• In this system, cell-surface receptor proteins regulate a histidine protein kinase, CheA, that autophosphorylates and then transfers its phosphate to an effector protein, CheY. (umd.edu)
  • This sequence of biochemical events establishes a chain of communication that ultimately allows the chemotaxis receptor proteins to regulate the swimming pattern of the bacterial cell when it encounters gradients of attractant and repellent chemicals in its environment. (umd.edu)
  • However, since most zinc ions are strongly combined with proteins, the concentration of free zinc ions in a cell is at the millimolar level or lower. (dojindo.com)
  • Pure T-cell deficiencies are caused by defects in either a CD3 subunit (such as CD3 δ, CD3 ζ, CD3 ε ) or in CD45 tyrosine phosphatase, key proteins involved in pre-TCR and/or TCR signaling at the positive selection stage. (medscape.com)
  • She and her team are honing in on studying the structures of some of these proteins and how they interact with copper ions to learn more about how they function within bacterial cells. (lehigh.edu)
  • All of the proteins and pathways that we're studying are used by this species, even though versions of them are also employed by many other bacterial species as well. (lehigh.edu)
  • According to the current view, prokaryotic signal transduction is conducted mostly by two-component regulatory systems that function as a result of phosphotransfer between two key proteins: a sensor histidine kinase and a response regulator [1-6]. (handlebar-online.com)
  • What are the two key proteins that are present in two-component signal transduction systems? (handlebar-online.com)
  • The proteins comprising the bacterial two-component system (TCS) are the sensor histidine kinase (HK) and the response regulator (RR) (Fig. 1A. (handlebar-online.com)
  • During her postdoctoral work at Stanford Medical School, she demonstrated that bacteria can localize regulatory proteins to specific intracellular regions to control signal transduction and the cell cycle, uncovering a new, unsuspected level of bacterial regulation. (stanford.edu)
  • It was found that the C . crescentus genome encodes for more two-component signal transduction proteins that assist in cell cycle progression than any other bacterial genome sequenced so far. (kenyon.edu)
  • Several two-component signal transduction proteins are involved in the cell cycle progression by accumulating at one or both poles "in a spatial and temporal pattern that is reproduced during each cycle" (Jacobs-Wagner 2003). (kenyon.edu)
  • Throughout the cell cycle, the chromosome progressively goes from being fully methylated to hemimethylated during DNA replication - this results in differential binding of regulatory proteins to activate or repress transcription. (kenyon.edu)
  • The bacterial SH2 domains are not only capable of binding proteins or peptides in a Tyr phosphorylation-dependent manner, some bind pTyr itself with micromolar affinities, a property not observed for mammalian SH2 domains. (rcsb.org)
  • Our work expands the boundary of phosphotyrosine signalling to prokaryotes, suggesting that some bacterial effector proteins have acquired pTyr-superbinding characteristics to facilitate bacterium-host interactions. (rcsb.org)
  • We conclude from this observation that the primary requirement for S-adenosylmethionine during bacterial chemotaxis is in the methylation of receptor proteins. (princeton.edu)
  • In this report, we took advantage of the tractability of the prokaryotic model Bacillus subtilis to provide evidence for the coexistence of two distinct families of FMMs in bacterial membranes, displaying a distinctive distribution of proteins specialized in different biological processes. (uni-wuerzburg.de)
  • One family of microdomains harbors the scaffolding flotillin protein FloA that selectively tethers proteins specialized in regulating cell envelope turnover and primary metabolism. (uni-wuerzburg.de)
  • Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
  • Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
  • Membrane proteins play a key role in the cell's energy metabolism and in its signalling and communication with its environment. (lu.se)
  • The lectures address the three different main types of membrane proteins and associated cellular processes: transport and transporters, signal transduction and receptors, bioenergetics and photosynthetic and respiratory proteins. (lu.se)
  • The investigation of signal transduction pathways is critical to the basic understanding of cellular processes as these pathways function to regulate diverse processes in both eukaryotes and prokaryotes. (umd.edu)
  • The second main research area supported by the NIH funding will focus on enzymes involved in bacterial signal transduction pathways. (lehigh.edu)
  • Bacteria can respond to their environment using signal transduction pathways that lead to the regulation of sets of genes by transcription factors, Fisher says. (lehigh.edu)
  • These pathways are comprised of many different enzymes that collaborate to deliver signals from the environment into the cell. (lehigh.edu)
  • Signal transduction pathways regulate gene expression in part by modulating the stability of specific mRNAs. (ed.ac.uk)
  • We recently discovered that bacterial membranes organize their signal transduction pathways in functional membrane microdomains (FMMs) that are structurally and functionally similar to the eukaryotic lipid rafts. (uni-wuerzburg.de)
  • A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)
  • This dissertation focuses on understanding some of the biochemical events that take place in the chemotaxis signal transduction pathway of bacteria. (umd.edu)
  • Our research focuses on the fundamental understanding of how bacteria regulate flagellar assembly, how a cell coordinates the assembly of unrelated molecular machines and how hosts recognise this important antigen. (ncl.ac.uk)
  • These problems are being investigated in systems that range from bacteria and bacteriophage to yeast to human cells and their viruses. (berkeley.edu)
  • bacteria: The colony diameter is 5 cm and the colors indicate the bacterial density (bright yellow for high density). (wikipedia.org)
  • The bacteria adhere to nasopharyngeal, pulmonary, and endothelial cells. (stjude.org)
  • However, as an endosymbiotic bacterium, Wolbachia does not grow outside the host cell environment, and large-scale recovery of the bacteria required mass rearing of their host, preferably clones of a single individual to avoid strain genetic diversity, or amplification of cell cultures infected with a single Wolbachia strain. (bvsalud.org)
  • It can be used with a set of predefined MacSyFinder models, "TXSScan," to identify all major secretion systems of diderm bacteria (i.e., with inner and LPS-containing outer membranes) as well as evolutionarily related cell appendages (pili and flagella). (bvsalud.org)
  • Violacein exhibits broad spectrum activity against bacteria, protozoans (including malaria), viruses and mammalian cell lines. (toku-e.com)
  • Microscopic analysis of cell and colony structure indicates that CmrRST promotes the formation of elongated bacteria arranged in bundled chains, which may contribute to bacterial migration on surfaces. (nih.gov)
  • Small talk: cell-cell communication in bacteria. (microbiologyresearch.org)
  • Bacterial lipoproteins are structurally divided into two groups, based on their lipid moieties: diacylated (present in Gram-positive bacteria) and triacylated (present in some Gram-positive and most Gram-negative bacteria). (bvsalud.org)
  • Toll-like receptors are a family of receptors that recognize components of bacteria and induce a proinflammatory response by cells, including macrophages and endothelial cells. (ox.ac.uk)
  • They respond to various components, including lipopolysaccharide of Gram-negative bacteria, lipopeptides of Gram-positive cell walls, bacterial DNA, and flagella. (ox.ac.uk)
  • In this report, we show that infection with influenza A virus and treatment with the resulting host signals (febrile-range temperatures, norepinephrine, extracytoplasmic ATP, and increased nutrient availability) induce the release of bacteria from biofilms in a newly developed biofilm model on live epithelial cells both in vitro and during in vivo colonization. (lu.se)
  • We show that these interkingdom signals are recognized by bacteria and are induced by influenza virus infection, which is epidemiologically strongly associated with transition to secondary pneumococcal disease. (lu.se)
  • and, regulation of biological processes such as chromosomal folding, protein secretion and intracellular signaling. (berkeley.edu)
  • It carries messages that help in muscle contraction, nerve cell signal transmission, hormone secretion, immune cell activation, and other cellular functions. (dojindo.com)
  • Here, we describe how to identify protein secretion systems in bacterial genomes using the MacSyFinder program. (bvsalud.org)
  • Our research expertise is world-recognized in areas such as bacterial secretion, aging, signal transduction, protein folding, drug metabolism and cellular protein trafficking. (ucl.ac.uk)
  • Biochemical data suggest that SA potentiates the signal pathway for HR by affecting an early phosphorylation-sensitive step preceding the generation of pro-death signals, including those derived from the oxidative burst. (springer.com)
  • Portions of this work were in Regulation of Drug Metabolizing Enzymes in Inflammation: Role of the Toll-Like Receptor 4 Signaling Pathway (R. Ghose, D. White, J. Vallejo, and S. J. Karpen), which was presented at Experimental Biology 2007 in Washington, DC, April 28-May 2, 2007. (aspetjournals.org)
  • For example, the mitogen-activated protein kinase (MAPK) p38 pathway mediates stabilization of tumor necrosis factor alpha (TNF-alpha) mRNA in myeloid cells stimulated with bacterial lipopolysaccharide (LPS). (ed.ac.uk)
  • Our findings demonstrate a direct link between a specific signal transduction pathway and a specific RNA-binding protein, both of which are known to regulate TNF-alpha gene expression at a posttranscriptional level. (ed.ac.uk)
  • In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
  • They can be divided into two distinct types based on their sequence as well as the retinal isomer they contain at the ground state and their signal transduction mechanisms. (wikipedia.org)
  • As NTPs, particularly GTP, are important for cellular macromolecular synthesis and signalling mechanisms, Ndk plays an important role in bacterial growth, signal transduction and pathogenicity. (embl.de)
  • She is interested in understanding the fundamental mechanisms and principles by which cells, and, in particular, bacterial cells, are able to multiple. (stanford.edu)
  • Over the years, her group made major contributions in the emerging field of bacterial cell biology and provided key molecular insights into the temporal and spatial mechanisms involved in cell morphogenesis, cell polarization, chromosome segregation and cell cycle control. (stanford.edu)
  • Current research examines the general principles and spatiotemporal mechanisms by which bacterial cells replicate, using Caulobacter crescentus and Escherichia coli as models. (stanford.edu)
  • Caulobacter crescentus is a single-celled, small bacterium that divides asymmetrically producing cells that differ in structure and function - it is an ideal model system for the mechanisms of asymmetric cell division and has been studied thoroughly. (kenyon.edu)
  • In order to analyze the cell cycle regulatory mechanisms and other mechanisms of Caulobacter , many mutant strains have been made and studied. (kenyon.edu)
  • I also have a strong background in bacterial pathogenesis of both Animal and Plant Hosts. (ncl.ac.uk)
  • Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacterial pathogenesis and eukaryotic immunity. (nih.gov)
  • Jarzab M, Posselt G, Meisner-Kober N, Wessler S . Helicobacter pylori -derived outer membrane vesicles (OMVs): role in bacterial pathogenesis? (plus.ac.at)
  • The major focus of this research is the molecular pathogenesis of invasion and inflammation induced by Streptococcus pneumoniae, the leading invasive bacterial pathogen of children. (stjude.org)
  • Our findings indicate that C. difficile employs phase variation of the CmrRST signal transduction system to generate phenotypic heterogeneity during infection, with concomitant effects on bacterial physiology and pathogenesis. (nih.gov)
  • My laboratory uses, bacterial genetics, protein biochemistry, structural biology, bioinformatics and microscopic techniques to validate our genetic findings. (ncl.ac.uk)
  • This new grant will fund Fisher's lab to pursue two primary research directions to shed light on bacterial biochemistry: investigating how these organisms regulate uptake of the essential trace element copper and how different members of a family of bacterial enzymes each catalyze distinct chemical reactions. (lehigh.edu)
  • She received her PhD in Biochemistry in 1996 from the University of Liège, Belgium where she unraveled a molecular mechanism by which some bacterial pathogens sense and respond to antibiotics attack to achieve resistance. (stanford.edu)
  • My expertise utilise bacterial genetics to study fundamental aspects of the bacterial life cycle and host-microbe interactions. (ncl.ac.uk)
  • Streptococcus pneumoniae, a leading cause of bacteremia, sinusitis, otitis media, bacterial meningitis, and bacterial pneumonia, causes substantial illness and death in persons worldwide ( 1 ). (cdc.gov)
  • It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)
  • Those immune defects lead to infections with bacterial, viral, and fungal pathogens that begin during infancy and, if untreated, result in a fatal outcome in the first few years of life. (medscape.com)
  • There are a wide variety of applications for biosensors, such as homeland security biological countermeasures, clinical diagnosis, food and water safety, fermentation control, bacterial and viral analysis, industrial effluent control, military operations, and space applications. (msu.edu)
  • In addition to bacterial organisms, oral microorganisms can include fungal, protozoal, and viral species. (medscape.com)
  • during viral and bacterial infections, as well as with the use of certain drugs. (medscape.com)
  • The research strategy is to develop process-monitoring tools for the quantification of contaminating compounds (e.g. bacterial toxins, viral markers) at extremely low levels. (lu.se)
  • LPS binds to the cell-surface receptor, Toll-like receptor 4 (TLR4), which initiates a signal transduction cascade, including recruitment of the Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP). (aspetjournals.org)
  • Human polymorphisms of Toll-like receptor genes have been discovered and are associated with hyporesponsiveness to bacterial components. (ox.ac.uk)
  • At present it is assumed that the relationship between an individual's susceptibility and bacterial virulence determines the balance between tolerance of invading pathogens and the mounting of an immune response, which in turn dictates the course of infection and subsequent recurrence. (ncl.ac.uk)
  • During my career I have gained valuable experience working with a range of bacterial pathogens. (ncl.ac.uk)
  • Specific examples of the role of Ndk in regulating growth, NTP formation and cell surface polysaccharide synthesis in two respiratory tract pathogens, Pseudomonas aeruginosa and Mycobacterium tuberculosis, are discussed. (embl.de)
  • Cell lines and transfected cell systems augment this study with particular emphasis on perturbations in the biology of selectins, integrins, matrix adhesion, and chemokine receptors. (stjude.org)
  • This 5 weeks full-time practical course provides an introduction into modern cell and developmental biology-related methods with a focus on Bio-Imaging techniques. (uni-wuerzburg.de)
  • Well-defined aspects of scientific projects are addressed with independently designed experiments in the context of current research projects in the field of cell and developmental biology. (uni-wuerzburg.de)
  • The participants are qualified to carry out scientific experiments in the field of cell and developmental biology independently and modify them according to the outcome. (uni-wuerzburg.de)
  • Our part focuses on the cell biology of parasites. (uni-wuerzburg.de)
  • The lecture series is a joint activity of the chairs of Cell- and Developmental Biology, Microbiology, Biophysics and Bioinformatics and deals with concepts of modern molecular biology from the point of view of these different disciplines. (uni-wuerzburg.de)
  • The section Cell Biology mainly regards the eukaryotic cell and intends to elucidate the vast diversity in structure and function of molecules, organelles and cells in addition to basic principles of modern molecular cell biology. (uni-wuerzburg.de)
  • The bioinformatics section contains a large amount of examples for applications which allow the investigation of the molecular biology of a cell with bioinformatics tools. (uni-wuerzburg.de)
  • The topics range from classical developmental subjects such as tissue regeneration and morphogenetic cell migration to molecular stem cell biology, epigenetic plasticity, origins of multicellularity and development within changing environments. (uni-wuerzburg.de)
  • For her distinguished work, she received the Pew Scholars award from the Pew Charitable Trust, the Woman in Cell Biology Junior award from the American Society of Cell Biology and the Eli Lilly award from the American Society of Microbiology. (stanford.edu)
  • We use state-of-the-art facilities in X-ray crystallography, NMR spectroscopy, mass spectrometry, cryo-electron microscopy, imaging, biophysical and biochemical analysis, molecular and cell biology. (ucl.ac.uk)
  • While rhodopsin in the narrow sense refers to a dim-light visual pigment found in vertebrates, usually on rod cells, rhodopsin in the broad sense (as used here) refers to any molecule consisting of an opsin and a retinal chromophore in the ground state. (wikipedia.org)
  • interkingdom signaling molecule. (nih.gov)
  • Their fluorescent signal intensities or wavelengths change because each intracellular calcium probe has a calcium-selective chelator and a fluorescent moiety in its molecule. (dojindo.com)
  • however, whilst GABA accumulates in plants under stress it has not been determined if, how, where and when GABA acts as an endogenous plant signalling molecule. (nature.com)
  • We will cover different aspects of the host/parasite interaction, the complex life cycles of these parasites and motility of parasites on a single cell level. (uni-wuerzburg.de)
  • We identified an atypical phase-variable signal transduction system consisting of a histidine kinase and two response regulators, named herein colony morphology regulators RST (CmrRST), which mediates the switch in colony morphology and motility behaviors. (nih.gov)
  • The CmrRST-regulated surface motility is independent of flagella and type IV pili, suggesting a novel mechanism of cell migration in C. difficile. (nih.gov)
  • Primarily, a source they require to follow up this communication is the two-component signal transduction system (TCS), which typically comprises a sensor Histidine kinase for receiving external input signals and a response regulator that conveys a proper change in the bacterial cell physiology. (handlebar-online.com)
  • The discovery that the activity of aluminium-activated malate transporters (ALMTs) can be regulated by GABA 18 represents a plausible mechanism by which GABA signals could be transduced in plants, providing a putative-but unproven-novel signalling link between primary metabolism and physiology 19 . (nature.com)
  • Plant and Cell Physiology 2007, 48 (8):1132-1147. (lu.se)
  • This change acts as a molecular switch to activate a signal transduction mechanism within the cell. (wikipedia.org)
  • Caulobacter also uses DNA methylation as a regulatory mechanism in cell cycle progression. (kenyon.edu)
  • Ferreira CV et al (2004) Molecular mechanism of Violacein-mediated human leukemia cell death. (toku-e.com)
  • Here, we establish endogenous GABA as a bona fide plant signal, acting via a mechanism not found in animals. (nature.com)
  • A living cell has many different receptors on its surface by the activation of which information is transferred to the intracellular spaces. (dojindo.com)
  • Monitoring and control of the intracellular ion concentration is extremely important in understanding second messengers and intracellular signal transduction. (dojindo.com)
  • Urinary tract infections (UTIs) are a common bacterial infection with symptoms that include urinary frequency, urgency to void, dysuria and abdominal pain. (ncl.ac.uk)
  • Recent studies have explored the requirement of S A for mounting the hypersensitive response (HR) against an invading pathogen, where a particular cell death process is activated at the site of attempted infection causing a confined lesion. (springer.com)
  • Foci of infection in the oral cavity arising from chronic periodontitis or chronic periapical abscesses (ie, inflammation and abscess of the tissue attached to the apex of the root) may lead to subacute bacterial endocarditis (BE) and glomerulonephritis (GN). (medscape.com)
  • Periodontitis is a common chronic bacterial infection of the supporting structures of the teeth. (medscape.com)
  • Despite a low invasive disease rate, widespread carriage ensures that infection occurs often enough to make S. pneumoniae a leading bacterial cause of respiratory disease worldwide. (lu.se)
  • In this report, we show that infection with influenza A virus and treatment with the resulting host signals (febrile-range temperatures, norepinephrine, extracytoplasmic ATP, and. (lu.se)
  • As virus infection is a common inducer of transition to disease among species occupying the nasopharynx, the results of this study may provide a basis for better understanding of the signals involved in the transition from colonization to disease in the human nasopharynx. (lu.se)
  • We have studied how bacterial species such as the pathogen Salmonella enterica maintain a discrete number of flagellar per cell during cell growth and division. (ncl.ac.uk)
  • Although extensive data has described the key role of salicylic acid (SA) in signaling pathogen-induced disease resistance, its function in physiological processes related to cell death is still poorly understood. (springer.com)
  • Cell-autonomous recognition of the rust pathogen determines Rpl-specified resistance in maize. (springer.com)
  • Bernegger S, Vidmar R, Fonovic M, Posselt G, Turk B, Wessler S . Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells. (plus.ac.at)
  • Other projects aim at characterizing the properties of an assembled toxin pore on the surface of red blood cells and exploring the effect of the toxin on other cell types such as lung epithelial cells. (wheaton.edu)
  • According to the type of defect that leads to a SCID phenotype, Combined B- and T-cell disorders can be divided into specific groups with unique pathophysiologies that invariably result in an absence of nonfunctional B cells and absence of T cells (see Table 1). (medscape.com)
  • Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)
  • The mRNA expression of HIF target genes, namely glucose transporter-1, carbonic anhydrase-9, vascular endothelial growth factor, B-cell lymphoma 2/adenovirus E1B 19-kDa protein-interacting protein 3, prolyl hydroxylase domain-2, and prolyl hydroxylase domain-3, was not significantly altered in NVVs and VVs exposed to hypoxia and treated with doxycycline or MPFF compared with those untreated. (ox.ac.uk)
  • Our results demonstrate that despite the lack of a paternal genome, hpESCs generate proliferating NSCs that are capable of differentiation into physiologically functional neuron-like cells and maintain allele-specific expression of imprinted genes. (uni-wuerzburg.de)
  • The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
  • In addition to this, DNA methylation is main component of signaling differentiation. (kenyon.edu)
  • Parent of origin imprints on the genome have been implicated in the regulation of neural cell type differentiation. (uni-wuerzburg.de)
  • The ability of human parthenogenetic (PG) embryonic stem cells (hpESCs) to undergo neural lineage and cell type-specific differentiation is undefined. (uni-wuerzburg.de)
  • Under culture conditions promoting neural differentiation, hpESC-derived neural stem cells (hpNSCs) gave rise to glia and neuron-like cells that expressed subtype-specific markers and generated action potentials. (uni-wuerzburg.de)
  • Analysis of imprinting in hpESCs and in hpNSCs revealed that maternal-specific gene expression patterns and imprinting marks were generally maintained in PG cells upon differentiation. (uni-wuerzburg.de)
  • Nucleoside diphosphate kinase: role in bacterial growth, virulence, cell signalling and polysaccharide synthesis. (embl.de)
  • The flagellar filament is a major antigen recognized by hosts during bacterial infections. (ncl.ac.uk)
  • T cell immunodeficiencies and severe combined immunodeficiencies (SCIDs) are marked with opportunistic infections caused by common environmental microorganisms. (lu.se)
  • The bacterial endotoxin, lipopolysaccharide (LPS), induces expression of proinflammatory cytokines in the liver, which contribute to altered DME expression. (aspetjournals.org)
  • When the genetic information containing the "blueprint" for these substances is disrupted, cell homeostasis is disrupted, resulting in a wide-range of immediate and/or delayed toxicological effects. (cdc.gov)
  • Staining of such tissues with TSQ has demonstrated that zinc ions play very important roles in neuronal cell death, endocrine functions, and other physiological phenomena. (dojindo.com)
  • These enzymes play important roles in bacterial growth, signal transduction and pathogenicity. (embl.de)
  • Reactive oxygen intermediates mediate a systemic signal network in the establishment of plant immunity. (springer.com)
  • This interaction allows bacterial entry into cells and results in transmigration. (stjude.org)
  • Our genetic and biochemical analysis shows that BamE stabilizes the Bam complex and promotes bidirectional signaling interaction between BamA and BamD. (bvsalud.org)
  • Nowadays, the production of full Wolbachia genomes does not require the physical isolation of the bacterial strains from their respective hosts, and the bacterium is often sequenced as a by-catch of host genomic projects. (bvsalud.org)
  • Ho YJ, Burden LM, Hurley JH: "Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor. (wheaton.edu)
  • Caulobacter asymmetrically divides to produce two types of daughter cells that are functionally and structurally different. (kenyon.edu)
  • however, chromosome replication begins immediately in the daughter cell with the stalk and when the swarmer loses its tail (Stanford). (kenyon.edu)
  • P1 transduction map spanning the replication terminus of Escherichia coli K12. (microbiologyresearch.org)
  • The results offer novel and important insights into the role of interkingdom signaling between microbe and host during biofilm dispersion and transition to acute disease. (lu.se)
  • We're hoping that we can take what we learned in this really nice model system and use that information to understand more about how similar processes work in pathogenic bacterial strains. (lehigh.edu)
  • Cell Host & Microbe 31:681-682, 2023. (stjude.org)
  • Typical biological recognition elements used in biosensors range from DNA probes, antibodies, enzymes, cells and tissues. (msu.edu)
  • To avoid pH dependence of the fluorescent signal in calcium detection, Dr. Tsien changed the aliphatic amines of EGTA to aromatic amines, thereby transforming EGTA into a new calcium chelator, BAPTA. (dojindo.com)
  • Here we focus on the flagellated bacterium {\it E. coli}, for which a great deal is known about signal detection, transduction and cell-level swimming behavior. (mpg.de)
  • Src homology 2 (SH2) domains play a critical role in signal transduction in mammalian cells by binding to phosphorylated Tyr (pTyr). (rcsb.org)
  • On the basis of the structure of RseB, we suggest that it acts as a sensor of periplasmic stress with a dual functionality: it detects mislocalized lipoproteins and propagates the signal to induce the sigma(E)-response. (mpg.de)
  • MacCain W, Tuomanen E . Taste vs pain: a sensory feast in bacterial meningitis. (stjude.org)
  • Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. (mdpi.com)
  • Signal transduction in phototaxis involves depolarization of the cell membrane. (wikipedia.org)
  • This regulation ensures a sequential assembly of functionally specialized membrane microdomains to strategically organize signaling networks at the right time during the lifespan of a bacterium. (uni-wuerzburg.de)
  • This is followed by experimental determination using genetic construction and expression of a fusion protein of the membrane protein and a marker protein in a bacterial system which is subsequently analysed. (lu.se)