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  • allografts
  • 1 2 Corticosteroids and cyclosporin A greatly reduce the rejection rate of corneal allografts, but high doses and/or long-term administration of these drugs can produce deleterious side effects, such as glaucoma, cataract formation, nephrotoxicity, hypertension, and hepatotoxicity. (arvojournals.org)
  • edema
  • D, After EDTA chelation and AMT, covering the area outlined by a purse-string suture, the corneal surface healed without edema and was stable for 3.2 months. (jamanetwork.com)
  • persistent
  • A 45-year-old man received growth factor-mobilized blood cells from an HLA-matched unrelated male donor after conditioning with 12 Gy total body irradiation and cyclophosphamide for treatment of acute myeloid leukemia with persistent disease. (bloodjournal.org)
  • collagen
  • This collagen-based corneal equivalent simulated the native cornea. (molvis.org)
  • Keratoconus is a bilateral ocular disorder in which the cornea assumes a conical shape due to thinning of the stromal collagen tissue.It is a relatively frequent disease with an incidence of 1 in 2000 in the general population.It classically has its onset at puberty and is progressive until the third or fourth decade of life when it usually arrests. (bwlionseyehospital.org)
  • The corneal collagen is cross-linked with the help of ultraviolet rays ( UVA ) and a photo sensitiser, Riboflavin , thus enhancing the rigidity of corneal tissue and stabilizing the condition. (bwlionseyehospital.org)
  • recipients
  • Most importantly, it facilitates actions to prevent other recipients of tissues or cells or organs being affected by an event or from suffering a reaction that has happened with the index case. (springer.com)
  • Glaucoma
  • The primary goal in repairing the corneal perforation is to achieve a watertight globe with structural integrity in order to prevent severe complications such as globe tissue prolapse, endophthalmitis, and glaucoma [ 1 , 3 ]. (hindawi.com)
  • Corneal eye disease is the fourth most common cause of blindness (after cataracts, glaucoma and age-related macular degeneration) and affects more than 10 million people worldwide. (bwlionseyehospital.org)
  • membrane
  • In contrast to fibroblasts within connective tissues, epithelial cells are polarized and have distinct plasma membrane domains on their apical and basolateral sides. (molvis.org)
  • LMD techniques rely on a thermo labile membrane placed either on top of, or underneath, the tissue section. (jove.com)
  • In one method, focused laser energy is used to melt the membrane onto the underlying cells, which can then be lifted out of the tissue section. (jove.com)
  • cultures
  • There was no statistically significant difference in the rate of positive cultures in DSAEK (2.6%) versus PKP (2.4%) tissue, p = 0.79. (arvojournals.org)
  • Results: The analysis comprised 725 samples of corneal preservation fluid, of which 32 (4.4%) samples tested positively in microbiological cultures. (aspergillus.org.uk)
  • Surgical
  • To report the surgical approach, anatomical and functional results, and complications in the group of patients with corneal perforation. (hindawi.com)
  • A diagnosis of corneal perforation does not always require immediate surgical treatment. (hindawi.com)
  • In this speciality service, we provide quality medical and surgical care to a multitude of corneal problems with utmost care supported by eye bank of international standards and state of art equipment. (bwlionseyehospital.org)
  • physiological
  • There is a need to design and manufacture new corneal biomaterial devices able to mimic in detail the physiological environment where stem cells reside in the cornea. (jove.com)
  • Cells
  • Human corneal cells are also known to interact with endotoxins, which stimulate either directly or indirectly, via cytokines, the secretion of interleukins (IL). (bmj.com)
  • 2006/86/EC) into national law in each European Union Member State, there is now a statutory requirement to report to each national Competent Authority serious adverse events and reactions (SAER) relating to tissue or cells for therapeutic purposes. (springer.com)
  • This is necessary because tissues and cells are frequently supplied across national boundaries. (springer.com)
  • A serious adverse event is defined in the EUTCD as "any untoward occurrence associated with the procurement, testing, processing, storage or distribution of tissues or cells that might lead to the transmission of a communicable disease or to death or a life threatening, disabling or incapacitating condition for patients or which might result in, or prolong, hospitalisation or morbidity. (springer.com)
  • There are potentially numerous types of serious adverse events that may occur at each stage during the procurement, testing, processing, storage or distribution of tissue or cells. (springer.com)
  • Mammalian cells stably expressing the full bacterial bioluminescence ( luxCDABEfrp ) gene cassette autonomously produce an optical signal that peaks at 490 nm without the addition of an expensive and possibly interfering luciferin substrate, excitation by an external energy source, or destruction of the sample that is traditionally performed during optical imaging procedures. (jove.com)
  • Laser capture microscopy, also known as laser microdissection (LMD), enables the user to isolate small numbers of cells or tissues from frozen or formalin-fixed, paraffin-embedded tissue sections. (jove.com)
  • In the other, the laser energy vaporizes the foil along a path "drawn" on the tissue, allowing the selected cells to fall into a collection device. (jove.com)
  • chemical
  • Corneal disease can be caused by illnesses such as Aniridia or Steven Johnson Syndrome as well as by external factors such as chemical burns or radiation. (jove.com)
  • surface
  • H, The use of AMT resulted in a stable and corneal surface with noninflamed perilimbal tissue 2.5 months later. (jamanetwork.com)
  • An outer surface of the locking member a collar extending from the support and disposed around the optic member is also metal, preferably titanium, and is similarly treated to promote soft tissue adhesion. (patents.com)
  • conditions
  • 1-4 The majority of corneal grafting (CGs) are performed under elective conditions, however, a smaller and more critical group of patients are operated in emergency situations. (bmj.com)
  • stem cell
  • Tseng SCGChen JJYHuang AJWKruse FEMaskin SLTsai RJF Classification of conjunctival surgeries for corneal disease based on stem cell concept. (jamanetwork.com)
  • therapeutic
  • General recommendations and organism-specific therapeutic regimens for bacterial conjunctivitis are provided below, including those for Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, and Chlamydia species. (medscape.com)