into basal keratinocytes in vitro in petri dishes. (singularityhub.com)

If every pigment-carrying Melanosome is transferred to a keratinocyte, and every keratinocyte ultimately desquamates in 30 days, why do I have pigmentation? (virtualbeauty.co.nz)

Subcutaneous layer is also known as hypodermis . (bioexplorer.net)

The hypodermis is the innermost layer of the skin. (bioexplorer.net)

In the United States, about 3 million cases of nonmelanoma skin cancer or keratinocyte carcinoma are diagnosed each year, and rates have likely been increasing for decades but have recently stabilized. (cancer.gov)

Keratinocytes respond to various environmental factors and play a crucial role in the regulation of skin inflammation. (heraldopenaccess.us)
Five proinflammatory cytokines produced by keratinocytes have been shown to be involved in the induction of the skin inflammation: IL-17A, IL-22, oncostatin M, TNF-α, and IL-1α [1]. (heraldopenaccess.us)

as cells start to emerge and transform themselves into upper layer cells, they lose their nuclei and the shape become more squamous until they are part of the stratum corneum and they are finally eliminated as dead cells. (vin.com)
Once they reach the stratum corneum, they are fully differentiated keratinocytes devoid of nuclei and are subsequently shed in the process of epidermal turnover. (medscape.com)

Peptide-induced keratinocyte migration was mediated by purinergic receptors and metalloproteases. (nature.com)

The layer is devoid of blood vessels. (blackpaint.com.sg)

This is the deepest layer of the skin, also known as hypodermis or subcutis. (blackpaint.com.sg)
the deepest layer of the skin. (limamemorial.org)

This is the outer most superficial layer which is made up of 5 inner layers. (bioexplorer.net)
Because they don't penetrate as deeply as UVA rays, UVB rays damage the superficial layer of the skin cells where most skin cancers occur. (creativeimagelasersolutions.com)

Such ulcers destroy multiple layers of skin, leading to infections. (singularityhub.com)

Thus, they provide the keratinocytes (prickle cells) of the stratum spinosum, which later migrate through the other layers to the topmost layer (stratum corneum) of the skin. (biologyonline.com)

Altogen Biosystems offers advanced cationic lipid-based Keratinocyte transfection reagent kits that can efficiently aid biomedical research related to keratinocytes. (altogen.com)

Our skin is made of several layers which are held together with an advanced membrane (dermo-epidermal junction) that consists of different types of collagens. (chloeevelyn.com)

As keratinocytes divide and differentiate, they move from this deeper layer to the more superficial layers. (medscape.com)

The definitive multi-layered skin is present at birth, but skin is a dynamic organ that undergoes continuous changes throughout life as outer layers are shed and replaced by inner layers. (medscape.com)
Keratinocyte cells are continuously shed and replaced from the outer layer. (altogen.com)
If it is put on the outer layer, then it will be worn out as time progresses. (bioexplorer.net)

We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
For example, studies have shown that exposure to ultraviolet radiation can induce DNA damage and promote the development of skin cancer through the activation of certain signaling pathways in keratinocyte cells. (altogen.com)
We hypothesized that differences in keratinocyte cancer incidence may be reflected in the normal skin mutational landscape. (cdc.gov)

Anatomy4

Diseases1

Chemicals and Drugs6

Phenomena and Processes2

Epidermis44

Stratified squamous1

Human keratinocytes4

Differentiation12

Longer have any basal keratinocytes2

Proliferation3

Dermis7

Melanocytes4

Cell38

Keratin2

Melanin3

Spinous1

Suprabasal2

Fibroblasts1

Stratum germinativum2

Squamous cells1

Outermost layer1

Epidermal cells1

Cytokine1

Melanocyte2

Lesions3

Epithelium3

Originate1

Cutaneous3

Wound4

Cellular3

Apoptosis4

Carcinomas1

Overexpression1

Vitro2

Melanosome1

Subcutaneous layer1

Innermost layer1

Nonmelanoma1

Inflammation2

Nuclei2

Migration1

Devoid1

Deepest2

Superficial layer2

Ulcers1

Prickle1

Lipid1

Dermo-epidermal junction1

Divide1

Outer3

Cancer3