• Several "Flandersviridae" phages encode enzymes of the isoprenoid pathway, a lipid biosynthesis pathway that so far has not been known to be manipulated by phages. (biomedcentral.com)
  • Geranylgeranyl reductase (GGR) is a flavin-containing redox enzyme that hydrogenates a variety of unactivated polyprenyl substrates, which are further processed mostly for lipid biosynthesis in archaea or chlorophyll biosynthesis in plants. (biomedcentral.com)
  • The contemporary archaea , comprising of methanogens, halobacteria and thermoacidophiles, are living under extreme conditions reminiscent of primitive environment and may indicate the origin of one ancient evolution path of lipid biosynthesis. (mdpi.com)
  • Toward this goal, we are pursuing studies of bacterial isoprenoid biosynthetic enzymes comprising the methylerythritol phosphate (MEP) pathway essential in many human pathogens. (hopkinsmedicine.org)
  • Studies focus on understanding mechanism and regulation in the pathway toward the development of selective inhibitors of isoprenoid biosynthesis. (hopkinsmedicine.org)
  • Deep genome analysis, identified MVA pathway involved in biosynthesis of isoprenoids, more precisely "Squalene. (bvsalud.org)
  • 2 C -methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) catalyzes the conversion of 4-diphosphocytidyl-2 C -methyl-D-erythritol-2-phosphate to 2 C -methyl-D-erythritol-2,4-cyclodiphosphate and cytidine monophosphate in production of isoprenoid-precursors via the methylerythritol phosphate biosynthetic pathway. (biomedcentral.com)
  • For the new study, researchers placed their central focal point toward a pathway known as methyl-D-erythritol phosphate (MEP), associated with the biosynthesis of isoprenoids in bacterial cells. (mentaldaily.com)
  • Here I studied the control of the isoprenoid pathway during plant-pathogen interactions using tobacco and its fungal pathogen Phytophthora. (tamu.edu)
  • Both strains have native metabolic pathways generating prenyl pyrophosphate precursors for the terpene biosynthesis, namely, the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway in E. coli and the mevalonate (MVA) pathway in S. cerevisiae [ 6 ]. (biomedcentral.com)
  • UPPS lies between FPPS and UPPP in the cell wall biosynthesis pathway and we have leads that inhibit [UPPS+UPPP] or [UPPS+FPPS], some active in vivo , that also synergize with other antibiotics. (illinois.edu)
  • The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has come under increased scrutiny as a target for novel antimalarial, antibacterial and herbicidal agents. (unboundmedicine.com)
  • Two distinct biosynthetic routes supply the universal isoprenoid-precursors isopentenyl pyrophosphate and dimethylallyl pyrophosphate. (biomedcentral.com)
  • During my Ph.D. studies I collaborated with Shigeru Okada from the University of Tokyo on cloning isoprenoid hydrocarbon biosynthetic genes from the green microalgae Botryococcus braunii . (tamu.edu)
  • The two biosynthetic pathways for terpene monomer biosynthesis are the mevalonate and 1-deoxy- d -xylulose 5-phosphate pathways, where pyruvate is ultimately converted into either of the C 5 terpene building blocks, isopentenyl pyrophosphate or dimethylallyl pyrophosphate [ 1 , 2 ]. (biomedcentral.com)
  • A Versatile Tool for Biosynthetic Study of Isoprenoids. (nii.ac.jp)
  • We hypothesize that isoprenoid biosynthesis enzymes, prenylsynthases and prenyltransferases, involved in cell wall and quinone biosynthesis, represent a new generation of targets whose inhibition will lead to new drug leads that synergize with existing antibiotics. (illinois.edu)
  • This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides. (shengsci.com)
  • Genes coding for defense-related transcription activators, reactive oxygen species metabolism, terpene biosynthesis, and energy conversion pathways were upregulated in inoculated samples of L. dendroidea , indicating an integrated defensive system in seaweeds. (asm.org)
  • During iron starvation, HapX represses iron-consuming pathways, including heme biosynthesis and respiration, to spare iron and activates synthesis of ribotoxin AspF1 and siderophores, the latter partly by ensuring supply of the precursor, ornithine. (frontiersin.org)
  • This was accomplished following the introduction of isoprenoid biosynthesis pathways. (openwetware.org)
  • In a 2010 publication, LS9, Inc. reported the discovery of alkane biosynthesis pathways in a diverse set of cyanobacteria. (openwetware.org)
  • Furthermore, genome analysis of this strain suggested the presence of gene clusters involved in iron acquisition ( fhuABD , afuABC , fbpABC , and fepCDG ) and phosphate solubilization ( pstABCHS , phoABHLU , and phnCDEP ) and other phytohormone biosynthesis genes, including indole-3-acetic acid ( trpABCDEFG ), in the genome. (springeropen.com)
  • More knowledge is required on the functional and allelic diversity of terpene synthase (TPS) genes responsible for the biosynthesis of volatile terpenes to assist in flavour-directed hop breeding. (biomedcentral.com)
  • ll human pathogens, including bacterial pathogens and malaria parasites, with the ultimate objective of developing potential therapeutic agents. (hopkinsmedicine.org)
  • My research interests range from the molecular and biochemical mechanisms involved in the resistance of plants against pathogens to the biosynthesis of hydrocarbon compounds by algae that can be used as fuel in modern combustion engines. (tamu.edu)
  • Microbial toluene biosynthesis was reported in anoxic lake sediments more than three decades ago, but the enzyme catalyzing this biochemically challenging reaction has never been identified. (jbei.org)
  • Recent genomics investigations have predicted a large untapped reservoir of bacterial terpene synthases residing in the genomes of uncultivated organisms living in the soil, indicating a vast array of putative terpenoids waiting to be discovered. (biomedcentral.com)
  • We aimed to develop a high-throughput functional metagenomic screening system for identifying novel terpene synthases from bacterial metagenomes by relieving the toxicity of terpene biosynthesis precursors to the Escherichia coli host. (biomedcentral.com)
  • As mono or diiron center as well as incorporated into heme or iron-sulfur clusters, this metal is an indispensable cofactor for a variety of cellular processes including electron transport, amino acid metabolism, and biosynthesis of DNA and sterols. (frontiersin.org)
  • Directly targeting menaquinone (MK), which plays an important role in bacterial electron transport, is an appealing, yet underexplored, mode of action due to a dearth of MK-binding molecules. (nature.com)
  • First, it is a vital enzyme for synthesis of isoprenoids in algae, plants, several eubacteria including the pathogenic bacteria like Bacillus anthracis, Helicobacter pylori, Yersinia pestis, Mycobacterium tuberculosis and the malarial parasite, Plasmodium falciparum. (unboundmedicine.com)
  • However, these approaches have been limited in the prediction of bacterial TSs because of their low levels of sequence similarity to plant and fungal TSs and their relatively low mutual similarities [ 17 ]. (biomedcentral.com)
  • Fungal polyketide biosynthesis - a personal perspective. (shengsci.com)
  • This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. (shengsci.com)
  • For example, isoprenoids have been considered as a promising precursor of alternative fuels, but reduction of isoprenoid double bonds is required to decrease the reactivity and sensitivity to oxidation and make them better fuels. (biomedcentral.com)
  • Biosynthesis and incorporation of an alkylproline-derivative (APD) precursor into complex natural products. (shengsci.com)
  • More recently, researchers engineered strains of E. coli and yeast with the capacity to produce taxidene and other isoprenoid compounds [ 4 ][ 6 ]. (openwetware.org)
  • Recently, the sterol regulatory element binding protein SrbA was found to be essential for adaptation to iron starvation, thereby linking regulation of iron metabolism, ergosterol biosynthesis, azole drug resistance, and hypoxia adaptation. (frontiersin.org)
  • A distance-based phylogenetic treeyielded a classification into 11 subfamilies, nine exclusively containingplant sequences and two subfamilies of bacterial proteins. (embl.de)
  • SlMYC1 Regulates Type VI Glandular Trichome Formation and Terpene Biosynthesis in Tomato Glandular Cells. (uva.nl)
  • From the findings: "The prodrugs we describe here synergize the direct killing of bacteria with a simultaneous rapid immune response by cytotoxic γδ T cells, which may limit the increase of antibiotic-resistant bacterial populations. (mentaldaily.com)
  • By expanding knowledge about seaweed-bacterium interactions and about the integrated defensive system in seaweeds, this work offers the basis for the development of tools to increase the resistance of cultured seaweeds to bacterial infections. (asm.org)
  • I did my B.S. (1991) and M.S. (1993) studies at Michigan Technological University where I studied with John Adler working on the biosynthesis of insect molting hormones in plants as a defense mechanism against insect attack. (tamu.edu)
  • Other names in common use include isoprenoid alcohol kinase, isoprenoid alcohol phosphokinase, C55-isoprenoid alcohol phosphokinase, isoprenoid alcohol kinase (phosphorylating), C55-isoprenoid alcohol kinase, C55-isoprenyl alcohol phosphokinase, and polyisoprenol kinase. (wikipedia.org)
  • The taxonomicdistribution of these families extracted from the Pfam protein familydatabase showed that members of the polyketide cyclase family and theactivator of Hsp90 ATPase homologue 1 family were distributed among allthree superkingdoms, while members of some bacterial families wereconfined to a small number of species. (embl.de)
  • The typical bacterial scenario seemed to be a two-component sHsps system of two homologous sHsps, such as the Escherichia coli sHsps IbpA and IbpB. (cipsm.de)