Bacterial binds. Medical search. Frequent questions

In molecular biology, bacterial DNA binding proteins are a family of small, usually basic proteins of about 90 residues that bind DNA and are known as histone-like proteins. (wikipedia.org)
Since bacterial binding proteins have a diversity of functions, it has been difficult to develop a common function for all of them. (wikipedia.org)
in these processes, bacterial DNA binding proteins have an architectural role, maintaining structural integrity as transcription, recombination, replication, or any other DNA-dependent process proceeds. (wikipedia.org)
Upon further investigation, it was discovered that the amino acid composition of HU resembles that of eukaryotic histones, thus prompting further research into the exact function of bacterial DNA binding proteins and discoveries of other related proteins in bacteria. (wikipedia.org)
Initially, bacterial DNA binding proteins were thought to help stabilize bacterial DNA. (wikipedia.org)
Currently, many more functions of bacteria DNA binding proteins have been discovered, including the regulation of gene expression by histone-like nucleoid-structuring protein, H-NS. (wikipedia.org)
This sequence of biochemical events establishes a chain of communication that ultimately allows the chemotaxis receptor proteins to regulate the swimming pattern of the bacterial cell when it encounters gradients of attractant and repellent chemicals in its environment. (umd.edu)
In this thesis we have produced proteins that are densely decorated with carbohydrate determinants in order to study the glycosylation capacity of cell lines (paper I) and generate efficient binders of antibodies (paper II), bacterial toxins (paper III) and virus receptors such as the influenza hemagglutinin (paper IV). (avhandlingar.se)
X-ray structures of membrane proteins have revealed tight and specific binding of lipids. (pasteur.fr)
Protein stabilization upon ligand binding has frequently been used to identify ligands for soluble proteins. (nih.gov)
Here the authors used MsbA (an adenosine triphosphate binding cassette transporter), CorA (a Mg(++) channel), and CpxA (a histidine kinase) as model proteins and show that DSLS is not sensitive to the presence of detergents or protein hydrophobicity and can be used to monitor thermodenaturation of membrane proteins, assess their stability, and detect ligand binding in a 384-well format. (nih.gov)
Body 1 PFO framework and structural modifications No crystals of CDC pore complexes possess however been reported but crystallography greater than 15 bacterial external membrane proteins demonstrated the fact that tilt of β-strands in accordance with the pore axis was 37° or even more in each case10. (research-in-field.com)
Proteins are major chromophores and targets for damage due to their abundance, but the role of proteins in inducing damage to bound DNA, and the effects on DNA-protein interactions is less well characterized. (ku.dk)
Here we describe an African swine fever virus (ASFV) protein encoded by the open reading frame 5-AR that shares structural and functional similarities with the family of bacterial histone-like proteins which include histone-like DNA binding proteins, integration host factor, and Bacillus phage SPO1 transcription factor, TF1. (illinois.edu)
Catalyzed by primosome proteins such as PriA, PriB, PriC, DnaT, and DnaG, DNA replication restart pathways facilitate origin-independent reloading of the replicative helicase onto a repaired DNA replication fork in a process that involves coordinated protein and nucleic acid binding within a nucleoprotein complex called the DNA replication restart primosome [ 2 ]. (biomedcentral.com)
PriA is thought to recognize and bind to repaired DNA replication forks and D-loop recombination intermediates, facilitate assembly of the primosome complex by recruiting other primosome proteins, and catalyze duplex DNA unwinding using energy furnished by hydrolysis of ATP [ 4 , 5 ]. (biomedcentral.com)
The study identified the ways in which proteins cross a cell membrane, a finding that could create a scientific foundation for better ways of delivering drugs into cells in the future, or for treating illnesses caused by bacterial toxins. (scitechdaily.com)
Recently, it has been recognized that membrane-bound ribosomes are crucial for biogenesis of integral membrane proteins in E. coli , thus renewing interest in ribosome targeting to and association with the membrane in this organism. (rupress.org)
Antimicrobial proteins and peptides offer a multifaceted mechanism suitable to fight bacterial resistance. (frontiersin.org)
Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins. (bvsalud.org)
Analogues of c-di-GMP, which can selectively modulate the activities of c-di-GMP processing proteins , will be useful chemical tools for studying and altering bacterial behavior . (bvsalud.org)
Consequently, endo-S-c-di-GMP has selectivity for proteins that bind monomeric but not dimeric c-di-GMP, which form from the "closed" conformer. (bvsalud.org)
This work demonstrates that selective binding to different classes of c-di-GMP binding proteins could be achieved by altering analogue conformer populations (conformational steering). (bvsalud.org)
We provide important design principles for the preparation of selective PDE inhibitors and reveal the role played by the c-di-GMP backbone in c-di-GMP polymorphism and binding to processing proteins . (bvsalud.org)

The role of single-stranded DNA binding (SSB) protein during DNA replication in Escherichia coli cells has been studied, specifically the interactions between SSB and the χ subunit of DNA polymerase III in environments of varying salt concentrations. (wikipedia.org)
Research has shown that the ssDNA is stabilized by the interaction of SSB and the χ subunit of DNA polymerase III in E. coli, thus preparing for replication by maintaining the correct conformation that increases the binding affinity of enzymes to ssDNA. (wikipedia.org)
b FtsZ84 contains a mutation in the GTP binding site that reduces GTP binding and hydrolysis, thereby weakening FtsZ dimerization and subunit-subunit assembly. (biomedcentral.com)
c FtsZ84*M206I and FtsZ84*V293I mutations compensate for FtsZ84's GTP binding defect and help to restore subunit-subunit interactions. (biomedcentral.com)
by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis. (msdmanuals.com)

Following elution, the protein readily binds DNA, indicating the protein's high affinity for DNA. (wikipedia.org)
Streptococcus pneumoniae and Neisseria meningitidis have is specific to the mechanism of resistance to penicillin G com- very similar mechanisms of resistance to penicillin G, which mon to S. pneumoniae and N. meningitidis and mediated by the are mediated by the decreased affinity of penicillin-binding decrease in affinity of their PBPs. (cdc.gov)
By monitoring the fluorescence of TNP-ATP when it bound to CheA, I examined the affinity of the binding interaction and discovered that the two ATP binding sites of each CheA dimer exhibited negative cooperativity in their interactions with TNP-ATP. (umd.edu)
Antibody binding to bacterial surfaces plays a crucial role in immunity, and a key characteristic of this protein-protein interaction is the binding affinity. (lu.se)
Determining the affinity of an antibody binding to its antigen is the first step in predicting the function in a physiological environment where other competing protein interactions may be present. (lu.se)
In this chapter, we present a flow cytometry-based assay to measure and calculate the cell surface binding affinity or avidity of any mono- or polyclonal antibody solution. (lu.se)
Biacore biosensor assays indicated that PSGL - 1/mIgG 2b carrying the blood group P1 determinant in multiple copies bound with high affinity to Stx1 and Stx2, while PSGL - 1/mIgG 2b presenting multiple copies of Sia α 2,3Gal on different O - linked cores bound with high affinity to avian influenza H5. (avhandlingar.se)
Kumra Ahnlide, V & Nordenfelt, P 2023, Measurement of Antibody Binding Affinity on Bacterial Surfaces Using Flow Cytometry . (lu.se)
Independent evidence shows that it binds iron directly, although with very distinct features and low affinity. (cnr.it)
We demonstrate that the protein has low cation specificity and contains multiple binding sites able to chelate divalent and trivalent metals with low affinity. (cnr.it)

Proline-rich antimicrobial peptides (PrAMPs) produced as part of the innate immune response of animals, insects and plants represent a vast, untapped resource for the treatment of multidrug-resistant bacterial infections. (cipsm.de)
An important concept in the evaluation of data regarding transfusion-transmitted bacterial infections (TTBIs) is the definition of a case. (medscape.com)
4]. Neutrophils are involved in the body's infection, cold, fever, chest congestion, defence against microorganisms, especially stomach upset or loose bowel motions were against pyogenic bacterial infections [5]. (who.int)

A ligand fixation into DNA structure can be performed by electrostatic binding between a positively charged guest and negatively charged DNA host by binding to the major and minor groove of DNA and by intercalation, meaning the insertion of the ligand molecule between DNA base pairs. (databasefootball.com)

AfuABC is conserved across a wide range of bacterial genera, including the enteric pathogens EHEC O157:H7 and its murine-specific relative Citrobacter rodentium, where it lies adjacent to genes implicated in sugar sensing and acquisition. (rcsb.org)

PrAMPs such as oncocin or bactenecin-7 (Bac7) interact with the bacterial ribosome to inhibit translation, but their supposed specificity as inhibitors of bacterial rather than mammalian protein synthesis remains unclear, despite being key to developing drugs with low toxicity. (cipsm.de)
These findings highlight the need to consider the specificity of PrAMP derivatives for the bacterial ribosome in future drug development efforts. (cipsm.de)
Here we show that RF2 is in an open conformation when bound to the ribosome, allowing GGQ to reach the PTC while still allowing SPF-stop-codon interaction. (nature.com)

Bacterial Pathogenesis: Methods and Protocols (2 ed., pp. 251-259). (lu.se)
Efficient acquisition of extracellular nutrients is essential for bacterial pathogenesis, however the identities and mechanisms for transport of many of these substrates remain unclear. (rcsb.org)
Our study shows that AfuABC-dependent uptake of sugar-phosphates plays a critical role during enteric bacterial infection and uncovers previously unrecognized roles for these metabolites as important contributors to successful pathogenesis. (rcsb.org)

Moreover, we demonstrate that Bac7 allows initiation complex formation but prevents entry into the elongation phase of translation, and show that it inhibits translation on both mammalian and bacterial ribosomes, explaining why this peptide needs to be stored as an inactive pro-peptide. (cipsm.de)
Membrane-bound ribosomes in E. coli were extensively studied over 20 years ago. (rupress.org)

If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it triggers a response to attack the invading viruses or bacteria. (medlineplus.gov)
index in the 1st trimester, the increases were bacterial, viral or parasitic) of Vidyasagar statistically significant (Table 1). (who.int)

Here, we have carried out an extensive study of the binding properties of CyaY, the bacterial ortholog of frataxin, to different divalent and trivalent cations, using NMR and X-ray crystallography. (cnr.it)

H-NS is about 15.6 kDa and assists in the regulation of bacterial transcription in bacteria by repressing and activating certain genes. (wikipedia.org)
The signal conversion takes advantage of the noncovalent and reversible nature of the self-assembled system, i.e., the multivalent binding of bacteria induces conformational changes in the supramolecular state, which is translated into differential fluorescence emissions. (elsevierpure.com)
The chloromelamine-based fibrous materials provided potent, durable, and rechargeable biocidal functions against bacteria (including multi-drug resistant species), yeasts, viruses, and bacterial spores. (cdc.gov)
Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum. (bvsalud.org)

HU is a small (10 kDa) bacterial DNA-binding protein, which structurally differs from a eukaryotic histone but functionally acts similarly to a histone by inducing negative supercoiling into circular DNA with the assistance of topoisomerase. (wikipedia.org)
Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1. (nature.com)
The team subsequently observed that two structurally different bacterial toxins also employed this same mechanism. (scitechdaily.com)

A meta-analysis of 22 studies of bacterial contamination rate estimates for apheresis (AP), platelet-rich plasma (PRP), and buffy coat (BC) collection methods found an overall mean contamination rate of 0.51 per 1000 components (95% confidence index [CI], 0.38-0.67). (medscape.com)

The ParB protein forms DNA bridging interactions around parS to condense DNA and earmark the bacterial chromosome for segregation. (elifesciences.org)
Carbohydrate - protein inte ractions in nature are often mediated via multivalent binding where the combined strength of multiple receptor - ligand interactions results in a binding that is highly specific and strong. (avhandlingar.se)

The researchers think that the lipid may help the binding pocket adapt to different ligands, thus contributing to polyspecificity. (acs.org)
Furthermore, differential binding was observed also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA. (researchgate.net)

Quinolones inhibit two enzymes that are required for bacterial DNA synthesis, i.e. (cdc.gov)
they inhibit bacterial DNA-dependent RNA polymerase, suppressing RNA synthesis. (msdmanuals.com)
For example, endo-S-c-di-GMP can inhibit the hydrolysis of c-di-GMP by RocR (a PDE enzyme that binds monomeric c-di-GMP) but did not bind to Alg44 (a PilZ protein ) or regulate WspR (a DGC enzyme that has been shown to bind to dimeric c-di-GMP). (bvsalud.org)

Monospecific antiserum prepared to the 5-AR bacterial expression product specifically immunoprecipitated a protein of approximately 11.6kDa from ASFV infected swine macrophages at late times post-infection. (illinois.edu)
One such example is diphtheria toxin, which is produced by Corynebacterium diphtheriae and causes diphtheria, a serious and potentially fatal bacterial infection of the nose and throat. (scitechdaily.com)
Whether regular exercise also affects bacterial infection susceptibility is unknown. (ku.dk)

The model suggests that simple differences in the impact of antibiotic exposure does not differ according to the natural history of colonization, interhuman contact, and expo- mechanism of resistance and do not consider the particular nat- sure to -lactam antibiotics explain major differences in the epi- ural history of the colonization of the bacterial species. (cdc.gov)
In the second project, I focused on elucidating the binding mechanism that underlies formation of the CheA:TNP-ATP complex. (umd.edu)
The identification of this pore binding site sheds light on the mechanism of barbiturate inhibition of cationic pLGICs and allows the rationalization of several structural and functional features previously observed for barbiturates. (nih.gov)
We have related how such an ability to bind cations on a relatively large area through an electrostatic mechanism could be a valuable asset for protein function. (cnr.it)
DNA replication restart pathways provide bacterial cells with a mechanism to reactivate replisomes that are disrupted in this manner [ 2 ]. (biomedcentral.com)
Recruitment of PriB to a PriA:DNA complex stabilizes PriA on the DNA [ 6 ] and enhances its helicase activity through a mechanism that involves PriB's single-stranded DNA-binding activity [ 7 ]. (biomedcentral.com)
The function of DnaT is not well understood, but it has been proposed that DnaT binding leads to dissociation of single-stranded DNA (ssDNA) from PriB through a competition mechanism, possibly exposing the ssDNA on the lagging strand template for reloading the replicative helicase, which ultimately leads to fork reactivation [ 8 ]. (biomedcentral.com)
Furthermore, it is unclear if bacterial size modulation is simply a byproduct of the complex cellular response to changing environmental conditions, or if it serves as an adaptive mechanism employed by the cell to improve fitness in time-varying environments. (nature.com)

Many bacterial cells defend themselves against antibiotics by expelling the drugs using multidrug efflux pumps. (acs.org)
Therefore, -lactam antibiotics, such as penicillin G, bind to PBPs in better understanding of S. pneumoniae resistance selection and the bacterial cell wall. (cdc.gov)
However, it still detectably increases the permeability of the bacterial cell wall to other antibiotics, indicating that it still causes some degree of membrane disorganization. (wikipedia.org)

Microbiota oral contains bacterial spores. (medscape.com)

Moreover, the free C-terminal domain can rapidly decondense ParB networks independently of its ability to bind DNA. (elifesciences.org)

Patients with pre-existing moderate/severe renal impairment (CrCl ≤50 mL/min)who were treated with VIBATIV for hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia had increased mortality observed versus vancomycin. (nih.gov)

While it remains unclear if N. gonorrhoeae PriB's weak DNA binding activity is required for PriB stimulation of PriA helicase, the ability of PriB to stimulate PriA-catalyzed ATP hydrolysis could play an important role. (biomedcentral.com)

In E. coli, H-NS binds to a P1 promoter decreasing rRNA production during stationary and slow growth periods. (wikipedia.org)
We report that N. gonorrhoeae PriA's DNA binding and unwinding activities are similar to those of E. coli PriA, and N. gonorrhoeae PriA's helicase activity is stimulated by its cognate PriB, as it is in E. coli . (biomedcentral.com)
This finding is significant because N. gonorrhoeae PriB's single-stranded DNA binding activity is weak relative to that of E. coli PriB, and in E. coli , PriB's single-stranded DNA binding activity is important for PriB stimulation of PriA helicase. (biomedcentral.com)
To understand the dynamics of bacterial growth physiology and size control in dynamic nutrient environments, we have developed a coarse-grained proteome sector model which connects gene expression to growth rate and division control, and accurately predicts the cell-level E. coli response to nutrient perturbations in both exponential and stationary phase seen in experimental data 5 , 25 . (nature.com)

And it is also how bacterial toxins enter human cells and wreak havoc. (scitechdaily.com)
Pei's research team at Ohio State has spent years trying to understand how biomolecules such as bacterial toxins get inside a human cell, with the goal of finding ways to get medications into those cells. (scitechdaily.com)
Reference: "Bacterial Toxins Escape the Endosome by Inducing Vesicle Budding and Collapse" by Ashweta Sahni and Dehua Pei, 23 September 2021, ACS Chemical Biology . (scitechdaily.com)

In these high salt concentrations, the eukaryotic histone protein is eluted from a DNA solution in which single stranded DNA is bound covalently to cellulose. (wikipedia.org)
These nucleoprotein complexes act as a positional marker of the origin and earmark this region for segregation in a manner somewhat analogous to eukaryotic centromeres and their binding partners. (elifesciences.org)
To our knowledge, p11.6 is the first bacterial histone-like DNA-binding protein found in an animal virus or eukaryotic cell system. (illinois.edu)

In addition, docking calculations around the observed binding site for all three states of the receptor, including a model of the desensitized state, showed that barbiturates preferentially stabilize the closed state. (nih.gov)
Here, we exploited this immune Boost (iBoost) technology to enhance the immune response against the receptor-binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. (amsterdamumc.org)
The outlined protocol describes the procedure for producing the HiBiT-receptor-binding domain protein complex and its application for fast and sensitive detection of SARS-CoV-2 antibodies. (jove.com)
Complejo de proteínas que forma un receptor para la TRANSFERRINA en BACTERIAS. (bvsalud.org)

Cholesterol-dependent cytolysins (CDCs) certainly are a huge category of secreted bacterial pore-forming poisons that particularly bind to cholesterol-containing mammalian membranes1. (research-in-field.com)

In this review, we describe current knowledge of the functions associated with cardiolipin binding to respiratory complexes in prokaryotes as a frame to discuss how specific lipid binding may tune their reactivity towards quinone and participate to supercomplex formation of both aerobic and anaerobic respiratory chains. (pasteur.fr)
and amount of monomers per pore (35-50) may differ relatively for different CDCs the system of pore development requires membrane binding from the monomer and their oligomerization into round prepore complexes (PPCs) accompanied by significant supplementary and tertiary structural adjustments as the PPC becomes a membrane-spanning β-barrel pore2. (research-in-field.com)
Here we show that in cells depleted of the SRP protein, Ffh or the translocon component SecE, the ribosomal targeting pathway is blocked downstream and unprecedented, membrane-bound FtsY-ribosomal complexes are captured. (rupress.org)
An efficient tool for investigating a target binding sites on the DNA double helix structure, sequence preference, DNA secondary structure, and the structural variations in DNA-drug complexes is an infrared spectroscopic study. (databasefootball.com)

PFO can be an elongated four-domain proteins3 that binds towards the membrane on the suggestion4 of area 4 (D4) and tasks approximately perpendicularly through the surface area5 6 (Fig. 1a). (research-in-field.com)
Nevertheless D4 binding towards the membrane initiates conformational adjustments in monomer framework2 that trigger β5 to rotate from the primary β-sheet in D321 22 and exposeβ4 for hydrogen bonding using the always-exposed primary β1 strand of another membrane-bound PFO (Fig. 1c). (research-in-field.com)
Researchers have known how small molecules penetrate cell membranes, typically by binding to the membrane and then diffusing through it. (scitechdaily.com)
[1] Polymyxin B works by breaking down the cytoplasmic membrane which generally results in bacterial cell death . (wikipedia.org)
Do bacterial cells have membrane-bound organelles and chromosomes? (answerbag.com)

CEFTIN tablets are indicated for the treatment of pediatric patients (who can swallow tablets whole) with acute bacterial otitis media caused by susceptible strains of Streptococcus pneumoniae , Haemophilus influenzae (including β-lactamase-producing strains), Moraxella catarrhalis (including β-lactamase-producing strains), or Streptococcus pyogenes . (rxlist.com)
CEFTIN for oral suspension is indicated for the treatment of pediatric patients aged 3 months to 12 years with acute bacterial otitis media caused by susceptible strains of Streptococcus pneumoniae , Haemophilus influenzae (including β-lactamase-producing strains), Moraxella catarrhalis (including β-lactamase-producing strains), or Streptococcus pyogenes . (rxlist.com)

The new structures show that a lipid is embedded in the binding pocket along with the substrate. (acs.org)
In this study, we present the first X-ray structures of barbiturates bound to GLIC, a cationic prokaryotic pLGIC with excellent structural homology to other relevant channels sensitive to general anesthetics and, as shown here, to barbiturates, at clinically relevant concentrations. (nih.gov)
Tests the new methods in well-controlled systems, determining x-ray crystal structures and measuring binding thermodynamics. (ucsf.edu)

Cloned p11.6 bound both double and single stranded DNA-cellulose columns. (illinois.edu)

To boost immune recognition of non- or low-immunogenic antigens, we developed a vaccine platform based on the conjugation of a target protein to a chimeric designer peptide (CDP) of bacterial origin. (amsterdamumc.org)

In conclusion, PSGL - 1/mIgG 2b carrying specific carbohydrates is a versatile tool that can be used in a range of applications where the multivalency confers a biologically relevan t binding. (avhandlingar.se)
Confers responsiveness to intracellular bacterial lipopolysaccharides (lps). (lu.se)

A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. (yeastgenome.org)
The cyclic dinucleotide c-di-GMP is a master regulator of bacterial virulence and biofilm formation. (bvsalud.org)

After treatment with diluted chlorine bleach, the covalently bound ACHT moieties were transformed into chloromelamines. (cdc.gov)

The crystal structure of the multidrug transporter LmrP, shown here as side (left) and top views, reveals a lipid (blue) in the binding pocket along with the substrate (green). (acs.org)
By exploiting saturation transfer difference (STD) NMR spectroscopy, the structural requirements necessary for API substrate recognition and binding were identified, with the aim of designing new API inhibitors. (unimib.it)

Inhibits bacterial growth by inhibiting synthesis of dihydrofolic acid. (medscape.com)

It is informative to also be able to assess antibody binding to a bacterial surface where many antigens might be present, including multiple copies of the specific antigen the antibody recognizes, and in a context where the antigen might be in a more natural conformation. (lu.se)

It has been found that H-NS and RNA polymerase both bind to the P1 promoter and form a complex. (wikipedia.org)
Together, they form a functional protein complex called the HLA-DR antigen-binding heterodimer. (medlineplus.gov)
We assumed the formation of DNA-TP complex was based on TP binding to the oxo-form of guanine through hydrogen bonding (NH-CO) or to the enol form of guanine while the oxo-form showed a higher stability. (databasefootball.com)
In the case of TP binding to adenine moiety, the complex might be formed by only one possible concept with significantly lower constant of stability. (databasefootball.com)

The type I ATP-binding cassette (ABC) transporter LpqY-SugABC is the only trehalose import pathway in Mtb. (rcsb.org)

Genes are transcriptional units, and include bacterial operons. (yeastgenome.org)

In DNA replication at the lagging strand site, DNA polymerase III removes nucleotides individually from the DNA binding protein. (wikipedia.org)
When H-NS is bound with RNA Polymerase to the promoter region, there are structural differences in the DNA that are accessible. (wikipedia.org)

Several derivatives of barbiturates containing anomalous scatterers were synthesized, and these derivatives helped us unambiguously identify a unique barbiturate binding site within the central ion channel pore in a closed conformation. (nih.gov)

Binding does not involve cavities or pockets, but exposed glutamates and aspartates, which are residues that are unusual for iron chelation when not assisted by histidines and/or cysteines. (cnr.it)
In this study we show that exposure of isolated dimeric CRP-cAMP to UV modifies specific Met, Trp, Tyr, and Pro side-chains, induces inter-protein Tyr63-Tyr41 cross-links, and decreases DNA binding via oxidation of Met114/Pro110 residues in close proximity at the CRP dimer interface. (ku.dk)
UV exposure also modifies DNA-bound cAMP-CRP, with this resulting in DNA cleavage at specific G/C residues within the sequence bound to CRP, but not at other G/C sites. (ku.dk)

Probable contamination - The blood culture from the recipient is negative or could not be done, but there is definite bacterial growth in the donor blood product. (medscape.com)
While previous studies have characterized bacterial growth physiology at steady-state, a quantitative understanding of bacterial physiology in time-varying environments is lacking. (nature.com)
Here we develop a quantitative theory connecting bacterial growth and division rates to proteome allocation in time-varying nutrient environments. (nature.com)

Seit-Nebi, A., Frolova, L., Justesen, J. & Kisselev, L. Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosomal binding but not for stop codon recognition. (nature.com)
The phagocytic cells use years) in different trimesters who were at- primitive, non-specific recognition systems tending the outpatient department of J.B. which allow them to bind to a variety of Roy State Ayurvedic Hospital, Kolkata, microbial products. (who.int)

Such a beneficial effect seems to result in a reduction of the duration of diarrhea of about one day and seems to be exerted mostly on rotaviral diarrhea, with much less evidence of efficacy in invasive bacterial diarrhea. (medscape.com)

Anatomy22

Organisms17

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes80

Information Science3

Health Care1

Proteins24

Subunit5

Affinity10

Infections3

Negatively charged1

Pathogens1

Ribosome3

Pathogenesis3

Ribosomes2

Viral2

Crystallography1

Bacteria4

Structurally3

Studies of bacterial1

Interactions2

Ligands2

Inhibit3

Infection3

Mechanism8

Antibiotics3

Spores1

Ability to bind1

Pneumonia1

Unclear1

Coli4

Toxins3

Eukaryotic3

Receptor4

Mammalian1

Complexes4

Membrane5

Caused by susceptible2

Structures3

Single-stranded1

Peptide1

Confers2

Regulator2

Covalently1

Substrate2

Inhibits1

Antibody1

Complex4

Transporter1

Genes1

Polymerase2

Conformation1

Residues3

Growth3

Recognition2

Efficacy1