• June 10, 2018 - Atlanta, GA - In the first study of its kind, researchers from the New York-based Human Microbiology Institute have discovered the role certain bacteriophages may play in the onset of Parkinson's disease (PD). (asm.org)
  • Wallace will present the results from the Bacteriophage for Gastrointestinal Health (PHAGE) Study-the first clinical study in the Western hemisphere to provide patients with bacteriophages-at the American Society for Nutrition annual meeting, Nutrition 2018 , held June 9-12, 2018 in Boston. (medicalxpress.com)
  • Chapters guide readers through regulatory compliance and safety aspects of bacteriophage therapy. (springer.com)
  • Authoritative and cutting-edge, Bacteriophage Therapy: From Lab to Clinical Practice aims to ensure successful results in the further study of this vital field. (springer.com)
  • Having gained a BSc (Cardiff University, UK) and PhD (University of Reading, UK), he has worked in the contract biomedical research industry and for AmpliPhi Biosciences Corporation (formerly Biocontrol Ltd) on the commercial development of bacteriophage therapy products. (springer.com)
  • Bacteriophage cell-wall hydrolases, or lysins, have recently been exploited for their bacteriolytic activity as an alternative to antibiotic therapy ( 1 , 2 ). (pnas.org)
  • These may be used, among others, in the constantly developing bacteriophage therapy. (turbosquid.com)
  • An attractive mechanism under evaluation, and in current use in some countries, is bacteriophage therapy. (atcc.org)
  • Despite these drawbacks, there have been numerous studies depicting bacteriophage therapy as a safe possible alternative to antibiotic therapy in the treatment of bacterial infections. (atcc.org)
  • Based on the high lytic activity and the potential of resistance optimization by direct adaption of bacteriophages as reported in this study, and in view of the continuing increase of antibiotic resistance worldwide, bacteriophage therapy is a promising treatment option for UTIs highly warranting randomized controlled trials. (frontiersin.org)
  • However, bacteriophage therapy (3) is only currently allowed in human medicine in certain countries such as Poland, Georgia and Russia. (lesaffre.com)
  • The range of infections treated by bacteriophage therapy, whether authorised or tolerated on an exceptional basis, is quite wide (including the treatment of infected wounds, gastro-intestinal infections, infections of the respiratory, osteoarticular, urinary and genital tracts, etc. (lesaffre.com)
  • Although a senior account executive in the pharmaceutical industry, at the time she was diagnosed she was unfamiliar with the treatment that would cure her: bacteriophage therapy. (heartland.org)
  • Juhala, R.J., M.E. Ford, R.L. Duda, A. Youlton, G.F. Hatfull, and R.W. Hendrix (2000) Genomic sequences of bacteriophages HK97 and HK022: pervasive geneti mosaicism in the lambdoid bacteriophages . (factbites.com)
  • On May 8, 2019, Nature Medicine Published online "Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus. (emaxhealth.com)
  • Experiments in mice revealed that 75% of those infected with a lethal dose of Pseudomonas survived if the antibiotic gentamicin was administered in the presence of bacteriophages. (bio-medicine.org)
  • The intention is to provide a definitive reference work on the technological and therapeutic applications of bacteriophages. (springer.com)
  • Being natural predators of bacteria, bacteriophages have been long considered as potential therapeutic agents. (news-medical.net)
  • Dr Ben Burrowes gained his PhD in Medical Microbiology from Texas Tech University Health Sciences Center in 2010, where his research focus was the development of therapeutic bacteriophages with extended host range using in vitro evolution. (springer.com)
  • Lytic bacteriophages have shown clinical promise as therapeutic agents for topical or systemic treatments of bacterial infections ( 11 ) or for their ability to block and subvert essential host metabolic pathways ( 12 ). (pnas.org)
  • 1 Because bacteriophages are species-specific, and in some cases strain-specific, they can be used to target the infecting pathogen without harming human cells or surrounding microflora. (atcc.org)
  • Host specificity of these bacterial viruses are also an issue, where an infecting bacterial species would need to be identified in order to determine which bacteriophage is optimal for use. (atcc.org)
  • In addition, the comparative analysis of multiple bacteriophages from a single bacterial species offers a unique opportunity to study the mechanisms driving prokaryotic genetic diversity, including lateral gene transfer and illegitimate recombination ( 4 , 8 - 10 ). (pnas.org)
  • Antibacterial Efficacy of Lytic Bacteriophages against Antibiotic-Resistant Klebsiella Species," TheScientificWorldJOURNAL , vol. 11, pp. 1332-1340, 2011. (hindawi.com)
  • Some bacteria species including E. coli , Streptococcus pyogenes (causes flesh-eating disease), Vibrio cholerae (causes cholera), and Shigella (causes dysentery) become harmful when genes that produce toxic substances are transferred to them via bacteriophages. (thoughtco.com)
  • This volume details the experimental approaches suitable for isolating and characterizing bacteriophages to formulating bacteriophage medicinal products and clinical application. (springer.com)
  • He was the founder, CEO and CSO of Biocontrol Limited and CSO of AmpliPhi Biosciences and managed the first modern regulated clinical trial to demonstrate the efficacy of bacteriophages. (springer.com)
  • The first regulated, randomized, double-blind clinical trial was reported in the Journal of Wound Care in June 2009, which evaluated the safety and efficacy of a bacteriophage cocktail to treat infected venous leg ulcers in human patients. (wikipedia.org)
  • Despite the absence of lytic bacteriophages, two of the clinical isolates studied contained mitomycin C-inducible prophages. (innovations-report.com)
  • Graham Hatfull (University of Pittsburgh/HHMI) Part 1: Bacteriophages: What are they? (youtube.com)
  • In Part 1, Hatfull describes what bacteriophage are, some of their biological properties and how they were discovered. (youtube.com)
  • The work is the first to demonstrate the safe and effective use of engineered bacteriophages in a human patient, says Graham Hatfull, a Howard Hughes Medical Institute (HHMI) Professor at the University of Pittsburgh. (emaxhealth.com)
  • In October 2017, Hatfull received the email that set his team on a months-long bacteriophage-finding quest. (emaxhealth.com)
  • Two years later, the Russian bacteriologist Gamaleya observed a similar phenomenon while working with Bacillus subtilis ( 48 ), and the observations of several other investigators are also thought to have been related to the bacteriophage phenomenon ( 72 ). (asm.org)
  • Bacteriophage T4 presents numerous technical advantages as a model for studying virus reproduction or gene organisation and expression. (els.net)
  • First, can we address deficiencies in past simulations and measurements of bacteriophage T7 to improve models of gene expression? (mit.edu)
  • Bacteriophages are numerically the most abundant DNA-containing entities in the oligotrophic ocean, yet how specific phage populations vary over time and space remains to be fully explored. (asm.org)
  • The ability of bacteriophages to impart novel biochemical and physiological properties not only provides the host with the opportunity to adapt to new environments, but, in some instances, confers novel virulence properties associated with pathogenesis in human bacterial infections. (pnas.org)
  • Use of polyvalent bacteriophages to combat biofilm of Proteus mirabilis causing catheter-associated urinary tract infections. (urotoday.com)
  • I. The appeal lies from the decision of the examining division posted on 20 January 2006, by which the European patent application No. 97 916 278.1 published as WO 97/39111 with the title 'Compositions containing bacteriophages and methods of using bacteriophages to treat infections', was refused under Article 97(1) EPC 1973. (epo.org)
  • Bacteriophages were discovered independently by Frederick Twort in 1915 and Felix d'Herelle in 1917-a full decade before the discovery of penicillin. (biospace.com)
  • However, for various reasons-including financial difficulties ( 68 , 70 )-Twort did not pursue this finding, and it was another 2 years before bacteriophages were "officially" discovered by Felix d'Herelle, a French-Canadian microbiologist at the Institut Pasteur in Paris. (asm.org)
  • Molecular tools and enzymes derived from the study of bacteriophage (see text for details). (els.net)
  • Gindreau E and Lonvaud‐Funel A (1999) Molecular analysis of the region encoding the lytic system from Oenococcus oeni temperate bacteriophage phi 10MC. (els.net)
  • zebrafish and mice, bacteriophage T4 still presents the best opportunities for understanding at the molecular level DNA replication and recombination, and macromolecular assembly. (els.net)
  • Molecular analysis of the g23 sequence revealed a remarkable level of diversity of T4-type bacteriophages isolated from rice straw and surface soil in a Japanese rice field. (wiley.com)