Bacterial surface adhesins. Medical search. Frequent questions

In molecular biology, YadA is a protein domain which is short for Yersinia adhesin A. These proteins have strong sequence and structural homology, particularly at their C-terminal end. (wikipedia.org)
The YadA protein domain adheres to the following substrates: epithelial cells extracellular matrix collagen cellular fibronectin laminin The C-terminal domain consists of 120 amino acids which belong to a family of surface-exposed bacterial proteins. (wikipedia.org)
The interaction of LF with microbial surfaces-OMPs of Gram-negative bacteria in particular-has led to other antimicrobial mechanisms, such as the inhibition of microbial attachment to sub-epithelial matrix proteins and detachment of bacteria from mucosal surfaces. (ift.org)
Fibrillar adhesins are proteins located on the bacterial cell surface, which mediate interactions with the environment, e.g. with host cells or other bacteria. (embl-em.de)
These proteins usually have a stalk, which helps them cross the bacterial cell surface and be projected closer to their targets - regardless of what they are trying to bind to. (embl-em.de)
As no surface expressed α-actinin was found on any of the eight cell lines examined, and as Opc interactions with endothelial cells in the presence of serum lead to bacterial entry into the target cells, we examined the possibility of the two proteins interacting intracellularly. (bris.ac.uk)
Here we present a protocol for visualisation and quantification of the colocalisation of the bacterium with intracellular proteins after bacterial entry into human endothelial cells, although the procedure is also applicable to human epithelial cells. (bris.ac.uk)
This study of bacterial biofilm proteins can be used in the manufacture of kits for the detection of infectious diseases such as caries in the oral cavity. (kemdikbud.go.id)
Pneumococcal surface proteins represent challenging candidates for the development of new therapeutic targets against the bacteria. (biomedcentral.com)
Availability of genome sequences facilitated the identification of pneumococcal surface proteins bearing characteristic motifs such as choline-binding proteins (Cbp) and peptidoglycan binding (LPXTG) proteins. (biomedcentral.com)
We designed a medium throughput approach to systematically test for interactions between these pneumococcal surface proteins and host proteins (extracellular matrix proteins, circulating proteins or immunity related proteins). (biomedcentral.com)
We cloned, expressed and purified 28 pneumococcal surface proteins. (biomedcentral.com)
We conclude that whether peptidoglycan binding proteins do not appear to be major adhesins, most of the choline-binding proteins interact with host proteins (elastin and C reactive proteins are the major Cbp partners). (biomedcentral.com)
It now appears clearly that cell-surface proteins participate in many stages of the colonization process and/or the disease transition. (biomedcentral.com)
We demonstrate that S. salivarius expresses three large and glycosylated surface‐exposed proteins - SrpA, SrpB and SrpC - that show characteristics of SRR glycoproteins and are secreted through the accessory SecA2/Y2 system. (helmholtz-hzi.de)
Surface proteins involved in the adhesion of Streptococcus salivarius to human intestinal epithelial cells. (helmholtz-hzi.de)
Bacteria attach to the host by exposing the specialised proteins on its surface. (vibrant-itn.eu)
As these proteins are adhesive in nature, they are known trimeric autotransporter adhesins (TAA). (vibrant-itn.eu)

Viral and Bacterial Adhesion Network Training (ViBrANT) places adhesion at the heart of virulence: it plays the first and decisive role in the infection process of pathogens. (europa.eu)
Fluid flow is thought to prevent bacterial adhesion, but some bacteria use adhesins with catch bond properties to enhance adhesion under high shear forces. (biorxiv.org)
However, many studies on bacterial adhesion either neglect the influence of shear force or use shear forces that are not typically found in natural systems. (biorxiv.org)
Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. (wakehealth.edu)
Pathogenesis varies based on the strain, but it can include toxin production, invasion of the mucosal surface, and adhesion with alteration of enterocyte structure. (lecturio.com)
Two classes have been characterized: toxins, biological and surface adhesion molecules that affect the ability of the microorganism to invade and colonize a host. (lecturio.com)
Bacterial adhesion is a critical step for colonization of the host. (helmholtz-hzi.de)
Serine‐rich repeat (SRR) glycoproteins are a family of adhesins that fulfil an important role in adhesion. (helmholtz-hzi.de)
Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. (qub.ac.uk)
The unique architecture of this newly recognized superlectin correlates with multiple functions including bacterial cell cross-linking, adhesion to human epithelia, and stimulation of inflammation. (qub.ac.uk)
However, this study demonstrated the surface adhesion-related properties of Blp1 protein that strongly left 4 dead 2 free download its role as a bacterial adhesin. (mahavirelectricalsfurnitures.com)

Differences in architecture and cell-surface morphology were observed in biofilms formed by the M1- and M41-wild-type strains, accompanied by varying amounts of deposited extracellular matrix and differences in cell-to-cell junctions within each biofilm. (cdc.gov)
Pathogens use adhesins to colonize tissues and cause infections, to bind host molecules for immune evasion and, for bacteria, to create antibiotic-resistant biofilms on implanted devices. (europa.eu)
Bacterial biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and relapses. (mdpi.com)
What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin. (wakehealth.edu)
Regarding the effects of green tea polyphenols on the S. moorei colonization properties, it was found that biofilm formation on EGCG-treated surfaces was significantly affected, and that green tea extract and EGCG can cause the eradication of pre-formed S. moorei biofilms. (biomedcentral.com)
But the bacterial growth in biofilms requires a varied but coordinated transcriptional, proteomic and metabolomic profile. (microbialcell.com)
Finally, bioinformatic analysis shows the widespread abundance of cupE genes in isolates of P. aeruginosa and the co-occurrence of cupE with other cup clusters, suggesting interdependence of cup pili in regulating bacterial adherence within biofilms. (cam.ac.uk)
Lo que en ocasiones se denomina adhesina polimérica (BIOFILMS) es distinta de la adhesina proteica. (bvsalud.org)

Like many bacteria, Enterococcus faecalis encodes a number of adhesins involved in colonization or infection of different niches. (nih.gov)
IMPORTANCE Most bacteria express multiple adhesins that contribute to surface attachment and colonization. (nih.gov)
Further experiments showed that compared to bacteria grown in liquid culture, bacterial cells in the resistant colonies had often acquired multiple spacers and were able to fight off phages with other mutations ( Figure 1 , right). (elifesciences.org)
Bacteria and viruses adhere to different surfaces, to each other, to host molecules or to host cells. (europa.eu)
This work has fed into WP3 and WP4, demonstrating that biosensors can be used to detect the presence of adhesins on the outside of bacteria, opening a route to point-of-care diagnostics (WP4). (europa.eu)
Activated lactoferrin (ALF) is a new form of a naturally occurring protein from milk that acts as a powerful deterrent to pathogenic bacteria that may be present on a meat surface. (ift.org)
The development of antibiotic resistance in periodontopathogens is a major issue given that these bacteria may migrate from the oral cavity to other organs where they may cause infections or transfer their antibiotic resistances to other bacterial species. (nature.com)
On surfaces, bacteria swarm collectively in a thin layer of fluid powered by the rotation of rigid helical filaments, they twitch by assembling and disassembling type IV pili, they glide by driving adhesins along tracks fixed to the cell surface and, finally, non-motile cells slide over surfaces in response to outward forces due to colony growth. (uncommondescent.com)
We determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram-negative Escherichia coli bacteria can form extracellular amyloid and Gram-negative bacteria have been reported as the predominant bacteria found in normal human brains. (neurology.org)
Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. (wakehealth.edu)
In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. (wakehealth.edu)
By understanding how bacteria interact with biotic or abiotic surfaces, researchers can start to explore how drugs can be used to target these interactions, or whether the bacteria living in our bodies or our environments can be changed. (embl-em.de)
The green sulfur bacterial epibionts are related to more 'typical' green sulfur bacteria, complete with chlorosomes and an autotrophic reverse TCA pathway to assimilate carbon. (asmblog.org)
Bacterial gliding is defined as steady movement over a surface, of bacteria that have neither flagella nor pili. (harvard.edu)
Streptococcus pneumoniae is a common bacteria of the commensal flora and together with other bacterial species, colonizes the nasopharyngeal niche and upper respiratory tract. (biomedcentral.com)
Three models of Mtb biofilm formation have been proposed to study the factors regulating biofilm formation, the physiology of the resident bacteria, and the nature of the biomaterial that holds these bacterial masses together. (microbialcell.com)
There are many advantages of studying bacteria in the planktonic cultures such as development of a homogenous population of bacterial cells having similar transcriptomic, proteomic and metabolomic profile etc. (microbialcell.com)
Chaperone-Usher Pathway (CUP) pili are major adhesins in Gram-negative bacteria, mediating bacterial adherence to biotic and abiotic surfaces. (cam.ac.uk)
To combat this situation our approach is to exploit the very first step of bacterial infection, that is adherence of bacteria to the host. (vibrant-itn.eu)
Many adhesins from staphylococci, including clumping factor A (ClfA) and ClfB, are known to contain minisatellite SDR (serine-aspartate repeats) that converts host fibrinogen to fibrin and promotes its agglutination with fibrin fibrils, thereby shielding bacteria from immune defenses. (tmu.edu.tw)
Most bacterial nosocomial pneumonias occur by aspiration of bacteria colonizing the oropharynx or upper gastrointestinal tract of the patient. (cdc.gov)

Bacterial adherence to the uroepithelium is recognized as an important mechanism in the initiation and pathogenesis of urinary tract infections (UTI). (uwo.ca)
Knowledge of bacterial adherence mechanisms may permit alternative methods of prevention and management of urinary infection, including the use of subinhibitory concentrations of antibiotics, vaccine development, nonimmune inhibition of bacterial adhesins and receptor sites, and the use of autochthonous flora, such as lactobacilli, to exclude uropathogens from colonizing the urinary tract. (uwo.ca)
The surface protein Srr-1 of Streptococcus agalactiae binds human keratin 4 and promotes adherence to epithelial HEp-2 cells. (helmholtz-hzi.de)
Following entry into the circulation, S. aureus expresses a family of surface protein adhesins that mediate the adherence of the organism to extracellular matrix (ECM) components of the host. (tmu.edu.tw)
The ability of Elizabethkingia meningoseptica isolate CH2B from freshwater tilapia ( Oreochromis mossambicus ) and E. meningoseptica strain NCTC 10016 T to adhere to abiotic surfaces was investigated using microtiter plate adherence assays following exposure to varying physico-chemical challenges. (biomedcentral.com)
The role of cell-surface properties was investigated using hydrophobicity (bacterial adherence to hydrocarbons), autoaggregation and coaggregation assays. (biomedcentral.com)
Both isolates displayed a hydrophilic cell surface following the bacterial adherence to xylene assay. (biomedcentral.com)

This study advances our understanding of how E. faecalis , a ubiquitous member of the human gut microbiome and an opportunistic pathogen, uses multiple surface structures to evolve and thrive. (nih.gov)
In this study, we use microfluidics and single-cell imaging to examine how the human pathogen Pseudomonas aeruginosa interacts with surfaces when exposed to shear forces typically found in the human body (0.1 pN to 10 pN). (biorxiv.org)
Recall that an adhesin is a protein or glycoprotein found on the surface of a pathogen that attaches to receptors on the host cell. (pressbooks.pub)
Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium. (ox.ac.uk)
Staphylococcus aureus is a major bacterial pathogen that can cause a range of diseases from mild skin infections to life-threatening sepsis in humans. (tmu.edu.tw)
The bacterial foodborne pathogen Listeria monocytogenes clonal 41 complex 1 (Lm-CC1) is the most prevalent clonal group associated with listeriosis, and is 42 strongly associated with cattle and dairy products. (cdc.gov)
Borrelia burgdorferi , an emerging bacterial pathogen, is maintained in nature by transmission from one vertebrate host to another by ticks. (cdc.gov)

Intracellular events, such as blocking of microbial attachment factors such as fimbriae (hairlike structures) and other adhesins (putative receptors), have been observed (Naidu and Bidlack, 1998). (ift.org)
Recall that fimbriae are hairlike protein bristles on the cell surface. (pressbooks.pub)
Type 1 fimbrial adhesin allows the fimbriae of ETEC cells to attach to the mannose glycans expressed on intestinal epithelial cells. (pressbooks.pub)

The YadA protein domain, is a form of trimeric autotransporter adhesins (TAAs). (wikipedia.org)

Two well-studied E. faecalis adhesins, aggregation substance (AS) and endocarditis- and biofilm-associated pili (Ebp), both contribute to biofilm formation on abiotic surfaces and in endocarditis, suggesting that they may be expressed at the same time. (nih.gov)
Here, we examined two well-characterized adhesins in Enterococcus faecalis , aggregation substance and endocarditis- and biofilm-associated pili, and found that they exhibit distinct functional contributions depending on the growth stage of the bacterial community. (nih.gov)
Pili interfere with aggregation substance-mediated clumping and plasmid transfer under planktonic conditions, whereas the two adhesins structurally complement one another during biofilm development. (nih.gov)
Uropathogenic Escherichia coli (UPEC) attach specifically to human bladder cells using surface structures known as type 1 pili. (esrf.fr)
Imaging CupE pili on the surface of P. aeruginosa cells using electron cryotomography shows that CupE pili adopt variable curvatures in response to their environment, which might facilitate their role in promoting cellular attachment. (cam.ac.uk)

Attachment further allows more interactions and increase of biofilm formation to aid bacterial colonization. (wikipedia.org)
Bacterial surface motility is important for colonization, biofilm formation and pathogenicity. (harvard.edu)
There are a number of challenges to applying GWAS to bacterial infections, including the difficulty of obtaining matched controls, multiple strain colonization and the possibility that causative strains may not be present when disease is detected. (biomedcentral.com)

Similarly, this kind of close-up on bacterial interactions is essential for infection biology, to help researchers map what molecular mechanisms help pathogens find, invade host cells, and then survive and proliferate within them. (embl-em.de)
Every year, millions of people die of infectious diseases worldwide, most of which are caused by pathogens invading the host via mucosal surfaces, including the respiratory tract. (bmj.com)
Table 16.7 lists common adhesins found in some of the pathogens we have discussed or will be seeing later in this chapter. (pressbooks.pub)
The principal physiological characteristic of lactoferrin as an antibacterial agent is binding to the iron and or sequestering iron as an important requirement for maximum bacterial pathogens . (diabetesasia.org)

In general, Gram‐positive bacterial genomes have a unique SRR glycoprotein‐encoding gene. (helmholtz-hzi.de)
The aCL antibodies bind to b2GPI, or a complex formed by this b2GPI is a platelet adhesin glycoprotein and cardiolipin. (medscape.com)

The ability of E. meningoseptica isolates to adhere to abiotic surfaces and form biofilm structures may result from the hydrophilic cell surface and multiple adhesins located around the cell. (biomedcentral.com)

Simplistically, this means the protein is made of three of the same subunits, on the outer surface of the membrane. (wikipedia.org)
In this study, we demonstrate that surface-associated streptococcal collagen-like protein-1 (Scl1) plays an important role in GAS biofilm formation. (cdc.gov)
Furthermore, the Scl1 protein expressed on the surface of a heterologous host, Lactococcus lactis, was sufficient to induce biofilm formation by this organism. (cdc.gov)
CONCLUSIONS: Overall, this work (i) identifies variations in biofilm formation capacity among pathogenically different GAS strains, (ii) identifies GAS surface properties that may aid in biofilm stability and, (iii) establishes that the Scl1 surface protein is an important determinant of GAS biofilm, which is sufficient to enable biofilm formation in the heterologous host Lactococcus. (cdc.gov)
ESR12 studied the interactions of M-protein, the main virulence factor and adhesin of Streptococcus pyogenes. (europa.eu)
By state-of-the-art sequencing ESR6&7 showed that Bartonella henselae adhesin A (BadA) is nearly 4000 residues long (not ≈3000), and with ESR12 determined which parts of this very long protein bound human fibronectin as a promising basis for novel antimicrobial therapies. (europa.eu)
Viruses 14: v14040792 (2022)), and mapped 59 host protein interactions to the viral surface. (europa.eu)
The Opc protein of Neisseria meningitidis (Nm, meningococcus) is a surface-expressed integral outer membrane protein, which can act as an adhesin and an effective invasin for human epithelial and endothelial cells. (bris.ac.uk)
We observed time-dependent increase in colocalisation of Nm with the cytoskeletal protein, which was considerable after an eight hour period of bacterial internalisation. (bris.ac.uk)
Milk lactoferrin is one multifunctional protein to sell bacterial clearance. (diabetesasia.org)

The human urinary tract is one of the most common sites of bacterial infection and most of them are caused by uropathogenic Escherichia coli (UPEC). (esrf.fr)
Bacterial translocation from the gut and subsequent immune activation are hallmarks of HIV infection and are thought to determine disease progression. (prelekara.sk)
Intestinal barrier integrity is impaired early in acute retroviral infection, but levels of plasma lipopolysaccharide (LPS), a marker of bacterial translocation, increase only later. (prelekara.sk)
Macrophages are essential in controlling systemic bacterial translocation, and this function might be hindered in chronic HIV infection. (prelekara.sk)

We have identified endothelial surface-located integrins as major receptors for Opc, a process which requires Opc to first bind to integrin ligands such as vitronectin and via these to the cell-expressed receptors1. (bris.ac.uk)

Considered generally recognized as safe (GRAS) by the Food and Drug Administration and recently approved by the U.S. Dept. of Agriculture for use on fresh beef, ALF can be sprayed onto carcasses to help prevent bacterial contamination during processing or can be applied to a subprimal or finished beef surface prior to final packaging to inhibit bacterial growth and extend shelf life. (ift.org)

The surface is entirely covered in the YadA lollipop structures. (wikipedia.org)
ViBrANT provided Europe-wide world-class training to our 15 students (ESR1-15) through bottom-up research: clinical microbiology, functional studies of adhesins, elucidating structures and designing new diagnostic tests and devices. (europa.eu)
Anyone working on bacterial adhesive structures can find the AlphaFold structure model from Monzon's paper , as well as the random forest prediction results in this institutional repository of the University of Cambridge . (embl-em.de)

The N-terminal domain is a novel TNF-alpha-like fucose-binding lectin, while the C-terminal part is similar to a superfamily of calcium-dependent bacterial lectins. (qub.ac.uk)
The protective effect afforded by the secretor gene might be due to the ability of glycocompounds in the body fluids of secretors to inhibit adhesins (attachment lectins) on the surface of the yeast. (n-equals-one.com)

According to research, iron sequestration through apo-Lf can successfully inhibit the increase of many bacterial species because of iron deprivation and maybe completely ( Berlutti et al. (diabetesasia.org)

Thereafter, depending on host factors and bacterial virulence factors, the organisms may further ascend and give rise to pyelonephritis. (uwo.ca)

Bacteriostasic effect is enhanced when LF binds to a microbial cell surface (Dalamastri et al. (ift.org)
We propose that BC2L-C binds to the bacterial surface in a mannose/heptose-dependent manner via the C-terminal domain. (qub.ac.uk)
The Helicobacter pylori adhesin BabA binds mucosal ABO/Le(b) blood group (bg) carbohydrates. (diamond.ac.uk)

2009). Lactoferrin consequences towards Gram-advantageous microorganisms are binding to anionic molecules, including lipoteichoic acid , and saving you the attachment of that microorganism to the host mobile surfaces ( Queiroz et al. (diabetesasia.org)
Iron difficulty in mucosal secretions , as the first protection line towards microorganisms, hinders bacterial increase. (diabetesasia.org)

Furthermore, the immobilization of LF to mucosal surfaces containing sulfated glycans such as heparan sulfate or its closely related analogs, including galactose-rich polysaccharide (a water-soluble fraction from agar) and carrageenans, were found to enhance the antimicrobial spectrum of LF multi-fold. (ift.org)
can penetrate and traverse intact eukaryotic cells, facilitating entry from mucosal surfaces. (msdmanuals.com)
produce IgA-specific proteases that cleave and inactivate secretory IgA on mucosal surfaces. (msdmanuals.com)
IgA is the predominant immunoglobulin class produced at mucosal surfaces. (msdmanuals.com)

BabA facilitates bacterial attachment to gastric surfaces, increasing strain virulence and forming a recognized risk factor for peptic ulcers and gastric cancer. (diamond.ac.uk)
Partial inhibition of coaggregation was observed when isolate CH2B was treated with heat or protease exposure, suggesting the presence of heat-sensitive adhesins, although sugar treatment resulted in increased coaggregation and may be associated with a lactose-associated lectin or capsule-mediated attachment. (biomedcentral.com)
In attachment studies, preincubation of certain bacterial spores with boiled secretor saliva significantly reduced their ability to bind to epithelial cells. (n-equals-one.com)

However, capsule-specific opsonic antibodies can bind to the bacterial capsule and facilitate phagocytosis. (msdmanuals.com)

Two black lines indicate the position of the usher within the bacterial outer-membrane. (esrf.fr)

Adhesins, Bacterial" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)

Recent technological advances, especially in cryo-electron microscopy, have greatly improved our knowledge of the molecular machinery that powers the various forms of bacterial motility. (uncommondescent.com)
Bacterial motility: machinery and mechanisms. (uncommondescent.com)
Discovery of the gliding motor is a significant advance towards our understanding of surface motility. (harvard.edu)

However, the network and relationships between the various adhesins of a single bacterial species are less well understood. (nih.gov)

In summary, the GAS surface adhesin Scl1 may have an important role in biofilm-associated pathogenicity. (cdc.gov)

It forms the fibrillar matrix on the bacterial cell surface. (wikipedia.org)
Fibrillar adhesins are essential for bacterium-host interactions, but they also evolve quickly, which makes them difficult to study. (embl-em.de)
Excitingly, our analysis yielded over 6,500 fibrillar adhesins, many of which had never been seen before. (embl-em.de)

The first subunit to be engaged is FimH, the adhesin at the very tip of the pilus, and subsequent subunits are added one at a time from the base up. (esrf.fr)
The adhesin subunit FimH is in green (FimH L and FimH p stand for the lectin and the pilin domains respectively) and the periplasmic chaperone FimC is in yellow. (esrf.fr)

The tea extracts and components displayed various degrees of antibacterial activity that may involve damage to the bacterial cell membrane and the chelation of iron. (nature.com)
Their effects on bacterial cell membrane integrity were investigated by transmission electron microscopy and a fluorescence-based permeability assay. (biomedcentral.com)
Transmission electron microscopy analysis and a permeabilization assay brought evidence that the bacterial cell membrane was the target of green tea polyphenols. (biomedcentral.com)

One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, anti-fibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). (kemdikbud.go.id)
Also it could change anti-bacterial lipids and prolong survival of MRSA in wound. (powershow.com)
Anti-bacterial agents. (bvsalud.org)

Endotoxin triggers humoral enzymatic mechanisms involving the complement, clotting, fibrinolytic, and kinin pathways and causes much of the morbidity in gram-negative bacterial sepsis. (msdmanuals.com)

Here, we use comparative genomics approaches to understand how genetic variation amongst bacterial strains influences disease progression. (biomedcentral.com)

Sections on the prevention of bacterial pneumonia in mechanically ventilated and/or critically ill patients, care of respiratory-therapy devices, prevention of cross-contamination, and prevention of viral lower respiratory tract infections (e.g., respiratory syncytial virus {RSV} and influenza infections) have been expanded and updated. (cdc.gov)
A particulate matter: How environmental irritants and particulate matter increase sensitivity to bacterial respiratory tract infections. (lu.se)

Evidently, interaction of the adhesins with a surface causes the cells to glide. (harvard.edu)
It shall be noted that these components impart a hydrophobic character to the mycobacterial cell surface that facilitates cell to cell interaction. (microbialcell.com)

Consists of thick polysaccharide capsule (slime layer adhesin). (powershow.com)

Because intubation and mechanical ventilation alter first-line patient defenses, they greatly increase the risk for nosocomial bacterial pneumonia. (cdc.gov)

On 13thAugust, 2018 I covered a distance of 6,744km to be a part of the Innovative Training Network ViBrANT (Viral and Bacterial Adhesin Network Training). (vibrant-itn.eu)

When growing in a liquid environment (left), individual bacterial cells usually acquire a single spacer that targets just one region of the wild-type (WT) phage (shown in grey). (elifesciences.org)
When growing on a solid surface (right), if an individual cell acquires, say, a pink spacer, it will go on to form a colony of phage resistant cells (inset). (elifesciences.org)
In order to stay protected, some bacterial cells within the colony acquire multiple spacers (multi-colored bacterial cells) and can fight off various mutant phages. (elifesciences.org)
Pyenson and Marraffini hypothesized that this is because bacterial cells move more freely when in this environment and are thus able to work together to defend themselves ( Figure 1 , left). (elifesciences.org)
We discover that at lower shear forces, type IV pilus retraction tilts cells away from the surface, promoting surface departure. (biorxiv.org)

They also prevented biofilm formation by F. nucleatum at concentrations that did not interfere with bacterial growth. (nature.com)

The data show that Gram-negative bacterial molecules are associated with AD neuropathology. (neurology.org)

Anatomy9

Organisms18

Diseases2

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes24

Information Science3

Proteins18

Adhesion11

Biofilms8

Bacteria21

Adherence7

Pathogen7

Fimbriae3

Trimeric Autotransporter Adhesins1

Pili5

Colonization3

Pathogens4

Glycoprotein2

Multiple adhesins1

Protein10

Infection4

Receptors1

Prevent bacterial1

Structures3

Lectins2

Inhibit1

Virulence factors1

Binds3

Microorganisms2

Mucosal surfaces4

Attachment3

Antibodies1

Outer membrane1

MeSH1

Motility3

Species1

Biofilm-associated1

Fibrillar3

Subunit2

Cell membrane3

Anti-bacterial3

Sepsis1

Strains1

Infections2

Interaction2

Polysaccharide1

Nosocomial1

Viral1

Cells5

Interfere1

Molecules1