• Basal ganglia disease is a group of physical problems that occur when the group of nuclei in the brain known as the basal ganglia fail to properly suppress unwanted movements or to properly prime upper motor neuron circuits to initiate motor function. (wikipedia.org)
  • Research indicates that increased output of the basal ganglia inhibits thalamocortical projection neurons. (wikipedia.org)
  • If something causes too much basal ganglia output, then the ventral anterior (VA) and ventral lateral (VL) thalamocortical projection neurons become too inhibited, and one cannot initiate voluntary movement. (wikipedia.org)
  • However, a disorder leading to abnormally low output of the basal ganglia leads to reduced inhibition, and thus excitation, of the thalamocortical projection neurons (VA and VL) which synapse onto the cortex. (wikipedia.org)
  • Reasons for abnormal increases or decreases of basal ganglia output are not yet well understood. (wikipedia.org)
  • One possible factor could be the natural accumulation of iron in the basal ganglia, causing neurodegeneration due to its involvement in toxic, free-radical reactions. (wikipedia.org)
  • Though motor disorders are the most common associated with the basal ganglia, recent research shows that basal ganglia disorders can lead to other dysfunctions such as obsessive-compulsive disorder (OCD) and Tourette syndrome. (wikipedia.org)
  • The basal ganglia is a collective group of structures in the brain. (wikipedia.org)
  • Along with other structures, the basal ganglia are part of a neural circuit that is integral to voluntary motor function. (wikipedia.org)
  • It was once believed that the primary function of the basal ganglia was to integrate projections from the cerebral cortex, and project information via the thalamus to the motor cortex. (wikipedia.org)
  • Research has shown that the basal ganglia can be modeled as a group of components of parallel, re-entrant cortico-subcortical circuits, which originate in cortical areas, traverse the basal ganglia and terminate in specific areas in the frontal lobe. (wikipedia.org)
  • Understanding these circuits has led to breakthroughs in understanding the disorders of the basal ganglia. (wikipedia.org)
  • Through this pathway the basal ganglia is able to initiate voluntary movements by disinhibiting thalamic neurons that drive upper motor neurons. (wikipedia.org)
  • Proper striatal dopamine release is integral in the suppression of the basal ganglia output, which is needed for increased activity of the thalamic neurons. (wikipedia.org)
  • This inhibitory effect of dopamine on the indirect pathway serves the same function as its excitatory effects in the direct pathway in that it reduces basal ganglia output, leading to the disinhibition of motor neurons. (wikipedia.org)
  • This is generally attributed to higher than normal basal ganglia output causing inhibition of thalamocortical motor neurons. (wikipedia.org)
  • The muscle rigidity, tremor at rest, and slowness in initiation and execution of movement that are the cardinal motor symptoms of Parkinson's disease are attributed to a reduction in dopaminergic activity in the basal ganglia motor areas, particularly the putamen, due to gradually reduced innervation from the pars compacta of substantia nigra. (wikipedia.org)
  • Due to the undoubted efficacy of dopamine antagonists (such as haloperidol) in ameliorating the symptoms of Tourette Syndrome (TS), it is now thought that the basal ganglia nuclei may hold the key to discovering the etiology of this movement disorder. (tourette.org)
  • It is my intention to attempt to unravel some of the neurochemical complexities of the basal ganglia by selectively identifying which neuropeptide and neurotransmitter messenger RNA's (mRNA's) are co-expressed with dopamine D2 receptor mRNA's in human and rat striatal cells using the combined techniques of radioactive and non radioactive in situ hybridization. (tourette.org)
  • This type of detailed analysis of the chemical circuitary of the striatum is likely to be fundamental to the understanding of human basal ganglia function as our earlier studies of primate and rat striatal tissue indicate that a complex cascade of changes in gene expression occurs following dopamine D2 receptor blockade (with drugs such as haloperidol). (tourette.org)
  • However, prior studies have primarily focused on biological tissues outside of the basal ganglia, despite the known relevancy of this brain region in motor and cognitive dysfunction associated with PD and LBD. (mdpi.com)
  • Expression of the GFRα3 receptor is primarily restricted to the peripheral nervous system and is found in a subpopulation of nociceptive sensory neurons of the dorsal root ganglia (DRGs) that coexpress the Ret and TrkA receptor tyrosine kinases and the thermosensitive channel TRPV1. (jneurosci.org)
  • The mammalian telencephalon, which comprises the cerebral cortex, olfactory bulb, hippocampus, basal ganglia (striatum and globus pallidum), and amygdala, is a highly complex and evolutionarily advanced brain structure. (intechopen.com)
  • It results from dysfunction of the language centers in the cerebral cortex and basal ganglia or of the white matter pathways that connect them. (msdmanuals.com)
  • Nevoid basal cell carcinoma syndrome (NBCCS), also known as basal cell nevus syndrome (BCNS), represents a series of multiorgan abnormalities known to be the consequence of abnormalities in the PTCH gene. (medscape.com)
  • Go to Basal Cell Carcinoma for more complete information on this topic. (medscape.com)
  • Multiple organ systems may be impacted in nevoid basal cell carcinoma syndrome (NBCCS). (medscape.com)
  • The lone study evaluating an African cohort found that only 20% with NBCCS had basal cell carcinoma. (medscape.com)
  • Skin cancers are also associated with BAP1 tumor predisposition syndrome, including cutaneous melanoma and basal cell carcinoma . (medlineplus.gov)
  • The naevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant multisystem disorder with variable expression. (bmj.com)
  • NBCCS patients have variable susceptibility to development of basal cell carcinoma (BCC). (bmj.com)
  • This study focused on the expression and functionality of TRPV1, a nonselective cation channel that was found to be expressed in different carcinoma tissues. (dovepress.com)
  • Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
  • Basal cell carcinoma of the right lower lid. (medscape.com)
  • Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases. (bvsalud.org)
  • 9. Iamaroon A, Khemaleelakul U, Pongsiriwet S, Pintong J. Co-expression of p53 and Ki67 and lack of EBV expression in oral squamous cell carcinoma. (bvsalud.org)
  • Expression of p53 in leukoplakia and squamous cell carcinoma of the oral mucosa: correlation with expression of Ki67. (bvsalud.org)
  • Single-cell RT-PCR detects shifts in mRNA expression profiles of basal forebrain neurons during aging. (wakehealth.edu)
  • EPHA1, EPHA2, EFNA3, and EFNA4 mRNA expression was significantly higher in human epidermal growth factor receptor 2- (HER2-) positive tumors than in HER2-negative tumors. (hindawi.com)
  • The Kaplan-Meier plotter indicated that high EphA7 mRNA expression was associated with poor overall survival (OS) and recurrence-free survival (RFS), especially in the HER2 and luminal A subtypes. (hindawi.com)
  • Oncotarget published 'Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients' which reported that LMNB2 is a chromatin remodeling protein that also plays a role in eukaryotic cell proliferation by organizing the nuclear membrane during mitosis. (news-medical.net)
  • The El-Deiry Research Team concluded in their Oncotarget Research Output that surprisingly, there were no genes that correlated with BRCA1 mRNA expression uniquely in BC, but there were several genes that correlated with BRCA1 expression uniquely in CRC. (news-medical.net)
  • 2021) Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients. (news-medical.net)
  • To identify genetic programs of human colonic epithelial cell differentiation in vivo as well as candidate marker genes that define colonic epithelial stem/progenitor cells and the stem cell niche, we applied gene expression analysis of normal human colon tops and basal crypts by using expression microarrays with 30,000 genes. (utmb.edu)
  • Collectively, the expression data set provides a comprehensive picture of human colonic epithelial cell differentiation. (utmb.edu)
  • beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells. (igbmc.fr)
  • Methods: Normal human bronchial epithelial cells (NHBEpC) (at ≥ 90% viability) were seeded on 12-well porous 0.4 µm- cell culture inserts in basal cell culture medium. (cdc.gov)
  • The expression of p53 in epithelial hyperkeratosis was mainly localized to basal epithelial cells whereas in epithelial dysplasia, it was predominantly localized to spinous epithelial cells. (bvsalud.org)
  • PTCH1 is frequently mutated on one allele in sporadic basal cell carcinomas (BCCs), and according to Epstein, "upregulation of HH signaling is the pivotal abnormality in all BCCs. (medscape.com)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • HE4 is one of more than 8900 different human genes represented on U95a GeneChips (Affymetrix, Santa Clara, CA, USA), which we used previously to develop a molecular classification of 175 human carcinomas based on patterns of gene expression. (nature.com)
  • 18 With the exception of the ovarian neoplasms, the same carcinomas analyzed for gene expression were also examined for HE4 by immunohistochemistry on tissue microarrays (see below). (nature.com)
  • In a separate study, we showed that transformation of the immortalized urothelial cells with the environmental carcinogen arsenite (As 3+ ) results in an increase in expression of genes associated with the basal subtype of bladder cancer. (oncotarget.com)
  • The results of our study indicate that there is a decrease in expression of genes associated with keratinization and cornification and this gene signature includes the genes associated with the basal subtype of breast cancer. (oncotarget.com)
  • EFNA4 was predicted to have poor OS and RFS in breast cancers, especially in luminal B, basal-like subtype, and patients treated with adjuvant chemotherapy. (hindawi.com)
  • High EPHA3 expression was significantly associated with better OS and RFS, especially in the luminal A subtype, but with poor RFS in BrCa patients receiving chemotherapy. (hindawi.com)
  • A high expression of the CD44v2-v10 isoform, which retain all variant exons, was correlated to positive steroid receptor status, low proliferation and luminal A subtype. (lu.se)
  • The CD44v3-v10 isoform showed similar correlations, while high expression of CD44v8-v10 was correlated to positive EGFR, negative/low HER2 status and basal-like subtype. (lu.se)
  • Pathway analysis revealed the differential expression of genes involved in cell cycle maintenance and apoptosis, as well as genes in bone morphogenetic protein (BMP), Notch, Wnt, EPH, and MYC signaling pathways. (utmb.edu)
  • We hypothesized that if the dysregulation of the Wnt/β-catenin signaling pathway could be attributed to the tumorigenesis of BCA/BCAC, there might be differences in TLE1 expression between BCA and BCAC. (biomedcentral.com)
  • The association of TLE1 and tumors was first detected in synovial sarcomas through gene expression profiling, and TLE1 was found to be profoundly involved in the Wnt/β-catenin signaling pathway in synovial sarcomas [ 12 , 13 ]. (biomedcentral.com)
  • This system regulates the expression of the genes involved in the degradation of toluene, benzene, and ethylbenzene through the toluene dioxygenase pathway. (nih.gov)
  • Previous studies reported increased basal HSP70 protein levels in homokaryotypic strains for a warm-climate arrangement compared to a cold-climate one. (uab.cat)
  • These findings do not match the similar hsp70 genomic organization between arrangements, where gene expression levels are expected to be similar. (uab.cat)
  • In order to test this hypothesis and understand the molecular basis for hsp70 expression, we compared basal hsp70 mRNA levels in males and females, and analysed the 5′ and 3′ regulatory regions of hsp70 genes in warm- and cold-climate isochromosomal O 3 + 4 + 7 and O ST lines of D. subobscura. (uab.cat)
  • Results: We observed comparable mRNA levels between the two arrangements and a sex-biased hsp70 gene expression. (uab.cat)
  • Conclusions: The equivalent hsp70 mRNA amounts in O ST and O 3 + 4 + 7 arrangements provide the first evidence of a parallelism between gene expression and genetic organization in D. subobscura lines having these arrangements. (uab.cat)
  • Therefore, the basal levels of hsp70 mRNA cannot account, in principle, for the adaptive variation of the two arrangements studied. (uab.cat)
  • We determined if basal HSP expression (HSP70, HSP60, HSP25) was impaired in sedentary or exercised rats following the onset of diet-induced obesity. (lidsen.com)
  • Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) are benign and malignant, basaloid salivary gland neoplasms, respectively. (biomedcentral.com)
  • These tumors show a dual-cell proliferation of inner luminal/ductal cells and outer abluminal/myoepithelial or basal cells. (biomedcentral.com)
  • Immunohistochemical analysis for TLE1 can identify BCA and BCAC by luminal cell staining difference, especially indistinct luminal cell expression for TLE1 in invasive areas of BCAC. (biomedcentral.com)
  • A basal cell adenoma (BCA) is a benign salivary gland basal cell neoplasm (BCN) that shows a dual-cell proliferation of inner luminal/ductal cells and outer abluminal/ myoepithelial or basal cells [ 1 ]. (biomedcentral.com)
  • Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. (nih.gov)
  • Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome. (nih.gov)
  • In conclusion, the current study revealed the expression profiles of human TRP channels in 60 different breast cancer tissues and cell lines and furthermore validated the antitumor activity of TRPV1 against SUM149PT breast cancer cells, indicating that activation of TRPV1 could be used as a therapeutic target, even in the most aggressive breast cancer types. (dovepress.com)
  • Foxo3a was expressed in 82.1%, 78.3%, and 77.5% of neutrophils, T lymphocytes, and B lymphocytes, respectively, and statistical analysis using the Kruskal-Wallis test followed by the Steel-Dwass test showed no significant difference of Foxo3a expression among the three cell types. (go.jp)
  • The adult human airway epithelium is comprised of four major cell types, basal, club, goblet, and ciliated cells. (cdc.gov)
  • The basal cell (stem/progenitor cell) marker (KRT5) shows an initial increase in expression, but did not vary much during differentiation. (cdc.gov)
  • In parallel, the expression of basal cell marker(KRT5) was partially modulated by nZnO exposure. (cdc.gov)
  • OBJECTIVES: The expression patterns of various cell-associated heparan and chondroitin/dermatan-sulphate PGs in human skin and chronic venous ulcers were investigated. (lu.se)
  • CONCLUSIONS: The altered expression patterns of glypican and syndecan-1 and -4 in chronic ulcers reflect their possible roles during inflammation and cell proliferation. (lu.se)
  • Expression of cell cycle proteins in head and neck cancer correlates with tumour site rather than tobacco use. (bvsalud.org)
  • We used q-RT-PCR and exon-exon spanning assays to analyze the expression of four alternatively spliced CD44 isoforms as well as the total expression of CD44 in 187 breast tumors and 13 cell lines. (lu.se)
  • Breast cancer cell lines showed a heterogeneous expression pattern of the CD44 isoforms, which shifted considerably when cells were grown as mammospheres. (lu.se)
  • Les enfants présentant un syndrome néphrotique idiopathique ont été répartis en trois groupes de 20 : première manifestation, rémission et récidive. (who.int)
  • The nuclear expression of β-catenin is considered a characteristic feature of BCA because other salivary gland tumors rarely show nuclear staining [ 2 ]. (biomedcentral.com)
  • High expression of LMNB2 in CRC tumors correlates with worse disease-free cumulative and overall survival, and that knocking out the LMNB2 gene allowed for the development of CRC tumors through a mechanism that involved silencing of p21 expression. (news-medical.net)
  • In line with this, these authors found that young CRC patients, who tend to express high levels of BRCA1 in their tumors, also tend to express low levels of p21 and this may be due to simultaneous high expression of LMNB2. (news-medical.net)
  • Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
  • Conversely, tumors with strong expression of the CSC marker ALDH1 had elevated expression of CD44S. (lu.se)
  • High expression of CD44S was associated with strong HER2 staining and also a subgroup of basal-like tumors. (lu.se)
  • Unsupervised hierarchical cluster analysis of CD44 isoform expression data divided tumors into four main clusters, which showed significant correlations to molecular subtypes and differences in 10-year overall survival. (lu.se)
  • Thus, our study suggests that transformation of the MCF-10A cells with Cd 2+ produces a decreased basal gene expression profile that correlates to patient outcome. (oncotarget.com)
  • Quantitative measurements of immunohistochemical expression of TP53INP1 using high-throughput densitometry, assessed on digitized microscopic tissue micro-array images, were correlated with clinicopathological parameters in 91 human PC. (urotoday.com)
  • Monocyte chemoattractant protein (MCP-1) anti-sense RNA probes yielded abundant signals over the proliferating basal keratinocytes of the tips of the rete ridges, and, to a lesser extent, in cells in the papillae. (elsevierpure.com)
  • Whereas the expression of syndecan-4 and glypican in intact skin was mostly in the pericellular regions of keratinocytes, the epidermal cells from the wound edge contained mostly intracellular PGs. (lu.se)
  • Knowledge of the expression patterns of HE4 in our survey is useful for application in histopathologic diagnosis, and should be taken into consideration in future studies that examine the role of HE4 as a serological tumor biomarker or as a target for gene-based therapy. (nature.com)
  • GenePaint.org: an atlas of gene expression patterns in the mouse embryo. (jax.org)
  • Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
  • ALDH1 protein expression was determined by IHC on TMA. (lu.se)
  • The signature of our top screening hits is significantly correlated with gene expression data from clinical melanoma samples. (cdc.gov)
  • Efforts to link CD44 to CSCs and tumor progression should consider the expression of various CD44 isoforms. (lu.se)
  • Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. (harvard.edu)
  • Asthma and COPD are complex diseases involving both genetic and environmental factors resulting in disease expression. (nottingham.ac.uk)
  • Logic-based analysis of gene expression data predicts association between TNF, TGFB1 and EGF pathways in basal-like breast ca. (ornl.gov)
  • Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
  • Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
  • To demonstrate the anatomical specificity of nNOS silencing in vivo, vectors were used to selectively knock-down the endogenous nNOS expression in cortical GABAergic interneurons of rat piriform cortex. (johnshopkins.edu)
  • The study examined the expression of Neuroglobin (Ngb) and Hypoxia-inducible factor-1α (Hif-1α) in adult and young yak brain tissues, and provided researchers with meaningful insight into the anatomy, physiology, and biochemistry of this mammal. (scielo.br)
  • 0.05) expressed in the cerebellar cortex, piriform lobe, medulla, and corpus callosum of the adult yak while in the young yak brain tissues, the protein expressions were significantly found in the white matter of the cerebellum, pineal gland, corpus callosum, and cerebellar cortex. (scielo.br)
  • Multiple roles in the brain tissues of the adult and young yaks are involved in the expression and distribution and are proposed to play a significant role in the adaptation of the yak to the high altitude environment. (scielo.br)
  • however, the expression in normal and malignant adult tissues has not been examined in detail. (nature.com)
  • Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
  • Next-generation sequencing analyses revealed the expression of TRPV1 in several native breast cancer tissues, which was subsequently validated via reverse transcriptase-polymerase chain reaction. (dovepress.com)
  • In normal prostate tissues, TP53INP1 is only expressed in prostate basal cells. (urotoday.com)
  • There is a de novo TP53INP1 expression in prostate luminal cells in inflammatory prostate tissues, high grade PIN lesions and in PC. (urotoday.com)
  • The present study was performed to compare the expression of Foxo3a in periapical granulomas and healthy gingival tissues. (go.jp)
  • TIF) ppat.1005738.s002.tif (532K) GUID:?C7A7D414-E620-4646-A7A5-A46AA4B1570F S3 Fig: Related to Fig 2: The lectin WGA primarily binds to sialic acid on the surface of HPMEC, and DENV2 NS1 disrupts Sia expression about the surface of different endothelial cells. (ebat2018.org)
  • In this study, we determined if transformation of the MCF-10A cells with Cd 2+ would have a similar effect on the expression of basal genes. (oncotarget.com)
  • By investigating which neuropeptide/neurotransmitter mRNA containing striatal cells also express the dopamine D2 mRNA's, I will be able to study further, at the cellular level, how neuroleptic treatment modulates the expression of co-expressed neuropeptide mRNA's such as enkephalin, dynorphin, substance P and neurotensin in addition to the effect D2 receptor blockade has on GABA mRNA â€" the major inhibitory neurotransmitter contained within many striatal cells. (tourette.org)
  • It is our hope that knowledge of the regulation and co-expression of neuropeptide mRNA's with the D2 receptor mRNA's in striatal cells will enable us to begin to understand when, where and how neuroleptics produce their effects at the cellular level. (tourette.org)
  • In BCA, the expression of TLE1 was confined to luminal cells of glandular structures, in contrast to the expression of β-catenin in abluminal cells. (biomedcentral.com)
  • These a putative fusion peptide is readily identifiable based on genes' expression in human kidney mesangial cells was homology to those of other paramyxoviruses (Figure 1B). (cdc.gov)
  • Insights into H 2 O 2 -induced signaling in Jurkat cells from analysis of gene expression. (otago.ac.nz)
  • Exposure to high dose of nZnO induced a significant decrease in expression of club (SCGB1A1), goblet (MUC5AC) and ciliated cells (FoxJ1) markers at mRNA levels. (cdc.gov)
  • In the wound edge, syndecan-4 was predominantly expressed by epidermal basal layer cells. (lu.se)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
  • The localization of these p53 positive cells within the strata (i.e. basal/suprabasal, spinous and superficial layers) of epithelium between 3 groups, and also within each group according to histological grades was recorded. (bvsalud.org)
  • Expression was weak in the pallidum (medial ganglionic eminence). (jax.org)
  • Thus, the strongest MCP-1 message in psoriatic lesions is found above the dermal-epidermal junction and this may explain the characteristic sub-basal distribution of dermal macrophages. (elsevierpure.com)
  • OBJECTIVES: To evaluate the expression of COX-2 and HER2 and determine their correlation with clinicopathologic parameters in surgically resected histologically diagnosed cases of colorectal cancer. (bvsalud.org)
  • CONCLUSION: This study detects a high COX-2 and low HER2 expression in colorectal cancer using immunohistochemistry,suggesting a possible role for COX-2 in CRC pathogenesis.This report should trigger further investigations of both markers vis-à-vis the management of CRC in our environment. (bvsalud.org)
  • Likewise, the knockdown of hsa-miR-7-5p increased the expression of EGFR. (um.edu.my)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • The ability of our nNOS silencing vectors to effectively and precisely silence nNOS expression shows their value as research tools for further studies of the role of nNOS in specific brain circuits. (johnshopkins.edu)
  • Expression of artemin caused a 20.5% increase in DRG neuron number and increased the level of mRNA encoding GFRα3, TrkA, TRPV1, and the putative noxious cold-detecting channel TRPA1. (jneurosci.org)
  • These results indicate that the level of artemin in the skin modulates gene expression and response properties of afferents that project to the skin and that these changes lead to behavioral sensitivity to both hot and cold stimuli. (jneurosci.org)
  • METHODS: Fifty-three paraffin-embedded tissue blocks of colorectal resections and corresponding patient information were retrieved from the archives of the Anatomic and Molecular Pathology Department of Lagos University Teaching Hospital.A 4-micron slide section was obtained from each specimen and immunohistochemistry for COX-2 and HER-2 expression was performed. (bvsalud.org)
  • Here, we examined the expression pattern and prognostic value of the EPHA/EFNA family in patients with breast cancer, including patients with different subtypes or different chemotherapy cohorts. (hindawi.com)
  • Our findings systematically elucidate the expression pattern and prognostic value of the EPHA/EFNA family in BrCa, which might provide potential prognostic factors and novel targets in BrCa patients, including those with different subtypes or treated with chemotherapy. (hindawi.com)
  • Hence, analysis of PG expression should be of interest in future studies on normal as well as defective wound healing. (lu.se)
  • however, no study has examined the expression profiles of human TRP channels in breast cancer on a large scale. (dovepress.com)
  • Human emotional interchange implicates expression/recognition of emotions. (bvsalud.org)
  • Nuclear CSPP1 expression defined subtypes of basal-like breast cancer. (nih.gov)
  • 2 - 4 Expression profiling on a genomic scale led to the classification of the intrinsic subtypes of breast cancer, thus allowing for the prediction of disease progression and patient stratification. (dovepress.com)
  • Of the siRNA sequences screened, one corresponding to exon 10 of the rat nNOS specifically and efficiently inhibited nNOS expression at the mRNA and protein level. (johnshopkins.edu)
  • cultured on TCP were used to determine the basal level of SMA and TN-C expression. (researchgate.net)
  • These results provide new insights into the dynamic role of miRNA expression in DPSCs. (um.edu.my)