• Cm r E. coli prey cells were incubated with the V. cholerae predator strains indicated at a ratio of 1:10 on membrane filters on LB agar to measure bacterial killing. (nih.gov)
  • The bacterial pathogen Vibrio cholerae can occupy both the human gut and aquatic reservoirs, where it may colonize chitinous surfaces that induce the expression of factors for three phenotypes: chitin utilization, DNA uptake by natural transformation, and contact-dependent bacterial killing via a type VI secretion system (T6SS). (nih.gov)
  • The effects of the bacterial preparation method on the activation of innate signalling pathways by the common opportunistic pathogen Staphylococcus epidermidis (SE) are unknown. (edu.au)
  • One possible approach would be to enhance the innate immune response of the infected host, which would restore the defense ability to kill the bacterial pathogen in a relatively risk-free manner ( 5 ). (frontiersin.org)
  • any observed bacterial killing is the combined effect of low concentrations in relation to minimum inhibitory concentration and the action of host factors such as neutrophils and macrophages. (nih.gov)
  • The presence of OG1RF_12399-12402 is not required for E. faecalis colonization of the mouse intestine but is associated with an accelerated onset of experimental colitis in interleukin-10-deficient mice, altered bacterial composition in the colon, enhanced E. faecalis survival within macrophages, and increased proinflammatory cytokine secretion by colon tissue and macrophages. (asm.org)
  • Since rough mutants of B. melitensis are protected from extracellular complement-mediated killing, we decided to investigate whether the attenuation in virulence previously observed in these strains was associated with differences in their interaction with macrophages. (asm.org)
  • Since viscoelasticity of biofilms has been related with antimicrobial penetration, but not yet with bacterial killing, this study aims to relate killing of P. aeruginosa in its biofilm-mode of growth by three antimicrobials with biofilm viscoelasticity. (rug.nl)
  • P. aeruginosa in LB-grown biofilms were killed most by exposure to tobramycin, colistin or an antimicrobial peptide, while ASM+ provided the most protective matrix with less water and most insoluble polysaccharides and eDNA. (rug.nl)
  • The study by the labs of Professor Liz Sockett and Dr Andrew Lovering at the Universities of Nottingham and Birmingham offers insights into early steps in the evolution of bacterial predators and will help to inform new ways to fight antimicrobial resistance. (healthcanal.com)
  • The research, published in Nature Communications , offers insights into early steps in the evolution of bacterial predators and will help to inform new ways of combatting antimicrobial resistance. (eurekalert.org)
  • Impaired bicarbonate transport because of the defective CFTR could cause increased acidity in the ASL, which the study shows reduces the ASL bacterial killing capability. (scienceblog.com)
  • The lymphocyte-enhanced epithelial HCO(3)- secretion and bacterial killing activity was abolished when Calu3 cells were co-cultured with lymphocytes from CFTR knockout mice, or significantly reduced by interfering with E-cadherin, a putative binding partner of CFTR. (blogspot.com)
  • Moreover, making the airway liquid less acidic with a simple solution of baking soda restores bacterial killing in CF airways to almost normal levels. (scienceblog.com)
  • These studies provide basic molecular insights into MAC assembly and bacterial killing by the immune system. (bioportfolio.com)
  • Using newly developed transgenic mice expressing a bioluminescent ATP probe on the cell surface, we found that extracellular ATP levels increase during sepsis, indicating that ATP may contribute to bacterial killing in vivo. (jci.org)
  • Pharmacological targeting of P2X4Rs with the allosteric activator ivermectin protects against bacterial dissemination and mortality in sepsis. (jci.org)
  • In conclusion, results suggest a novel neutrophil defect potentially contributing to the defective bacterial clearance observed in the CF airways and suggest that manipulation of the TIM-3 signaling pathway may be of therapeutic value in CF, preferably in conjunction with antiprotease treatment. (jimmunol.org)
  • Materials and Methods: Mononuclear cell cytokine expression patterns induced by live (LSE), heat-killed (HKSE) and ethanol-killed SE (EKSE) were characterized at the transcriptional and translational level. (edu.au)
  • We generated E. faecalis strains containing deletions/point mutations in this PTS and measured bacterial growth and PTS gene expression in minimal medium supplemented with selected carbohydrates. (asm.org)
  • Constitutive contact-dependent killing of Escherichia coli prey, which is indicative of a functional T6SS, was rare among clinical isolates (only 4 of 29) but common among environmental isolates (22 of 24). (nih.gov)
  • OBJECTIVE: To characterize the population pharmacokinetics and pharmacodynamics of oral grepafloxacin in patients with acute bacterial exacerbations of chronic bronchitis (ABECB), with particular attention to the speed of bacterial killing. (hindawi.com)
  • The amphipathic structure of HDPs plays an important role in the process of endotoxin removal as well as in bacterial killing through hydrophobic and electrostatic interaction with toxic lipid A. This interaction occurs when the positively charged fragments within HDPs attract negatively charged phosphates of lipids A, and the hydrophobic fragments of HDPs bind with lipid A fatty acid moieties. (springer.com)
  • Diversity of Clinical and Environmental Isolates of Vibrio cholerae in Natural Transformation and Contact-Dependent Bacterial Killing Indicative of. (nih.gov)
  • These results bolster the pathoadaptive model in which tight regulation of T6SS-mediated bacterial killing is beneficial in a human host, whereas constitutive killing by environmental isolates may give a competitive advantage in natural settings. (nih.gov)
  • therefore, bacterial killing requires both in situ conversion of C5 and immediate insertion of C5b67 into the membrane. (bioportfolio.com)
  • It terrorized centuries of humans and was known to kill entire groups of children in families. (listverse.com)
  • Five dolphins were killed by a disease that is better known for killing cattle, but researchers don't know whether oil from the BP spill played a role in their deaths, or in the strandings since last February of another 580 marine mammals along the northern Gulf of Mexico coast, most of which were bottlenose dolphins. (parade.com)
  • Careful attention to time-related events such as speed of bacterial killing versus global endpoints such as bacteriologic cure allows optimal break points to be defined. (nih.gov)
  • Using a unique animal model of CF, a team of scientists from the University of Iowa has discovered a surprising difference between healthy airways and airways affected by CF that leads to reduced bacterial killing in CF airways. (scienceblog.com)
  • This disease has killed quite a few famous people, including Franz Kafka and Henry David Thoreau. (listverse.com)
  • β-peptide polymer-modified PA beads are efficient in bacterial killing and endotoxin adsorption. (springer.com)
  • Ankyrin-Mediated Self-Protection During Cell Invasion by the Bacterial Predator Bdellovibrio bacteriovorus, Nature Communications . (eurekalert.org)