Basal integral membrane aquaporin 3. Medical search. Frequent questions

AQP-4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane. (wikipedia.org)
PC2 and FPC both interact with kinesin 2 (KIF 3A/B). Localization of disease proteins in the cilium, the transition zone, and the basal body is color coded. (basicmedicalkey.com)
During vesiculation, bioactive lipids and receptors re- main associated with vesicle membranes, and cytosolic proteins and nucleic acids are contained within the vesicles [11]. (unicyte.ch)
The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)
All Siglecs are single-pass type 1 integral membrane proteins containing extracellular domains with one (or two, in the case of Siglec-12) unique and homologous N-terminal V-set Ig domain, followed by variable numbers of C2-set Ig domains, ranging from 16 in sialoadhesin to 1 in CD33. (medchemexpress.com)

Aquaporin-3 (AQP3), a transporter of water, glycerol and H2O2, is expressed in basolateral membranes of principal cells in kidney collecting duct. (bvsalud.org)
Following IR, AQP3 deletion inhibited activation of mitogen-activated protein kinase (MAPK) signaling and produced an increase in the ratios of Bax/Bcl-2, cleaved caspase-3/caspase-3 and p-p53/p53. (bvsalud.org)
Here, we show that signal transduction by H2O2 depends on entry into the cell by transit through aquaporin-3 (AQP3), a plasma membrane H2O2-conducting channel. (bvsalud.org)
we previously demonstrated that aquaporin 3 (AQP3) is expressed in goblet cells and is positively correlated with GIM severity. (oncotarget.com)

For instance, mitochondrial membranes can create 2 distinct regions within the organelle - the inner matrix and the inter-membrane space. (biologydictionary.net)
However, they do need to cross multiple lipid bilayers - from mitochondrial membranes, to the plasma membrane of the cell, and then the lipid bilayers of endothelial cells lining blood capillaries, the plasma membranes of red blood cells and finally the membranes of cells forming the alveolar sacs in lungs. (biologydictionary.net)
The heparan Golgi-resident selenide receptors in interconnectivity a state of interactions that are to mitochondrial influx membrane used by the irreversible expression( HA) response, and the sustained polypeptide of the archival distinct knot km2 into the tail of the complex dementia. (evakoch.com)

Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. (wikipedia.org)
Facilitated diffusion is a form of facilitated transport involving the passive movement of molecules along their concentration gradient, guided by the presence of another molecule - usually an integral membrane protein forming a pore or channel. (biologydictionary.net)
This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
A 210 kDa protein is located in a membrane-microtubule linker at the distal end of mature and nascent basal bodies. (lookformedical.com)
A monoclonal antibody raised against purified flagellar basal apparatuses from the green flagellate Spermatozopsis similis reacted with a protein of 210 kDa (p210) in western blots. (lookformedical.com)
Using a polyclonal antibody (anti-p210) raised against the C-terminal part of p210, it was shown that the protein was highly enriched in the basal apparatuses. (lookformedical.com)
The protein was part of the Y-shaped fibrous linkers between the doublet microtubules and the flagellar membrane, as indicated by statistical analysis of post-labeled sections using anti-centrin and anti-tubulin as controls. (lookformedical.com)
During deflagellation the protein remained at the basal body but we observed changes in its distribution, indicating that p210 partially moved to the tip of the basal body. (lookformedical.com)

In these specific cases of epithelial cell expression, AQP4 is concentrated within the basolateral membrane layer of these locations. (wikipedia.org)
It is constitutively expressed in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells. (wikipedia.org)

Other performances that aquaporin-4 is involved in are synaptic plasticity, astrocyte migration, regulation of extracellular space volume, and the homeostasis of potassium. (wikipedia.org)

old transporters Activated at the zone of activation and on elucidated authorities are with membrane cycle, splicing to a polymerization of modifications that conducts with the DNA of an national action activation. (evakoch.com)

Previous studies reported aquaporin (AQP)-3 expression in cysts derived from collecting ducts in ADPKD. (bvsalud.org)

Within living systems, the presence of lipid-based membranes creates compartments that allow the selective concentration of water-soluble substances. (biologydictionary.net)

72 CHAPTER 4 TEXT Figure 4-9.Bouchard, D. In- terferon then binds to plasma-membrane receptors on the secreting cell and on other cells, cooled, and filtered. (forexsignal300.com)

Moreover, polar, charged or hydrophilic molecules cannot traverse biological membranes. (biologydictionary.net)
While this is useful for maintaining the integrity of each compartment, it is equally necessary for molecules to move across membranes, along their concentration gradient, when needed. (biologydictionary.net)
Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. (unicyte.ch)
Membrane vesicles, actively released by cells, represent a mechanism of intercellular communication that is conserved evolutionarily and involves the transfer of molecules able to induce epigenetic changes in recipient cells. (unicyte.ch)

The aquaporin-4 tetramers accumulate to transform into orthogonal arrays of particle (OAPs) in the cell plasma membrane. (wikipedia.org)
Classification of vesicles into exosomes, originating from the membrane of the endosomal compartment, and microvesicles, derived from plasma membrane budding, is based on their biogenesis [9]. (unicyte.ch)
We suppose that p210 is involved in linking basal bodies to the plasma membrane, which is an important step during ciliogenesis. (lookformedical.com)

Mutations in four genes have been identified in familial hemiplegic migraine (FHM), from which CACNA1A (FHM type 1) and SCN1A (FHM type 3) code for neuronal voltage-gated calcium or sodium channels, respectively, while ATP1A2 (FHM type 2) encodes the α 2 isoform of the Na + ,K + -ATPase's catalytic subunit, thus classifying FHM primarily as an ion channel/ion transporter pathology. (frontiersin.org)
The final two papers are focused on research in wheat, first led from the University of Leicester that looks at recombination in durum wheat and secondly from Rothamsted in which they have identified a whole family of NPF membrane transporter genes. (garnetcommunity.org.uk)

Within the retina, AQP4 is highly concentrated where the processes of Müller cells have a basal lamina around blood vessels and inner limiting membrane and to a lesser degree in the inner and outer plexiform layers. (wikipedia.org)
PC1 and PC2 are found on the primary cilium, a hair-like structure present on the apical membrane of a cell, in addition to the cell membranes and cell-cell junctions of tubular epithelial cells. (basicmedicalkey.com)
Cells can communicate via physical interactions, in- cluding membrane bridge formation, such as tunneling nanotubes and cytonemes, and/or through the release of soluble factors [1-3]. (unicyte.ch)
In premitotic cells p210 was located in a fibrous layer at the distal end of nascent basal bodies, which was perforated by the outgrowing axoneme. (lookformedical.com)
RNAi-mediated cell-specific knockdown in C. elegans is a currently available technique [ 3 ] based on driving the expression of double-stranded RNA in target cells via cell-specific promoters. (biomedcentral.com)

The assembly of AQP4 monomers into tetramers is similar to other aquaporin channels. (wikipedia.org)

IL23 is the Janus mitochondria JAK2 and TYK2, rotting in membrane of the combination senescence, which is the being enzymes for Signal efficiency and water of library 3( STAT3) and STAT4 to be and be Prolonged. (evakoch.com)

The cilium is connected to the basal body through the transition zone. (basicmedicalkey.com)
p210 can be used as a marker to determine basal body position, orientation (parallel or antiparallel) and number in S. similis by indirect immunofluorescence. (lookformedical.com)

A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. (wikipedia.org)
Aquaporin-4 is the most common aquaporin in the brain, spinal cord, and optic nerve. (wikipedia.org)
brain abundant membrane at. (gsea-msigdb.org)

Aquaporin-4's overall function is to provide fast water transportation as well as maintain homeostatic balance within the central nervous system. (wikipedia.org)
Aging was found to have a profound effect on the TBI-induced loss of astrocyte function needed for maintaining water transport and edema-namely, aquaporin-4. (biomedcentral.com)

Aquaporin-4 is essential in the formation of memory as well as synaptic plasticity. (wikipedia.org)
and are generally portrayed in the liver organ and catalyze the desaturation guidelines in the formation of n-3 and n-6 PUFAs. (tech-strategy.org)

Through x-ray crystallography, it was found that "each AQP4 monomer consists of six helical, membrane-spanning domains and two short helical segments surrounding a narrow aqueous pore. (wikipedia.org)

So far, it is well recognized that a multistep process is involved in the progression from normal gastric mucosa to intestinal-type GC, including chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and invasive carcinoma, which was originally proposed by Correa [ 2 , 3 ]. (oncotarget.com)

stomatin like 3 [Source:HG. (gsea-msigdb.org)

The aquaporin-4 tetramers accumulate to transform into orthogonal arrays of particle (OAPs) in the cell plasma membrane. (wikipedia.org)
Selective permeability is achieved by the structure of the plasma membrane and the availability of channel proteins, carrier proteins, or other forms of transport. (lmelectricals.com)
These proteins are embedded in the plasma membrane and contain a central pore. (lmelectricals.com)
The plasma membrane is made of fatty acids, lipids, carbohydrates, and proteins with the most abundant type of lipid in the cell membrane being the phospholipid. (lmelectricals.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Secretagogues bind to their receptors at the basolateral membrane of acinar cells and trigger the activation of intracellular signaling pathways to elicit fusion of secretory granules with the apical plasma membrane that is followed by exocytosis of digestive pro-enzymes (the "zymogens") into the lumen. (pancreapedia.org)

This gene encodes the water channel protein aquaporin 3. (nih.gov)
Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. (wikipedia.org)
The expression of genes well known to be estrogen regulated, such as progesterone receptor, intestinal calcium-binding protein, and complement component 3, is not affected by consumption of the soy/alfalfa-based diet when assessed by microarray or quantitative reverse transcriptase-polymerase chain reaction analysis. (nih.gov)
GLUT4 is a protein that regulates glucose transport through the cell membrane. (lmelectricals.com)
Facilitated diffusion is a form of facilitated transport involving the passive movement of molecules along their concentration gradient, guided by the presence of another molecule usually an integral membrane protein forming a pore or channel. (lmelectricals.com)
HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)

In these specific cases of epithelial cell expression, AQP4 is concentrated within the basolateral membrane layer of these locations. (wikipedia.org)

Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. (nih.gov)
It is constitutively expressed in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells. (wikipedia.org)

4) Concomitantly, the prospective secretory cell attains its characteristic subcellular organization by the invagination of a small patch of apical membrane domain, its extension to a tube of about 100 μm in length (termed a canaliculus), and the expansion of the tube to a diameter of about 3 μm. (biomedcentral.com)
Elaboration of the secretory cell as a unicellular seamless epithelial tube occurs by invagination of the apical membrane, its extension likely by targeted exocytosis and its expansion, and finally the reorganisation of the membrane-associated F-actin system. (biomedcentral.com)

In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. (wikipedia.org)
Through x-ray crystallography, it was found that "each AQP4 monomer consists of six helical, membrane-spanning domains and two short helical segments surrounding a narrow aqueous pore. (wikipedia.org)
The assembly of AQP4 monomers into tetramers is similar to other aquaporin channels. (wikipedia.org)
Within the retina, AQP4 is highly concentrated where the processes of Müller cells have a basal lamina around blood vessels and inner limiting membrane and to a lesser degree in the inner and outer plexiform layers. (wikipedia.org)

Water channel required to promote glycerol permeability and water transport across cell membranes. (nih.gov)

The secretory cell discharges its products into the canaliculus, a blind-ending membrane-bound tubule that meanders within the cell and that is covered on its lumenal side by a thin fenestrated cuticular lining termed the end apparatus [ 22 , 35 ]. (biomedcentral.com)

Previous functional and pharmacological studies in pancreatic acinar cells and zymogen granules (ZG) had suggested that ion channels and transporters are expressed in the membrane of ZG where they contribute to maturation, fusion, exocytosis and/or fluidization of zymogens. (pancreapedia.org)

use DICARBOXYLIC ACIDS 1970-1979 MH - 3-Phosphoshikimate 1-Carboxyvinyltransferase UI - D051229 MN - D8.811.913.225.735 MS - An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylshikimate 3-phosphate and ORTHOPHOSPHATE from PHOSPHOENOLPYRUVATE and SHIKIMATE-3-PHOSPHATE. (nih.gov)

3) The three-cell units of flask-shaped cells undergo complex changes in cell morphology. (biomedcentral.com)

6) Finally, the canaliculus-associated F-actin system becomes reorganized into rings of bundled actin filaments that are positioned at regular distances along the membrane tube. (biomedcentral.com)

In the 3 + oxidation state Mn binds to the transferrin receptor (TfR) and its transport competes with iron (Fe) [ 18 ]. (biomedcentral.com)

3 Laboratory for Viral Vector Technology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Campus Gasthuisberg, B-3000 Leuven, Belgium. (nih.gov)

HN - 2006(1983) MH - 2-Oxoisovalerate Dehydrogenase (Acylating) UI - D050645 MN - D8.811.682.657.350.825 MS - An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. (nih.gov)
use ANTHRANILIC ACID 1974-1979 MH - 3-Isopropylmalate Dehydrogenase UI - D050539 MN - D8.811.682.47.500 MS - An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. (nih.gov)

The molecules should be small and non-polar to traverse the membrane. (lmelectricals.com)

For instance, hepatic cells can generate glucose even from non-carbohydrate sources to maintain a basal blood sugar concentration and prevent hypoglycemia. (lmelectricals.com)

A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. (wikipedia.org)
On the other hand, in humans excess deposition of Mn in the central nervous system (CNS) leads to neurological abnormalities, referred to as manganism [ 3 ]. (biomedcentral.com)

9/3/2005) TOTAL DESCRIPTORS = 935 MH - 1-Acylglycerol-3-Phosphate O-Acyltransferase UI - D051103 MN - D8.811.913.50.173 MS - An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. (nih.gov)

Aquaporins( AQP's) are form sufficient 1970s that include coactivators in structures. (evakoch.com)

Mn is an integral component of multiple enzymes, including glutamine synthetase (GS), mitochondrial superoxide dismutase (SOD), arginase and pyruvate carboxylae [ 2 ]. (biomedcentral.com)

Anatomy34

Organisms11

Diseases3

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes44

Disciplines and Occupations1

Technology, Industry, Agriculture6

Information Science3

Health Care1

Proteins5

AQP34

Mitochondrial3

Protein10

Basolateral2

Extracellular1

Transporters1

ADPKD1

Compartments1

Receptors1

Molecules4

Plasma3

Genes2

Cells5

Channels1

STAT31

Body2

Brain3

Water2

Formation2

Domains1

Type1

Source1

Plasma membrane6

Protein8

Basolateral membrane1

Collecting duct cells2

Apical2

AQP44

Permeability1

Secretory1

Exocytosis1

Pathway1

Cell1

Filaments1

Binds1

Gene1

Oxidation2

Small1

Blood1

Central2

Transfer1

Include1

Component1