Basal cell overexpression cell cycle. Medical search. Frequent questions

The authors showed that excessive expression of FOXM1 exploits the inherent self-renewal proliferation potential of stem cells by interfering with the differentiation pathway, thereby expanding the progenitor cell compartment. (wikipedia.org)
Transforming growth factor beta (TGF-beta) inhibits proliferation and promotes cell migration. (nih.gov)
Endogenous RPTPkappa associated with EGF receptor and HER2, resulting in suppression of basal and ErbB ligand-induced proliferation and receptor phosphorylation. (nih.gov)
Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
Overexpression of Notch1 can also supress proliferation in breast epithelial cells depending on dosage and cell type. (iyte.edu.tr)
It was recently identified that IRF6 is a mediator of Notch in proliferation and transformation of breast epithelial cells. (iyte.edu.tr)
In conclusion, our previous observation was supported that IRF6 is a mediator of Notch in cell proliferation. (iyte.edu.tr)
These interactions begin during the early stages of embryonic development and coordinate events such as cell proliferation and differentiation in complex tissues, crucial processes for the functional maintenance of whole organs [ 10 ]. (biomedcentral.com)
Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
Androgen receptor (AR)-regulated transcription is critical for the proliferation of the molecular apocrine breast cancer subtype, which is characterized by HER2 overexpression and estrogen receptor negativity. (aacrjournals.org)
Cancer cells demand high energy production to sustain their pathological increase in proliferation rate. (hindawi.com)
Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow. (haematologica.org)
The DEmRNAs were mainly enriched in tumorigenesis‑associated GO terms (angiogenesis, positive regulation of cell proliferation, positive regulation of fibroblast apoptotic processes and regulation of neutrophil migration) and pathways (Hippo signaling pathway, cancer pathways, and Wnt signaling pathway). (spandidos-publications.com)
The results demonstrate that DLEU1 and TRAF4 is highly expressed in GBM tissues and promotes proliferation of GBM cells. (spandidos-publications.com)
For example, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in GBM tissues and perturbed expression of NEAT1 suppresses cell proliferation and invasion ( 10 ). (spandidos-publications.com)
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and cell proliferation assay were used to explore the functional role of the key lncRNAs in GBM. (spandidos-publications.com)
Negative WT1 staining implies a nonproliferative nature of the oral lymphangiomas, thus growth is most likely secondary to enlargement of lymphatic vessels and not neoplastic proliferation of lymphatic endothelial cells. (medscape.com)
Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
In addition, we found that BMP-2, a 4HPR target with antiangiogenic activity, decreased prostate cancer cell proliferation, migration and invasion by down-regulating the pathway described involving AKT phosphorylation, β-catenin stability and cyclin D1 expression. (biomedcentral.com)
As a consequence, 4HPR led to the regulation of genes controlling cell proliferation, angiogenesis and metastasis. (biomedcentral.com)
They can be grown in culture and used as a model system for studying various aspects of skin biology, including the mechanisms underlying keratinocyte differentiation and proliferation, wound healing, and the response of skin cells to environmental stressors. (altogen.com)
Low levels of ROS can promote cell proliferation but high levels induce cell death [ 13 ]. (biomedcentral.com)

Also, expression analysis of p53 targets in APTX knockdown MCF7 cells revealed that extrinsic apoptosis pathway might be induced. (iyte.edu.tr)
In this study, it was aimed to identify whether IRF6 has any effect on cell cycle regulation, apoptosis and breast cancer stem cell population (BCSCs) under Notch and whether IRF6 has a role in expression of luminal and basal markers in breast cell lines. (iyte.edu.tr)
Furthermore, these data showed that IRF6 has a novel role on early apoptosis and stem cell population independent of Notch signaling. (iyte.edu.tr)
Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. (mdpi.com)
To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)
Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
The tumor suppressor gene LKB1, also known as serine/threonine protein kinase 11 (STK11 ), encodes a serine/threonine protein kinase that has multiple cellular functions, including tumor suppression, cell cycle regulation, and promotion of apoptosis. (biomedcentral.com)
The TP53 gene plays an important role in regulating the cell cycle, apoptosis and DNA damage repair ( 8 , 9 ). (spandidos-publications.com)
Studies have found that Bcl-2 overexpression protects keratinocytes from induced apoptosis. (altogen.com)
Despite its pro-apoptotic role, caspase-2-deficient tumors have comparable basal apoptosis levels to wild-type tumors [3, 4]. (nature.com)
These cells do not undergo apoptosis, and the primary outcome of caspase-2 activation is continued, cell division. (nature.com)
This indicates a role distinct from caspase-2's reported role in inducing apoptosis to remove damaged or aneuploid cells [7][8]. (nature.com)
therefore, we overexpressed Bcl-X L to distinguish caspase-2's role in cell division and DNA protection from its role in apoptosis. (nature.com)
While other groups have demonstrated non-apoptotic roles for caspase-2 in DNA repair, cell cycle arrest [2], this is the first demonstration that these roles are regulated by a distinct pathway to apoptosis. (nature.com)
If apoptosis is not an essential mechanism for its tumor suppression function, then a role in regulating the cell cycle may be. (nature.com)
In addition to inducing necrosis and apoptosis, ROS induces autophagic cell death. (biomedcentral.com)
Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
Immunopathologic examination during infection showed cleavage of caspase 3 in brain cells adjacent to CD8+ cells and widespread p53 expression, hallmarks of apoptosis. (cdc.gov)

IRF6 overexpression induces cell cycle arrest in breast cancer cells showing a tumor suppressor role. (iyte.edu.tr)
It has long been noted that caspase-2-deficient cells proliferate faster [2], and elegant studies have shown that caspase-2 induces cell cycle arrest following cytokinesis failure [5]. (nature.com)

Stable F98 glioma cell lines with MCT4 overexpression, normal expression, and knockdown were generated. (hindawi.com)
Our results showed that IRF6 knockdown in normal breast epithelial cell line, MCF10A, reduced percentage of cells in S-phase, which was increased by Notch activation. (iyte.edu.tr)
The knockdown of ATG9B expression in GBM cells suppressed TMZ-induced autophagy as well as TMZ-resistance. (nature.com)
Finally, it was found for the first time that endogenous LKB1 knockdown resulted in abnormal cell polarity in acini formed by non-transformed breast epithelial cells grown in 3D culture. (biomedcentral.com)
Knockdown of endogenous LKB1 gave rise to dysregulation of cell polarity and invasive phenotype of breast cancer cells. (biomedcentral.com)
Knockdown of autophagy-related gene 5 inhibited basal autophagy and diminished oxidative stress-induced autophagy and cell death. (biomedcentral.com)

However, a major unresolved question is how each cell regulates the precise number of its motile cilia during differentiation. (elifesciences.org)
This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
The MC3T3-E1 cells were cultured and incubated in the osteogenic differentiation medium for 14 days. (frontiersin.org)
There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
Our study characterizes miR-211-5p targeting Arhgap11a promotes the osteogenic differentiation of MC3T3-E1 cells, which provides novel targets to promote the osteogenesis process during bone repair. (frontiersin.org)
In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. (genome.jp)
During his postdoc, he carried out research to determine the role of Kruppel-like factor 2 (KLF2) during osteoblast (OB) differentiation of dental pulp-derived stem cells (DPSC). (nih.gov)
During the cellular differentiation process, cellular metabolism alters as the cell prepares for ongoing changes. (nih.gov)
Simultaneous measurements of glycolysis and oxidative phosphorylation in live cells revealed that OB differentiation decreased the oxygen consumption rate, which indicates reduced ATP production and mitochondrial respiration. (nih.gov)
A stem cell commences as an undifferentiated cell that can either undergo self-renewal, whereby it generates daughter cells that remain as stem cells, or mature into a specific cell type via differentiation (Can/Hematol 2008). (papersowl.com)

Insulin produces the dephosphorylation of only a small subset of proteins at discrete locations, whereas PP1 is ubiquitously expressed and is found in virtually all cellular compartments, suggesting that mechanisms exist for the targeted regulation of PP1 in insulin-responsive cells that selectively permit activation of the enzyme only at these sites. (jci.org)
In the present study, researchers devised high-throughput cellular assays that can differentiate between young, older, and aged cells of the body, including transcriptomic aging clocks and real-time quantitative nucleocytoplasmic compartmentalization (NCC) assays, to identify compounds that can reverse the aging process without genomic alterations. (news-medical.net)
The team investigated molecules participating in the early stages of human CiPSC generation, including C1 and C6NYSA (C4, CHIR-99021, Y-27632, E-616452, TTNPB, and ABT-869 as basal cocktails for cellular reprogramming. (news-medical.net)
The team identified six chemical cocktails that can restore a youthful genome-wide transcript profile and reverse transcriptomic age in less than a week without compromising cellular identity to a similar extent as OSK overexpression. (news-medical.net)
We had no idea about the characteristics of T cells, the pathogenic T-cell subsets, associated cytokines or cellular and molecular drivers' that drove pathogenic immunity. (dermatologytimes.com)
Resisting cell death', 'genome instability and mutation' and 'deregulating cellular energetics' refine breast cancer classification with their predictive values. (jcancer.org)
We found that Dusp4 loss alone is insufficient in mediating tumorigenesis, but alternatively converges with loss in Trp53 and MYC amplification to induce tumorigenesis primarily through chromosome 5 amplification, which specifically upregulates Dbf4 , a cell cycle gene that promotes cellular replication by mediating cell cycle checkpoint escape. (biomedcentral.com)
This study identifies a novel mechanism for breast tumorigenesis implicating Dusp4 loss and p53 mutations in cellular acquisition of Dbf4 upregulation as a driver of cellular replication and cell cycle checkpoint escape. (biomedcentral.com)
During the past decades, an increasing body of work has shed light on the cellular and molecular mechanisms involved in the transformation of normal cells into cancerous cells. (biomedcentral.com)
Cellular interactions lie at the core of metazoan physiology and encompass an effective and elegant signaling repertoire that integrates up to trillions of cells in a single organism. (biomedcentral.com)
Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
These findings bring along a paradox - not only do signals instruct cells and organize discrete cellular patterns, but cells also control the patterns of signal presentation and reception by organizing the distribution of cytonemes and cytoneme contacts 6 , 9 . (biorxiv.org)
These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
Dr. Jyoitirindra Maity has focused on cellular and molecular biology in rare disease models and cancer and stem cell modeling throughout his career. (nih.gov)
WRN critically regulates autophagy in various cellular stresses, including starvation, endoplasmic reticulum (ER) stress conditions to rescue the cell, and basal situations to restore proper cellular function. (nih.gov)
In studies focusing on NPC and cells of epithelial origin, LMP1 has been described as a potent regulator of cellular migration and invasion. (kspinhibitors.com)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)

Here, we show that FGF is Glycosylphosphatidylinositol-anchored to the producing cell surface and that this modification both inhibits free FGF secretion and activates target-specific bidirectional FGF-FGFR signaling through cytonemes. (biorxiv.org)
FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling. (cancerindex.org)
Our results suggest that overexpression of IRS-1 promotes cells growth, inhibits basal autophagy, reduces oxidative stress-induced autophagy, and diminishes oxidative stress-mediated autophagy-dependent cell death. (biomedcentral.com)

In TGF-beta-treated MCF10A mammary epithelial cells overexpressing HER2 and by chromatin immunoprecipitation, we identified novel Smad targets including protein tyrosine phosphatase receptor type kappa (PTPRK). (nih.gov)
Primary mouse mammary epithelial cells (mMEC) with defined genetic features were used to delineate the combined action of RB and/or p 53 in the genesis of TNBC. (elsevierpure.com)
Using a genetically engineered mouse model, we generated mammary-specific Dusp4 -deleted primary epithelial cells to investigate the necessary conditions in which DUSP4 loss may drive breast cancer oncogenesis. (biomedcentral.com)
The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. (genome.jp)

Osteoblast mainly originates from mesenchymal stem cells (MSCs), and it is involved in bone formation, remodeling, and reconstruction via the formation of a bone matrix and regulation of bone resorption ( 6 ). (frontiersin.org)
However, little work has been done on the roles of LKB1 in cell polarity and epithelial-mesenchymal transition in breast cancer. (biomedcentral.com)
The roles of LKB1 in cell polarity and epithelial-mesenchymal transition in breast cancer were determined by using immunofluorescence, western blot assay, and cell migration and invasive assays. (biomedcentral.com)
In vitro analysis revealed that loss of LKB1 expression enhanced migration, invasion and the acquisition of mesenchymal phenotype, while LKB1 overexpression in MDA-MB-435 s cells, which have a low basal level of LKB1 expression, promoted the acquisition of epithelial phenotype. (biomedcentral.com)

FOXM1 overexpression is involved in early events of carcinogenesis in head and neck squamous cell carcinoma. (wikipedia.org)
An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)

Unresponsiveness may result, at least in part, because these therapies only target cancer cells and neglect the complex microenvironment around tumors that undergo drastic changes during disease development [ 7 ]. (biomedcentral.com)
A multistage process has been proposed for the evolution of esophageal squamous cell carcinoma (ESCC), in which normal squamous epithelia undergo a series of histological and genetic progression towards noninvasive precursor lesions, i.e., dysplasia (DYS) and carcinoma in situ (CIS), then towards invasive cancer, and, finally towards deep invasion and metastasis to lymph nodes and other organs. (biomedcentral.com)

Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. (molvis.org)
In this study, we tried to prove that loss of LKB1 disrupts breast epithelial cell polarity and causes tumor metastasis and invasion. (biomedcentral.com)
Finally, the non-transformed human breast cell line MCF-10A was cultured in three dimensions to further reveal the role of LKB1 in breast epithelial cell polarity maintenance. (biomedcentral.com)

Hh proteins are secreted morphogens that play essential roles in regulation of embryogenesis, development, tissue homeostasis, regeneration and stem cell maintenance in a concentration-dependent manner [ 6 ]. (biomedcentral.com)
The hypoxic regulation of CXCL12 was examined in multiple myeloma plasma cell lines using polymerase chain reaction and western blotting. (haematologica.org)
LKB1, also known as STK11 , is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. (biomedcentral.com)
Since angiogenesis and metastatic spread are strictly related, in this study we analyzed the regulation of multiple signaling pathways responsible for cancer cell invasion. (biomedcentral.com)

The study assessed the genetic expression patterns of chemically treated cells compared to aged human-origin cells and OSK(MYC)-induced murine and human iPSC. (news-medical.net)
The researchers discovered that OSK expression in cells, such as murine and human fibroblasts, may significantly repair the epigenetic environment and patterns of gene expression of aged cells. (news-medical.net)
Primary cultures of murine alveolar epithelial cells provide a robust model to perform mechanistic studies that can be correlated with studies to identify cell type-specific factors that contribute to pathology within the alveoli of the lung during viral infection. (cancercurehere.com)
In this study, we established an model to compare the responses of type I (ATI) and type II (ATII) alveolar epithelial cells to infection by respiratory viruses used in murine models: mouse-adapted severe acute respiratory syndrome-associated coronavirus (SARS-CoV, v2163), murine coronavirus MHV-1, and influenza A (H1N1) virus, strain PR8. (cancercurehere.com)
Murine alveolar cells cultured to maintain an ATII cell phenotype, determined by expression of LBP180, were susceptible to infection by all three viruses. (cancercurehere.com)
2007). Infection of alveolar epithelial cells is also associated with severe disease in murine models of respiratory viral infections, including mouse-adapted IAV and SARS-CoV (Blazejewska et al. (cancercurehere.com)
While promising, these cells were solely murine-derived, limiting their applicability to humans. (papersowl.com)

Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. (wikipedia.org)
Carcinoma squamous cell. (lookformedical.com)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive lesions and final metastasis. (biomedcentral.com)
Squamous cell carcinoma is the most common histological type of esophageal cancer in China. (biomedcentral.com)
Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)
The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)
Approximately one-half of new cases each year are recorded in China, and the majority is squamous cell carcinoma ( 3 - 5 ). (spandidos-publications.com)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)

A recent report by the research group which first found that the over-expression of FOXM1 is associated with human cancer, showed that aberrant upregulation of FOXM1 in adult human epithelial stem cells induces a precancer phenotype in a 3D-organotypic tissue regeneration system - a condition similar to human hyperplasia. (wikipedia.org)
Interestingly, Hh ligand overexpression is associated with the BLBC phenotype and a poor outcome in terms of metastasis and breast cancer-related death. (biomedcentral.com)
In contrast, ATII cells that were cultured to trans-differentiate into an ATI-like cell phenotype were susceptible to MHV-1 and PR8, but not mouse-adapted SARS-CoV. (cancercurehere.com)
Each tumor type reflected the initial phenotype from the parent culture cells. (suamaytinhhaiphong.com)
This non-migratory phenotype was similarly produced in both cell lines by stable silencing of β-catenin. (biomedcentral.com)
These data point to 4HPR as a negative regulator of AKT phosphorylation, effectively targeting the β-catenin pathway and inducing a relatively benign phenotype in prostate cancer cells, limiting neoangiogenesis and cell invasion. (biomedcentral.com)
In complementary experiments the overexpression of Buffy in the developing eye suppressed the mild rough eye phenotype that results from Gal4 expression and from alpha-synuclein expression. (sdbonline.org)

Consistent with the aggressive behavior of the preclinical models of MYC overexpression and RB loss, human TNBC tumors that express high levels of MYC and are devoid of RB have a particularly poor outcome. (elsevierpure.com)
Recent studies have shown that in these tumors, AR cooperates with other transcription factors such as the pioneer factor forkhead box A1 (FOXA1) and components of the canonical WNT pathway to enhance androgen-responsive gene expression, but it is likely that other feedback loops also modulate AR signaling and restrain basal gene expression. (aacrjournals.org)
We demonstrated that both GS5 and Huh7.5 cells could form solid tumors in athymic nude rodents. (suamaytinhhaiphong.com)
exhibited greater expression of DCAMKL-1, CK19, and AFP compared to control cells or tumors (Fig. 5, 6, and seven). (suamaytinhhaiphong.com)
This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)

It is thought that upregulation of FOXM1 promotes oncogenesis through abnormal impact on its multiple roles in cell cycle and chromosomal/genomic maintenance. (wikipedia.org)
Contact-mediated FGF-FGFR binding induces bidirectional signaling, which, in turn, promotes ASP and source cells to polarize cytonemes toward each other and reinforce signaling contacts. (biorxiv.org)
High expression of lncRNA H19 promotes cell migration and enhances angiogenesis ( 11 , 12 ). (spandidos-publications.com)

To analyse whether inhibition of NF ��B, which leads to re duction of Fascin, also affects invasion of EBV transformed lymphocytes, LCL B cells were incubated in the presence of ACHP and serum starved for 4 h. (kspinhibitors.com)
The mechanism of action for this antifungal activity is through the decrease of ergosterol synthesis, required for membrane integrity of fungal cells, via inhibition of the lanosterol 14 alpha-demethylase (14DM) catalyst. (ecancer.org)
We found that 4HPR-induced inhibition of PC cell migration and invasion correlates with decreased FAK and AKT phosphorylation, activation of the glycogen synthase kinase 3β(GSK3β) and β-catenin destabilization. (biomedcentral.com)
Overexpression of IRS-1 resulted in inhibition of basal autophagy, and reduced oxidative stress-induced autophagy and cell death. (biomedcentral.com)
ROS decreased the mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase signaling, while overexpression of IRS-1 attenuated this inhibition. (biomedcentral.com)

FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases. (wikipedia.org)
RNA interference (RNAi) of PTPRK accelerated cell cycle progression, enhanced response to epidermal growth factor (EGF), and abrogated TGF-beta-mediated antimitogenesis. (nih.gov)
In response to AR activation, MYC binding was enriched at the promoters of AR target genes involved in translation and cell-cycle progression. (aacrjournals.org)
The biological functions of HMGB1 are diverse in normal cells and during the start and progression of cancer. (hindawi.com)

During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
As the dividing cells of the alveolar epithelium, ATII cells serve as progenitors to repair damaged epithelium. (cancercurehere.com)

More recently a study using transgenic/knockout mouse embryonic fibroblasts and human osteosarcoma cells (U2OS) has shown that FOXM1 regulates expression of a large array of G2/M-specific genes, such as Plk1, cyclin B2, Nek2 and CENPF, and plays an important role in maintenance of chromosomal segregation and genomic stability. (wikipedia.org)
HER2 overexpression down-regulated its expression. (nih.gov)
While the effects of MYC overexpression had a dominant impact on gene expression, loss of RB further enhanced the deregulation of a gene expression signature associated with invasion. (elsevierpure.com)
Dendritic cells in psoriasis lesions are marked by increased expression of TNF and the enzyme iNOS, which makes nitrous oxide. (dermatologytimes.com)
Interestingly, replication stress in Brca2-null cells activates p53 and the expression of its target genes, including senescence-inducing Ink4/Arf. (biomedcentral.com)
On the other hand, IRF6 did not play an essential role on expression of luminal and basal markers. (iyte.edu.tr)
MiR-211-5p upregulation by its mimic increased Arhgap11a expression in MC3T3-E1 cells. (frontiersin.org)
Although cDNA microarray has been successfully used to explore the gene expression in ESCC, it is difficult to be used in the precursor lesions due to the difficulty to obtain the dysplastic cells accurately. (biomedcentral.com)
Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
Thus, virus-induced cytokine expression was quantified in ATI and ATII cells. (cancercurehere.com)
Both cell types had increased expression of IL-1 mRNA upon viral infection, though at different levels. (cancercurehere.com)
While MHV-1 and PR8 induced expression of a number of shared cytokines in ATI cells, there were several cytokines whose expression was induced uniquely by MHV-1 infection. (cancercurehere.com)
Conversely, the expression of constitutively active AKT (myr-AKT) overcame the effects of 4HPR and β-catenin-silencing on cell migration. (biomedcentral.com)
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. (lu.se)

The engrafted basal-like cells retain extensive self-renewal potential, evident by the capacity to reconstitute the tracheal epithelium through seven generations of secondary transplantation. (bvsalud.org)
While Akt Ser 473 phosphorylation was readily detectable in AND-34 +/+ lens epithelial cells, it was markedly reduced in the AND-34 −/− lens epithelium. (molvis.org)
Basal levels of p130Cas phosphorylation were higher in AND-34 +/+ than in AND-34 −/− lens epithelium. (molvis.org)
The extensive surface area of the alveolar epithelium is composed of two morphologically and functionally distinct cell types. (cancercurehere.com)
Type I alveolar (ATI) cells, which cover 95% of the surface area of the epithelium, are large thin cells that function in gas and ion exchange and fluid transport (Williams, 2003). (cancercurehere.com)
2007). Viral infection Roflumilast N-oxide of these physiologically critical cell types causes direct damage to the alveolar epithelium and also immune-mediated pathology, both of which will impair respiration and/or lead to lung collapse due to impaired surfactant production. (cancercurehere.com)
Superficial lesions consist of dilated lymph vessels lined by flat endothelial cells in a discontinuous layer immediately subjacent to the oral epithelium. (medscape.com)

These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
These conserved families of secreted morphogens/signals, such as Fibroblast Growth Factor (FGF), Hedgehog (Hh), Wingless (Wg)/Wnt, Epidermal Growth Factor (EGF), and Decapentaplegic (Dpp - a BMP homolog), act away from their sources and, upon binding to receptors, activate gene regulatory pathways to induce functions in recipient cells 1 , 2 . (biorxiv.org)
Thus, LKB1 regulates multiple biological pathways involved in cell growth and metabolism. (biomedcentral.com)
For example, studies have shown that exposure to ultraviolet radiation can induce DNA damage and promote the development of skin cancer through the activation of certain signaling pathways in keratinocyte cells. (altogen.com)

In MCF10A/HER2 cells, TGF-beta enhanced cell motility, FAK phosphorylation, F-actin assembly, and focal adhesion formation and inhibited RhoA activity. (nih.gov)

According to results, Aprataxin overexpression leads to cell cycle arrest in low stress levels. (iyte.edu.tr)
In contrast, while caspase-2-deficiency led to an increased proportion of S-phase cells and a progressive decrease in the proportion of G1-phase cells following treatment with arresting concentrations of the DNA damaging agent camptothecin and increased DNA damage following S-phase arrest, overexpression of Bcl-X L did not change the cell cycle profiles or the amount of DNA damage. (nature.com)

Therapeutic screening revealed that RB-deficient cells were particularly resistant to agents targeting PI3K and MEK pathway. (elsevierpure.com)
Strikingly, each signal and signaling pathway can generate a wide range of cell types and organizations in diverse contexts 3 . (biorxiv.org)
The Hh pathway is an evolutionarily conserved system for regulating patterning and cell fate from Drosophila to humans. (biomedcentral.com)
We propose a model where caspase-2 regulates the cell cycle and protects DNA replication forks to prevent DNA damage accrual in a pathway distinct from its apoptotic role. (nature.com)
If caspase-2 regulates cell division through the same pathway, it would be expected to phenocopy the cell cycle results of caspase-2 null cells. (nature.com)

Moreover, MCT4 overexpression enhances cell migration and invasiveness via reorganization of the actin cytoskeleton. (hindawi.com)

Subsequently, invasion assays were performed util izing basement membrane coated inserts which separate the cells from medium with 20% fetal calf serum in the lower well. (kspinhibitors.com)
Cancer is characterized by uncontrolled growth and division of a cell with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)

Progress in microenvironment genetic studies represents a formidable opportunity for the development of new selective drugs because stromal cells have lower mutation rates than malignant cells, and should prove to be good targets for therapy. (biomedcentral.com)
Therefore, the overexpression of p53 does not always indicate a mutation in the TP53 gene. (spandidos-publications.com)
Similarly, TP53 mutation does not always lead to the accumulation of p53 protein in cells. (spandidos-publications.com)

This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)
In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic rearrangements. (hindawi.com)
Cancer cells produce greater levels of ROS than normal cells do because of increased metabolic stresses. (biomedcentral.com)

His research focused on dental pulp stem cells (DPSC) and autophagy. (nih.gov)
Using various cell lines, including normal and WRN mutant fibroblast lines, Dr. Maity's previous research showed that WRN mutant cells respond weakly to different stress-induced autophagy in addition to basal levels. (nih.gov)
Autophagy usually serves as a survival mechanism in response to stress conditions, but excessive induction of autophagy results in cell death. (biomedcentral.com)
Evidence for GO induced autophagy includes increased levels of isoform B-II microtubule-associated protein 1 light chain 3 (LC3), aggregation of green fluorescence protein-tagged LC3, and increased numbers of autophagic vacuoles in cells. (biomedcentral.com)

Here, we demonstrate the engraftment of the airway epithelial stem cell compartment via intra-airway transplantation of mouse or human primary and pluripotent stem cell (PSC)-derived airway basal cells (BCs). (bvsalud.org)
A pluripotent stem cell has the potential to form all cells of the embryo, but cannot form a placenta. (papersowl.com)

Given the role in progenitor/stem cells expansion, FOXM1 has been shown to modulate the epigenome. (wikipedia.org)

More than 90% of head and neck cancers are squamous cell carcinomas, which originate from the mucosal surfaces of the lip and oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx. (cancernetwork.com)
Keratinocyte cells originate in the basal skin layer and grow densely outward through the layers of the epidermis. (altogen.com)

DUSP4 alterations lead to hyperactivation of MAPK signaling in many cancers, including breast cancer, which often harbor mutations in cell cycle checkpoint genes, particularly in TP53. (biomedcentral.com)
14 , 15 HIF-1 and HIF-2 mediate adaptive responses to hypoxia by inducing the transcription of genes associated with erythropoiesis, glycolytic metabolism, cell survival and angiogenesis. (haematologica.org)
We found that 4HPR impairs DU145 and PC3 prostate cancer cells migration and invasion by down-regulating FAK and AKT activation and by enhancing β-catenin degradation, causing the downregulation of target genes like cyclin D1, survivin and VEGF. (biomedcentral.com)
The methodology included inducing differentiated somatic cells with the primary genes responsible for embryonic stem cell potency. (papersowl.com)
Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
Expected and potentially novel resistance genes are enriched in the top hits and are validated using individual sgRNA as well as cDNA overexpression. (cdc.gov)

This lack of success may result in part from the fact that most studies focus on tumor cells as potential therapeutic targets and neglect the complex microenvironment that undergoes profound changes during tumor development. (biomedcentral.com)
In this way, tumor microenvironment cells could represent an extremely attractive therapeutic target either along the course of the disease or during the first steps of malignant transformation. (biomedcentral.com)
This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. (biomedcentral.com)
Additionally, keratinocyte cells have been used to test the efficacy of various therapeutic agents for skin diseases, including topical medications and gene therapy approaches. (altogen.com)
Before delving into the molecular biology and therapeutic potentials of induced pluripotent stem cells, it is crucial to provide foundational definitions and descriptions. (papersowl.com)

This molecule binds to high affinity IL-2 receptors and when internalized into cells, releases enzymatic fragments that inhibit protein synthesis and lead to apoptotic cell death. (dermatologytimes.com)
Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. (molvis.org)
HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
Cerebrospinal fluid analyses over time demonstrated increasing protein concentrations and cell counts, paralleled by pathologic lactate elevations in all patients. (cdc.gov)
Using affinity purification-mass spectrometry and global phosphoproteomic and protein abundance analyses using three IAV strains (pH1N1, H3N2, H5N1) in three human cell types (A549, NHBE, THP-1), we map 332 IAV-human protein-protein interactions and identify 13 IAV-modulated kinases. (cdc.gov)

It was therefore hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. (wikipedia.org)
Life-long reconstitution of a tissue's resident stem cell compartment with engrafted cells has the potential to durably replenish organ function. (bvsalud.org)
The team compiled a list of compounds that effectively converted human and mouse somatic cells into chemically induced pluripotent stem cells (CiPSCs) and assessed them using the NCC assay. (news-medical.net)
In June 2018, Dr. Maity became a research associate in the Vascular Biology and Stem Cell Research Laboratory in the department of Pharmaceutical Sciences at Texas Tech University Health Sciences Center, Amarillo. (nih.gov)
These HCV-caused stem cell-like features were clearly absent in Huh7.5 culture cells as well as their tumor xenografts. (suamaytinhhaiphong.com)
Specific stem cell types possess unique potencies, or abilities to self-renew. (papersowl.com)
That is to say, one type of stem cell may be capable of differentiating into all adult cell types, while another may only be capable of maturing into one specific somatic cell type. (papersowl.com)
Overall, the presence of stem cells is essential for proper human development and function as they contribute to the growth, maintenance, and repair of numerous physiological systems (Kara et al. (papersowl.com)
On a macro scale, the two classifications of stem cells are embryonic and adult stem cells. (papersowl.com)
Embryonic stem cells have the unique ability to exist in an undifferentiated state indefinitely while also being pluripotent. (papersowl.com)
In contrast, adult stem cells can only give rise to differentiated somatic cells of the particular tissue from which these cells originated (Can/Hematol 2008). (papersowl.com)
To delve further into the specifics, embryonic and adult stem cells fall into potency categories reflecting their ability to differentiate: totipotent, pluripotent, multipotent, and unipotent. (papersowl.com)
Totipotent stem cells contain all the constituents necessary to produce a living being, given that these cells can supply all embryonic and extraembryonic tissues required for proper growth (Can/Hematol 2008). (papersowl.com)
Multipotent stem cells are capable of forming many, but not all, cell types of the body. (papersowl.com)
Hematopoietic stem cells, which can produce several different types of blood cells, are prime examples of multipotency. (papersowl.com)
Oligopotent stem cells, though not often widely discussed, have the ability to differentiate into a few cells (Kara et al. (papersowl.com)
Lymphoid and myeloid stem cells are ideal examples of oligopotent stem cells. (papersowl.com)
Finally, unipotent stem cells, which can only produce differentiated daughter cells of one type, are another category of stem cells. (papersowl.com)
Muscle stem cells are the typical example of unipotency. (papersowl.com)
Using these definitions, embryonic stem cells can be classified as totipotent or pluripotent at different developmental stages and locations, whereas adult stem cells can be categorized as pluripotent, multipotent, or unipotent (Figure 1). (papersowl.com)
In the early 1980s, scientists began to exploit two major classes of stem cells: embryonic and non-embryonic, or adult stem cells. (papersowl.com)
It wasn't until over a decade later, in the late 1990s, that human-derived stem cells were propelled to the forefront of experimentation. (papersowl.com)
Marking a vast leap in reproductive therapy, it became possible to isolate these human embryonic stem cells for reproductive purposes, such as in vitro fertilization. (papersowl.com)
However, the crowning achievement arose in 2006 when researchers at Kyoto University discovered the necessary means to reprogram differentiated adult cells to possess embryonic stem cell-like functionality, as if reversing time itself. (papersowl.com)
Two theories predominate: the bicellular stem cell theory and the multicellular theory. (medscape.com)
Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)

To confirm the immunohistochemical results, three proteins, fascin, CK14 and laminin-5γ2, which were overexpressed in ESCC on tissue microarray, were detected in 12 ESCC cell lines by Western blot assay. (biomedcentral.com)

Given the previously reported role of DUSP4 as a p53 target, a potential cell cycle checkpoint, and in mediating senescence downstream of replication stress, we hypothesized that DUSP4 may be a critical oncogenic driver in breast cancer. (biomedcentral.com)
In our paper published in Oncogene [6], we show that caspase-2 plays an essential role in regulating normal cell division by protecting DNA replication forks from replication stress. (nature.com)
We show that caspase-2 protects cells from a range of S-phase-related defects, including delayed exit from S-phase, increased stalled replication forks, increased new replication origins, and decreased repair of S-phase-associated chromosomal aberrations [6]. (nature.com)
Consistent with this, we noted a caspase-2-dependent slowdown of the cell cycle following mild replication stress. (nature.com)
Consistent with our evidence that caspase-2 regulates a replication checkpoint, the chromosomal aberrations detected in caspase-2-deficient cells are not repaired before metaphase. (nature.com)

6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)
When lncHERG is highly expressed, cell multiplication, invasion and migration are inhibited in GBM ( 16 ). (spandidos-publications.com)

However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)
rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)

The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
Taken all together this demonstrates a role for Buffy, a Bcl-2 pro-cell survival gene, in neuroprotection. (sdbonline.org)

They were "early" corresponding to mild and moderate DYS with overexpression of fascin, FADD and CDC25B and underexpression of Fas, caspase 8, CK4 and annexin I, "intermediate" to severe DYS and CIS with overexpression of FADD and CK14, and "late" to invasive lesions (ESCC) and to advanced pTNM stage ESCC lesions with overexpression of CK14, laminin-5γ2 and SPARC. (biomedcentral.com)
In summary, these data show that Fascin is regulated by canonical NF ��B signals not only in LMP1 transfected cells, but also in LMP1 e pressing, EBV transformed lymphoblastoid B cells. (kspinhibitors.com)
Fascin contributes to invasion of cancer cells and HTLV 1 transformed T lymphocytes, however, the relative contribution of Fascin to the motility of EBV transformed lymphocytes has not been investigated. (kspinhibitors.com)
We observed slight reduction of cell vital ity in presence of the inhibitor, but we measured significant impairment of NF ��B activity and Fascin e pression. (kspinhibitors.com)
To test, whether sole e pression of LMP1 induces invasion of lymphocytes, too, and whether this specifically depends on Fascin, invasion assays were performed in transiently transfected cells. (kspinhibitors.com)
For this purpose, Jurkat cells were transfected http://www.selleckchem.com/products/VX-770.html with LMP1 e pression plasmids, two different shRNA constructs tar geting Fascin or unspecific control shRNAs. (kspinhibitors.com)

The development of multiple squamous cell carcinomas (SCC) in the upper aerodigestive tract, which includes the oral cavity, pharynx, larynx, and esophagus, is explained by field cancerization and is associated with alcohol consumption and cigarette smoking. (bvsalud.org)
Traditionally, 80%-90% of head and neck squamous cell carcinomas (HNSCCs) have been attributed to tobacco and alcohol use, but with growing public awareness and tobacco control efforts over the past few decades, there has been a downward trend in smoking prevalence in the US. (cancernetwork.com)
PC cells usually remain confined in the organ, while a small proportion of carcinomas acquire the ability to metastasize and approximately 80% of patients who have died of advanced hormone refractory PC have clinical evidence of bone metastasis. (biomedcentral.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)

The second invariable feature in psoriasis is a large infiltrate of T cells - mostly CD4+ in the dermis, and CD8+ in the epidermis, Dr. Krueger says. (dermatologytimes.com)
Keratinocytes are the most prevalent type of skin cells, comprising nearly 95% of the epidermis. (altogen.com)
Keratinocyte cells are tightly interwoven and form seams between the nerves and underlying tissues of the epidermis. (altogen.com)
The cells are also the principal source of the proinflammatory cytokine IL-1 in the epidermis. (altogen.com)

In cells expressing RPTPkappa RNAi, phosphorylation of Src at Tyr527 was increased and (activating) phosphorylation of Src at Tyr416 was reduced. (nih.gov)
We find that together with loss-of-function mutations in p53 and, to some degree, potentiated by cMyc overexpression, Dusp4 deletion aids in cell cycle checkpoint escape while simultaneously potentiating hallmarks of replicative stress, including multinucleation and Chk1 phosphorylation. (biomedcentral.com)
4HPR was able to decrease AKT phosphorylation also when powerfully upregulated by IGF-1 and, consequently, to impair IGF-1-stimulated cell motility. (biomedcentral.com)

Here, we show that IFN-β sensitizes glioma cells that harbor the unmethylated MGMT promoter and are resistant to temozolomide. (aacrjournals.org)
In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)

Lilli plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. (sdbonline.org)

CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)

To increase the sensitivity of our analysis, cells were co transfected with an e pression plasmid for LNGFR, which encodes a cytoplasmic trun cated, low affinity nerve growth factor receptor that is not e pressed on Jurkat cells, and therefore allows positive selection of transfected cells by mag netic separation. (kspinhibitors.com)

As we continued to study the TIP dendritic cell, we found many other markers that distinguish it from background dendritic cells. (dermatologytimes.com)

Airway progenitor cells contain two parental centrioles (PC) and form structures called deuterosomes that nucleate centrioles during amplification. (elifesciences.org)

Our results demonstrate that a cell-intrinsic surface area-dependent mechanism controls centriole and cilia abundance in multiciliated cells. (elifesciences.org)
Further, they demonstrate that MYC overexpression in concert with RB can promote a particularly aggressive form of TNBC. (elsevierpure.com)
These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)
In contrast to vascular malformations, electron microscopy and immunohistochemical techniques demonstrate irregular and fragmented basal lamina in the lymphatic malformations. (medscape.com)

In a vast majority of organs, distinct epithelial tissues form the parenchyma, whereas the stroma constitutes a complex compartment composed of different cell types including fibroblasts and myofibroblasts, vessel cells, pericytes, endothelial and smooth muscle cells, as well as immune cells such as macrophages, lymphocytes and mast cells. (biomedcentral.com)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
Processes involved in later stage disease, like development of androgen independence as a consequence of androgen depletion therapy, neoangiogenesis and homing of metastatic cells in lymphatic or bone tissues are generally undetectable at early stages. (biomedcentral.com)

Invasive cells are able to degrade the matri , pass through the pores Inhibitors,Modulators,Libraries of the polycarbonate mem brane, and attach either to the bottom of the membrane, or they migrate to the lower well after invasion. (kspinhibitors.com)

We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)

Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
Until recently, it was believed that they were tissue-specific…however, this concept has been challenged… (multipotent cells) can differentiate in vitro and in vivo into various cell types not only from the tissue of origin" (Can/Hematol 2008). (papersowl.com)

Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)

Anatomy28

Organisms11

Diseases21

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes71

Disciplines and Occupations1

Information Science3

Health Care2

Proliferation24

Apoptosis21

Induces cell cycle arrest2

Knockdown6

Differentiation12

Cellular17

Inhibits3

Mammary4

Mesenchymal4

Head and neck squamous cell carc3

Undergo2

Epithelial cell3

Regulation4

Murine7

Carcinoma14

Phenotype7

Tumors5

Promotes3

Inhibition5

Progression4

Progenitors2

Expression20

Epithelium7

Pathways5

HER21

Arrest2

Pathway5

Invasiveness1

Basement membrane2

Mutation3

Metabolic6

Autophagy4

Pluripotent stem2

Modulate1

Originate2

Genes6

Therapeutic6

Protein5

Stem27

Assay1

Replication5

Migration2

Apoptotic2

Survival2

Fascin6

Carcinomas4

Epidermis4

Phosphorylation3

Glioma3

Tumor suppressor1

Downstream1

Regulates cell1

Receptor1

Markers1

Airway1

Demonstrate4

Tissues3

Invasion1

Lymphatic2

Vitro2

Induce cell death1