• Clarence Cook Little begins to develop the first inbred strain, designated DBA for dilute, brown, and non-agouti. (jax.org)
  • L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
  • The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
  • Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
  • C57BL/6 (B6), C57BL/10 (B10), and SJL mice showed markedly suppressed secondary anti-DNP responses when infected. (uky.edu)
  • The same methodology was applied to MEL mice treated with the clinically approved anti-fibrotic drug nintedanib. (ibecbarcelona.eu)
  • The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
  • Peter Gorer shows in mouse studies at JAX that transplant rejection is primarily governed by what he calls the H2 genetic locus, later described as the major histocompatibility complex, a key component of immunity. (jax.org)
  • The fate of the human MSC injected IP into immune-competent mice was studied. (biomedcentral.com)
  • Attachment to the omentum and mesentery was accompanied by the recruitment of immune cells and changes in the production of a series of mouse cytokines. (biomedcentral.com)
  • BALB/c mice are a widely used general-purpose model in biomedical research. (hylascobio.in)
  • C3H/HeNCrl mice are a widely used animal model in biomedical research. (hylascobio.in)
  • Due to their well-defined genetic background, CD2F1 mice are valuable tools in biomedical research and have been used as a model for studying diseases and conditions such as cancer and immunological disorders. (hylascobio.in)
  • Additionally, BALB/c mice have been used extensively in hybridoma development and monoclonal antibody production. (hylascobio.in)
  • These mice are designated as CD2F1/Crl and are commonly used in various research applications, including safety and efficacy testing, transplantation research, and monoclonal antibody production. (hylascobio.in)