UptakeMetabolismBolusConcentrationsLevelsPostprandial plasmaDiabetesIntracellular glucoseHemoglobinNormal glucose toleranceGangliaHypoglycemiaAdjustmentsDexcom G6Amount of glucoseHomeostasisToleranceMetabolic rateCarbohydrateHigh glucoseAffect glucoseHbA1cMmolBaselineTypeIntoleranceAbstractPlasma670GPhysiologicalDecreasesStarvationPatientsCSIITransporterTriglycerides
Uptake13
- Basal forearm uptake of glucose, isotopically determined glucose turnover and serum levels of GH, insulin and C-peptide were unaltered. (nih.gov)
- This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
- DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
- Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
- Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
- DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
- 3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
- Since the mid-1960s, it has been known that there are energy-dependent, sodium-coupled glucose transporter (SGLT) and energy-independent, facilitative glucose transporter (GLUT) pathways for glucose uptake in the lung [ 1 ], and that glucose can permeate the alveolar epithelial barrier [ 2 ]. (ersjournals.com)
- Glucose removal is determined by cellular glucose uptake and metabolism ( fig. 1 ) [ 4 , 12 - 14 ]. (ersjournals.com)
- Salmonella infection resulted in decreased phosphorus and glucose intestinal transport, and increased glutamine uptake. (usda.gov)
- Metformin hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. (nih.gov)
- GH initially exerts insulin -like effects, increasing glucose uptake in muscle and fat, stimulating amino acid uptake and protein synthesis in liver and muscle, and inhibiting lipolysis in adipose tissue. (msdmanuals.com)
- They include inhibition of glucose uptake and use, causing blood glucose and lipolysis to increase, which increases plasma free fatty acids. (msdmanuals.com)
Metabolism13
- The present study was accordingly designed to assess the effects of such GH exposure on basal and insulin stimulated intermediary metabolism. (nih.gov)
- Glucose metabolic images obtained by [ 18 F]-2-fluoro-2-deoxy-D-glucose positron emission tomography showed diffusely reduced whole brain metabolism and strongly decreased metabolism in the frontal and parietal lobes, orbital gyrus, and thalamus. (ajnr.org)
- Another showed a marked decrease of glucose metabolism in the frontal and temporo-parieto-occipital association cortices (5) , and a single-photon emission CT (SPECT) study showed a hypoperfusion in the frontoparietal region, including the primary sensorimotor strip (3) . (ajnr.org)
- We report a patient with MBD, in whom cerebral metabolism and blood flow were studied with [ 18 F]-2-fluoro-2-deoxy-D-glucose (FDG) PET and N -isopropyl- p -[ 123 I]iodoamphetamine (IMP) SPECT. (ajnr.org)
- C) Brain positron emission tomography-computed tomography suggested reduced glucose metabolism in the left basal ganglia. (cdc.gov)
- Impaired glucose metabolism and insulin sensitivity have been linked to the pathogenesis of gestational diabetes mellitus (GDM). (hindawi.com)
- Taken together, the inhibition of hsa_circ_0046060 expression in exosomes from GDM-derived UMSCs can alleviate GDM by reversing abnormal glucose metabolism and insulin resistance in vivo and in vitro . (hindawi.com)
- Although the precise pathogenic mechanism of GDM has not been fully elucidated, it may occur as a result of abnormal glucose regulation and increased IR, inducing the disorders of glucose metabolism. (hindawi.com)
- Glucose is removed from ASL in proximal airways via facilitative glucose transporters, down a concentration gradient generated by intracellular glucose metabolism. (ersjournals.com)
- Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)
- We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
- Obese patients were spited in subgroups based on the degree of glucose metabolism disorder. (medsci.org)
- Aims/hypothesis: Using a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose metabolism (IGM) and type 2 diabetes in a Black South African cohort. (lu.se)
Bolus4
- Most people follow twice-daily or basal bolus insulin regimes. (diabetes.org.uk)
- This system enables automated basal adjustments every 5 minutes and bolus corrections delivered from an insulin pump. (medpagetoday.com)
- To determine your exact need, use a basal-bolus calculator like the one that comes with Tandem Diabetes Care's t:slim® Insulin Pump. (brynfest.com)
- Subsequent basal bolus regime required rapid increments to achieve normo-glycaemia. (bmj.com)
Concentrations7
- Here, we consider a newly identified role for pulmonary glucose transport in maintaining low airway surface liquid (ASL) glucose concentrations and propose that this contributes to lung defence against infection. (ersjournals.com)
- These processes vary between species but universally maintain ASL glucose at 3-20-fold lower concentrations than plasma. (ersjournals.com)
- ASL glucose concentrations are increased in respiratory disease and by hyperglycaemia. (ersjournals.com)
- This is in contrast to conditions in the gut and kidney, where luminal glucose concentrations regularly exceed plasma glucose concentrations [ 6 , 7 ]. (ersjournals.com)
- ASL glucose concentrations are the net result of diffusion of glucose from blood and interstitial fluid across the respiratory epithelium into the ASL, and removal of glucose from ASL by epithelial glucose transport processes. (ersjournals.com)
- Current model of the mechanisms controlling glucose concentrations in the surface liquid lining the airway and distal lung epithelium. (ersjournals.com)
- Blood samples for determination of blood lactate and plasma glucose concentrations were collected 1 minute before IET and during the 15 seconds immediately preceding each speed change. (avma.org)
Levels33
- Blood glucose monitors are devices that measure blood glucose levels electronically. (medscape.com)
- Blood glucose meters measure blood glucose levels electronically. (medscape.com)
- A continuous blood glucose monitor (CGM) assesses blood glucose levels on a near-continuous basis. (medscape.com)
- A typical system consists of a glucose sensor placed subcutaneously, a non-implanted transmitter, and a receiver worn like a pager, which records blood glucose levels at frequent intervals and monitors trends. (medscape.com)
- CGM systems monitor interstitial fluid glucose levels. (medscape.com)
- Overnight monitoring may identify problems with insulin dosing and allow adjustments of basal levels. (medscape.com)
- Also, medications you take, blood glucose levels and insulin levels. (apple.com)
- Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
- DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)
- The type, and amount, you consume can make a difference to your blood glucose levels and diabetes management. (diabetes.org.uk)
- For example, one person trying to lose weight and manage their blood glucose levels on a low-carb diet would restrict their carb intake, while another person who is happy with their weight may decide to eat more healthy carbs. (diabetes.org.uk)
- The total amount of carbohydrate eaten will have the biggest effect on your glucose levels after eating, so it is important to know how much you're eating. (diabetes.org.uk)
- Learn about which foods contain carbohydrates, how to estimate carbohydrate portions and how to monitor their effect on blood glucose levels. (diabetes.org.uk)
- Generally, lower GI foods can be useful for managing blood glucose levels. (diabetes.org.uk)
- More carbohydrate than usual can cause blood glucose levels to go too high, and less than usual can cause a hypo (low blood glucose levels). (diabetes.org.uk)
- 5. Typically onset in children is acute and dramatic with frequent urination, thirst, extreme hunger and fatigue, rapid weight loss, and profoundly elevated glucose levels. (disabilityuk.com)
- It is an average of blood glucose levels for the last 120 days, which is consistent with the average life span of a red blood cell (RBC).Compensation for the lack of insulin-secreting βeta-cells is accomplished through administration of insulin. (nih.gov)
- Endurance exercise induced fatigue factors such as a decrease in blood glucose, an increase in blood lactate, and the depletion of muscle glycogen, but those parameters recovered to basal levels within 6 h after exercise. (frontiersin.org)
- 0.001), and had significantly lower mean glucose levels (mean difference -17.7 mg/dL, 95% CI -23.2 to -12.2) and HbA1c levels (-0.42%, 95% CI -0.62 to -0.22). (medpagetoday.com)
- Laboratory test results showed a fasting blood glucose level of 188 mg/dL and a haemoglobin A1c level of 14.8% without the elevation of urine and serum ketone body levels. (bmj.com)
- Moreover, additional anti-chorea medications may be needed in patients whose symptoms cannot be controlled by regulating blood glucose levels. (bmj.com)
- Pinealectomy, however, totally reversed the decreased levels of insulin under short days and the photoperiodic variations in mean levels of blood glucose (i.e., reduction and increase in long and short days, respectively). (frontiersin.org)
- The physiological indicators of the stress were blood glucose, cortisol and chloride levels, hematocrit, hemoglobin and total protein. (thieme-connect.de)
- Plasma cortisol levels were elevated on arrival but not significantly compared to the basal values for fish from W + HP and D + SU groups. (thieme-connect.de)
- Sucrose supplementation altered the cortisol and blood glucose levels, suggesting a moderating effect on these stress indicators. (thieme-connect.de)
- To get glucose into cells (including muscle cells), you need healthy insulin levels. (brynfest.com)
- To keep blood sugar levels steady between meals, your body releases a type of insulin that's called basal. (brynfest.com)
- Persistently elevated glucose levels were stabilised with an insulin infusion and DKA resolved. (bmj.com)
- Significant relationships were found between levels of glucose and sICAM-1and also E-selectin and HOMA-IR. (medsci.org)
- At the beginning of the study, participants performed their usual diabetes management routine for two weeks to establish their baseline glucose levels. (diabetesdaily.com)
- Kids check their glucose levels regularly, as a group or individually, if someone feels low. (diabeteshealth.com)
- It has been shown that elevated serum levels of low-density lipoprotein (LDL) cholesterol, total cholesterol and triglycerides, low levels of high-density lipoprotein (HDL) cholesterol and abnormal blood glucose levels are the dominant risk factors for CVD [4,5]. (who.int)
- Omega-3 fatty acids had no significant effect on serum lipid levels, ApoA-I, glucose, insulin and HbA1c. (who.int)
Postprandial plasma1
Diabetes17
- The expert faculty, Dr. Neil S. Skolnik, will outline the importance of improving patients' glucose to time-in-range, minimize glucose variability, and incorporate continuous glucose monitoring in patients with diabetes. (academiccme.com)
- Pregnancy in Patients with Type One Diabetes Mellitus Treated with Continuous Subcutaneous Insulin Infusion-Preconception Basal Insulin Dose as a Potential Risk Factor for Fetal Overgrowth? (mdpi.com)
- They are indicated for individuals with diabetes mellitus type 1 or 2.In December 2016, the FDA expanded its approval of the Dexcom G5 Mobile Continuous Glucose Monitoring System (CGM) system as a replacement for traditional fingerstick testing in adults and children aged 2 years or older. (medscape.com)
- A diabetes screening usually involves a fasting blood glucose test or a post-glucose challenge test . (medicalnewstoday.com)
- In someone without diabetes, the body produces insulin automatically to deal with the glucose that enters the blood from the carbohydrate-containing food that we eat and drink. (diabetes.org.uk)
- The review question is: Are metabolic outcomes improved in outpatient adolescents (aged 13 to 19 years) with type 1 diabetes on a Continuous Subcutaneous Insulin Infusion (CSII) when continuous glucose monitoring is used, compared to self-glucose monitoring alone? (nih.gov)
- However, much subsequent research in this area was focused on the role of pulmonary SGLT transport as a modifier of lung liquid volume [ 3 , 4 ], and the effects of starvation and diabetes on glucose transport [ 1 , 5 ]. (ersjournals.com)
- Rodolfo J. Galindo, MD, provides insight on the benefit of fixed-ratio combinations of basal insulin and GLP1 agonists for the optimal management of type 2 diabetes. (managedhealthcareexecutive.com)
- It suppresses that endogenous glucose production, which happens uncontrolled in patients with type 2 diabetes. (managedhealthcareexecutive.com)
- Besides linagliptin, BI and Lilly's diabetes pact includes BI's BI10773 and Lilly's two basal insulin analogues LY2605541 and LY2963016. (genengnews.com)
- Tehran Lipid and Glucose Study was initiated in 1998 to determine the risk factors of arteriosclerosis among the urban population of Tehran and to develop population-based measures to control the rising trend of diabetes mellitus and dyslipidaemia. (who.int)
- An OGTT was performed on participants without diabetes, and peripheral insulin sensitivity (Matsuda index), HOMA-IR, basal insulin clearance, insulin secretion (C-peptide index) and beta cell function (disposition index) were estimated. (lu.se)
- Type 2 diabetes treated with a basal insulin injection regimen with or without other antihyperglycaemic therapy at enrolment. (who.int)
- The data showed, compared to baseline, that three-month use of this system in all three age groups improved the average glucose value as depicted by hemoglobin A1c, reduced day and night variability of glucose, improved time in target range, and reduced hypoglycemia," Dr. Michael Wood, clinical director of the pediatric diabetes program at the University of Michigan Medical School in Ann Arbor, noted during a press briefing. (medscape.com)
- Personalized Prediction of Change in Fasting Blood Glucose Following Basal Insulin Adjustment in People With Type 2 Diabetes: A Proof-of-Concept Study. (cdc.gov)
- Predicting three-month fasting blood glucose and glycated hemoglobin changes in patients with type 2 diabetes mellitus based on multiple machine learning algorithms. (cdc.gov)
- Since the DCCT was conducted, significant advances in diabetes management have occurred, including newer and more physiologic insulin analogs, sophisticated blood glucose monitoring, and insulin delivery technologies such as continuous subcutaneous insulin pump therapy (CSII) and continuous glucose monitoring (CGM). (cdc.gov)
Intracellular glucose1
- The intracellular glucose intake and glycogen content were measured using a High Sensitivity Glucose Assay Kit and Glycogen Assay Kit, respectively. (hindawi.com)
Hemoglobin1
- This technology uses interstitial fluids instead of blood to measure blood glucose.CGM technology is underprescribed and, if better utilized, could provide better hemoglobin A1c (HbA1c) control and decrease the incidence of diabetic complications. (medscape.com)
Normal glucose tolerance1
- Although young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging. (jci.org)
Ganglia8
- CMRglcs in the basal ganglia are preserved. (ajnr.org)
- B) A T2-weighted fluid-attenuated inversion recovery image with hyperintense signal changes in the left basal ganglia. (cdc.gov)
- CT scans showed high-intensity lesions in bilateral basal ganglia ( figure 1A ). (bmj.com)
- Basal ganglia lesions on MRI remained 4 weeks after the onset. (bmj.com)
- A) CT scans showed high-intensity lesions in the basal ganglia bilaterally. (bmj.com)
- B) MRI showed increased signal intensity on T1-weighted images in the bilateral basal ganglia. (bmj.com)
- CT hyperintensity and increased signal intensity on T1WI MRI in basal ganglia are characteristic findings observed in 79% and 95% of patients with DS, respectively. (bmj.com)
- Among them, similar radiological findings on basal ganglia can be observed in patients with Wilson's disease, hepatic encephalopathy and poisoning (manganese and organic mercury). (bmj.com)
Hypoglycemia1
- Numerically, results suggest that basal insulin type, starting PPG, and starting HbA1c, but not prandial dosing plan, may influence the magnitude of the HbA1c improvement and/or hypoglycemia risk reduction among patients treated with URLi. (diabetesjournals.org)
Adjustments1
- In addition to automatic basal rate adjustments, the AHCL algorithm can also deliver automatic correction boluses and has an adjustable glucose target that goes down to 100 mg/dl. (diabetesdaily.com)
Dexcom G61
- The insulin pump was paired with a Dexcom G6 continuous glucose monitor that sent glucose values to the pump. (medpagetoday.com)
Amount of glucose1
Homeostasis3
- Together, these findings in Syrian hamsters show that circulating melatonin at night drives the daily rhythmicity of plasma leptin, participates in the phase control of cortisol rhythm and modulates glucose homeostasis according to photoperiod-dependent metabolic state. (frontiersin.org)
- Understanding of mechanisms underlying lung glucose homeostasis could identify new therapeutic targets for control of ASL glucose and prevention and treatment of lung infection. (ersjournals.com)
- These observations potentially highlight an additional layer of involvement of BCAA in the regulation of glucose homeostasis. (doaj.org)
Tolerance1
Metabolic rate2
- Whole-brain cerebral metabolic rate of glucose (CMRglc) is reduced diffusely and strongly in the frontal and parietal lobe and the thalamus. (ajnr.org)
- Basal metabolic rate is the number of calories your body needs to maintain basic functions such as breathing, heart rate, and digestion. (medlineplus.gov)
Carbohydrate3
- All carbohydrate is converted into glucose. (diabetes.org.uk)
- This will help to lower the glucose in the blood after eating carbohydrate-containing foods. (diabetes.org.uk)
- The calculator determines your pre meal glucose level, as well as your carbohydrate intake. (brynfest.com)
High glucose1
- Likewise, kids with high glucose scores are given guidance on insulin dosages. (diabeteshealth.com)
Affect glucose1
HbA1c1
- Randomization to treatment was stratified by basal insulin type, baseline HbA1c and prandial insulin dosing plan (carb counting, yes/no). (diabetesjournals.org)
Mmol1
Baseline4
- In the closed-loop group, the mean percentage of time that the glucose level was within the target range increased from 56.7±18.0% at baseline to 69.3±11.1% during follow-up, while those receiving standard-of-care -- consisting of either an insulin pump or multiple daily injections of insulin plus a continuous glucose monitor -- went from spending 54.9±14.7% of time in range at baseline to 55.9±12.6% at week 13. (medpagetoday.com)
- At baseline, most were using an insulin pump but nearly none were using a continuous glucose monitoring system. (medpagetoday.com)
- However, it doesn't control the second portion of the A1C, which has the baseline hyperglycemia postprandial, so the glucose is elevated after a meal. (managedhealthcareexecutive.com)
- The graph below shows the time spent in glucose ranges during baseline, MiniMed 670G, and AHCL periods. (diabetesdaily.com)
Type1
- Your body uses glucose, a type of sugar, for energy. (brynfest.com)
Intolerance1
- GDM characterized by irregular glucose intolerance was initially reported during pregnancy [ 1 ]. (hindawi.com)
Abstract1
Plasma8
- For that purpose, daily variations of plasma leptin, cortisol, insulin and glucose were analyzed in pinealectomized hamsters, as compared to sham-operated controls kept under very long (16 h light/08 h dark) or short photoperiods (08 h light/16 h dark). (frontiersin.org)
- Neither plasma insulin, nor blood glucose displays robust daily rhythmicity, even in sham-operated hamsters. (frontiersin.org)
- 0.01 mM and plasma glucose 0.19 mM [ 3 ]. (ersjournals.com)
- Basal insulin acts primarily by reducing fasting plasma glucose. (managedhealthcareexecutive.com)
- You get that result early in the morning-when the patient wakes up fasting-that you have a reduction in the fasting plasma glucose. (managedhealthcareexecutive.com)
- Basal insulin works only on the fasting plasma glucose. (managedhealthcareexecutive.com)
- One would suppress fasting plasma glucose, and the other would suppress postprandial glucose exposures or spikes. (managedhealthcareexecutive.com)
- Following administration of a single glipizide and metformin hydrochloride 5 mg/500 mg tablet in healthy subjects with either a 20% glucose solution or a 20% glucose solution with food, there was a small effect of food on peak plasma concentration (C ma x ) and no effect of food on area under the curve (AUC) of the glipizide component. (nih.gov)
670G3
- Medtronic's newer Advanced Hybrid Closed Loop (built into the MiniMed 780G system) improved glucose management more than the MiniMed 670G, though both systems showed impressive increases in Time in Range for this population. (diabetesdaily.com)
- The system includes the MiniMed 670G pump, the Guardian Sensor 3 continuous glucose monitor ( CGM ), and an automated insulin adjustment algorithm. (diabetesdaily.com)
- The MiniMed 670G continuous glucose monitoring system automates and personalizes the delivery of basal insulin 24 hours a day. (medscape.com)
Physiological1
- Some devices utilize nanoparticle sensors to determine the physiological range as a tool for real-time glucose tracking. (medscape.com)
Decreases1
- CVD mortality [ 30 ], and that intensive considered to be one of the epidemics of the blood glucose control decreases the risk of new century. (who.int)
Starvation1
Patients2
- Clinicians should be aware of the occurrence of DKA in patients prescribed sodium-glucose co-transporter 2 inhibitors. (lww.com)
- Elevated ASL glucose in intensive care patients was associated with increased Staphylococcus aureus infection. (ersjournals.com)
CSII1
Transporter1
- BI10773 is a sodium-dependent glucose co-transporter-2 (SGLT-2) inhibitor that started in Phase III trials during 2010 as an oral medication. (genengnews.com)
Triglycerides1
- The aim of this study was to determine the predictors of diet and lifestyle-related CVD risk factors (total cholesterol, LDL, HDL, triglycerides, blood glucose and systolic and diastolic blood pressure) in adults residing in an urban district of Tehran. (who.int)