• In mammalian hosts, iron is tightly bound to proteins such as hemoglobin, transferrin, lactoferrin and ferritin. (wikipedia.org)
  • Lactoferrin is a 77-kDa iron-binding protein to which a wide variety of divergent biologic functions have been ascribed. (nih.gov)
  • It has recently been reported that lactoferrin interacts with bacterial lipopolysaccharide (LPS) in such a fashion as to affect the binding of lactoferrin to myeloid cells. (nih.gov)
  • Lactoferrin prevents hydroxyl radical formation by binding iron, even at low pH. (nih.gov)
  • Lactoferrin inhibited LPS priming of neutrophils if LPS contamination of the protein (provided by commercial suppliers) was first reduced. (nih.gov)
  • These results show that LPS should not be expected to affect the free radical biology of lactoferrin, which is a crucial physiologic function of this protein. (nih.gov)
  • Lactoferrin is an intriguing protein with an interesting structure and several known or suggested biological activities. (kisch-online.de)
  • In this book, experts from a variety of disciplines describe the present knowledge of the structural features of lactoferrin, its carbohydrate side chains and its capacity to bind different metal ions and anions. (kisch-online.de)
  • Several of the possible physiological functions of lactoferrin are described in detail, including the role of lactoferrin in bacterial killing, its involvement in growth and proliferation, in immune function and in iron absorption. (kisch-online.de)
  • Catecholamine stress hormones are in a position to bind transferrin and lactoferrin, to kind direct complexes with ferric iron, and to scale back ferric to ferrous iron with subsequent liberation from transferrin (Sandrini et al. (wagergun.com)
  • This capability of stress hormones to mediate bacterial iron acquisition from transferrin and lactoferrin has been proposed to perform in biofilm formation in intravenous lines by the Gram-optimistic bacterium S. (wagergun.com)
  • The results of recently conducted clinical trials suggest that lactoferrin, an iron-binding protein that is abundant in mammalian colostrum and milk, may be an effective agent in preventing sepsis in newborns. (springer.com)
  • However, despite numerous basic studies on lactoferrin, very little is known about how metal saturation of this protein affects a host's health. (springer.com)
  • There was also no change in the production of tight junction proteins regardless of lactoferrin metal saturation status. (springer.com)
  • Lactoferrin that was not bound to its cognate receptor was able to bind and neutralize lipopolysaccharide. (springer.com)
  • Lactoferrin (Lf) is an 80-kDa glycoprotein that belongs to the transferrin family and is abundant in the colostrum and milk of mammals. (springer.com)
  • Lactoferrin (Lf) is an iron-binding milk glycoprotein that promotes the growth of selected probiotic strains. (encyclopedia.pub)
  • Bovine and human milk contains a wide array of bioactive components, including the iron-binding glycoprotein known as lactoferrin (Lf). (encyclopedia.pub)
  • Activated lactoferrin (ALF) is a new form of a naturally occurring protein from milk that acts as a powerful deterrent to pathogenic bacteria that may be present on a meat surface. (ift.org)
  • Lactoferrin binding protein B (LbpB) is a bi-lobed outer membrane-bound lipoprotein that comprises part of the lactoferrin (Lf) receptor complex in Neisseria meningitidis and other Gram-negative pathogens. (ucalgary.ca)
  • Although a widening range of siderophore functions is now being appreciated, siderophores are among the strongest (highest affinity) Fe3+ binding agents known. (wikipedia.org)
  • Early-arriving proteins may be partially or wholly displaced by later-arriving proteins that have a greater affinity for the particular surface, a phenomenon widely known as the Vroman effect [ 950 , 1442 ]. (nanomedicine.com)
  • If nanorobots have a higher affinity for protein binding sites than certain drugs used in concert with the nanorobots during a nanomedical treatment, then those drugs could be displaced, consequently increasing the number of biologically active drug molecules and increasing the risk of toxic drug levels [ 5489 ]. (nanomedicine.com)
  • Its ability to bind two Fe +3 ions with high affinity, in cooperation with two HCO 3 - ions, contributes to its major structure-functional properties, including antimicrobial activity. (ift.org)
  • The high-affinity interaction of LF with pore-forming outer-membrane proteins (OMPs) of Gram-negative enterics, including Escherichia coli , is critical for the antimicrobial outcome of LF (Gado et al. (ift.org)
  • In this work FrpB3 was purified by haem-affinity chromatography and its capacity of haem-binding was analyzed. (walshmedicalmedia.com)
  • A glycoprotein albumin from hen's egg white with strong iron-binding affinity. (lookformedical.com)
  • The principle of glycan structure profiling analysis using LecChip™ is based on the lectin to glycan binding affinity. (bmgrp.com)
  • Fortunately, evanescent-field fluorescence excitation allows for generation of lectin-glycan affinity data from unwashed samples by taking advantage of the higher signal strength of specifically bound glycans. (bmgrp.com)
  • Besides siderophores, some pathogenic bacteria produce hemophores (heme binding scavenging proteins) or have receptors that bind directly to iron/heme proteins. (wikipedia.org)
  • In bacteria, Fe2+-dependent repressors bind to DNA upstream to genes involved in siderophore production at high intracellular iron concentrations. (wikipedia.org)
  • Meningitis-causing bacteria exerted strong evolutionary pressure on an iron-binding protein in primates, a study shows. (the-scientist.com)
  • In primates, the iron-carrying protein transferrin likely evolved to inhibit meningitis-causing bacteria from scavenging iron, an essential but limited nutrient, researchers reported last week (December 11) in Science . (the-scientist.com)
  • A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. (bvsalud.org)
  • Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum. (bvsalud.org)
  • coli and Salmonella produce invasins that bind host cells, thus inflicting the cells toA) release TNF.B) produce iron-binding proteins.C) engulf the bacteria.D) destroy the micro organism.E) launch cytokines. (wagergun.com)
  • It is best in case of planktonic micro organism and less efficient in the eradicating of encapsulated bacteria and bacterial L-varieties. (wagergun.com)
  • 1993). Accordingly, specific LF-binding microbial targets exist in a variety of Gram-positive and Gram-negative bacteria (Naidu et al. (ift.org)
  • The interaction of LF with microbial surfaces-OMPs of Gram-negative bacteria in particular-has led to other antimicrobial mechanisms, such as the inhibition of microbial attachment to sub-epithelial matrix proteins and detachment of bacteria from mucosal surfaces. (ift.org)
  • The protein project is working on characterizing the proposed Fet3p-Ftr1p type Fe 2+ uptake system in Gram negative bacteria. (ecu.edu)
  • It induces both local effects in the gut, as well as alterations in distant organs through stimuli generated by bacteria, structural bacterial components, and microbial metabolites [ 7 ]. (biomedcentral.com)
  • In response to iron limitation in their environment, genes involved in microbe siderophore production and uptake are derepressed, leading to manufacture of siderophores and the appropriate uptake proteins. (wikipedia.org)
  • 2010). Free iron can then be used for bacterial development through other specific iron uptake techniques. (wagergun.com)
  • Upon Fe3+ uptake, transferrins undergo a large scale conformational transition: the apo structure with an opening of the interdomain cleft is transformed into the closed holo structure, implying initial Fe3+ binding in the open form. (lookformedical.com)
  • The majority of iron is intracellular, bound within the iron storage proteins (ferritin and haemosiderin) or associated with proteins in the form of haem. (vitaminexpert.co.uk)
  • Transferrin-bound iron enters target cells (erythroid, immune, and hepatic cells) is stored as ferritin (the major iron storage protein). (vitaminexpert.co.uk)
  • among other well-known iron-binding proteins such as hemoglobin, ferritin and transferrin, but also perhaps because its biological functions are so diverse. (kisch-online.de)
  • We feel that attention on this protein has been too limited and diffuse, partly because it has been "hidden" among other well-known iron-binding proteins such as hemoglobin, ferritin and transferrin, but also perhaps because its biological functions are so diverse. (scienzaonline.com)
  • Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. (icr.ac.uk)
  • I am interested in exploring the role of transition metal ions in various biological systems, with an emphasis on protein-metal ions interactions. (ecu.edu)
  • They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released. (umassmed.edu)
  • Tracking the abundance of TfR on the cell surface and the internalization of its ligand transferrin revealed that USMB acutely enhances the rate of CME. (plos.org)
  • 2016, Ligand binding specificity of the Escherichia coli periplasmic histidine binding protein, HisJ. (ecu.edu)
  • VEGF transcription leads to Ras frame in a Ras-guanine state curvature ligand( GEF) NOX2 protein. (erik-mill.de)
  • For example, the anthrax pathogen Bacillus anthracis releases two siderophores, bacillibactin and petrobactin, to scavenge ferric ion from iron containing proteins. (wikipedia.org)
  • 2016 , FecB, a periplasmic ferric-citrate transporter from E. coli, can bind different forms of ferric-citrate as well as a wide variety of metal-free and metal-loaded tricarboxylic acids. (ecu.edu)
  • Matthew Barber and Nels Elde from the University of Utah School of Medicine compared transferrin-encoding genes from 21 primate species, and found remarkable variation at sites known to interact with a bacterial transferrin binding protein, TbpA. (the-scientist.com)
  • A further investigation of transferrin sequence differences among humans revealed a variant that was unable to interact with the TbpA protein from H. influenzae . (the-scientist.com)
  • and tbpA and hgbB, transferrin-binding protein and hemoglobin-binding protein genes involved in iron acquisition. (biomedcentral.com)
  • Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. (frontiersin.org)
  • Despite its small genome and limited number of effector proteins, Ehrlichia efficiently establishes an intracellular infection and avoids immune defenses in vertebrate and invertebrate hosts through complex molecular and cellular reprogramming strategies. (frontiersin.org)
  • Western Blot: NOD2 Antibody (2D9) [NB100-524] - HCMV infection induces NOD2 mRNA and protein in HFFs and U373 cells. (novusbio.com)
  • The majority of the up-regulated cytokines are involved in the IL-23/IL-17 cytokine-regulated network, which is crucial for host defense against bacterial infection. (biomedcentral.com)
  • Elevated neutrophils levels are typically a sign of a recent or ongoing bacterial infection. (goodbodyclinic.com)
  • microbiology of a "slow" bacterial infection. (microbiologyresearch.org)
  • Recombinant human NOD2 protein corresponding to residues 28-301. (novusbio.com)
  • Two of them: FrpB1 and FrpB2 were purified as recombinant proteins and their haem- or haemoglobin-binding capability was demonstrated. (walshmedicalmedia.com)
  • Similar inhibition of LPS priming was observed when neutrophils were incubated with other serum proteins (e.g., albumin, apotransferrin, or iron-saturated transferrin). (nih.gov)
  • With many hundreds of plasma proteins (the predominant plasma protein is albumin) to choose from, unmodified implanted devices may quickly adsorb a monolayer containing many proteins in a distribution of conformational and orientational states. (nanomedicine.com)
  • One early strategy to try to accomplish this in implants was to coat the artificial surface with an adsorbed protein, usually bovine serum albumin (BSA) or high-density lipoproteins, to serve as cell adhesion inhibiting proteins that would resist the adsorption of other proteins. (nanomedicine.com)
  • The 2 major types of protein present in the serum are albumin and the globulin proteins. (medscape.com)
  • Albumin is the major protein component of serum and represents the largest peak that lies closest to the positive electrode. (medscape.com)
  • Cells constitutively utilize several distinct mechanisms of endocytosis, including clathrin-mediated endocytosis (CME) for the internalization of receptor-bound macromolecules such as Transferrin Receptor (TfR), and distinct mechanism(s) that mediate the majority of fluid-phase endocytosis. (plos.org)
  • specifically acted, the FGFR preventing download manual of structural kinesiology 2011 traffics found by intracellular intracellular matrix proteins. (erik-mill.de)
  • I am also interested in determining the electrochemical properties of proteins, containing redox active metal centers (Hemoglobin, myoglobin, Hemoglobin-haptoglobin complex etc.) using spectroelectrochemical technique. (ecu.edu)
  • Antimicrobial properties may include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. (icr.ac.uk)
  • This protein displays antimicrobial, anti-inflammatory, and immunomodulatory activities that contribute to the maintenance of homeostasis and to the control of life-threatening diseases in the intestine of consumers, mainly in neonates [ 1 ] . (encyclopedia.pub)
  • The antimicrobial functionality of LF is dependent on its protein conformation and milieu conditions (Naidu and Arnold, 1997). (ift.org)
  • An in silico analysis has shown that H. pylori genome has a family of three outer membrane protein regulated by iron (FrpB). (walshmedicalmedia.com)
  • Previously, two serotyping systems were developed based on the bacterial capsular antigens or the lipopolysaccharide (LPS) antigens which assigned P. multocida isolates into five serogroups (A, B, D, E and F) (Carter 1955 ) and/or 16 serovars (serovars 1 ~ 16), respectively (Heddleston et al. (biomedcentral.com)
  • Iron is exported into the circulation, where it binds to transferrin, which is able to bind iron tightly but reversibly, and is transported to sites of use and storage. (vitaminexpert.co.uk)
  • Mass spectrometry-guided optimization and characterization of a biologically active transferrin-lysozyme model drug conjugate. (umassmed.edu)
  • We describe the design and synthesis of a novel set of iso-baric tags for quantitative glycan profiling, which will have broad applications in carbohydrate based biomarker dis-covery, therapeutic protein characterization, and vaccine development. (nist.gov)
  • Receptors, Transferrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Receptors, Transferrin" by people in this website by year, and whether "Receptors, Transferrin" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Receptors, Transferrin" by people in Profiles. (umassmed.edu)
  • Haem iron is absorbed into the enterocytes by a haem carrier protein 1, a membrane protein found in the intestine. (vitaminexpert.co.uk)
  • Western Blot: NOD2 Antibody (2D9) [NB100-524] - Whole cell protein from THP-1 cells was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. (novusbio.com)
  • Both 3D models showed that they are structurally conserved because they have the typical barrel structure, which is inserted in membrane, also, the motifs necessary for Hb-binding were identified in all the structures. (walshmedicalmedia.com)
  • This bacterium synthesizes three membrane proteins of 48, 50 and 77 kDa capable of binding haem, unfortunately their identities remains undetermined [ 17 ]. (walshmedicalmedia.com)
  • DOC 28 KB) Additional file 3: Figure S3: Cumulative effect of BDSF and AHL systems in regulation of bacterial motility, biofilm formation, and protease production. (pdesignal.com)
  • 2020 , Investigating the roles of the conserved Cu 2+ -binding residues on Brucella FtrA in producing conformational stability and functionality. (ecu.edu)
  • Relative to its homolog, transferrin-binding protein B (TbpB), there currently is little evidence for its role in iron acquisition and relatively little structural and biophysical information on its interaction with Lf. (ucalgary.ca)
  • Our results are consistent with LbpB serving dual roles focused primarily on iron acquisition when exposed to limited levels of iron-loaded Lf on the mucosal surface and effectively binding apo Lf when exposed to high levels at sites of inflammation. (ucalgary.ca)
  • H. pylori habits an environment, where the availability of iron is limited [ 11 ], and has a large amount of proteins for acquisition iron for instance metalloproteins [ 12 , 13 - 16 ]. (walshmedicalmedia.com)
  • After protein quantification, 500 μg of each cell lysis was added with 1 μg of CD44 monoclonal antibody and shaken at 4°C overnight, then added with 40 μL of Protein A-agarose and shaken at 4°C for 2 h, finally centrifuged at 2500 rpm for 5 min and washed to collect the precipitation. (pdesignal.com)
  • Absolute quantification of viral proteins during single-round replication of MDCK suspension cells. (mpg.de)
  • A Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C- and O-Mannosylated Peptides. (mpg.de)
  • In light of rising antibiotic resistance, "people have been toying with providing patients with more transferrin" to fight infections, Elde told Not Exactly Rocket Science. (the-scientist.com)
  • Cytopathic results are changes in host cells due toA) viral infections.B) protozoan infections.C) fungal infections.D) bacterial infections.E) helminthic infections. (wagergun.com)
  • High leukocyte counts (Leukocytosis) may indicate bacterial infections, autoimmune disease or side effects from medications. (slidetodoc.com)
  • Liver disease, autoimmune disease, chronic viral or bacterial infections and various malignancies may cause a polyclonal rise in the gamma fraction (see Table 2 below). (medscape.com)
  • Mutants of residues in the transition-metal ion-binding site severely affect transport, whereas a mutation of a conserved histidine located near this site results in metal ion transport that appears uncoupled to proton transport. (nature.com)
  • The final model, which comprises 5312 protein atoms (residues 1 to 686) and 28 carbohydrate atoms (from two monosaccharides attached to Asn(473)), gives an R-factor of 0.231 for the 11,989 observed reflections between 20.0- and 3.0-A resolution. (lookformedical.com)
  • a messenger ribonucleic acid (mRNA) comprising an open reading frame encoding a betacoronavirus (BetaCoV) S protein or S protein subunit formulated in a lipid nanoparticle. (patentdocs.org)
  • Two bacterial species, Haemophilus influenzae and Neisseria meningitidis , are among the main causes of meningitis, a life-threatening inflammation of the membranes surround the brain and spinal cord. (the-scientist.com)
  • In general, fungi use transporters of the major facilitator protein superfamily, quite than ABC transporters, for siderophore internalization (Haas et al. (wagergun.com)
  • The membranes inhibitory for the NTs download manual of structural kinesiology 2011 of sufficient synapsis and homodimeric excitability corepressor of protein by ciliary early transporters and tails are found in this domain as six unintegrated dynamics: protein 1. (erik-mill.de)
  • Lectins are glycan binding proteins and each lectin will only bind to particular glycans. (bmgrp.com)
  • If a washing process is applied to the LecChip™ to remove non-lectin binding redundant glycoproteins, many of the specifically bound glycans are also lost. (bmgrp.com)
  • By contrast, the nonprotein and protein fractions of cow milk had similar growth-promoting effects on B . infantis , B . bifidum , and B . breve [ 5 ] . (encyclopedia.pub)
  • The form depends on the balance of nonprotein and protein sources of energy. (msdmanuals.com)
  • Gonococcal transferrin-binding protein 2 facilitates however just isn't essential for transferrin utilization. (wagergun.com)
  • Here, we examined landscapes of realized homologous recombination of 500 genomes from ten bacterial species and found all species have "hot" regions with elevated rates relative to the genome average. (ox.ac.uk)
  • For example, ribosomal proteins showed low recombination in all of the species. (ox.ac.uk)
  • Among specific genes, transferrin-binding proteins are recombination hot in all three of the species in which they were found, and are subject to interspecies recombination. (ox.ac.uk)
  • Proteins which are found in eggs (OVA) from any species. (lookformedical.com)
  • Protein separation conditions always pose the risk of denaturation or structural alteration of the LF molecule. (ift.org)
  • Alternative structural state of transferrin. (lookformedical.com)
  • An analysis of milk fractions separated by ultrafiltration demonstrated that, in human milk, the bifidogenic activity of the nonprotein fraction (containing glycans, among other components) was greater than that of the protein fraction for B . Pennsylvanicus, B. bifidum, and B . longum [ 5 ] . (encyclopedia.pub)
  • These findings may reflect the divergent composition of glycans and proteins in human and cow milk. (encyclopedia.pub)
  • The Cy3 molecules attached to glycans that have successfully bound to lectins will fluoresce and the total LecChip™ fluorescence pattern can be captured with the scanner. (bmgrp.com)
  • Serum protein electrophoresis (SPEP) is an easy, inexpensive method of separating proteins based on their net charge, size, and shape. (medscape.com)
  • [ 1 ] Globulins comprise a much smaller fraction of the total serum protein but represent the primary focus of interpretation of serum protein electrophoresis. (medscape.com)
  • Various disease states or conditions alter the pattern of proteins in electrophoresis (see Table 1 below). (medscape.com)
  • Monoclonal pattern serum protein electrophoresis (SPEP). (medscape.com)
  • Acute phase reactants are proteins that rise or fall in the presence of inflammation. (rmalab.com)
  • This depends, in turn, upon whether specific active peptide sequences in specific proteins are accessible to arriving cells such as neutrophils and macrophages. (nanomedicine.com)
  • Bacteriostasic effect is enhanced when LF binds to a microbial cell surface (Dalamastri et al. (ift.org)
  • H. pylori express FrpB1, FrpB2 and FrpB3 proteins to scavenge iron and they are regulated according to availability of iron source, maybe in order to withstand the extreme environment present in the stomach. (walshmedicalmedia.com)
  • The nature of case reporting and notification varies across the region, with many countries using bacterial meningitis as an IMD case definition in lieu of meningitis and septicemia. (bvsalud.org)
  • Neisseria meningitidis , a leading cause of bacterial meningitis and septicemia globally, causes ≈1.2 million invasive meningococcal disease (IMD) cases annually and a case-fatality rate of 11% ( 1 ). (cdc.gov)
  • Ø All antibodies are in a class of proteins called Immunoglobulins. (slidetodoc.com)
  • A dense narrow band that is composed of a single class of immunoglobulins secreted by an abnormally expanded clone of plasma cells is known as M-protein (paraprotein, monoclonal protein or M-component). (medscape.com)
  • Forced expression of lcn2 or treatment with LCN2 protein increased the sensitivity of astrocytes to cytotoxic stimuli. (jneurosci.org)
  • Crabtree J. E. , Taylor J. D. , Wyatt J. I. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. (microbiologyresearch.org)
  • Helicobacter pylori is a gram-negative spiral bacterial, has been associated with peptic ulcers, gastritis, duodenitis, and is believed to be the causative agent of gastric cancer. (walshmedicalmedia.com)
  • Co-immunoprecipitation The protein was extracted from cells before and after transfection with the method described in Western Blot section. (pdesignal.com)
  • In eukaryotic cells, chromatin comprises a complex consisting of DNA, RNA, and proteins where covalent modifications correlate with regulation of gene expression [ 1 ]. (biomedcentral.com)
  • The concentrations of total protein samples were measured and normalized. (pdesignal.com)
  • Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). (jensenlab.org)
  • Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. (umassmed.edu)
  • This protein was identified by mass spectrometry and its expression was quantified by real time technique under different human iron sources. (walshmedicalmedia.com)
  • While bacillibactin has been shown to bind to the immune system protein siderocalin, petrobactin is assumed to evade the immune system and has been shown to be important for virulence in mice. (wikipedia.org)
  • A model showing the structure of the human transferrin protein WIKIMEDIA, EMW Damaging toxins and antibody-epitope interactions are frequently the battlegrounds of host-pathogen arms races, but a new study suggests a role for a different, so-called "nutritional" immune system. (the-scientist.com)
  • M. Sprintz notes that the binding of plasma proteins has relevance to the displacement of other highly protein-bound drugs, such as phenytoin (Dilantin), barbiturates, propranolol, and benzodiazepines. (nanomedicine.com)
  • Lipocalin 2 (lcn2) is a member of the lipocalin family that binds to small hydrophobic molecules. (jneurosci.org)
  • As a result of the toxicity of free iron and its low solubility in the presence of oxygen and neutral pH conditions, organisms have been forced to develop proteins (e.g., transferrin) that are able to bind Fe3+ and maintain its stable form but, simultaneously, make it available for biological processes. (vitaminexpert.co.uk)
  • A variety of local and systemic cellular processes may be triggered depending upon which proteins are adsorbed to the surface (e.g., as opsonins) and their biological activity. (nanomedicine.com)
  • Cell adhesion, thrombogenicity, foreign body response and other reactions to implanted materials are related to the amount of adsorbed proteins, hence as an implanted object shrinks to smaller sizes (i.e., to micron-scale) the biological signal to local cell populations can increase enormously because the total amount of protein adsorbed on the implant mass is much greater. (nanomedicine.com)
  • The non-specific adsorption of blood proteins on nanorobot surfaces could lead to clinical difficulties such as thrombosis and unwanted protein-mediated recognition interactions such as cell-nanorobot and nanorobot-nanorobot adhesion (aggregation). (nanomedicine.com)
  • The Lf N-lobe is also capable of binding to negatively charged regions of the LbpB C-lobe and possibly other sites such that a variety of higher order complexes are formed. (ucalgary.ca)
  • The axonal transmembrane decreases in the bind negatively from modification class, and acts named the proteasome-mediated signal. (erik-mill.de)
  • Comparative analysis of transferrin and IgG N-glycosylation in two human populations. (mpg.de)
  • In the last decade, filamentous M13 bacteriophage has emerged into numerous biotechnological applications as a promising nontoxic and self-assembling biomaterial with specific binding properties. (nist.gov)
  • Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). (jensenlab.org)
  • Cy3 labeled glycoproteins are applied to the LecChip™ surface which then bind to specific lectins on the chip. (bmgrp.com)
  • Considered generally recognized as safe (GRAS) by the Food and Drug Administration and recently approved by the U.S. Dept. of Agriculture for use on fresh beef, ALF can be sprayed onto carcasses to help prevent bacterial contamination during processing or can be applied to a subprimal or finished beef surface prior to final packaging to inhibit bacterial growth and extend shelf life. (ift.org)