Bacterial infections microbial biofilms. Medical search. Frequent questions

Moreover, the occurrence of antibiotic-resistant bacteria in the clinical environment is dramatically growing, making treatment of bacterial infections very challenging. (who.int)
The biofilm bacteria can share nutrients and are sheltered from harmful factors in the environment, such as desiccation, antibiotics, and a host body's immune system. (wikipedia.org)
They can be found very early in Earth's fossil records (about 3.25 billion years ago) as both Archaea and Bacteria, and commonly protect prokaryotic cells by providing them with homeostasis, encouraging the development of complex interactions between the cells in the biofilm. (wikipedia.org)
The first colonist bacteria of a biofilm may adhere to the surface initially by the weak van der Waals forces and hydrophobic effects. (wikipedia.org)
Hydrophobicity can also affect the ability of bacteria to form biofilms. (wikipedia.org)
1,2 The unique structure of biofilms protects bacteria from the surrounding environment, conferring a capacity for persistence against phagocytosis, oxidative stresses, nutrient/oxygen restriction, metabolic waste accumulation, interspecies competition, and conventional antimicrobial agents. (rsc.org)
2,9-11 A comprehensive understanding of the interactions between bacteria and materials with different surface topographies may pave the way for more effective strategies to control biofilm growth. (rsc.org)
Bacterial attachment is favoured on recessed portions of patterned surfaces, and bacteria tend to attach preferentially to patterns in the micro or nanometre range rather than to smooth surfaces. (rsc.org)
As much as we large lifeforms are dogged by teeny, single-celled bacterial pathogens, they, too, get infected - by bacteria-specific viruses called bacteriophages ("phages" for short). (stanford.edu)
But, the scientists demonstrated, P. aeruginosa - as well as other species of biofilm-producing bacteria - can team up with a family of phages that, instead of destroying the bacterial cells they invade, join them in constructing the bacterial equivalent of a gummy termite's nest and rendering the bacteria extremely antibiotic-resistant. (stanford.edu)
Biofilm is a complex matrix consisting of extracellular polysaccharides, DNA, and proteins that protect bacteria from a variety of physical, chemical, and biological stresses allowing them to survive in hostile environments. (intechopen.com)
Bacteria can be found in planktonic form or in specific conditions, as sessile aggregates on both biotic and abiotic surfaces originating complex structures known as biofilm. (intechopen.com)
The biofilm matrix consists of polysaccharides, proteins, and DNA and constitutes a stubborn source that protects bacteria from a variety of physical, chemical, and biological stresses. (intechopen.com)
I previously showed that bacteria persist both in biofilms and intracellularly, in biofilm pods, in the middle ears of children who have chronic and recurrent otitis media. (thelimbic.com)
We know from lab-based studies that some bacteria that cause chest infection in kids can produce biofilm, but it's not a universal response. (thelimbic.com)
We don't understand why biofilm manifests in a subset of children, but it's likely to be triggered by a range of environmental pressures, including interactions among different bacteria or due to immune pressures. (thelimbic.com)
Probably the most important thing from a treatment perspective, is that when bacteria are in biofilms they are up to a thousand times more resistant to antibiotics than the planktonic bacteria which typically cause acute infections. (thelimbic.com)
The microarray technology enables the user to rapidly compare hundreds or thousands of individual cultures of bacteria or fungi, a big benefit in the search for new drugs to treat infections. (medicalnewstoday.com)
Going forward, Ramasubramanian says he and his colleagues are testing the microarrays with polymicrobial cultures - mixtures of fungi and bacteria - to see whether the technology can be used to explore treatments for mixed infections. (medicalnewstoday.com)
Now that the device is ready and has shown promise in a proof-of-concept study published in journal ACS Sensors , the researchers are planning on conducting studies on various bacteria that are the cause of infections affecting clinical facilities, potentially leading to new drugs and other treatments. (medgadget.com)
Bacteria tend to aggregate on these implants and form slimy layers called biofilms, and biofilms can also form on chronic wounds, impairing wound-healing. (frontiersin.org)
To do this, they treated the bacteria in cell suspensions, where the bacterial cells float freely, or in biofilms. (frontiersin.org)
The complexes caused rapid bacterial death in all the tested strains, in some instances killing the bacteria within 30 seconds, even in small doses. (frontiersin.org)
They could kill both free-floating bacteria and those in biofilms, suggesting that they could be used for decontamination in a variety of situations. (frontiersin.org)
The way that bacteria grow-either floating in liquid or attached to a surface-affects their ability to evolve antimicrobial resistance and our ability to treat infections. (elifesciences.org)
Resistant bacteria are more likely to survive antimicrobial treatments and go on to spread the infection to other people. (elifesciences.org)
Biofilms promote communication and cooperation, and physically shield bacteria from antimicrobials and the host immune system. (elifesciences.org)
It has been suggested that bacteria growing in biofilms may evolve AMR more rapidly, making treatment outcomes harder to predict. (elifesciences.org)
To do this, they compared bacteria that had been floating in liquid culture as they grew to bacteria that had been growing as biofilms. (elifesciences.org)
Experimental evolution of resistance to ciprofloxacin (CIP) in liquid-grown and biofilm-grown bacteria. (elifesciences.org)
found that liquid-grown and biofilm-grown strains of A.baumannii evolved resistance to the antimicrobial CIP in different ways: liquid-grown bacteria evolved a single resistant lineage that dominated the population ( C ), whereas biofilm-grown bacteria evolved multiple resistant lineages that co-exist within the population ( D ). Other important characteristics of the two evolved strains (such as resistance to CIP) are discussed in the main text. (elifesciences.org)
However, for the bacteria grown in biofilms, the researchers found that there was less competition between lineages - presumably because they are not as free to move as the liquid-grown bacteria - and that multiple co-existing lineages were able to emerge ( Figure 1D ). (elifesciences.org)
Further experiments showed that liquid-grown and biofilm-grown bacteria had evolved unique strategies to resist CIP, resulting in different degrees of CIP resistance. (elifesciences.org)
The human mouth serves as the best habitat for numerous bacterial species due to its alkaline condition, favourable to most bacteria and fungi. (scielo.br)
Therefore, biofilm matrix gives the additional resistance power to bacteria which makes them to not only tolerate harsh conditions but also resistant to antibiotics which lead to the emergence of bad bugs infections like multi drug resistant, extensively drug resistant and totally drug resistant bacteria. (biomedcentral.com)
Bacteria infecting wounds arrange themselves in polymicrobial communities known as biofilms. (ibecbarcelona.eu)
The understanding of the interaction between the components of this microbial community within the host is essential in order to develop new healing strategies that target bacteria growing in wounds. (ibecbarcelona.eu)
This in vitro multispecies biofilm model resembles the natural conditions present in wounds and allows us to study a Pseudomonas aeruginosa and Staphylococcus aureus co-culture, which are the predominant bacteria found in wounds. (ibecbarcelona.eu)
Just a ten-minute treatment with low-temperature plasma supposedly destroys drug-resistant bacteria causing wound infections in rats. (healthjockey.com)
Plasma was probably lethal for almost 99 percent of bacteria in laboratory-grown biofilms after five minutes. (healthjockey.com)
Dr. Svetlana Ermolaeva, lead researcher and colleagues note that the cold plasmas destroy bacteria by damaging microbial DNA and surface structures without being harmful to human tissues. (healthjockey.com)
While homogeneous planktonic populations were studied in sterile labs, the heterogeneous (mixed bacteria, virus, fungus) biofilms represent reality in our body. (blogspot.com)
The extracellular polymeric substance (EPS), also called 'slime', covering and cementing of biofilm colonies protects the bacteria from antibiotics, bacteriocins (produced by probiotics), antibodies, and other medicines/herbs which might kill it. (blogspot.com)
This was not a typical upper respiratory infection - this was Legionnaire's disease, an acute respiratory infection caused by the Legionella bacteria. (rdhmag.com)
Bacteria pick up eukaryotic sequences encoding different characters, such as nutrition , but the most notable use of "higher" organism DNA is to infect and manipulate eukaryotic cells in the service of bacterial survival and multiplication. (huffpost.com)
Biofilms protect the bacteria from the host immune system and enable them to persist in adverse environmental conditions. (uni-lj.si)
An important benefit of phage therapy is that bacteriophages can be much more specific than more common drugs, so can be chosen to be harmless to not only the host organism (human, animal or plant), but also other beneficial bacteria, such as gut flora , reducing chance for opportunistic infections . (wikidoc.org)
Other biofilms include those on medical instruments, so an enzyme added to a phage can effectively and selectively wipe out even bacteria beneath these films, which is impossible currently in Western medicine. (wikidoc.org)
Clumps of bacteria are much more difficult for the immune system to clear, because immune cells are specialized to attack individual bacterial cells. (mit.edu)
However, bacteria are sometimes able to break through this defense system and cause infections. (mit.edu)
One pertinent complication in bacterial infection is the growth of biofilms, that is, communities of surface-adhered bacteria resilient to antibiotics. (scilifelab.se)
This underlying chronic infection leaves COPD patients particularly vulnerable to acute viral infections, which further destabilize host immunity to bacteria. (frontiersin.org)
We propose that the anti-microbial and anti-inflammatory actions of specialized pro-resolving mediators, such as resolvin-D1 should be harnessed for the treatment of AECOPD that are complicated by the co-pathogenesis of viruses and bacteria. (frontiersin.org)
For those wanting to take a deeper dive and learn more about the science behind bacterial biofilms, Coursera offers an online, non-accredited program you can take and really dive deep into Bacteria and Chronic Infections . (diseasesolutions.net)
It turns out certain human immune cells, called neutrophils, do something similar to trap bacteria in people who develop sepsis, an uncontrolled, systemic infection that poses a major challenge in hospitals. (nih.gov)
Here in red you see one of these so-called neutrophil extracellular traps (NETs) that's ensnared Staphylococcus aureus (green), a type of bacteria known for causing a range of illnesses from skin infections to pneumonia. (nih.gov)
In the first few years of life, the bacterial microbiota within the mouth is predominantly aerobic, but, as the teeth develop, favorable sites supporting pathogenic anaerobic bacteria emerge. (medscape.com)
Most bacterial nosocomial pneumonias occur by aspiration of bacteria colonizing the oropharynx or upper gastrointestinal tract of the patient. (cdc.gov)
Therefore, effective strategies must be implemented to combat antibiotic-resistant bacteria, along with stricter adherence to infection control programmes. (who.int)

The antimicrobial coating efficiently inhibited the growth of the nosocomial pathogens Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Enterococcus faecium as demonstrated by the growth inhibition on agar surface and in biofilms of antibiotic resistant clinical E. faecalis, E. faecium, and S. aureus isolates. (who.int)
Saiman L, Siegel J. Infection control recommendations for patients with cystic fibrosis: microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission. (cdc.gov)
Her laboratory investigates the mechanisms used by bacterial pathogens to cause inflammation and cancer. (ucsc.edu)
The principal physiological characteristic of lactoferrin as an antibacterial agent is binding to the iron and or sequestering iron as an important requirement for maximum bacterial pathogens . (diabetesasia.org)
therefore, the current study was designed to assess the efficacy of certain antibiotics, toothpaste, and medicinal plant extracts ( Ajuga bracteosa and Curcuma longa ) versus the bacterial pathogens isolated from the human oral cavity. (scielo.br)
Among all the bacterial species, Staphylococcus aureus (29.62%) and Proteus mirabilis (22.2%) were found to be more prevalent oral pathogens. (scielo.br)
The data obtained through this study revealed that antibiotics were more effective for oral bacterial pathogens than toothpaste and plant extracts which showed moderate and low activity, respectively. (scielo.br)
These microbial communities are home to helpful germs and pathogens (harmful germs). (cdc.gov)
We have a better chance of fighting infections when our microbiomes are in balance -a mix of "good" beneficial germs to help keep the "bad" pathogens in check. (cdc.gov)
In recent years, we observed an alarming increase in life-threatening infections due to resistant Gram-positive and Gram-negative pathogens and mycobacteria. (uni-lj.si)
There is an urgent need for new therapies and new antibiotics to treat deadly infections caused by so-called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species), which are often resistant to available antibiotics. (uni-lj.si)
Pathological inflammation is worsened by chronic bacterial lung infections and susceptibility to recurrent acute exacerbations of COPD (AECOPD), typically caused by viral and/or bacterial respiratory pathogens. (frontiersin.org)
Thus, the dual effects of riboflavin on both pathogens and host immunity, reflected by its potent bactericidal effect and alleviation of inflammation in host cells further imply that riboflavin could be a potential candidate for therapeutic intervention in resolving microbial infections. (bioseek.eu)
Hence, this review aimed to provide some insights on the promising role of riboflavin as an antimicrobial candidate and also a host immune-modulator from a multi-perspective view as well as to discuss the application and challenges on using riboflavin in photodynamic therapy against various pathogens and microbial biofilm-associated infections. (bioseek.eu)

Microbial growth on medical and technical devices is a big health issue, particularly when microorganisms aggregate to form biofilms. (who.int)
A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface. (wikipedia.org)
Biofilms can attach to a surface such as a tooth or rock, and may include a single species or a diverse group of microorganisms. (wikipedia.org)
The formation of a biofilm begins with the attachment of free-floating microorganisms to a surface. (wikipedia.org)
Biofilms (so called because macroscopically they do look like a thin layer of slime) have a distinct architecture, consisting of tower- and mushroom-shaped microcolonies encased in a hydrated matrix of exopolymeric substances, polysaccharides and proteins that are produced by the resident microorganisms. (biomedcentral.com)
Iron difficulty in mucosal secretions , as the first protection line towards microorganisms, hinders bacterial increase. (diabetesasia.org)
The exposure of host tissue to the external environment allows the proliferation of a broad variety of pathogenic microorganisms, causing severe infections that are difficult to eradicate, such as diabetic foot ulcers, burn and surgery wounds. (ibecbarcelona.eu)
In addition to bacterial organisms, oral microorganisms can include fungal, protozoal, and viral species. (medscape.com)
3] Biofilms consist of microorganisms encased within a self-produced matrix of exoproteins and exopolysaccharides, which strongly attach themselves to interfaces and highly resist dislodgement. (blogspot.com)
Following placement, the surface of an implant is immediately covered by a layer of protein - the salivary pellicle - which is colonised by microorganisms that form a microbial biofilm. (bdnj.co.uk)

Historically, multicellular bacterial communities, known as biofilms, have been thought to be held together solely by a self-produced extracellular matrix. (nature.com)
Slimy layers of bacterial growth, known as biofilms, pose a significant hazard in industrial and medical settings. (mit.edu)
Some bacterial species engage in two well-documented social behaviors: the formation of surface-associated communities known as biofilms, and intercellular signaling, or quorum sensing. (nih.gov)

Scientists at the University of Texas at San Antonio and the U.S. Army Institute of Surgical Research at Fort Sam Houston have developed a microarray platform for culturing fungal biofilms, and validated one potential application of the technology to identify new drugs effective against Candida albicans biofilms. (medicalnewstoday.com)
The nano-scale platform technology could one day be used for rapid drug discovery for treatment of any number of fungal or bacterial infections, according to the authors, or even as a rapid clinical test to identify antibiotic drugs that will be effective against a particular infection. (medicalnewstoday.com)
Biotics Research FC Cidal 100 Capsules: provides Anti-Microbial & anti Fungal properties. (healthpalace.ca)
it may help with conditions of resistant fungal or yeast infections or molds, and for intestinal parasites. (healthpalace.ca)
Since its inception in 2016, Clarity Lab Solutions has been a leader in the clinical-lab space, offering specialty molecular testing in viral, bacterial, fungal infections. (claritylabsolutions.com)
Today we know that biofilms are involved in most (probably all) microbial, and even some viral or mixed multispecies (bacterial, viral, fungal) infections in the body. (blogspot.com)

Biofilms may form on living (biotic) or non-living (abiotic) surfaces and can be prevalent in natural, industrial, and hospital settings. (wikipedia.org)
Here, we investigated bacterial attachment, cell alignment and biofilm formation of Pseudomonas aeruginosa on periodic nano-pillar surfaces with different pillar spacing. (rsc.org)
Bacterial cells can colonize surfaces and form biofilms that consist of microbial cells embedded in extracellular polymeric substances (EPS). (rsc.org)
Yildiz is a leading authority on biofilms, microbial communities that grow on surfaces and are enclosed in a protective matrix. (ucsc.edu)
Staphylococcus aureus is a shrewd human bacterial microbe that essentially colonizes the front nares yet is often shed onto skin surfaces. (alliedacademies.org)
CDC invests in microbial ecology research to study the interactions of microbes among people, animals, plants, food, and surfaces (e.g., counter tops), all of which can serve as sources of microbes that can lead to infection. (cdc.gov)
In water supplies, Legionella can live either as multicellular biofilms on inorganic surfaces or as intracellular endosymbionts or parasites of amoeba and other eukaryotic microbes. (huffpost.com)
Biofilms are microbial communities protected by a self-synthesized layer of extracellular polymeric substance that form on surfaces. (uni-lj.si)
Study shows that key proteins in mucus prevent bacterial adhesion to surfaces, could help prevent growth of biofilms. (mit.edu)
Biofilms are sessile microbial communities growing on surfaces, frequently embedded in a matrix of extracellular polymeric substances (also known as slime). (medscape.com)
These findings are consistent with a tendency of other Acinetobacter species to survive on dry surfaces, form biofilms, and contribute to nosocomial outbreaks. (medscape.com)
The internal surfaces of T, RC, and C were examined for the presence of biofilm using scanning electron microscopy (SEM). (cdc.gov)

Microbes form a biofilm in response to a number of different factors, which may include cellular recognition of specific or non-specific attachment sites on a surface, nutritional cues, or in some cases, by exposure of planktonic cells to sub-inhibitory concentrations of antibiotics. (wikipedia.org)
The ability of C acnes to adhere to and form a biofilm, particularly on prosthetics, for example, is characteristic of the infections that it may cause. (medscape.com)
Moreover, neofiscalin A, when present at sub-MICs, hampered the ability of both MRSA and VRE strains to form a biofilm. (nih.gov)

Since the novel bacterial genus Neoehrlichia wass first described in 2004, its pathogenic role in humans has remained unexplained ( 1 ). (cdc.gov)
There are limited data in the literature quantifying the exact incidence of Cutibacterium endovascular, orthopedic, or neurosurgical shunt infections as frequently their pathogenic potential is overlooked given that it is considered to be of low virulence. (medscape.com)
Catching this pair of bad actors in flagrante delicto opens the gate to promising new ways of breaking up these pathogenic partnerships, thereby treating hospital-acquired infections and curing chronic disease. (stanford.edu)
According to research, iron withholding ability of lactoferrin affects the activation of immune cells and inhibit biofilm formation of pathogenic microorganism . (diabetesasia.org)
Bacteriostatic characteristic of lactoferrin is because of bind the Fe3 + ion and proscribing Fe3 + for microorganism increase and their virulence on the contamination web page, motility and biofilm formation of pathogenic microorganism could be inhibited (Gonzalez-Chavez et al. (diabetesasia.org)
Phage therapy is the therapeutic use of lytic bacteriophages to treat pathogenic bacterial infections. (wikidoc.org)
Several studies have illustrated the therapeutic efficacy of photoactivated riboflavin against nosocomial infections and multidrug resistant bacterial infections as well as microbial associated biofilm infections, revealing the potential role of riboflavin as a promising antimicrobial candidate, which could serve as one of the alternatives in fighting the global crisis of the emergence of antimicrobial resistance seen in different pathogenic microbes. (bioseek.eu)

These biofilms fill up all the air spaces, and antibiotics can't seem to penetrate them," he said. (stanford.edu)
Recurrent chest infections are a hallmark of these conditions, even when kids are treated with antibiotics that should work. (thelimbic.com)
These act as a bacterial reservoir which are not able to be eradicated by antibiotics and these kids end up needing grommet surgery. (thelimbic.com)
Microbial resistance to antibiotics and biocides is increasing, and our ability to effectively treat bacterial infections and contamination is under threat. (frontiersin.org)
It is important that scientists develop new antibiotic drugs, but we also need new strategies to deal with bacterial contamination that are not reliant on antibiotics. (frontiersin.org)
Think about the last time you or a loved one had a bacterial infection and needed antibiotics. (elifesciences.org)
The features displayed by the biofilm hinder and delay the healing processes, as such bacterial communities exhibit higher resistance to antibiotics and higher ability to evade the immune response. (ibecbarcelona.eu)
A team from the Gamaleya Institute of Epidemiology and Microbiology in Moscow claims that cold plasma jets can be a safe, effective alternative to antibiotics for treating multi-drug resistant infections. (healthjockey.com)
Phages are currently being used therapeutically to treat bacterial infections that do not respond to conventional antibiotics. (wikidoc.org)
They tend to be more successful where there is a biofilm covered by a polysaccharide layer, that antibiotics typically cannot penetrate. (wikidoc.org)

Bacteriophages are infections ready to taint exceptionally explicitly and kill the bacterial species designated yet not eukaryotic cells. (alliedacademies.org)
According to research, iron sequestration through apo-Lf can successfully inhibit the increase of many bacterial species because of iron deprivation and maybe completely ( Berlutti et al. (diabetesasia.org)
A total of 130 samples were collected from Khyber Teaching Hospital Peshawar, Pakistan, among those 27 species isolated, and eight bacterial species were identified from the samples. (scielo.br)
Growth pattern of Mycobacterium species are different such as M. chelonae and M. fortuitum form biofilm as vertical and entire surface growth, respectively [ 93 ]. (biomedcentral.com)
However, classic culture methods do not allow the simultaneous co-culture of different bacterial species, or the study in a more-realistic infection site environment, where several host factors are presented. (ibecbarcelona.eu)
The efficacy of low-temperature plasma torch was examined on bacterial species such as Pseudomonas aeruginosa and Staphylococcus aureus. (healthjockey.com)
Such species are generally considered responsible for chronic wound infections and are antibiotic resistant. (healthjockey.com)
Evidence of Borrelia burgdorferi (Lyme disease), Mycoplasma species, Chlamydia pneumoniae, human herpesvirus-1, -6 and -7 and other bacterial (Ehrlichia/Anaplasma, Babesia, Coxiella, Bartonella) and viral (Herpes Simplex, TBA-virus) infections revealed high infection rates in the patients affected by the above listed illnesses that were less likely or not found at all in controls. (blogspot.com)
Here, we review emerging mechanisms into why COPD patients are susceptible to chronic bacterial infections and highlight dysregulated inflammation and production of reactive oxygen species (ROS) as central causes. (frontiersin.org)
This chapter will review the role quorum sensing plays in biofilm formation for different species. (nih.gov)
Apical periodontal infection has been associated with 200 bacterial species, and 500 bacterial species have been reported with marginal periodontitis. (medscape.com)

Our risk of infection is even higher when we are colonized and have a disrupted microbiome . (cdc.gov)
However, more research is needed in the field of microbial ecology to expand upon and develop new therapeutic strategies that address colonization, healthcare-associated infections (HAIs), and antimicrobial resistance, all while considering patient safety and the implications for a patient's microbiome. (cdc.gov)
At present her interests are the molecular diagnosis of eye infections, the role of biofilm in bacterial and Candida eye infections, correlation of ocular and gut microbiome in keratitis and uveitis, antibiotic susceptibility of drugs for Pythium keratitis, evaluation of non-antibiotic therapy for eye infections and hospital infection control. (lvpei.org)

4,5 For example, Pseudomonas aeruginosa , an organism well-known for its capacity to form biofilms, is an opportunistic pathogen and is one of the top three causes of opportunistic human infections, 6 causing nosocomial infections in catheter lines, or chronically infecting the lungs of cystic fibrosis patients. (rsc.org)
Despite the reduction in culturability over time, all strains that recovered from starvation on solid-surface experiments retained their capacity to form biofilms after rehydration, an addition of nutrients, and changing temperature. (medscape.com)

Recent genomic and proteomic studies have identified many of the genes and gene products differentially expressed during biofilm formation, revealing the complexity of this developmental process. (biomedcentral.com)

Un 40% de esos trabajos han sido publicados en revistas del primer cuartil entre las que destacan New England Journal of Medicine, Lancet, Lancet Infectious Diseases, Clinical Infectious Diseases, Clinical Microbiology Reviews, Antimicrobial Agents and Chemotherapy, Journal Clinical Microbiology, Journal Antimicrobial Chemotherapy, Mayo Clinic Proceedings y Malaria Journal. (unav.edu)
Frontiers in cellular and infection microbiology. (lu.se)
We've been working with Professor Anne Chang for a while now to understand the microbiology underlying chest infections in kids with PBB or bronchiectasis. (thelimbic.com)

Eradication of endemic methicillin-resistant Staphylococcus aureus infections from a neonatal intensive care unit. (cdc.gov)
Herein, we present an approach employing multiphoton microscopy complemented with Airyscan super-resolution microscopy, to visualize the distribution of curcumin in Staphylococcus epidermidis biofilms. (scilifelab.se)

Yildiz has expanded her research to identify small molecules that target biofilm formation for potential therapeutic use, and to determine the relevance of biofilm antigens as targets for the immune system and thus for potential cholera vaccines. (ucsc.edu)
Recent advances in our understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections. (biomedcentral.com)
There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene editing technique) and photo dynamic therapy (PDT) are proposed to be used as therapeutic approaches to subside bacterial biofim infections, especially caused by deadly drug resistant bad bugs. (biomedcentral.com)
For biofilm control in patients at risk of caries, educational and therapeutic actions such as supervised brushing and topical application of fluoride are particularly encouraged in communities with limited access to health services, but there is little scientific evidence that these interventions may reduce dental caries in children [4,5]. (bvsalud.org)

The twenty-first century has seen a global rise in bacterial infections exhibiting antimicrobial-resistance (AMR). (sbir.gov)
Harris AD, Lautenbach E, Perencevich E. A systematic review of quasi-experimental study designs in the fields of infection control and antibiotic resistance. (cdc.gov)
Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
Bacterial communities that are attached to a surface, so-called biofilms, and their inherent resistance to antimicrobial agents are a cause of many persistent and chronic bacterial infections. (biomedcentral.com)
Compared with their planktonic (non-adherent) counterparts, the compact microbial consortia present in biofilms show extraordinary resistance to conventional biocides, antimicrobial treatments and the immune defense responses of the host. (biomedcentral.com)
Formation of these sessile communities and their inherent resistance to antimicrobial agents are at the root of many persistent and chronic bacterial infections. (biomedcentral.com)
The calcite-dependent patterns provide resistance to environmental insults and increase the overall fitness of the microbial community. (nature.com)
Resistance to antimicrobial treatments, also known as AMR, evolves rapidly, often over the course of a single infection. (elifesciences.org)
To understand how bacterial lifestyle influences the evolution antimicrobial resistance, strains of the bacterium A.baumannii were experimentally evolved either in liquid culture ( A ) or as biolfims on plastic beads ( B ). Santos-Lopez et al. (elifesciences.org)
Expanding our microbial ecology knowledge at the intersection of public health will lead us to new strategies to prevent infections and combat antimicrobial resistance, especially in healthcare settings. (cdc.gov)
However, thicker biofilms supposedly have some resistance to treatment. (healthjockey.com)
As a result of the development of antibiotic resistance since the 1950s and an advancement of scientific knowledge, there is renewed interest worldwide in the ability of phage therapy to eradicate bacterial infections and chronic polymicrobial biofilm, along with other strategies. (wikidoc.org)
Her doctoral research focused on Candida glabrata biofilms and the resistance to antifungal drugs. (fems-microbiology.org)
To investigate the incidence, microbial aetiology, antimicrobial resistance profile, and mortality rate of healthcare- associated infections in intensive care units in the Islamic Republic of Iran. (who.int)

Nosocomial respiratory syncytial virus infections: the "Cold War" has not ended. (cdc.gov)
A particulate matter: How environmental irritants and particulate matter increase sensitivity to bacterial respiratory tract infections. (lu.se)
We already have a clinical trial for this in otitis media, and there are also promising vaccine candidates that specifically target respiratory biofilms which have the potential to be gamechangers. (thelimbic.com)
All of these diseases were caused by infections of the respiratory tract by the coronavirus. (sanjosefuncmed.com)
As with SARS, COVID-19 disease occurs in stages: first, there is initial infection that allows viral replication, spread of the viral infection throughout the respiratory system, followed by an inflammatory response which can include in more serious cases immune hyper-reactivity. (sanjosefuncmed.com)
They specialize in testing four key categories of infectious diseases, including wounds, ENT specimens, urinary tract infections (UTIs), and respiratory infections. (claritylabsolutions.com)
He had symptoms of a typical upper respiratory infection. (rdhmag.com)
Sections on the prevention of bacterial pneumonia in mechanically ventilated and/or critically ill patients, care of respiratory-therapy devices, prevention of cross-contamination, and prevention of viral lower respiratory tract infections (e.g., respiratory syncytial virus {RSV} and influenza infections) have been expanded and updated. (cdc.gov)
Lower respiratory tract infection caused by Mycobacterium tuberculosis is not addressed in this document. (cdc.gov)
Traditional preventive measures for nosocomial pneumonia include decreasing aspiration by the patient, preventing cross-contamination or colonization via hands of personnel, appropriate disinfection or sterilization of respiratory-therapy devices, use of available vaccines to protect against particular infections, and education of hospital staff and patients. (cdc.gov)
Hospital-acquired pneumonia (HAP), or nosocomial pneumonia, is a lower respiratory infection that was not incubating at the time of hospital admission and that presents clinically 2 or more days after hospitalization. (medscape.com)

FEMS Microbes is excited to present its latest thematic issue, focusing on bacterial-viral co-infections. (fems-microbiology.org)
The pathogeneses of bacterial and viral exacerbations are significant as clinical symptoms are more severe and there is a marked increase in neutrophilic inflammation and tissue damage. (frontiersin.org)
AECOPD triggered by a bacterial and viral co-infection increases circulating levels of the systemic inflammatory marker, serum amyloid A (SAA). (frontiersin.org)
RSV infection usually occurs after viral inoculation of the conjunctivae or nasal mucosa by contaminated hands. (cdc.gov)

These iodo-thiocyanate complexes produce highly reactive anti-microbial substances, without a peroxidase enzyme. (frontiersin.org)

3,6 Biofilm formation by P. aeruginosa is responsible for antimicrobial tolerance and causes major problems for treatment of infections. (rsc.org)
Biofilm formation requires three different stages: cell attachment to a solid substrate, adhesion, and growth. (intechopen.com)
In this section, we will focus on proteins involved in biofilm formation as useful targets for the development of new drugs that can effectively and specifically impair biofilm formation with slight effects on cell survival, thus avoiding the generation of drug-resistant strains. (intechopen.com)
Her lab studies molecular mechanisms of biofilm formation and their consequences in the infection cycle of the cholera pathogen Vibrio cholerae, which causes periodic, seasonal outbreaks of disease in many parts of the world. (ucsc.edu)
Her lab also identified the regulatory network that governs V. cholerae biofilm formation and showed how extracellular and intracellular signals are integrated into regulation of biofilm formation. (ucsc.edu)
That significant fractions of the bacterial genome could be involved in, or affected during, biofilm formation was shown in Escherichia coli in a genome-wide screen using random chromosomal insertions of a lacZ reporter gene fusion construct [ 5 ]. (biomedcentral.com)
With so many genes involved, it is perhaps not surprising that biofilm formation is regarded as a developmental process (Figure 1 ), not unlike that observed in the formation of fruiting bodies containing spores by the soil bacterium Myxococcus xanthus and sporulation in Bacillus subtilis [ 6 ]. (biomedcentral.com)
We studied, for the first time, the effects of mutants defective in biomineralization and calcite formation on biofilm development, resilience and morphology. (nature.com)
Our results suggest that it is highly feasible that the formation of mineral scaffolds plays a cardinal and conserved role in bacterial multicellularity. (nature.com)
Quorum sensing plays an important role in regulating the biofilm formation. (biomedcentral.com)
iii) colony formation and biofilm maturation. (biomedcentral.com)
Metabolic activity of the bacterial biofilm communities have altered as compared to the planktonic one such as increased rates of EPS production, activation or inhibition of particular genes associated with biofilm formation and decreased growth rate [ 39 ]. (biomedcentral.com)
Formation of biofilms in mycobacteria can be defined as similar as other biofilms communities. (biomedcentral.com)
Panels of studies have reported the role of various molecules in the biofilm formation and maintenance of its composition. (biomedcentral.com)
Glycopeptidolipids are indispensable for initial surface attachment during biofilm formation in Mycobacterium smegmatis [ 111 ]. (biomedcentral.com)
It is estimated that 80% of all (and likely 100% of chronic) infections are biofilm related as biofilm formation is the preferred bacterial life style. (blogspot.com)
Results from a recent MIT study suggest a possible new source of protection against biofilm formation: polymers found in mucus. (mit.edu)
Mucin coatings may help prevent biofilm formation on medical devices and could also find applications in personal hygiene: Incorporating them into products such as toothpaste or mouthwash may supplement the body's own defenses, especially in people whose natural mucus has been depleted, Ribbeck says. (mit.edu)
In the new study, the researchers found that mucins block bacterial cluster formation by preventing them from adhering, which is necessary for them to clump together. (mit.edu)
Suboptimal environmental cleaning and reprocessing of instruments is a common problem in healthcare facilities, allowing for biofilm formation and risk for nosocomial transmission. (medscape.com)
Biofilm formation and bacterial viability during the survival analysis were assessed. (medscape.com)
Alfa and colleagues [ 2 ] looked at the impact of improper positioning of the elevator lever of a duodenoscope on bacterial persistence, biofilm formation, and endoscope contamination. (medscape.com)
Conclusions: This DUWL model effectively replicated biofilm formation inside DUWL with tap water as source water and was used to test the efficacy of rechargeable antimicrobial tubing compared with a treated and an untreated control line. (cdc.gov)

When the infection is antibiotic-resistant, serious illness or death can result. (frontiersin.org)
The team tested the complexes' ability to kill a variety of bacterial strains, including MRSA, an antibiotic-resistant strain. (frontiersin.org)
The company has developed a proprietary sensitivity testing platform ideal for antibiotic prescription and antibiotic recommendation to healthcare providers, allowing them to improve the treatment of complicated and advanced-stage infections. (claritylabsolutions.com)
Also, we use a set of biofilm-degrading enzymes targeting the wound biofilm so as to improve the antibiotic delivery in the local area of the infection site. (ibecbarcelona.eu)
contact lens associated microbial keratitis, infectious endophthalmitis, antibiotic susceptibility of ocular isolates, molecular typing of Acanthamoeba, diagnosis and treatment of Pythium keratitis etc. (lvpei.org)
Antibiotic-resistant infections appeared after surgery. (cdc.gov)

Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America. (cdc.gov)
When I listened to our professors, some 30 years ago, talking about infectious diseases or microbes, biofilms were never mentioned. (blogspot.com)

However, the underlying mechanisms linking surface topography to the inhibition of microbial attachment and growth still remain unclear. (rsc.org)

Pf phage produced by P. aeruginosa promote bacterial phenotypes associated with chronic infections. (stanford.edu)
Moreover, these phage act as structural elements in microbial biofilms. (stanford.edu)
Like any other virus, a phage can reproduce itself only by climbing into a cell - in this case, a bacterial cell - and, like buccaneers of yore, commandeering its replicative machinery. (stanford.edu)
Indeed, no phage, no biofilm. (stanford.edu)
The phage-encoded lysis proteins endolysin and holin cause the breakdown of the bacterial layer, bringing about cell passing and arrival of phage particles [ 3 ]. (alliedacademies.org)
After having been extensively used and developed mainly in former Soviet Union countries for about 90 years, phage therapy is now becoming more available in other countries such as USA for a variety of bacterial and poly-microbial biofilm infections. (wikidoc.org)
Following the discovery of bacteriophages by Frederick Twort and Felix d'Hérelle in 1915 and 1917, phage therapy was immediately recognized by many to be a key way forward for the eradication of bacterial infections. (wikidoc.org)

Bacterial contamination can occur on medical devices, such as catheters, which are embedded in patients. (frontiersin.org)
The injury climate is an ideal one for foundation of a bacterial contamination as it contains enormous totals of necrotic tissue and gatherings of protein exudate. (alliedacademies.org)
Bacteriophage treatment is a feasible other option/assistant to anti-toxins in treating bacterial contamination. (alliedacademies.org)
Know the main eukaryotes and metazoans related to infections, to toxins, to poisonings, and to environmental contamination. (unict.it)

At the next stage (3), the first maturation phase is reached, as indicated by early development of biofilm architecture. (biomedcentral.com)

Thus the increase of a large variety of bacterial traces could be inhibited (Jensen and Hancock, 2009). (diabetesasia.org)

The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides, proteins, lipids and DNA. (wikipedia.org)
Data-independent acquisition (DIA)-based proteomics was found to outperform data-dependent acquisition (DDA) workflows, especially in identifying the downregulated bacterial proteome response during infection progression by permitting quantification of low abundant bacterial proteins at early times of infection when bacterial infection load is low. (bvsalud.org)
S. Typhimurium invasion and replication specific proteomic signatures in epithelial cells revealed interdependent host/pathogen specific responses besides pointing to putative novel infection markers and signalling responses, including regulated host proteins associated with Salmonella-modified membranes. (bvsalud.org)
Some of the molecules Legionella injects into a microbial or mammalian eukaryotic host cell are called "effector proteins. (huffpost.com)
The presence of eukaryotic domains in these effector proteins indicates that Legionella acquired them from eukaryotic hosts, most probably their amoebal and other microbial hosts. (huffpost.com)
The external origin of the DNA encoding these proteins is confirmed because it has a lower GC content than the clearly bacterial DNA in the Legionella genome . (huffpost.com)

In addition, different aspects of quorum sensing in the context of multispecies biofilms will be discussed. (nih.gov)

Because intubation and mechanical ventilation alter first-line patient defenses, they greatly increase the risk for nosocomial bacterial pneumonia. (cdc.gov)

Bravo and colleagues [ 1 ] investigated the ability of Acinetobacter pittii strains to form biofilms after long-term desiccation if they were fed with nutrient media. (medscape.com)

Hyperthermophilic archaeon Pyrobaculum calidifontis produce bundling pili which are homologous to the bacterial TasA filaments, a major component of the extracellular matrix in bacterial biofilms, which contribute to biofilm stability. (wikipedia.org)
Biofilms are multicellular communities that were so far thought to be held together solely by a self-produced organic extracellular matrix. (nature.com)
We demonstrate that a mature 3D structure of mineral scaffolds holds the extracellular matrix and the bacterial cells together. (nature.com)

The study first focused on Pseudamonas aeruginosa , which accounts for one in ten hospital-acquired infections, many chronic pneumonia cases and much of the air-passage obstruction afflicting cystic-fibrosis patients. (stanford.edu)
Cystic fibrosis is deadly mainly because of biofilms formed by P. aeruginosa , Bollyky told me. (stanford.edu)
Biofilms have been shown to colonize a wide variety of medical devices and to be associated with several human diseases, such as native valve endocarditis, burn wound infections, chronic otitis media with effusion and cystic fibrosis. (biomedcentral.com)
From chronic and recurring strep throat to the day-to-day regiment of patients managing cystic fibrosis, this biofilm documentary personalizes the experience of enduring chronic bacterial infections. (diseasesolutions.net)

This allows pathologists to inform physicians about the ideal means to eradicate the entire aerobic biofilm of the infection. (claritylabsolutions.com)
Once established, biofilms are very difficult to remove, and a great deal of research has gone into figuring out how to prevent and eradicate them. (mit.edu)

In particular, surface modifications that physically create rational surface topographies have attracted attention in recent years, and have shown to inhibit bacterial attachment and biofilm growth without the use of antimicrobials. (rsc.org)

The lab has identified novel roles for bacteriophage in the pathogenesis of infections caused by the bacterial pathogen Pseudomonas aeruginosa. (stanford.edu)

In severe cases, the infection can cause pneumonia, shortness of breath and breathing difficulties. (sanjosefuncmed.com)
Legionella Infections Legionella pneumophila is a gram-negative bacillus that most often causes pneumonia with extrapulmonary features. (msdmanuals.com)
This revised guideline addresses common problems encountered by infection- control practitioners regarding the prevention and control of nosocomial pneumonia in U.S. hospitals. (cdc.gov)
Part I, 'An Overview of the Prevention of Nosocomial Pneumonia, 1994,' provides the background information for the consensus recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC) in Part II, 'Recommendations for Prevention of Nosocomial Pneumonia. (cdc.gov)
Pneumonia is the second most common nosocomial infection in the United States and is associated with substantial morbidity and mortality. (cdc.gov)
Although patients receiving mechanically assisted ventilation do not represent a major proportion of patients who have nosocomial pneumonia, they are at highest risk for acquiring the infection. (cdc.gov)

Bacterial biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and relapses. (mdpi.com)
3 Bacterial biofilms can cause persistent human infections and can foul the surface of medical devices. (rsc.org)
Cite this: Survival of the Slimiest: The Persistent Nature of Biofilms - Medscape - Mar 22, 2018. (medscape.com)

I have always been excited to unravel the underlying disease pathogenesis in chronic infections that don't respond well to standard treatments. (thelimbic.com)

Subpopulations of cells within the biofilm differentiate to perform various activities for motility, matrix production, and sporulation, supporting the overall success of the biofilm. (wikipedia.org)
For example, in many occasions bacterial colonies are sessile and their expansion is driven by growth rather than by cell motility, but these sessile colonies normally preserve a subpopulation of motile cells for reasons that are not well understood 17 . (nature.com)

Urinary tract infections (UTIs) are one of the most important causes of morbidity and health care spending affecting persons of all ages. (mdpi.com)
Ventilator-associated events (39.5%), urinary tract infections (22.7%), and bloodstream infections (14.8%) were the main types of infection. (who.int)

However, where intervention is required, practitioners should avoid using products or materials that could damage the implant component and increase the likelihood of bacterial adhesion. (bdnj.co.uk)

Thus, the novel antimicrobial coating could represent an alternative to combat microbial growth avoiding the toxic side effects of high levels of silver ions on eukaryotic cells. (who.int)
The microbial cells growing in a biofilm are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single cells that may float or swim in a liquid medium. (wikipedia.org)
Threadlike structures ("bacterial nanotubes") protruded from the majority of bacterial cells and appeared to link cells directly with the nanopillars. (rsc.org)
Cells in a bacterial colony move in confined space surrounded by boundaries between gas, liquid, and solid phases. (nature.com)
Biofilms are an ensemble of microbial cells irreversibly associated with a surface and enclosed in an essentially self-produced matrix. (intechopen.com)
Biofilms are large groups of bacterial cells that stick together and protect each other like a Roman legion. (medgadget.com)
Naturally present in bodily secretions such as saliva, milk and tears, these highly reactive substances can cause damage to bacterial cells, resulting in their death. (frontiersin.org)
At stage 1, the bacterial cells attach reversibly to the surface. (biomedcentral.com)
To assess the possible roles of biomineralization in biofilm development, we grew wild-type B. subtilis cells on media in the presence or absence of calcium acetate as a calcium source. (nature.com)
Once in a biofilm, bacterial cells experience more noteworthy security against anti-microbials and against components of the host safe framework than do cells filling in a planktonic state. (alliedacademies.org)
For instance, the exopolysaccharide lattice blocks counter acting agent infiltration into biofilm and phagocytes can't collaborate with bacterial cells [ 2 ]. (alliedacademies.org)
By applying dual proteome profiling to Salmonella enterica serovar Typhimurium (S. Typhimurium) encounters with its epithelial host (here, S. Typhimurium infected human HeLa cells), a detailed interdependent and holistic proteomic perspective on host-pathogen interactions over the time course of infection was obtained. (bvsalud.org)
Bacteriophages, or "phages" are viruses that invade only bacterial cells and, in the case of lytic phages, cause the bacterium to burst and die, thus releasing more phages. (wikidoc.org)
Riboflavin could also be involved in modulating host immune responses, which might increase the pathogen clearance from host cells and increase host defense against microbial infections. (bioseek.eu)

Measuring the ratio between the wavelengths that enter and escape and turning that map into an image provides a new look at the bacterial structures. (medgadget.com)
Get to know the bacterial cell structures in depth. (unict.it)
Periodontitis is a common chronic bacterial infection of the supporting structures of the teeth. (medscape.com)

It is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. (biomedcentral.com)
Three recent articles [ 1 , 2 , 3 ] highlight how our understanding of bacterial persistence and recent advances in disinfection modalities may provide a means for control of biofilms and nosocomial infections. (medscape.com)
This undermines the effectiveness of the available treatment options and thus contributes to the persistence of microbial infections. (who.int)

I'm sure we can find inspiration from it for new strategies to help prevent infections and bacterial colonization," says Katharina Ribbeck, the Eugene Bell Career Development Assistant Professor of Biological Engineering and senior author of the paper, which appears in the Nov. 8 online edition of the journal Current Biology . (mit.edu)
highlights several patient cases and discusses the topic with top leading scientists and medical professionals who give their expert presentation on what they know about microbial colonization inside the body. (diseasesolutions.net)

What's the current availability of specialised microscopy for biofilms? (thelimbic.com)
Exploring photoinactivation of microbial biofilms using laser scanning microscopy and confined 2-photon excitation. (scilifelab.se)
These results support the feasibility of advanced optical microscopy as a sensitive tool for evaluating treatment efficacy in biofilms toward improved mechanistic studies of PDI. (scilifelab.se)

Our findings present a unique form of bacterial self-organization that influences population structure and material distribution in colonies. (nature.com)
This type of bacterial self-organization has not yet been observed in the context of naturally developed colonies. (nature.com)
Here we sought to examine the behavior of motile cell populations in bacterial colonies and to explore their potential physiological functions. (nature.com)
Here, we asked whether the control of calcium carbonate minerals can structurally support morphogenesis of bacterial colonies. (nature.com)

HAP is a common nosocomial bacterial infection and is most prevalent in medical and surgical intensive care units (ICUs). (medscape.com)

It is hard to say, but we are hopeful that this won't be too far away given recent advances in the development of antibiofilm therapies, including treatments that target the host-microbial interactions that are likely essential for biofilm maintenance. (thelimbic.com)
Mucus is a material that has developed over millions of years of evolution to manage our interactions with the microbial world. (mit.edu)

Our study identified a novel mechanism maintaining Bacillus subtilis and Mycobacterium smegmatis biofilms-active production of calcite minerals. (nature.com)

Surface topography designed to achieve spatial segregation has shown promise in delaying bacterial attachment and biofilm growth. (rsc.org)
Surface patterning is an important determinant of bacterial attachment. (rsc.org)
Although Anthony van Leeuwenhoek, who discovered microbial attachment to his own tooth surface, is credited with the discovery of biofilm nearly 40 years ago, one of the major breakthroughs happened when Dr. G.D. Ehrlich confirmed the hypothesis in 2006, that indeed chronic middle-ear disorders are 'chronic' biofilm related and don't recur due to new infections. (blogspot.com)

Under the microscope, these nano-biofilms of C. albicans, each of which was only 30 nanoliters, exhibited the same growth habits and other outward characteristics as conventional, macroscopic biofilms, and achieved maximum metabolic activity within 12 hours. (medicalnewstoday.com)
[ 3 , 4 ] Evidence also exists that significant interaction of bacterial types within biofilm may either enhance or suppress metabolic activity that leads to dental infection. (medscape.com)

Current efforts are focused on understanding how bacteriophage influence mammalian immunity and clinical outcomes associated with wound and lung infections. (stanford.edu)
En mayo de 2007 obtuve el Certificate of Training in Molecular Biological Techniques en el Department of Molecular Biology y desde Junio de 2008 a Junio de 2009 completé el Certificate in Clinical Research en el Center for Translational Science Activities en Mayo Clinic College of Medicine, Rochester Minnesota. (unav.edu)
We have done this previously by demonstrating biofilm involvement in otitis media - here and here - and this has led to a clinical trial which is now underway. (thelimbic.com)
They are an important clinical and public health problem, as up to 80% of all bacterial infections in humans ar. (uni-lj.si)
The simple DUWL model described in this study is designed to replicate biofilm growth during clinical use, using tap water as source water, and measure its reduction and prevention with rechargeable antimicrobial dental tubing. (cdc.gov)
This study of Colorado preschool children models 6 categories of ECC intervention -- applying fluorides, limiting cariogenic bacterial transmission from mothers to children, using xylitol directly with children, clinical treatment, motivational interviewing, and combinations of these -- to compare their relative effect and cost. (cdc.gov)

Blood cultures remained negative for microbial growth, even after extended incubation. (cdc.gov)
A cell that switches to the biofilm mode of growth undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated. (wikipedia.org)
3,8 Therefore, it is important to develop biomaterials that can control biofilm growth thereby reduce infections. (rsc.org)
To know microbial genetics, cell growth, differentiation and other microbial vital forms. (unict.it)
As replication is a crucial step to initiate an infection, we have first focused on the study of the differential role of the different P. aeruginosa Ribonucleotide Reductase (RNR) enzymes in bacterial growth within the wound biofilm model, as RNR are essential enzymes in DNA replication. (ibecbarcelona.eu)
A simple model simulating DUWL biofilm growth, reduction, and prevention. (cdc.gov)
Results: Biofilm growth was constant on the inner walls of C and was confirmed with SEM. (cdc.gov)
The antimicrobial agent initially prevented, and then reduced biofilm growth for limited periods of time in T and RC. (cdc.gov)
Bacterial growth was evaluated by turbidity. (bvsalud.org)
Bacterial growth was evaluated according to turbidity. (bvsalud.org)
After 24 h of incubation, MIC was determined as the lowest concentration capable of inhibiting microbial growth, identified by the resazurin reaction (100 µg/mL). (bvsalud.org)

We are working to better understand what microbes and their surrounding environments can teach us about preventing infections, including antimicrobial-resistant infections . (cdc.gov)

Motile subpopulations in microbial communities are believed to be important for dispersal, quest for food, and material transport. (nature.com)
Understanding the physiology of these structured microbial communities is not only essential to the treatment of chronic infections, but also important to industrial applications, such as bioremediation, anti-biofouling and food hygiene. (nature.com)
We all have our own microbial communities, called microbiomes, on our skin and in our gut that help us maintain good health. (cdc.gov)
Stealth infections, hiding in biofilm communities, were never mentioned. (blogspot.com)

A biofilm usually begins to form when a free-swimming bacterium attaches to a surface. (wikipedia.org)
We propose that bacterial nanotubes are produced to aid in cell-surface or cell-cell connections. (rsc.org)
viii]Much of the literature covering strategies for peri-implantitis therapy is generally based on treatments for periodontal disease, due to the fact that bacterial colonisation on natural dentition is similar to that on an implant surface. (bdnj.co.uk)

It seems that cold plasmas treat chronic wound infections within ten minutes. (healthjockey.com)

But he and his colleagues found that P. aeruginosa forms biofilms only when it's been infected itself. (stanford.edu)

Objectives: A standard method to assess antimicrobial efficacy in dental unit waterlines (DUWL) using a microbial consortium and a chemical disinfectant has previously been presented by ADA/ANSI Working Group 9.48. (cdc.gov)

With this in mind, the researchers set out to develop an effective antibacterial treatment, drawing their inspiration from naturally-occurring peroxidase enzymes that play a role in immune defence against bacterial infections. (frontiersin.org)
Immunosuppressive drug therapy and any disease (eg, HIV infection) resulting in suppression of the normal inflammatory and immune mechanisms can cause or enhance severe periodontal diseases. (medscape.com)

This observational study retrospectively reviewed the medical records of 1722 intensive care units patients with confirmed healthcare-associated infections at hospitals affiliated with Mashhad University of Medical Sciences in 2017-2019. (who.int)

Anatomy1

Organisms12

Diseases5

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes4

Bacteria59

Pathogens14

Microorganisms10

Known as biofilms3

Fungal6

Surfaces12

Form a biofilm3

Pathogenic7

Antibiotics10

Species11

Microbiome3

Capacity to form biofilms2

Expressed during biofilm fo1

Microbiology3

Staphylococcus2

Therapeutic4

Resistance14

Respiratory11

Viral4

Anti-Microbial1

Formation23

Antibiotic6

Infectious diseases2

Inhibition1

Phage7

Contamination4

Development of biofilm1

Variety of bacterial1

Proteins6

Multispecies1

Risk for nosocomial1

Strains to form1

Extracellular matrix3

Cystic4

Eradicate2

Antimicrobials1

Pseudomonas1

Pneumonia6

Persistent3

Pathogenesis1

Motility2

Urinary Tract Infe2

Adhesion1

Cells14

Structures3

Persistence3

Colonization2

Microscopy3

Colonies4

Nosocomial bacterial1

Interactions2

Mycobacterium1

Attachment3

Metabolic activity2

Clinical6

Growth11

Microbes1

Communities4

Surface3

Wound Infections1

Aeruginosa1

Efficacy1

Immune2

20171