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Brucella abortusBrucellosisBrucellaBrucella melitensisBacteriaBrucella VaccineBrucella ovisBrucella canisBrucellosis, BovineGram-Negative BacteriaGram-Positive BacteriaBacteria, AnaerobicDNA, BacterialBacterial ProteinsMolecular Sequence DataRNA, Ribosomal, 16SPinnipediaPhylogenyBacteria, AerobicSequence Analysis, DNAOchrobactrum anthropiEscherichia coliDNA, RibosomalAntibodies, BacterialCetaceaGenes, BacterialGene Expression Regulation, BacterialAnti-Bacterial AgentsGenome, BacterialVirulenceCulture MediaAntigens, BacterialColony Count, MicrobialAgglutination TestsWater MicrobiologyBacterial Typing TechniquesSpecies SpecificityGram-Negative Anaerobic BacteriaBacterial Outer Membrane ProteinsRNA, BacterialGram-Negative Aerobic BacteriaBacterial Physiological PhenomenaSheep Diseases
BrucellosisAbortusCanisMelitensisPathogensGenusInfectionBacillusSalmonellaBartonellaFungiOrganismsListeriaAnti-Brucella treatmentAntibodiesBacterialVirusesGram-negativeYersiniaPathogenic bacteriaSuisMeningitisInfectionsCoxiellaAerobicIncubation periodStrainHumansGoatsPlagueContagiousMacrophagesVaccinesCetiAntibioticSymptomsAnaerobicPinnipedialisReproductiveContact with infected animalsAnthraxMilkBison
Brucellosis26
Abortus20
  • Research carried out with the participation of the University of Navarra has shown how a determinate molecule helps an important pathogen, Brucella abortus, escape destruction within the cells charged with eliminating infectious agents (macrophages). (sciencedaily.com)
  • Brucella abortus virulent strain S2308 was obtained from our laboratory collection [ 22 ]. (hindawi.com)
  • The most common animal host of Brucella abortus is the cow. (sciences360.com)
  • Brucella abortus causes spontaneous abortion in cattle. (sciences360.com)
  • Brucella abortus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Brucella abortus" by people in Harvard Catalyst Profiles by year, and whether "Brucella abortus" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Brucella abortus" by people in Profiles. (harvard.edu)
  • Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization. (harvard.edu)
  • Brucella abortus depends on pyruvate phosphate dikinase and malic enzyme but not on Fbp and GlpX fructose-1,6-bisphosphatases for full virulence in laboratory models. (harvard.edu)
  • B Lymphocytes provide an infection niche for intracellular bacterium Brucella abortus. (harvard.edu)
  • Other vaccines, such as Brucella abortus S19 for cattle and B. melitensis Rev-1 for sheep and goats, can also cause infection in humans. (cdc.gov)
  • Brucella are gram-negative coccobacilli that commonly infect cows (Brucella abortus), pigs (Brucella suis), goats (Brucella melitensis), and dogs (Brucella canis), along with wild animals such as deer, elk, and moose. (loinc.org)
  • The main pathogenic species of Brucella are Brucella melitensis, Brucella suis and Brucella abortus. (loinc.org)
  • Brucella abortus is a species of the genus Brucella. (loinc.org)
  • Wild bison and elk in the Greater Yellowstone Area are the last remaining reservoir of the bacterium Brucella abortus in the United States. (ens-newswire.com)
  • On May 26-27, 1997, nine persons (a farmer, four veterinary clinicians, and four veterinary students) in Manhattan, Kansas, participated in an attempted vaginal delivery, a cesarean delivery, and a necropsy on a stillborn calf that died because of Brucella abortus infection. (cdc.gov)
  • We report the complete genome sequence of Brucella abortus field isolate 9-941 and compare it to those of Brucella suis 1330 and Brucella melitensis 16 M. The genomes of these Brucella species are strikingly similar, with nearly identical genetic content and gene organization. (nih.gov)
  • The complete genomic sequence of B. abortus provides an important resource for further investigations into determinants of the pathogenicity and virulence phenotypes of these bacteria. (nih.gov)
  • C57BL/6 mice were immunized and challenged with B. abortus, showing lower recovery in the number of viable bacteria in the liver, spleen, and axillary lymph node and greater production of IgG and fractions when compared to non-vaccinated mice. (bvsalud.org)
  • Finally, people can become infected with Brucella RB51, a strain of B abortus that is used to vaccinate cattle in the United States and other parts of the world. (medscape.com)
Canis12
  • A new government risk assessment updated on Monday (18 September) found 97 dogs had tested positive for the Brucella canis bacteria in the year to June, largely linked to pets brought in from overseas. (scotsman.com)
  • But what is the risk of a person picking up Brucella canis, and how safe are dogs at home? (scotsman.com)
  • How is the Brucella canis bacteria affecting dogs in the UK? (scotsman.com)
  • The number of dogs who have tested positive for the Brucella canis bacteria has been steadily rising since 2020 - largely linked to pets being brought in from overseas. (scotsman.com)
  • The UK's chief veterinary officer, Dr Christine Middlemiss, said: "We take the risks posed by Brucella canis very seriously and require all cases to be reported to the Animal Plant Health Agency. (scotsman.com)
  • We continue to work closely with our colleagues at [the UK Health Security Agency], dog welfare groups and vets to minimise the risks posed and recommend prospective owners make sure any dog imported from regions where Brucella canis is present is tested before arrival. (scotsman.com)
  • If considering importing a dog into the UK (or rescuing a dog that has been imported) we recommend prospective owners ensure testing for other diseases including Brucella canis is carried out before the movement takes place. (scotsman.com)
  • The UK Health Security Agency (UKHSA) says there have been three cases of humans becoming infected with Brucella canis since 2022. (scotsman.com)
  • What Is Brucella Canis? (v4vg.com)
  • Dr. Kevin MacAulay, president of the Alberta Veterinary Medical Association, said Calgary has already had a case in which rescue dogs from the U.S. and Mexico infected others with Brucella canis, which affects the reproductive organs in dogs and can cause miscarriages in humans. (cbc.ca)
  • In this case, dogs brought in from the southern United States and Mexico in 2014 carried Brucella canis , bacteria that causes a disease that infects the reproductive organs in dogs, and can cause miscarriages in humans. (cbc.ca)
  • However, B canis and Brucella RB51 won't show up on serology, so culture is needed to confirm the infection. (medscape.com)
Melitensis3
Pathogens5
  • Raw milk and milk products from cows, goats, and sheep continue to be a source of bacterial infections attributable to a number of virulent pathogens, including Listeria monocytogenes, Campylobacter jejuni, Salmonella species, Brucella species, and Escherichia coli O157. (aap.org)
  • Additionally, Brucella is highly infectious through the aerosol route, thus is considered as one of the most common laboratory-acquired pathogens and is also classified as a category B agent on the biodefense list ( 4 ). (frontiersin.org)
  • Ticks, for example, transfer bloodborne pathogens, such as the bacteria that causes Lyme disease , from an infected animal to other animals and humans, according to the Global Lyme Alliance . (livescience.com)
  • Some of these furry refugees carry parasites, bacteria and viruses rarely seen in this country - pathogens that could pose a serious threat to local pets, wildlife and people. (cbc.ca)
  • Non-point source pollution including excess nutrients, organic particles, fecal coliform bacteria, and additional pathogens is considered high risk at many animal operations, especially equine facilities. (umass.edu)
Genus3
  • The past decade, however, has seen a rapid expansion of both known members of the Brucella genus and the variety of associated animal hosts, which now range from mammals to amphibians and fish ( 4 ). (cdc.gov)
  • A species of the genus BRUCELLA whose natural hosts are cattle and other bovidae. (harvard.edu)
  • It is caused by various species of the bacterial genus Brucella , which mainly infect domestic animals, especially goats, sheep, and cows, and use them as natural reservoirs. (frontiersin.org)
Infection11
  • The immune response against Brucella infection involves many molecules and cells to trigger a Th1 immune response and activation of CD8+ T cells [ 12 - 14 ]. (hindawi.com)
  • Moreover, our group and others have demonstrated that MyD88 is essential for host control of Brucella infection in vivo and the induction of proinflammatory cytokines [ 21 ]. (hindawi.com)
  • So far, no study has demonstrated the role of NOD-like receptors in the control of Brucella infection. (hindawi.com)
  • This is a zoonotic infection with the bacterium caught from animal products. (sciences360.com)
  • Serological testing for antibodies to Brucella will also indicate infection. (sciences360.com)
  • Aborted puppies will typically show signs of generalized infection, with the female presenting a brownish or green-grey discharge and being highly contagious with the bacteria for several weeks. (akc.org)
  • These bacteria go on to spread the infection to other human cells. (medicinenet.com)
  • A Brucella infection in dogs is considered very difficult to treat, and may never be fully cured. (scotsman.com)
  • A common route of Brucella infection is eating or drinking infected dairy products that have not been pasteurized. (loinc.org)
  • In Egypt, a cross-sectional study found that 11% of the population had serological evidence of infection with Brucella spp. (who.int)
  • The remainder of the lation had serological evidence of infection physical examination, including the neuro- with Brucella spp. (who.int)
Bacillus4
  • The bacterium is a gram-negative bacillus. (sciences360.com)
  • The basic premise behind these traditional fermented foods is this: lacto-bacillus bacteria cultures take over the food, producing lactic acid. (foodrenegade.com)
  • And, if people wanted to add a starter culture to the ferment to help make sure the lacto-bacillus bacteria could take off quickly, she recommended using whey strained from yogurt or raw milk. (foodrenegade.com)
  • The contamination can be from spores of Bacillus cereus, a bacterium that produces toxins that cause food poisoning. (thefashionablehousewife.com)
Salmonella3
  • For example, amphibians and reptiles normally have bacteria, like salmonella, that don't cause illness in the pet, but they may cause illness in people. (cdc.gov)
  • Other zoonoses, like salmonella, are bacteria that are also passed through a fecal-oral route from animals to people. (cdc.gov)
  • These bacteria include Salmonella, Listeria, and E. coli . (thefashionablehousewife.com)
Bartonella2
  • Diseases that move through animal bites or scratches include bacteria like Bartonella that cause cat scratch fever, viruses that cause rabies, or diseases like ringworm that are caused from fungi. (cdc.gov)
  • Dark field microscopy and various blood culturing techniques have demonstrated the presence of numerous bacteria and fungi circulating in the bloodstreams of healthy people, including Bartonella , Brucella , and Candida . (alive.com)
Fungi3
  • Chronic infectious arthritis develops over weeks and is usually caused by mycobacteria, fungi, or bacteria with low pathogenicity. (merckmanuals.com)
  • In the following list, the micro-organisms written in italics are bacteria, mycoplasma, rickettsia or fungi. (searates.com)
  • they can be caused by viruses , bacteria , parasites or fungi, and may cause mild or severe illness or death. (livescience.com)
Organisms4
  • Brucella penetrates the macrophages within membranous vesicles that are not fused with lysosomes (structures containing cellular products necessary to destroy bacteria) as occurs in other micro-organisms. (sciencedaily.com)
  • Strains of highly pathogenic Brucella have been considered to be used as a biological weapon because the organisms can be aerosolized and then easily inhaled. (medicinenet.com)
  • Although this risk is generally associated with people who work in laboratories studying Brucella organisms, it is possible that people working in meat-processing areas could be exposed to the bacteria by inhalation of droplets from contaminated meat (cattle, sheep). (medicinenet.com)
  • among large-animal practice respondents, 23% had accidentally self-injected vaccines containing live Brucella organisms. (cdc.gov)
Listeria1
  • Trimethoprim-sulfamethoxazole (TMP-SMX) is effective against many aerobic gram-positive and gram-negative bacteria, but its use in bacterial meningitis is limited to patients with Listeria monocytogenes meningitis who have a penicillin allergy. (medscape.com)
Anti-Brucella treatment2
  • Prior to transfer to the Chest Hospital, the patient was advised to continue anti-Brucella treatment for 3 months. (who.int)
  • 37 a14 days after start of anti-Brucella treatment. (who.int)
Antibodies2
  • According to health authorities on Tuesday, 3,245 people have tested positive for Brucella bacteria antibodies out of 21,847 people tested so far in Lanzhou, the South China Morning Post (SCMP) reported . (breitbart.com)
  • At least 210 employees of the Lanzhou Veterinary Research Institute, located just a few hundred meters from the plant, tested positive for Brucella bacteria antibodies. (breitbart.com)
Bacterial4
  • Characterization of the 2 bacterial isolates revealed that they represent a potential new species of Brucella . (cdc.gov)
  • The dimorphic bacterium Caulobacter crescentus is a model organism for studying the bacterial cell cycle. (csun.edu)
  • Similarly, since 1990 there has been mounting evidence that abnormal calcification may be caused by a bacterial organism about 1/100 the size of a conventional bacterium, called Nanobacterium sanguineum ("nano" is the Latin word for very small or minute). (alive.com)
  • Tetracyclines inhibit protein synthesis and, therefore, bacterial growth by binding with 30S and possibly 50S ribosomal subunits of susceptible bacteria. (medscape.com)
Viruses1
Gram-negative6
Yersinia1
  • Plague is a disease caused by Yersinia pestis ( Y. pestis ), a bacterium found in rodents and their fleas in many areas around the world. (cdc.gov)
Pathogenic bacteria2
  • Targeting intracellular pathogenic bacteria with unnatural proline-rich peptides: coupling antibacterial activity with macrophage penetration. (harvard.edu)
  • Caulobacter in contrast, as an alpha-proteobacteria, is closely related to human pathogenic bacteria, such as Brucella and Rickettsia . (csun.edu)
Suis1
  • Brucella suis are differentiated into five strains. (loinc.org)
Meningitis6
  • But, despite the frequent finding of Brucella bacteraemia, as far as we know the agent has not been previously reported in the medical literature as a cause of meningitis in Egypt. (who.int)
  • The current case thus represents the first report of cerebrospinal fluid (CSF) culture-positive Brucella meningitis in Egypt. (who.int)
  • The patient had some improvement in his clinical condition after anti-tuberculosis treatment, but once the diagnosis of Brucella meningitis was made, antibiotic therapy was changed to doxycycline (200 mg/day), trimethoprim/sulfmethoxazole (TMX/SMP) (2 double-strength tablets every 12 hours) and rifampicin (900 mg/day). (who.int)
  • This is the first reported case of Brucella meningitis in Egypt and illustrates many of the difficulties in diagnosing chronic meningitis. (who.int)
  • The use of doxycycline in meningitis is limited to cases of Brucella or rickettsial meningitis. (medscape.com)
  • 1). Samples of blood and CSF were sent to positive Brucella meningitis in Egypt. (who.int)
Infections2
  • Brucella infections respond to treatment with the antibiotics doxycycline combined with rifampacin. (sciences360.com)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of doxycycline capsules and other antibacterial drugs, doxycycline capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
Coxiella1
Aerobic1
  • Most infected dog- and cat-bite wounds contain mixed aerobic and anaerobic bacteria. (cdc.gov)
Incubation period2
  • Once infected with Brucella the incubation period can be from one to two months. (sciences360.com)
  • Although acquired outside the United States, these cases are not diagnosed until after the patient has returned home, due to the long incubation period for Brucella . (medscape.com)
Strain2
  • The strain S2308 was grown in Brucella Broth liquid medium (BB) (DIFCO) at 37°C under constant agitation. (hindawi.com)
  • RNA sequencing was performed in primary human macrophages (Mφ) and polymorphonuclear neutrophils (PMNs) infected with a clinical strain of Brucella spp. (frontiersin.org)
Humans5
  • Recently described Brucella species include B. ceti (cetaceans), B. pinnipedialis (pinnipeds), B. inopinata (humans), B. microti (voles), B. papionis (baboons), and B. vulpis (foxes). (cdc.gov)
  • The bacteria can also infect humans through breaks in the skin or through the mucous membranes. (medicinenet.com)
  • The bacteria, which can cause infertility in dogs, has also been discovered in two humans so far this year - making three total cases of people becoming infected in the UK. (scotsman.com)
  • The bacterium is transmissible to humans through contact with infected dairy products or tissue. (loinc.org)
  • In order to keep the animals away from humans they were placed in containers on dinghies - and had either bombs containing germs dropped on them or were sprayed with the deadly bacteria. (bbc.co.uk)
Goats1
  • If animals like sheep, goats, buffalo, cows, or camels are infected with Brucella , the milk they produce is contaminated with the bacteria. (medicinenet.com)
Plague4
  • One to six days after becoming infected with the bacteria, people would develop pneumonic plague. (cdc.gov)
  • If bubonic plague is not treated, however, the bacteria can spread through the bloodstream and infect the lungs, causing a secondary case of pneumonic plague. (cdc.gov)
  • Pneumonic plague may also occur if a person with bubonic or septicemic plague is untreated and the bacteria spread to the lungs. (cdc.gov)
  • How quickly would someone get sick if exposed to plague bacteria through the air? (cdc.gov)
Contagious1
  • Because of the delay between being exposed to the bacteria and becoming sick, people could travel over a large area before becoming contagious and possibly infecting others. (cdc.gov)
Macrophages1
  • Brucella infects macrophages and evades clearance mechanisms, thus resulting in chronic parasitism. (frontiersin.org)
Vaccines2
  • Local health authorities announced on December 26 that the Lanzhou Biopharmaceutical Plant, a unit of the state-run China Animal Husbandry Industry, "used expired sanitizers while producing Brucella vaccines between July 24 and August 20" last year. (breitbart.com)
  • Following an investigation into the scandal, Chinese government officials revoked the plant's license to manufacture Brucella vaccines and reprimanded eight of its senior managers, according to SCMP. (breitbart.com)
Ceti1
Antibiotic1
  • However, the bacterium is difficult to detect in early stages with antibiotic treatment affecting the results. (akc.org)
Symptoms1
  • People infected with the Brucella bacteria usually develop symptoms similar to a severe influenza which may include fever, chills, drenching sweats, headache, back pain, physical weakness and loss of weight and appetite. (gov.hk)
Anaerobic1
  • Fastidious Anaerobe Agar w/ Horse Blood (FAA-HB) is a plated medium used for the cultivation and antimicrobial susceptibility testing (AST) of anaerobic bacteria. (launchdiagnostics.com)
Pinnipedialis4
Reproductive1
  • In dogs, the bacteria tend to attack the reproductive organs (steroid-dependent tissues) but can also migrate to the eyes, spinal column, liver, spleen, and lymph nodes. (akc.org)
Contact with infected animals1
  • Bacteria are transmitted through direct contact with infected animals or an environment contaminated with discharges from infected animals, particularly during abortion or calving. (utah.gov)
Anthrax1
  • The top secret germ warfare trials, which resulted in the deaths of thousands of animals for little scientific benefit, involved anthrax and the brucella bacteria. (bbc.co.uk)
Milk7
  • Unpasteurized soft cheeses can present a risk and milk to produce such cheese is often sourced from certified Brucella free herds. (sciences360.com)
  • Since young children are at big risk for getting sick from any bacteria that may be in raw milk and they need vitamin D, it is important that you not give your child raw, unpasteurized cow's milk. (keepkidshealthy.com)
  • And remember that you are basically giving raw milk to your kids because you think it tastes better, as it certainly isn't better for them, is missing key nutrients, and it could be contaminated with dangerous bacteria. (keepkidshealthy.com)
  • Milk bacteria [ incl. (nih.gov)
  • Raw milk and raw milk products (such as cheeses and yogurts made with raw milk) can be contaminated with bacteria that can cause serious illness, hospitalization, or death. (marlerblog.com)
  • These outbreaks included a total of 1,505 reported illnesses, 185 hospitalizations and 2 deaths.These harmful bacteria can seriously affect the health of anyone who drinks raw milk, or eats foods made from raw milk. (marlerblog.com)
  • However, the bacteria in raw milk can be especially dangerous to pregnant women, children, the elderly, and people with weakened immune systems. (marlerblog.com)
Bison1
  • Commonly infected animals that are hunted that may contain Brucella are caribou, moose, wild hogs (feral hogs), elk, and bison. (medicinenet.com)