Bacterial and pathogen genomes. Medical search. Frequent questions

Three B. ancashensis strains were analyzed by using whole-genome restriction mapping and high-throughput pyrosequencing. (cdc.gov)
Whole-genome analysis indicates that B. ancashensis might represent a distinct Bartonella lineage phylogenetically related to B. bacilliformis . (cdc.gov)
citation needed] The 100K Pathogen Genome Project is conducting high-throughput next-generation sequencing (NGS) to investigate the genomes of targeted microorganisms, with whole genome sequencing to be carried out on a small number of microorganisms for use as a reference genome. (wikipedia.org)
Scientists use a standardized laboratory and data analysis method called whole genome sequencing to get detailed information about the bacterium, including whether it is closely related genetically to other bacteria. (cdc.gov)
Her work involves analysis of whole genome sequencing (WGS) data to study bacterial pathogens. (sanger.ac.uk)
Whole genome sequencing (WGS) is increasingly used for pathogen identification and surveillance. (eurosurveillance.org)
Currently I am employing genomic approaches on a polyploid plant species Phragmites australias as a model, to study the role of whole genome duplication and interspecific hybridization play in the intraspecific divergence of this widespread weed. (helsinki.fi)
By comparing the genome structure of different populations, we would be able to infer how modern genomes were formed after multiple whole genome duplication and diploidization events, and to understand whether reorganization of genomic structure helps plants with developing local adaptation and invasiveness to the changing environment. (helsinki.fi)
Bergen Open Research Archive: Whole genome sequencing of the fish pathogen Francisella noatunensis subsp. (uib.no)
This study re-analyzed, using multi-locus sequence typing (MLST) and whole genome sequence with single nucleotide polymorphism analysis (WGS-SNP), 52 strains which had been identified as Enterobacter sakazakii as according to the convention at the time of isolation. (biomedcentral.com)
The national network "PulseNet" for the detection of foodborne outbreaks, which includes more than 80 public health laboratories, has transitioned from pulsed-field gel electrophoresis to whole-genome sequencing. (cdc.gov)
Whole-genome sequencing allows for finer subtyping of pathogens and reveals evolutionary relationships between bacterial isolates, allowing for more rapid outbreak detection and a better understanding of transmission and links between cases. (cdc.gov)
Whole-genome sequencing can also predict phenotypic characteristics, such as virulence, serotype, and antimicrobial resistance. (cdc.gov)
Whole-genome sequencing offers subtyping at much finer resolution than was possible with older technologies and thus more confidence in the inferred relationships among cases. (cdc.gov)
After using whole-genome sequencing selectively for several years, investigators in U.S. tuberculosis control programs have now scaled up the process to sequence isolates from all culture-confirmed cases nationwide. (cdc.gov)
Next-generation sequencing now enables a more efficient "sequence-first" approach, in which original specimens are subjected directly to whole-genome reverse-transcriptase PCR, followed by sequencing. (cdc.gov)
in particular, whole genome sequencing (WGS) data can be used for molecular typing purposes with high resolution. (unige.ch)
The increasing accessibility of whole-genome sequencing across research and clinical settings has improved our ability to predict antibacterial susceptibility, to track epidemics at the level of individual outbreaks and wider historical trends, to query the efficacy of the bacille Calmette-Guérin (BCG) vaccine, and to uncover targets for novel antitubercular therapeutics. (jci.org)
Whole-genome sequencing (WGS) of M. tuberculosis and related mycobacteria is now routine, allowing comparisons across time and space. (jci.org)
Dr Kathie Grant is an internationally recognised expert in the field of foodborne pathogens with 30 years experience in clinical and public health microbiology and a research interest in exploiting whole genome sequencing (WGS) of bacterial pathogens to improve the understanding and control of foodborne bacterial illness. (nottingham.ac.uk)
What is the current and future role of whole genome sequencing in identifying and monitoring AMR and emerging threats? (meningitis.org)
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing. (cdc.gov)
Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data. (cdc.gov)
This study examined the added value of whole genome sequencing (WGS) for investigating a non-point source outbreak of Salmonella ser. (who.int)
2 Whole genome sequencing (WGS) is a high-resolution typing method that can help foodborne disease investigators distinguish outbreak cases from non-outbreak cases. (who.int)
For contact tracing or inquiries related to antibiotic resistance, whole genome sequencing (WGS) of bacterial isolates is offered. (folkhalsomyndigheten.se)
Whole genome sequencing can also provide insights into the specific genes or mutations that may be linked to antibiotic resistance. (folkhalsomyndigheten.se)
It is a platform and database for the automated analysis of whole genome sequencing data. (folkhalsomyndigheten.se)

Previously I was a PhD student in the Pathogen Genomics group at the Sanger Institute. (sanger.ac.uk)
In addition, I am looking into the genome annotation and comparative genomics of Tembusu to identify genes selected when adapting to nutrient poor soils. (helsinki.fi)
Rapid advances in pathogen genomics have ushered in a new era of "precision public health. (cdc.gov)
In a recent paper in the New England Journal of Medicine, Dr Greg Armstrong, director of the CDC's Office of Advanced Molecular Detection and coauthors describe how public health agencies have adopted pathogen genomics to improve their effectiveness in almost all domains of infectious disease. (cdc.gov)
The following are some examples from the article to highlight the value of pathogen genomics in public health. (cdc.gov)
In both academia and public health, pathogen genomics is ushering in a new era in data openness. (cdc.gov)
Sub-objective 1.A: Perform comparative genomics of bacterial pathogens. (usda.gov)
Population genomics of bacterial host adaptation. (cdc.gov)
Integrating pathogen genomics with epidemiology is enhancing public health efforts to prevent transmission of communicable diseases, such as tuberculosis (TB). (cdc.gov)

Home / Healthcare & Medicine / Antimicrobial & Antibiotic Resistance / Bacterial Genomes: Antimicrobial Resistance in Bacterial Pathogens / What are the Mechanisms of Antimicrobial Resistance? (futurelearn.com)
The gut is a key conduit for the genesis and spread of antimicrobial resistance in enteric bacterial pathogens. (cdc.gov)
The genome project-supported by the USDA through the Cooperative State, Research, Education & Extension Service s (CSREES) National Research Initiative Competitive Grants Program and the Agricultural Research Service (ARS)-is expected to provide a boost to wide-ranging research efforts for the development of the next generation of antimicrobial agents and vaccines to protect cattle against infection with the bacterium. (innovations-report.com)
Macrophages are central to host defense against microbes, but intracellular pathogens have evolved to evade their antimicrobial functions. (harvard.edu)
My group use microbial sequencing as a tool to gain insights into bacterial evolution, to determine reservoirs and transmission of antimicrobial resistance, and to define its potential utility in diagnostic and public health microbiology. (embo.org)
In addition to identifying pathogens faster and more precisely, high-throughput technologies and bioinformatics can provide new insights into disease transmission, virulence, and antimicrobial resistance. (cdc.gov)
Comparing the assembled genome with reference strains facilitates many different inferences, such as pathogen identification, high-resolution strain typing, and prediction of important phenotypic characteristics (e.g., virulence, antimicrobial resistance). (cdc.gov)
Well-curated and up-to-date reference databases are crucially important because microbial pathogens evolve rapidly and bacteria can exchange plasmids—often encoding virulence and antimicrobial resistance traits—across strains and species. (cdc.gov)

To further investigate the genomic diversity among this group and to help characterize lineages of the plague organism that have no sequenced members, we present here the genomes of two isolates of the "classical" antiqua biovar, strains Antiqua and Nepal516. (asm.org)
The genetic data also indicate that some outbreaks are caused by identical pathogen strains, while other outbreaks may be due to the coexistence of multiple strains. (usda.gov)
Furthermore, some bacterial species are endemic and, in some environments, a single bacterial species can be represented by a number of different strains, some of which are pathogens, and some of which are non-pathogens with beneficial biocontrol activities. (usda.gov)
Therefore, determining which bacteria are responsible for disease and furthermore how certain bacterial strains become pathogenic is an area of research that warrants further study. (usda.gov)
To this aim, we supplied [U-(13)C(6)]glucose to Caco-2 cells infected with the bacterial strains or mutants thereof impaired in the uptake of glucose, mannose and/or glucose 6-phosphate. (uni-muenchen.de)

Genome-wide comparative analysis of Bartonella species showed that B. ancashensis has features seen in modern and ancient lineages of Bartonella species and is more related to B. bacilliformis . (cdc.gov)
In this study, we undertook extensive genome-wide comparative analyses of twelve species that conform the Pectobacterium genus. (mdpi.com)
Renibacterium salmoninarum is the causative agent of bacterial kidney disease, a major pathogen of salmonid fish species worldwide. (usda.gov)
We exploited recent advances in Next Generation Sequencing (NGS) technology to generate genome wide single nucleotide polymorphism (SNP) data from 68 diverse R. salmoninarum isolates representing broad geographical and temporal ranges and different host species. (usda.gov)
Distinct bacterial species that cause enteric disease can exist as invasive enteropathogens that immediately evoke gastrointestinal distress, or pathobionts that can arise from established bacterial commensals to inflict dysbiosis and disease. (cdc.gov)
In this review, we present a comprehensive discussion on circulating resistance profiles and gene mobilization strategies of the most problematic species of enteric bacterial pathogens. (cdc.gov)
During the sequencing project, scientists discovered several genes that may help differentiate M. paratuberculosis from other closely related bacterial species. (innovations-report.com)
Previously, the microbe was thought to be a species of Campylobacter, the world's leading cause of bacterial diarrhoea. (thepigsite.com)
I am interested in evolutionary history and population genetics of plants and animals, especially in the reorganization of genome elements in accompany with species divergence. (helsinki.fi)
These genes which are identified could then be used in genome editing in other tree species for reforestation projects. (helsinki.fi)
Most of these genes might have transferred from bacterial species through horizontal gene transfer. (uib.no)
Evolutionary analysis of the Francisella genomes, strongly suggests that human and fish pathogenic Francisella species have evolved independently from free-living metabolically competent Francisella species. (uib.no)
Other chapters are devoted to the pathogenic mechanisms of specific bacterial species (e.g. (cshlpress.com)
Sub-objective 2.B: Discover and characterize genes involved with interactions between bacterial species. (usda.gov)
many bacterial species may be involved, with the pathogens being members of a broader community of plant-associated microbes. (usda.gov)
16S sequencing is performed to determine which bacterial species are present in a clinical sample or isolate. (folkhalsomyndigheten.se)
Each individ- cluding immune cells, but also the was previously cal ed the gastroin- ual harbours hundreds of different metabolic and nervous systems), testinal flora or microflora, the more species, most of which have not and protecting against pathogens pragmatic term "microbiota" is now yet been cultured. (who.int)
The microbiome, the "other ge- species have no representative in nome" or "second genome" of the culture collections. (who.int)
A catalogue of 178 reference bacterial birth, and the delivery type is the first core of species has been identified genomes distributed among different factor that has an impact. (who.int)

campestris (Xcc) genomes, but 245 genes apparently specific to Xoo were identified. (nih.gov)
The presence of these genes provides insights into the interactions of this pathogen with its gramineous host. (nih.gov)
In addition to the intrinsic mechanisms of resistance, bacterial pathogens can acquire genes and mutations that mediate resistance to antibiotics. (futurelearn.com)
Genes belonging to proteases, bacterial exporters and DNA stabilization were found to be under strong positive selection, thus facilitating pathogenicity and survival of the outliers. (frontiersin.org)
The genome sequence sheds new light on the genes and biochemical pathways in the bacterium, and the research offers a starting point for defining the mechanisms by which the organism causes disease and helping devise new strategies to detect infected animals and ultimately help control the spread of the organism. (innovations-report.com)
The analysis of the M. paratuberculosis genome found that its sequence contains nearly 5 million base pairs that are represented on a large circular chromosome with more than 4,500 predicted genes. (innovations-report.com)
The identification of all of the genes and key metabolic pathways in this organism may serve to explain some of the unique aspects of the biology of the pathogen, including its slow growth in laboratory culture (it may take up to six months to identify by growth in laboratory culture). (innovations-report.com)
I am interested in the evolutionary biology and especially how genes and genomes evolve. (helsinki.fi)
Comparing the novel genome with other available Francisella genomes, we found around 2.5% of unique genes present in Francisella noatunensis subsp. (uib.no)
Comparative analysis between human and fish pathogen also provide insights into genes responsible for pathogenecity. (uib.no)
Conclusions: The fish pathogen has lost non-essential genes some time ago. (uib.no)
Virulence genes are identified by genetic screens as well as by analysis of the completed genome. (stjude.org)
Remarkably, the majority of MTB genes found by this analysis to be required for survival are constitutively expressed rather than regulated by macrophages, revealing the host-adapted lifestyle of an evolutionarily selected intracellular pathogen. (harvard.edu)
2.A: Discover and characterize genes that contribute to disease and/or host adaptation of bacterial soft rot pathogens. (usda.gov)
Barrier agains t pathogen s gut bacterial genes in the MetaHIT ation when attempting to extrapolate [10], although Proteobacteria, Ver- catalogue were also well represent- results obtained in mouse models to rucomicrobia, and Fusobacteria are ed in the other metagenomes that the situation in humans. (who.int)
In 2014, the MetaHIT consortium by bacteria of the genera Lacto- alytical method used: 66 from 16S published an integrated catalogue bacillus , Prevotella , and Sneathia , rDNA sequencing [11] or 57 from of 10 million bacterial genes de- whereas for infants delivered by whole-metagenome sequencing [5]. (who.int)

It aims to sequence the genomes of 100,000 infectious microorganisms to create a database of bacterial genome sequences for use in public health, outbreak detection, and bacterial pathogen detection. (wikipedia.org)
The 100K Pathogen Genome Project was selected by the IBM/Mars Food Safety Consortium for metagenomic sequences. (wikipedia.org)
When they do this, occasionally mistakes in the DNA sequences get included (e.g. an A gets replaced with a C). These mistakes only happen very rarely, but the very large population sizes (billions and trillions) of bacteria, means that this happens frequently enough that occasionally these mutations are present in bacterial populations in the presence of antibiotics. (futurelearn.com)
The 100K Genome Project has added 20 newly completed genome sequences of foodborne pathogens generated using Pacific Biosciences' single-molecule sequencing technology to the National Center for Biotechnology Information's public database. (genomeweb.com)
The researchers also found that the chromosome has a large number of sequences repeated throughout the genome. (innovations-report.com)
His observation is based on comparing the genome sequence of A. butzleri with other sequences posted on the World Wide Web. (thepigsite.com)
Binning of the metagenomic sequences allowed de novo assembly of mulitple high quality genomes of different endophytic bacterial genera. (apsnet.org)
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount of information concerning their metabolic potential. (uni-muenchen.de)
Metagenomics using the latest high-throughput sequencing technologies and some smart bioinformatics, allows us to detect and characterize the bacteria that cause TB in a matter of a day or two, without having to grow the bacteria, while also giving us key insights into their genome sequences and the lineages that they belong to. (news-medical.net)
In contrast to metagenomic detection of unknown pathogens which sequences all available genetic material, 16S sequencing specifically targets the small ribosomal subunit. (folkhalsomyndigheten.se)
has been identified as the 2nd most consensus (ERIC) sequences which · 60 environmental samples were tak- frequent organism causing ventilator- are common to Gram-negative enteric en throughout the ICU, including associated pneumonia, the 4th most bacteria [11,12]. (who.int)

Jörg Vogel researches regulatory RNA molecules in bacterial pathogens such as Salmonella and in affected human cells. (uni-wuerzburg.de)

This information provides the public, academia, industry, public health partners and regulatory agencies with timely data on pathogen trends and serotype details to inform work to prevent illnesses from food, water, the environment, and animal contact. (cdc.gov)
Population-level data on pathogen genomes in turn supports the development of more precise and efficient clinical diagnostics. (cdc.gov)

As bacteria grow and replicate they copy their genetic material (the genome). (futurelearn.com)
A bacterial isolate is a group of the same type of bacteria. (cdc.gov)
University of Minnesota researchers, with collaborators at the U. S. Department of Agriculture s National Animal Disease Center in Ames, Iowa, have completed sequencing the genome of the bacteria that causes Johne s disease, a major chronic wasting disease found in dairy cattle. (innovations-report.com)
On episode #1 of This Week in Microbiology, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact. (virology.ws)
As a novel antibacterial agent against foodborne pathogens, endolysins are peptidoglycan hydrolases encoded by bacteriophages that lyse bacterial cells by targeting their cell wall, notably in Gram-positive bacteria due to their naturally exposed peptidoglycan layer. (usda.gov)
To address this, we will use genome sequencing methods to characterize populations bacteria present in diseased crops. (usda.gov)
To address this, we will first identify and characterize factors that bacteria use to cause disease and then use that information to guide discovery of bacterial control strategies. (usda.gov)
In our projects we look into bacterial infection and inflammation, fundamental problems in bacterial cell biology, heme proteins, stress responses, and adaptation in bacteria. (lu.se)

PLoS Pathogens Apr. (virology.ws)

The Smith Lab @ Duke MGM investigate the host-pathogen interactions that underlie tuberculosis infection. (duke.edu)
This is especially important in the context of host-pathogen interactions, in which a holistic view of the biological system can aid in better understanding the system in ways to provide alteration, like the development of novel treatment therapeutics. (biomedcentral.com)

Bart Weimer, the project's director and a professor at UC Davis, told In Sequence this week that these first 20 genomes represent a gearing-up phase for the project, in which his team worked through the logistics of automating its PacBio sequencing protocol for an acceleration of the project over the next year. (genomeweb.com)
The sequencing project represents part of an ambitious "microbial pathogenomics" research program at the University of Minnesota to sequence the genomes of a wide range of human and animal pathogens and use this information as a basis to understand the mechanisms by which they cause disease. (innovations-report.com)
Based at the ARS Western Regional Research Center in Albany, California, near San Francisco, he did the genome-sequencing work with colleagues there and with others in the United States and abroad. (thepigsite.com)
His article on sequencing the complete A. butzleri genome appeared in 2007 in the online journal, PloS ONE . (thepigsite.com)
Next-generation sequencing is applicable across the spectrum of important pathogens in public health. (cdc.gov)
Other applications for next-generation sequencing in public health include insecticide resistance in mosquito vectors of disease, monitoring streptococcal pathogens, and investigating potential clusters of meningitis. (cdc.gov)
[ 3 ] Genome sequencing has been performed. (medscape.com)
During this time, he pioneered the use of single-molecule sequencing for the reconstruction of complete genomes. (nottingham.ac.uk)
The US public health system is integrating pathogen genome sequencing into infectious disease surveillance with support from the Advanced Molecular Detection (AMD) program established by Congress at the Centers for Disease Control and Prevention (CDC) in 2014. (cdc.gov)
Although microbial genomes are generally smaller and less complex than human genomes, long-read sequencing technologies (such as single-molecule real-time (SMRT) sequencing, Pacific Biosciences, Menlo Park, CA) are useful for constructing complete, highly accurate genomes and sorting out plasmids, repeats, and other complex regions. (cdc.gov)
Because of device portability, fast sample preparation, flexibility, and relatively low cost, nanopore sequencing is becoming a feasible first-line strategy for pathogen sequencing in clinical and public health settings. (cdc.gov)
Metagenomic sequencing is offered in cases where infection is suspected but other methods have failed to identify a pathogen. (folkhalsomyndigheten.se)
By sequencing the entire genome, a comprehensive understanding of the genetic composition is obtained. (folkhalsomyndigheten.se)

and the US Food and Drug Administration, aims to sequence 100,000 bacterial and viral genomes overall. (genomeweb.com)
GrapeTree: Visualization of core genomic relationships among 100,000 bacterial pathogens. (cdc.gov)

Bartonelloses are major emerging infectious bacterial diseases because of the high prevalence of chronic Bartonella infections in mammals and humans and their increasing risk for infection of immunocompromised populations ( 1 - 4 ). (cdc.gov)
Over time, the biological scope of the research has widened from studying a single clone (Col-0) to looking at (gut) ecosystem and finally at NTU to the analysis of all plant genomes and (some) populations in an entire patch of rainforest. (helsinki.fi)
[ 5 ] The biotype 3 group of the human pathogen V vulnificus may have emerged in Israel due to genome hybridization of 2 bacterial populations. (medscape.com)
Bacterial diseases of potato and onion alone cause more than $60M in losses annually in the U.S. Despite the extensive amount of research available on bacterial plant pathogens, there is a lack of understanding about how bacterial plant pathogens enter and move within crop production systems and to what degree these diseases are caused by endemic populations. (usda.gov)
Large-Scale Simulations of Bacterial Populations Over Complex Networks. (cdc.gov)

however, the project has also produced closed genomes for a variety of enteric pathogens in the 100K bioproject. (wikipedia.org)
WGS has been widely acknowledged as a promising high-resolution typing tool for enteric pathogens. (who.int)
4-6 In Australia, several jurisdictional reference laboratories are developing WGS capacity and evaluating its utility for routine surveillance of enteric pathogens. (who.int)

But, caveats aside, let's celebrate the fact that metagenomics stands ready to document past and present infections, shedding light on the emergence, evolution and spread of microbial pathogens! (news-medical.net)
It is the most important type of antibacterial agent for fighting bacterial infections , and antibiotic medications are widely used in the treatment and prevention of such infections. (wikipedia.org)
Antibiotics are used to treat or prevent bacterial infections, [29] and sometimes protozoan infections . (wikipedia.org)

The major focus of this research is the molecular pathogenesis of invasion and inflammation induced by Streptococcus pneumoniae, the leading invasive bacterial pathogen of children. (stjude.org)
While the genome sequence was already transformative at the time, the past 25 years of progress have substantially increased its impact on TB taxonomy, drug discovery, resistance mechanisms, epidemiology, vaccine development, and pathogenesis. (jci.org)

The 100K Pathogen Genome Project is a public-private collaborative project to sequence the genomes of 100,000 infectious microorganisms. (wikipedia.org)

To control this pathogen, copper-based pesticides. (genomebc.ca)
To control this pathogen, it is critical to understand its cold tolerance because poultry products are usually distributed in the cold chain. (usda.gov)

We sequenced and constructed the complete genome of an environmental strain CR1 of P. aeruginosa and performed the comparative genomic analysis. (frontiersin.org)

This strategy enables worldwide collaboration to identify sets of genetic biomarkers associated with important pathogen traits. (wikipedia.org)
The genetic information reported in this paper will aid future outbreak investigation and improve our understanding of bacterial kidney disease transmission. (usda.gov)
Want to learn more about new bacterial genetic technologies? (duke.edu)
The host specificity of bacterial pathogens and the genetic basis of susceptibility are also considered. (cshlpress.com)

Genome Med, Aug 1, 2018. (cdc.gov)

In time, laboratories may be able to replace many traditional microbiology processes with a single workflow that accommodates a wide array of pathogens. (cdc.gov)

Bacterial illnesses such as tuberculosis, pneumonia, typhoid fever, meningitis, and dysentery are some of the most devastating worldwide. (cshlpress.com)
the complete genome sequence of Mycobacterium tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB), the leading cause of global infectious disease mortality. (jci.org)
At the 25-year anniversary of this accomplishment, we describe how insights gleaned from the M. tuberculosis genome have led to vital tools for TB research, epidemiology, and clinical practice. (jci.org)
The M. tuberculosis genome has ushered in a quarter century of substantial clinical and public health advancements. (jci.org)
Mycobacterium tuberculosis (MTB) has successfully exploited macrophages as its primary niche in vivo, but the bacterial genome-wide requirements that promote its intracellular survival remain undefined. (harvard.edu)

(http://apps.who.int/gb/ebwha/pdf_files/WHA68-REC1/A68_R1_REC1-en.pdf#page=1, accessed 18 April 2016). (who.int)

Facing multidrug resistant (MDR) bacterial pathogens is one of the most important challenges for our society. (unige.ch)

Aim Campylobacter is the leading bacterial pathogen that causes foodborne illnesses worldwide. (usda.gov)

Objective 1: Identify genomic resources for development of diagnostics and detection tools for emerging and re-emerging bacterial plant pathogens. (usda.gov)
Objective 2: Characterize biology and virulence factors of bacterial plant pathogens and identify their targets in host plants. (usda.gov)
Little is known about the relationships and interactions of plant pathogens with the host, the microbial community, and the environment and the impact on disease outcome. (usda.gov)

Surprisingly, the metabolism of the host cells, as judged by the efficiency of (13)C-incorporation into host cell amino acids, was not significantly affected by the infection with either of these intracellular pathogens. (uni-muenchen.de)

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology of these pathogens, their virulence mechanisms, and the host's response to infection. (cshlpress.com)
However, our knowledge of the actual metabolic pathways and metabolite fluxes occurring in these pathogens under infection conditions is still limited. (uni-muenchen.de)
Earlier this year, they recovered the genome of Brucella melitensis, which causes an infection called brucellosis in livestock and humans, from a 700-year-old skeleton from Sardinia, Italy. (news-medical.net)
This article is about treatment of bacterial infection. (wikipedia.org)
Introduction: Early neonatal bacterial infection (ENBI) is a major concern in neonatology. (bvsalud.org)
Conclusion: Early neonatal bacterial infection is a major cause of neonatal morbidity and mortality. (bvsalud.org)

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39. (cdc.gov)

Importantly, we present emerging approaches toward surveillance of pathogens and their resistance elements as well as promising treatment strategies that can circumvent common resistance mechanisms. (cdc.gov)
Sophia David is a Postdoctoral Scientist in the Centre for Genomic Pathogen Surveillance (CGPS). (sanger.ac.uk)
We evaluated costs and benefits of routine WGS through case studies at eight reference laboratories in Europe and the Americas which conduct pathogen surveillance for avian influenza (two laboratories), human influenza (one laboratory) and food-borne pathogens (five laboratories). (eurosurveillance.org)
However, WGS brought major benefits for pathogen identification and surveillance, substantially changing laboratory workflows, analytical processes and outbreaks detection and control. (eurosurveillance.org)

Subsequent trait-based analyses revealed numerous biosynthetic gene clusters (BGCs) overrepresented in the endophytic bacterial families of plants under pathogen attack, including BGCs involved in signal transduction, extracellular enzyme and secondary metabolite production. (apsnet.org)
Ewan led the analysis of the Human Genome gene set, mouse and chicken genomes and the ENCODE project, focusing on non-coding elements of the human genome. (nottingham.ac.uk)

My PhD research used genomic data to study the evolution and population dynamics of the bacterial pathogen, Legionella pneumophila , the causative agent of Legionnaires' disease. (sanger.ac.uk)

Check out how we combine diverse Mammalian and Mycobacterial genetics to map the host-interacting with pathogen loci (hipQTL) across the genome. (duke.edu)
Read our papers on the Collaborative Cross and BXD mammalian genome panels. (duke.edu)
2010). The mammalian and bacterial STAS domains reported to day have already been monomeric in answer. (exposed-skin-care.net)

In this article, we explain the mechanisms of bacterial resistance to antibiotics. (futurelearn.com)
We will investigate bacterial communication mechanisms involved in pathogen fitness and formation of complex communities in plants to identify factors critical for disease. (usda.gov)

The patterns that emerge at the intersection of pathogen diversity and geographical location will provide key insights on disease emergence as well as identify diagnostic markers able to distinguish pathogens from non-pathogens. (usda.gov)

Since joining the laboratory in 2001 she has championed the use of molecular methods leading to improvements in the detection and investigation of bacterial foodborne disease within the UK. (nottingham.ac.uk)
This allows for the detection and characterisation of pathogens with high precision. (folkhalsomyndigheten.se)

and how the human genome can be used to understand the evolution of modern humans. (princeton.edu)
In 2015, he joined the National Human Genome Research Institute as a founding member of the Genome Informatics Section. (nottingham.ac.uk)
The first draft of the human genome and thus provides a very rich function- der healthy conditions. (who.int)

Plasmids purified from genomic DNA, proteins, ribosomes, and the bacterial cell wall are used in molecular biology research. (sigmaaldrich.com)
Genome Biology and Evolution. (lu.se)

In addition to these 3 major infectious pathogens, an increasing number of new Bartonella spp. (cdc.gov)

Salmonid bacterial kidney disease is caused by the pathogen Renibacterium salmoninarum. (usda.gov)
Integrating genome-based informatics to modernize global disease monitoring, information sharing, and response. (eurosurveillance.org)
Tannerella forsythia is an anaerobic, fusiform Gram-negative oral pathogen strongly associated with periodontitis, a multibacterial inflammatory disease that leads to the destruction of the teeth-supporting tissue, ultimately causing tooth loss. (karger.com)
He identified periodic acid-Schiff (PAS)-staining granules, most likely representing degenerating bacterial forms, within macrophages isolated from the small bowel as well as other tissue and fluid specimens (eg, pericardium, endocardium, lymph nodes, synovia, lung, brain, meninges) obtained from patients in whom Whipple disease was suspected. (medscape.com)

Genomes contain information from the past, from different climate conditions, and this may help in identifying future "evolutionary winners and losers" and hopefully suggest ways to prevent the impending loss of biodiversity. (helsinki.fi)

The 100K Pathogen Genome Project was launched in July 2012 by Bart Weimer (UC Davis) as an academic, public, and private partnership. (wikipedia.org)
The 100K Genome Project will provide a roadmap for developing tests to identify pathogens and trace their origins more quickly. (wikipedia.org)
100K Pathogen Genome Project GOLD:Genomes OnLine Database Genome Project Database SUPERFAMILY The sea urchin genome database NRCPB. (wikipedia.org)
Jonas Korlach, PacBio's chief scientific officer, told In Sequence that PacBio and the 100K genomes team have been working with several vendors to adapt fluidic robot technology to automate library preparation steps. (genomeweb.com)
A third advance, which was not in play for the 20 genomes the 100K project just released - but which Korlach said is being incorporated into the workflow moving forward - is upfront DNA size selection using Sage Science's BluePippin platform, which PacBio agreed to co-market earlier this year. (genomeweb.com)

WGS data analysis can explain the spatiotemporal patterns of pathogen transmission. (unige.ch)
however, as evidenced by genome sequence analysis, the organism lacks common enzymes required for the de novo synthesis of precursors of PGN, which rationalizes its MurNAc auxotrophy. (karger.com)

Bacterial Peptidoglycan Traverses the Placenta to Induce Neuroproliferation and Aberrant Postnatal Behavior. (stjude.org)
For axenic growth under laboratory conditions, it specifically relies on the external supply of N -acetylmuramic acid (MurNAc), which is an essential constituent of the peptidoglycan (PGN) of bacterial cell walls. (karger.com)

Anatomy14

Organisms48

Diseases12

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes120

Disciplines and Occupations4

Technology, Industry, Agriculture6

Information Science12

Health Care4

Whole-genome28

Genomics9

Antimicrobial8

Strains5

Species19

Genes16

Sequences11

Salmonella1

Data on pathogen2

Bacteria8

Plos Pathogens1

Host-pathogen interactions2

Sequencing13

100,000 bacterial2

Populations5

Enteric pathogens3

Infections3

Pathogenesis2

Sequence the genomes1

Control this pathogen2

Constructed the complete genome1

Genetic4

20181

Microbiology1

Tuberculosis5

20161

Multidrug-resistant1

Campylobacter1

Plant Pathogens3

Intracellular pathogens1

Infection6

Annotation1

Surveillance4

Gene2

Causative agent1

Mammalian3

Mechanisms2

Insights1

Detection2

Human genome3

Biology2

Infectious1

Disease4

Evolutionary1

100K5

Analysis2

Peptidoglycan2